amide hydrolase

Summary

Gene Symbol: amide hydrolase
Description: fatty acid amide hydrolase
Alias: AW412498, fatty-acid amide hydrolase 1, amide hydrolase, anandamide amidohydrolase 1, fatty acid amide hydrolase protein, oleamide hydrolase 1
Species: mouse
Products:     amide hydrolase

Top Publications

  1. Moreira F, Kaiser N, Monory K, Lutz B. Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology. 2008;54:141-50 pubmed
    ..In addition, it indicates an increased activation of CB1 receptors as a mechanism underlying the effects of FAAH inhibition in two models of anxiety. ..
  2. Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, et al. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci. 2011;15:64-9 pubmed publisher
    ..Here we describe a partly cytosolic variant of the intracellular anandamide-degrading enzyme fatty acid amide hydrolase-1 (FAAH-1), termed FAAH-like anandamide transporter (FLAT), that lacked amidase activity but bound anandamide ..
  3. Ortega Gutierrez S, Hawkins E, Viso A, Lopez Rodriguez M, Cravatt B. Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. Biochemistry. 2004;43:8184-90 pubmed
    ..been proposed to involve two proteins, a transporter that promotes the cellular uptake of AEA and fatty acid amide hydrolase (FAAH), which hydrolyzes AEA to arachidonic acid...
  4. Varvel S, Wise L, Niyuhire F, Cravatt B, Lichtman A. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology. 2007;32:1032-41 pubmed
    ..through either genetic deletion or pharmacological inhibition of its primary catabolic enzyme fatty-acid amide hydrolase (FAAH) will potentiate extinction in a fixed platform water maze task...
  5. Maccarrone M, Rossi S, Bari M, De Chiara V, Fezza F, Musella A, et al. Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. Nat Neurosci. 2008;11:152-9 pubmed publisher
    ..Consistently, the interaction between AEA and 2-AG was lost after pharmacological and genetic inactivation of TRPV1 channels. ..
  6. Glaser S, Kaczocha M. Temporal changes in mouse brain fatty acid amide hydrolase activity. Neuroscience. 2009;163:594-600 pubmed publisher
    Fatty acid amide hydrolase (FAAH) activity is known to mediate the tone of endogenous fatty acid amides including the endocannabinoid anandamide...
  7. Bambico F, Cassano T, Dominguez Lopez S, Katz N, Walker C, Piomelli D, et al. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology. 2010;35:2083-100 pubmed publisher
    Pharmacological blockade of the anandamide-degrading enzyme, fatty acid amide hydrolase (FAAH), produces CB(1) receptor (CB(1)R)-mediated analgesic, anxiolytic-like and antidepressant-like effects in murids...
  8. Sun X, Xie H, Yang J, Wang H, Bradshaw H, Dey S. Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. Proc Natl Acad Sci U S A. 2010;107:16887-92 pubmed publisher
  9. Cravatt B, Demarest K, Patricelli M, Bracey M, Giang D, Martin B, et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci U S A. 2001;98:9371-6 pubmed
    ..Here we show that mice lacking the enzyme fatty acid amide hydrolase (FAAH(-/-)) are severely impaired in their ability to degrade anandamide and when treated with this compound, ..

More Information

Publications87

  1. Booker L, Kinsey S, Abdullah R, Blankman J, Long J, Ezzili C, et al. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. Br J Pharmacol. 2012;165:2485-96 pubmed publisher
    ..Blockade of the catabolic enzyme fatty acid amide hydrolase (FAAH) elevates AEA levels and elicits antinociceptive effects, without the psychomimetic side effects ..
  2. Egertová M, Cravatt B, Elphick M. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. 2003;119:481-96 pubmed
    Fatty acid amide hydrolase (FAAH) catalyses hydrolysis of the endocannabinoid arachidonoylethanolamide ("anandamide") in vitro and regulates anandamide levels in the brain...
  3. Cravatt B, Saghatelian A, Hawkins E, Clement A, Bracey M, Lichtman A. Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proc Natl Acad Sci U S A. 2004;101:10821-6 pubmed
    ..These data suggest that the central and peripheral FAA signaling systems regulate discrete behavioral processes and may be targeted for distinct therapeutic gain. ..
  4. Díaz Alonso J, Aguado T, Wu C, Palazuelos J, Hofmann C, Garcez P, et al. The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J Neurosci. 2012;32:16651-65 pubmed publisher
  5. Bilsland L, Dick J, Pryce G, Petrosino S, Di Marzo V, Baker D, et al. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB J. 2006;20:1003-5 pubmed
    ..Together these results show that cannabinoids have significant neuroprotective effects in this model of ALS and suggest that these beneficial effects may be mediated by non-CB1 receptor mechanisms. ..
  6. Carey L, Slivicki R, Leishman E, Cornett B, Mackie K, Bradshaw H, et al. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Mol Pain. 2016;12: pubmed publisher
    Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of anandamide, an endocannabinoid...
  7. Vázquez C, Tolón R, Grande M, Caraza M, Moreno M, Koester E, et al. Endocannabinoid regulation of amyloid-induced neuroinflammation. Neurobiol Aging. 2015;36:3008-3019 pubmed publisher
    ..Pharmacologic inhibition of the fatty acid amide hydrolase (FAAH) had little impact on the expression of key enzymes and cytokines and also on the cognitive impairment, ..
  8. Helfand A, Olsen C, Hillard C. Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..explore the role of endocannabinoid signaling in OSS utilizing cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) knock out mice...
  9. Wolfson M, Aisemberg J, Salazar A, Domínguez Rubio A, Vercelli C, Franchi A. Progesterone reverts LPS-reduced FAAH activity in murine peripheral blood mononuclear cells by a receptor-mediated fashion. Mol Cell Endocrinol. 2013;381:97-105 pubmed publisher
    ..Anandamide levels are regulated by the fatty acid amide hydrolase (FAAH)...
  10. Lin L, Metherel A, Jones P, Bazinet R. Fatty acid amide hydrolase (FAAH) regulates hypercapnia/ischemia-induced increases in n-acylethanolamines in mouse brain. J Neurochem. 2017;142:662-671 pubmed publisher
    ..Fatty acid amide hydrolase (FAAH) is largely responsible for the degradation of NAEs...
  11. Gobira P, Lima I, Batista L, de Oliveira A, Resstel L, Wotjak C, et al. N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus. J Psychopharmacol. 2017;31:750-756 pubmed publisher
    ..N-arachidonoyl-serotonin (AA-5-HT), a dual blocker of the anandamide-hydrolysing enzyme fatty acid amide hydrolase (FAAH) and the TRPV1 channel, induces anxiolytic-like effects...
  12. Bátkai S, Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Cravatt B, et al. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol. 2007;293:H909-18 pubmed
    ..Inhibition of the endocannabinoid anandamide metabolizing enzyme, the fatty acid amide hydrolase (FAAH), is emerging as a promising novel approach for the treatment of various inflammatory disorders...
  13. Goparaju S, Kurahashi Y, Suzuki H, Ueda N, Yamamoto S. Anandamide amidohydrolase of porcine brain: cDNA cloning, functional expression and site-directed mutagenesis(1). Biochim Biophys Acta. 1999;1441:77-84 pubmed
    ..The point mutation of Ser-217, Asp-237, Ser-241, or Cys-249 completely abolished the hydrolyses of all the above-mentioned substrates as well as the synthesis of anandamide in the reverse reaction. ..
  14. Patel S, Carrier E, Ho W, Rademacher D, Cunningham S, Reddy D, et al. The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. J Lipid Res. 2005;46:342-9 pubmed
    N-arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of ..
  15. Egertová M, Michael G, Cravatt B, Elphick M. Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat. J Chem Neuroanat. 2004;28:171-81 pubmed
    ..These substances are inactivated by fatty acid amide hydrolase (FAAH), an enzyme that is expressed by neurons and non-neuronal cells in the brain...
  16. Giang D, Cravatt B. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997;94:2238-42 pubmed
    Recently, we reported the isolation, cloning, and expression of a rat enzyme, fatty acid amide hydrolase (FAAH), that degrades bioactive fatty acid amides like oleamide and anandamide to their corresponding acids, thereby serving to ..
  17. Wang Z, Wang P, Hillard C, Bjorling D. Attenuation of cystitis and pain sensation in mice lacking fatty acid amide hydrolase. J Mol Neurosci. 2015;55:968-76 pubmed publisher
    ..Fatty acid amide hydrolase (FAAH) is primarily responsible for degradation of AEA, and deletion of FAAH increases AEA content in various ..
  18. Wang Z, Wang P, Bjorling D. Activation of cannabinoid receptor 1 inhibits increased bladder activity induced by nerve growth factor. Neurosci Lett. 2015;589:19-24 pubmed publisher
    ..We also examined the effects of intravesical NGF in female fatty acid amide hydrolase knock-out (FAAH KO) mice...
  19. Pacher P, Bátkai S, Osei Hyiaman D, Offertáler L, Liu J, Harvey White J, et al. Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol. 2005;289:H533-41 pubmed
    ..Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the in vivo degradation of anandamide...
  20. Vinod K, Sanguino E, Yalamanchili R, Manzanares J, Hungund B. Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol. J Neurochem. 2008;104:233-43 pubmed
    The aim of this study was to examine the role of fatty acid amide hydrolase (FAAH) on ethanol sensitivity, preference, and dependence...
  21. Xie H, Sun X, Piao Y, Jegga A, Handwerger S, Ko M, et al. Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration. J Biol Chem. 2012;287:32288-97 pubmed publisher
    ..This study provides evidence that a tightly regulated endocannabinoid signaling is critical to normal preimplantation embryo development and migration of trophoblast stem cells. ..
  22. Kim W, Doyle M, Liu Z, Lao Q, Shin Y, Carlson O, et al. Cannabinoids inhibit insulin receptor signaling in pancreatic ?-cells. Diabetes. 2011;60:1198-209 pubmed publisher
  23. Musella A, De Chiara V, Rossi S, Prosperetti C, Bernardi G, Maccarrone M, et al. TRPV1 channels facilitate glutamate transmission in the striatum. Mol Cell Neurosci. 2009;40:89-97 pubmed publisher
    ..TRPV1-mediated regulation of excitatory transmission in the striatum might be important for the final output to other basal ganglia structures, and might play a role in several physiological and pathological processes. ..
  24. Mulder J, Aguado T, Keimpema E, Barabas K, Ballester Rosado C, Nguyen L, et al. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A. 2008;105:8760-5 pubmed publisher
    ..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis. ..
  25. Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, et al. Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. J Lipid Res. 2013;54:1360-8 pubmed publisher
    ..Here, we studied a potential activation of the endocannabinoid system and the effect of FA amide hydrolase (FAAH) deficiency, the major enzyme responsible for endocannabinoid anandamide degradation, in arterial ..
  26. Dincheva I, Drysdale A, Hartley C, Johnson D, Jing D, King E, et al. FAAH genetic variation enhances fronto-amygdala function in mouse and human. Nat Commun. 2015;6:6395 pubmed publisher
    ..developed a knock-in mouse that biologically recapitulates a common human mutation in the gene for fatty acid amide hydrolase (FAAH) (C385A; rs324420), the primary catabolic enzyme for the endocannabinoid anandamide...
  27. Pisanu C, Congiu D, Costa M, Sestu M, Chillotti C, Ardau R, et al. No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample. Psychiatry Res. 2013;210:887-90 pubmed publisher
    ..in N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD), cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. No significant association was reported for FAAH or CNR1...
  28. Leishman E, Cornett B, Spork K, Straiker A, Mackie K, Bradshaw H. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. Pharmacol Res. 2016;110:159-172 pubmed publisher
    The enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) hydrolyze endogenous cannabinoids (eCBs), N-arachidonoyl ethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG), respectively...
  29. Puffenbarger R, Kapulina O, Howell J, Deutsch D. Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase. Neurosci Lett. 2001;314:21-4 pubmed
    Fatty acid amide hydrolase (FAAH) is critical for degradation of several important fatty acid amides including anandamide, an endocannabinoid, as well as oleamide, a sleep-inducing factor...
  30. Basavarajappa B, Yalamanchili R, Cravatt B, Cooper T, Hungund B. Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice. Neuropharmacology. 2006;50:834-44 pubmed
    ..Thus, the data suggest that FAAH may be indirectly related to ethanol intake and sensitivity and central endocannabinoidergic-mediated pathways may regulate ethanol consumption. ..
  31. Lenglet S, Thomas A, Soehnlein O, Montecucco F, Burger F, Pelli G, et al. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. Arterioscler Thromb Vasc Biol. 2013;33:215-23 pubmed publisher
    ..Therefore, we studied the involvement of fatty acid amide hydrolase (FAAH) deficiency, the major enzyme responsible for endocannabinoid anandamide degradation, in ..
  32. Leung K, Elmes M, Glaser S, Deutsch D, Kaczocha M. Role of FAAH-like anandamide transporter in anandamide inactivation. PLoS ONE. 2013;8:e79355 pubmed publisher
    ..an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase (FAAH)...
  33. Avraham H, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Wood J, et al. Impaired neurogenesis by HIV-1-Gp120 is rescued by genetic deletion of fatty acid amide hydrolase enzyme. Br J Pharmacol. 2015;172:4603-14 pubmed publisher
    ..neural functions, and their degeneration is controlled by hydrolysing enzymes such as the fatty acid amide hydrolase (FAAH)...
  34. Benito C, Tolón R, Castillo A, Ruiz Valdepeñas L, Martínez Orgado J, Fernández Sánchez F, et al. ?-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-?, PPAR-? and TRPV1, but not CB? or CB? receptors. Br J Pharmacol. 2012;166:1474-89 pubmed publisher
    ..the enhancement of endocannabinoid tone by blocking the activity of degradative enzymes, such as fatty acid amide hydrolase (FAAH). We examined the role of FAAH in the response of astrocytes to the pathologic form of ?-amyloid (A?)...
  35. Wan M, Cravatt B, Ring H, Zhang X, Francke U. Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. Genomics. 1998;54:408-14 pubmed
    Fatty-acid amide hydrolase (FAAH) is a membrane-bound enzyme that degrades neuromodulatory fatty acid amides, such as oleamide and anandamide, and is expressed in the mammalian central nervous system...
  36. Lichtman A, Shelton C, Advani T, Cravatt B. Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain. 2004;109:319-27 pubmed
    ..receptors and has been implicated in the suppression of pain, its rapid catabolism in vivo by fatty acid amide hydrolase (FAAH) has presented a challenge in investigating the physiological functions of this endogenous cannabinoid...
  37. Mallet C, Barrière D, Ermund A, Jönsson B, Eschalier A, Zygmunt P, et al. TRPV1 in brain is involved in acetaminophen-induced antinociception. PLoS ONE. 2010;5: pubmed publisher
    ..is further metabolized to N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z -eicosatetraenamide (AM404) by fatty acid amide hydrolase (FAAH) in the rat and mouse brain and that this metabolite is a potent activator of transient receptor ..
  38. Falenski K, Thorpe A, Schlosburg J, Cravatt B, Abdullah R, Smith T, et al. FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. Neuropsychopharmacology. 2010;35:1775-87 pubmed publisher
    ..AEA) on cannabinoid receptor regulation are unclear because of its rapid metabolism by fatty acid amide hydrolase (FAAH)...
  39. Pryce G, Cabranes A, Fernandez Ruiz J, Bisogno T, Di Marzo V, Long J, et al. Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors. Mult Scler. 2013;19:1896-904 pubmed publisher
    ..Spasticity eventually developed following the induction of EAE in either wild-type or congenic fatty acid amide hydrolase (FAAH)-deficient Biozzi ABH mice...
  40. Siegmund S, Wojtalla A, Schlosser M, Zimmer A, Singer M. Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. Biochem Biophys Res Commun. 2013;437:48-54 pubmed publisher
    ..In contrast to HSCs, hepatocytes highly express the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) that protects them from AEA-induced injury...
  41. Dainese E, De Fabritiis G, Sabatucci A, Oddi S, Angelucci C, Di Pancrazio C, et al. Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH. Biochem J. 2014;457:463-72 pubmed publisher
    ..A paradigmatic case is FAAH (fatty acid amide hydrolase), an enzyme critical in terminating endocannabinoid signalling and an important therapeutic target...
  42. Freigang S, Zadorozhny V, McKinney M, Krebs P, Herro R, Pawlak J, et al. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. J Clin Invest. 2010;120:1873-84 pubmed publisher
    ..In this report, we isolated the enzyme fatty acid amide hydrolase (FAAH) from mouse serum as an alphaGalCer-binding protein that modulates the induction of key effector ..
  43. Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt B, et al. The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest. 2004;113:1202-9 pubmed
    ..HU210) or genetic ablation of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) resulted in protection against DNBS-induced colitis...
  44. Sun X, Tavenier A, Deng W, Leishman E, Bradshaw H, Dey S. Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels. Biol Reprod. 2018;98:208-217 pubmed publisher
    Premature decidual senescence is a contributing factor to preterm birth. Fatty acid amide hydrolase mutant females (Faah-/-) with higher endocannabinoid levels are also more susceptible to preterm birth upon lipopolysaccharide (LPS) ..
  45. Grimaldi P, Pucci M, Di Siena S, Di Giacomo D, Pirazzi V, Geremia R, et al. The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1. Cell Mol Life Sci. 2012;69:4177-90 pubmed publisher
    ..Here, we cloned the proximal 5' flanking region of the mouse fatty acid amide hydrolase (faah) gene upstream of the luciferase reporter gene, and demonstrated its promoter activity and E(2) ..
  46. Dominguez Lopez S, Howell R, Gobbi G. Characterization of serotonin neurotransmission in knockout mice: implications for major depression. Rev Neurosci. 2012;23:429-43 pubmed publisher
    ..data from 5-HT transporter (5HTT), 5-HT?(A), 5-HT?, the neurokinin 1 (NK?) receptor, fatty acid amide hydrolase (FAAH) and the TWIK-1 related K+ (TREK-1) channel knockout mice are here analysed...
  47. Lichtman A, Hawkins E, Griffin G, Cravatt B. Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. J Pharmacol Exp Ther. 2002;302:73-9 pubmed
    ..to induce its behavioral effects by serving as a competitive substrate for the brain enzyme fatty acid amide hydrolase (FAAH) and inhibiting the degradation of endogenous anandamide...
  48. Webb M, Luo L, Ma J, Tham C. Genetic deletion of Fatty Acid Amide Hydrolase results in improved long-term outcome in chronic autoimmune encephalitis. Neurosci Lett. 2008;439:106-10 pubmed publisher
    The enzyme Fatty Acid Amide Hydrolase (FAAH) is a key regulator of the endogenous levels of a family of biologically active lipid mediators, the fatty acid amides...
  49. Blednov Y, Cravatt B, Boehm S, Walker D, Harris R. Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology. 2007;32:1570-82 pubmed
    Endocannabinoid signaling plays the important role in regulation of ethanol intake. Fatty acid amide hydrolase (FAAH) is a key membrane protein for metabolism of endocannabinoids, including anandamide, and blockade of FAAH increases the ..
  50. Capasso R, Matias I, Lutz B, Borrelli F, Capasso F, Marsicano G, et al. Fatty acid amide hydrolase controls mouse intestinal motility in vivo. Gastroenterology. 2005;129:941-51 pubmed
    Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis both of the endocannabinoids (which are known to inhibit intestinal motility) and other bioactive amides (palmitoylethanolamide, oleamide, and oleoylethanolamide), which might ..
  51. Saghatelian A, Trauger S, Want E, Hawkins E, Siuzdak G, Cravatt B. Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry. 2004;43:14332-9 pubmed
    ..We use this method to discover several brain lipids regulated by the mammalian enzyme fatty acid amide hydrolase (FAAH) in vivo, including known signaling molecules (e.g...
  52. De Filippis D, Iuvone T, D Amico A, Esposito G, Steardo L, Herman A, et al. Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. Neurogastroenterol Motil. 2008;20:919-27 pubmed publisher
    ..Cannabidiol also regulates the activity of fatty acid amide hydrolase (FAAH) which is the main enzyme involved in endocannabinoid breakdown and which modulates gastrointestinal ..
  53. Saghatelian A, McKinney M, Bandell M, Patapoutian A, Cravatt B. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. 2006;45:9007-15 pubmed
    Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that catabolizes several bioactive lipids in vivo...
  54. Siegmund S, Wojtalla A, Schlosser M, Schildberg F, Knolle P, Nüsing R, et al. Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. Biochem Biophys Res Commun. 2016;470:678-684 pubmed publisher
    ..Modulation of COX-2-driven metabolization of 2-AG may provide a novel physiological concept allowing the specific targeting of HSCs in liver fibrosis. ..
  55. Sun X, Wang H, Okabe M, Mackie K, Kingsley P, Marnett L, et al. Genetic loss of Faah compromises male fertility in mice. Biol Reprod. 2009;80:235-42 pubmed publisher
    ..Herein we show that genetic loss of Faah, which encodes fatty acid amide hydrolase (FAAH), results in elevated levels of anandamide, an endocannabinoid, in the male reproductive system, ..
  56. Pathak S, Kumar K, Kanta H, Carr Johnson F, Han J, Bashmakov A, et al. Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus. J Immunol. 2016;196:1507-16 pubmed publisher
    ..Fatty acid amide hydrolase (FAAH), a gene in the minimal subcongenic interval generated through recombinant mapping, was found to be ..
  57. Mukhopadhyay B, Cinar R, Yin S, Liu J, Tam J, Godlewski G, et al. Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. Proc Natl Acad Sci U S A. 2011;108:6323-8 pubmed publisher
    ..in the liver via an in vivo pathway involving conjugation of arachidonic acid and ethanolamine by fatty-acid amide hydrolase. In wild-type but not CB(1)R(-/-) mice, PHX induces robust up-regulation of key cell-cycle proteins involved ..
  58. Palumbo Zerr K, Horn A, Distler A, Zerr P, Dees C, Beyer C, et al. Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1. Ann Rheum Dis. 2012;71:2051-4 pubmed publisher
    ..endocannabinoids in mice were modulated by pharmacological or genetic inactivation of the enzyme fatty acid amide hydrolase (FAAH)...
  59. Mulder A, Cravatt B. Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. Biochemistry. 2006;45:11267-77 pubmed
    ..the endocannabinoid anandamide (AEA), is principally mediated by the integral membrane enzyme fatty acid amide hydrolase (FAAH) in vivo...
  60. Sasso O, Pontis S, Armirotti A, Cardinali G, Kovacs D, Migliore M, et al. Endogenous N-acyl taurines regulate skin wound healing. Proc Natl Acad Sci U S A. 2016;113:E4397-406 pubmed publisher
    The intracellular serine amidase, fatty acid amide hydrolase (FAAH), degrades a heterogeneous family of lipid-derived bioactive molecules that include amides of long-chain fatty acids with taurine [N-acyl-taurines (NATs)]...
  61. Ye T, Gordon C, Lai Y, Fujiwara Y, Peters L, Perkins A, et al. Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein. Gene. 2000;242:337-45 pubmed
    ..Northern blot analysis and in-situ hybridization demonstrated that Ermap expression was restricted to fetal and adult erythroid tissues. ERMAP is likely a novel adhesion/receptor molecule specific for erythroid cells. ..
  62. Wenzel D, Matthey M, Bindila L, Lerner R, Lutz B, Zimmer A, et al. Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 2013;110:18710-5 pubmed publisher
    ..endocannabinoid anandamide (AEA) is a key mediator of hypoxic pulmonary vasoconstriction (HPV) via fatty acid amide hydrolase (FAAH)-dependent metabolites...
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    ..PEA) due to genetic deletion or pharmacologic blockade of its degrading enzyme fatty acid amide hydrolase (FAAH) reduced neuroinflammatory changes in models of neurodegeneration...
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    ..However, administered intracerebroventricularly, URB937 (5 μg/mouse) reduced the action of paracetamol. These results demonstrate that the supra-spinally-located FAAH enzyme is necessary for the analgesic action of paracetamol. ..
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    ..anandamide from the plasma membrane to its intracellular targets such as the metabolic enzyme, fatty acid amide hydrolase, have been identified...
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    ..We have investigated the role of the main endocannabinoid anandamide-metabolizing enzyme (fatty acid amide hydrolase; FAAH) in myocardial injury induced by an important chemotherapeutic drug, doxorubicin (DOX; known for its ..
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    ..Taken together, our results suggest that oleamide shows an anti-inflammatory effect through inhibition of NF-kappaB activation in LPS-stimulated BV2 microglia. ..
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    ..we have exposed C57/Bl6 mice to chronic restraint stress, which results in an increase in fatty acid amide hydrolase (FAAH) activity and a reduction in the concentration of the eCB N-arachidonylethanolamine (AEA) within the ..
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    ..the activity of two hydrolytic enzymes, N-acylethanolamine-hydrolyzing acid amidase (NAAA) and fatty acid amide hydrolase (FAAH)...
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    ..Investigate the expression of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) in human, rat, and mouse bladders and study the effects of inhibition of FAAH during urodynamics in ..
  72. Straiker A, Wager Miller J, Hu S, Blankman J, Cravatt B, Mackie K. COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation. Br J Pharmacol. 2011;164:1672-83 pubmed publisher
    ..excitatory autaptic hippocampal neurons with putative 2-AG metabolizing enzymes: COX-2, fatty acid amide hydrolase (FAAH), ?/? hydrolase domain 6 (ABHD6), ?/? hydrolase domain 12 (ABHD12) or MGL. ..
  73. Siegmund S, Seki E, Osawa Y, Uchinami H, Cravatt B, Schwabe R. Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J Biol Chem. 2006;281:10431-8 pubmed
    ..In this study, we investigated the role of the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) in AEA-induced cell death in the liver...
  74. Karsak M, Gaffal E, Date R, Wang Eckhardt L, Rehnelt J, Petrosino S, et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science. 2007;316:1494-7 pubmed
    ..In contrast, fatty acid amide hydrolase-deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic ..
  75. Ueda N, Tsuboi K, Uyama T. Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. FEBS J. 2013;280:1874-94 pubmed publisher
    ..and N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, and are degraded by fatty acid amide hydrolase. However, recent studies have shown the involvement of other enzymes and pathways, which include the members ..
  76. Sun X, Deng W, Li Y, Tang S, Leishman E, Bradshaw H, et al. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. J Biol Chem. 2016;291:8231-40 pubmed publisher
    ..We show here that mice devoid of fatty acid amide hydrolase (FAAH) with elevated levels ofN-arachidonyl ethanolamide (anandamide), a major endocannabinoid lipid mediator,..
  77. Azad S, Monory K, Marsicano G, Cravatt B, Lutz B, Zieglgänsberger W, et al. Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. J Neurosci. 2004;24:9953-61 pubmed
    ..LTDi is significantly enhanced in mice lacking the anandamide-degrading enzyme fatty acid amide hydrolase. The present findings show for the first time that mGluR activation induces a retrograde endocannabinoid ..
  78. Marrs W, Horne E, Ortega Gutierrez S, Cisneros J, Xu C, Lin Y, et al. Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. J Biol Chem. 2011;286:28723-8 pubmed publisher
    ..This compound displays a unique pharmacological profile in that it inhibits fatty acid amide hydrolase and ?/?-hydrolase domain 6 but not monoacylglycerol lipase...