Amot

Summary

Gene Symbol: Amot
Description: angiomotin
Alias: CAG-2, D0Kist1, Sii6, angiomotin
Species: mouse
Products:     Amot

Top Publications

  1. Ernkvist M, Birot O, Sinha I, Veitonmaki N, Nyström S, Aase K, et al. Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells. Biochim Biophys Acta. 2008;1783:429-37 pubmed publisher
    We have previously shown that angiomotin (Amot) plays an important role in growth factor-induced migration of endothelial cells in vitro...
  2. Yi C, Troutman S, Fera D, Stemmer Rachamimov A, Avila J, Christian N, et al. A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell. 2011;19:527-40 pubmed publisher
    ..We have identified a tight-junction-associated protein complex comprising Merlin, Angiomotin, Patj, and Pals1...
  3. Bratt A, Wilson W, Troyanovsky B, Aase K, Kessler R, Van Meir E, et al. Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Gene. 2002;298:69-77 pubmed
    b>Angiomotin has previously been identified in a yeast two-hybrid screen by its ability to bind to angiostatin, an inhibitor of novel formation of blood vessels (angiogenesis)...
  4. Levchenko T, Bratt A, Arbiser J, Holmgren L. Angiomotin expression promotes hemangioendothelioma invasion. Oncogene. 2004;23:1469-73 pubmed
    b>Angiomotin was identified by its ability to bind angiostatin and has been shown to mediate its activity in vitro...
  5. Zhao B, Li L, Lu Q, Wang L, Liu C, Lei Q, et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 2011;25:51-63 pubmed publisher
    ..Here we report a novel mechanism of YAP regulation by angiomotin (AMOT) family proteins via a direct interaction...
  6. Bratt A, Birot O, Sinha I, Veitonmaki N, Aase K, Ernkvist M, et al. Angiomotin regulates endothelial cell-cell junctions and cell motility. J Biol Chem. 2005;280:34859-69 pubmed
    We have previously identified angiomotin by its ability to bind to and mediate the anti-angiogenic properties of angiostatin. In vivo and in vitro data indicate an essential role of angiomotin in endothelial cell motility...
  7. Ernkvist M, Aase K, Ukomadu C, Wohlschlegel J, Blackman R, Veitonmaki N, et al. p130-angiomotin associates to actin and controls endothelial cell shape. FEBS J. 2006;273:2000-11 pubmed
    b>Angiomotin, an 80 kDa protein expressed in endothelial cells, promotes cell migration and invasion, and stabilizes tube formation in vitro...
  8. Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, et al. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood. 2009;113:244-53 pubmed publisher
    ..We have previously shown that angiomotin (Amot), a membrane-associated scaffold protein, plays a critical role during vascular patterning and endothelial ..
  9. Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, et al. Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev. 2007;21:2055-68 pubmed
    ..We have previously identified angiomotin (Amot) as a receptor for the angiogenesis inhibitor angiostatin...

More Information

Publications28

  1. Shimono A, Behringer R. Angiomotin regulates visceral endoderm movements during mouse embryogenesis. Curr Biol. 2003;13:613-7 pubmed
    ..Little is known about the molecules that regulate this proximal displacement. Here we describe a role for mouse angiomotin (amot) in VE movements...
  2. Sugihara Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, et al. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells. 2007;12:473-86 pubmed
    ..Using yeast two-hybrid screening, we found here that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, which we refer to as Amot/JEAP family proteins...
  3. Zheng Y, Vertuani S, Nyström S, Audebert S, Meijer I, Tegnebratt T, et al. Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis. Circ Res. 2009;105:260-70 pubmed publisher
    We have previously shown that angiomotin (Amot) is essential for endothelial cell migration during mouse embryogenesis. However, approximately 5% of Amot knockout mice survived without any detectable vascular defects...
  4. Matsumoto H, Fukui E, Yoshizawa M, Sato E, Daikoku T. Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation. J Reprod Dev. 2012;58:649-53 pubmed
    Increased vascular permeability and angiogenesis are hallmarks of the implantation process in the uterus. Angiomotin (Amot), which is a vascular angiogenesis-related protein, belongs to the motin family...
  5. Hirate Y, Hirahara S, Inoue K, Suzuki A, Alarcon V, Akimoto K, et al. Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol. 2013;23:1181-94 pubmed publisher
    ..The cell fate is controlled by cell position-dependent Hippo signaling, although the mechanisms underlying position-dependent Hippo signaling are unknown...
  6. Shi X, Yin Z, Ling B, Wang L, Liu C, Ruan X, et al. Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst. Development. 2017;144:3957-3967 pubmed publisher
    ..Active Rho prevents the phosphorylation of Amot Ser176, thus stabilizing the interaction between Amot and F-actin, and restricting the binding between Amot and Nf2...
  7. Leung C, Zernicka Goetz M. Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms. Nat Commun. 2013;4:2251 pubmed publisher
    ..Here we identify Angiomotin as a key regulator of this process...
  8. Yi C, Shen Z, Stemmer Rachamimov A, Dawany N, Troutman S, Showe L, et al. The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis. Sci Signal. 2013;6:ra77 pubmed publisher
    ..Members of the scaffold protein angiomotin (Amot) family interact with several Hippo pathway components, including Yap (Yes-associated protein), and either ..
  9. Liu Y, Lu Z, Shi Y, Sun F. AMOT is required for YAP function in high glucose induced liver malignancy. Biochem Biophys Res Commun. 2018;495:1555-1561 pubmed publisher
    b>AMOT has been identified as a YAP interactor. However, how AMOT regulates YAP remains unclear and controversy. Here, we identified that besides YAP, AMOT was another Hippo signaling core factor which could be O-GlcNAcylated...
  10. Arigoni M, Barutello G, Lanzardo S, Longo D, Aime S, Curcio C, et al. A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors. Angiogenesis. 2012;15:305-16 pubmed publisher
    b>Angiomotin (Amot) is one of several identified angiostatin receptors expressed by the endothelia of angiogenic tissues...
  11. Levchenko T, Aase K, Troyanovsky B, Bratt A, Holmgren L. Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin. J Cell Sci. 2003;116:3803-10 pubmed
    We have recently identified a novel protein, named angiomotin, by its ability to bind the angiogenesis inhibitor angiostatin in the yeast two-hybrid system...
  12. Hallonet M, Kaestner K, Martin Parras L, Sasaki H, Betz U, Ang S. Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants. Dev Biol. 2002;243:20-33 pubmed
    ..Foxa2 therefore plays an integral role in the formation of axial mesendoderm, which is required to maintain the specification of the forebrain and the anterior definitive endoderm. ..
  13. Xiao J, Jin K, Wang J, Ma J, Zhang J, Jiang N, et al. Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway. Int J Cardiol. 2017;228:605-614 pubmed publisher
    ..An interaction between TFPI-1 and angiomotin (AMOT) was identified in human VSMCs by mass spectrometry, immunoprecipitation and co-localization analyses...
  14. Shimono A, Behringer R. Isolation of novel cDNAs by subtractions between the anterior mesendoderm of single mouse gastrula stage embryos. Dev Biol. 1999;209:369-80 pubmed
    ..The expression of one novel cDNA SII6 initially colocalizes with Lim1 in the anterior mesendoderm of gastrula stage embryos...
  15. Moore Scott B, Opoka R, Lin S, Kordich J, Wells J. Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation. Dev Dyn. 2007;236:1997-2003 pubmed
    ..We have identified three genes Slc39a8, Amot, and Dp1l1, which are expressed in the visceral endoderm at e7.5. Starting at e9...
  16. Campbell C, Samavarchi Tehrani P, Barrios Rodiles M, Datti A, Gingras A, Wrana J. The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin. J Cell Sci. 2016;129:3396-411 pubmed publisher
    ..We show that RNF146 binds a number of polarity-associated proteins, in particular members of the angiomotin (AMOT) family...
  17. Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher
    ..This work uncovers a mechanism for the restriction of heart growth at birth, a process which impedes the regenerative potential of the mammalian heart. ..
  18. Hsu Y, Hung J, Chou S, Huang M, Tsai M, Lin Y, et al. Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression. Oncogene. 2015;34:4056-68 pubmed publisher
    ..Lung cancer is the leading cause of cancer death worldwide, with metastasis underlying majority of related deaths. Angiomotin (AMOT), a scaffold protein, has been shown to interact with oncogenic Yes-associated protein/transcriptional co-..
  19. Kim S, Shon B, Kang J, Hahm K, Yoo O, Park Y, et al. Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997;240:239-43 pubmed
    ..All the 8 clones were originated from mouse DNA as judged by Southern blot analysis of mouse genomic DNA. The expression of the clones in mouse brain was addressed by RT-PCR and 4 clones showed specific expression. ..