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Genomes and Genes
| Aldh2SummaryGene Symbol: Aldh2 Description: aldehyde dehydrogenase 2, mitochondrial Alias: Ahd-5, Ahd5, AHD-M1, ALDH class 2, ALDH-E2, ALDHI, aldehyde dehydrogenase, mitochondrial Species: mouse Top Publications
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Publications
Aldehyde dehydrogenase is a positional marker in the retinaP McCaffery
Department of Neurobiology, Harvard Medical School Boston, MA 02115
Development 112:693-702. 1991....- Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout miceElizabeth Fernandez
Research Service and Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, USA
Alcohol Clin Exp Res 30:1650-8. 2006..addition to removing acetaldehyde produced during the metabolism of ethanol, mitochondrial aldehyde dehydrogenase (ALDH2) functions in the pathway by which aldehyde metabolites of the monoamines dopamine (DA) and serotonin (5-HT) are .. - Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 miceSanjiv V Bhave
Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
Alcohol Clin Exp Res 30:1659-69. 2006..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains... - Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liverAkiko Matsumoto
Department of Social and Environmental Medicine, Saga Medical School, Saga 849 8501, Japan
Alcohol 41:57-9. 2007Polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is far more common in East Asian countries... - Single-dose ethanol administration downregulates expression of cytochrome p450 2E1 mRNA in aldehyde dehydrogenase 2 knockout miceAkiko Matsumoto
Department of Social and Environmental Medicine, Saga Medical School, Saga 849 8501, Japan
Alcohol 41:587-9. 2007The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian origin... - ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative propertiesPhilip Wenzel
II Medizinische Klinik, Labor für Molekulare Kardiologie, Johannes Gutenberg Universitat Mainz, Langenbeck Str 1, 55131 Mainz, Germany
Biochem Biophys Res Commun 367:137-43. 2008..Our results suggest that ALDH-2 has an indirect antioxidative property independent of its thiol-moiety in disease states of cardiovascular oxidative stress... 
Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activityIkuroh Ohsawa
Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 211 8533, Japan
J Neurosci 28:6239-49. 2008..We have previously shown that mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies HNE by oxidizing its aldehyde group...- Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunctionPhilip Wenzel
Second Medical Clinic, Department of Cardiology, Johannes Gutenberg University, Mainz, Germany
Cardiovasc Res 80:280-9. 2008..In the present study, mitochondria as a source of reactive oxygen species (ROS) and the contribution of manganese superoxide dismutase (MnSOD, SOD-2) and aldehyde dehydrogenase (ALDH-2) were investigated... - Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout miceAkiko Matsumoto
Departments of Social and Environmental Medicine, Saga Medical School, Saga, Japan
Pharmacogenet Genomics 18:847-52. 2008The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian countries, and the mutated ALDH2 protein derived from ALDH2*2 lacks the ability of acetaldehyde metabolization... - Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanolHaruna Nagayoshi
Osaka Prefectural Institute of Public Health, Osaka 537 0025, Japan
Mutat Res 673:74-7. 2009..dehydrogenase (Aldh)-2-knockout mice that were fed with alcohol to determine effects of alcohol consumption and Aldh2 genotype on the level of DNA damage in stomach... - Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liverRui Guo
Center for Cardiovascular Research and Alternative Medicine, University of Wyoming School of Pharmacy, Laramie, WY 82071, USA
Clin Exp Pharmacol Physiol 36:463-8. 2009..to examine the impact of facilitated acetaldehyde metabolism via overexpression of aldehyde dehydrogenase-2 (ALDH2) on chronic alcohol ingestion-induced hepatic damage... 
Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stressShi Yan Li
Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
J Mol Cell Cardiol 47:247-55. 2009..This study was designed to examine the impact of aldehyde dehydrogenase-2 (ALDH2) transgenic overexpression on alcohol-induced insulin resistance and myocardial injury...- Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice modelsMostofa Jamal
Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki, Kita, Kagawa 761 0793, Japan
Brain Res 1295:37-43. 2009..acetaldehyde (ACe) on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the frontal cortex of Aldh2-/- (KO) mice. KO mice were used as models of Aldh2-deficient humans to examine ACe effects... - Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heartJin Endo
Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
Circ Res 105:1118-27. 2009..Aldehyde accumulation is regarded as a pathognomonic feature of oxidative stress-associated cardiovascular disease... - Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout miceHsu Sheng Yu
Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
Toxicol Mech Methods 19:535-40. 2009..It covalently binds to DNA, and is known as a carcinogen. Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde... - Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout miceGrant R Budas
Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305 5174, USA
J Mol Cell Cardiol 48:757-64. 2010..We recently identified aldehyde dehydrogenase 2 (ALDH2) as a PKCvarepsilon substrate, whose activation is necessary and sufficient to confer cardioprotection in vivo... - Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatasesHeng Ma
Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 China
J Mol Cell Cardiol 49:322-9. 2010..This study was designed to examine the influence of mitochondrial aldehyde dehydrogenase-2 (ALDH2) knockout (KO) on acute ethanol exposure-induced cardiomyocyte dysfunction... - Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted miceYuki Shimizu
Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
Bone 48:1075-86. 2011..Approximately 45% of Chinese and Japanese individuals have the inactive aldehyde dehydrogenase 2 (Aldh2) phenotype. The absence of the ALDH2*2 allele is found to adversely influence the risk of osteoporosis... - Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type miceToyohi Isse
Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
J Toxicol Sci 30:329-37. 2005Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde... - Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethalityToyohi Isse
Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
J Toxicol Sci 30:315-28. 2005Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde... - Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant miceA Wallen
Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, S 171 77, Sweden
Exp Cell Res 253:737-46. 1999..We conclude that NURR1 plays a critical role in the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic DA cells... - The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen developmentW K Greene
Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
Mol Cell Biol 18:7030-7. 1998..This result suggests that expression of Aldh1 protein is negatively regulated by Hox11 and that abnormal expression of Aldh1 in Hox11 null mice may cause loss of splenic precursor cells by aberrant retinoic acid metabolism... - Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrateX Wang
Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
J Biol Chem 271:16288-93. 1996..These data support a function for RalDH(II) in the pathway of retinoic acid biogenesis... - Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11K Huppi
Laboratory of Genetics, NCI/NIH, Bethesda, MD 20892
Immunogenetics 37:288-91. 1993 - Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenasesM Chen
Department of Pharmacology, Cornell University Medical College, New York, New York 10021
Mol Pharmacol 46:88-96. 1994..AHD-2 is more active than AHD-M1 in this conversion, but AHD-2 is not the enzyme responsible for this conversion in F9 embryonic stem cells... - Cloning and characterization of the gene encoding mouse mitochondrial aldehyde dehydrogenaseC Chang
Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
Gene 148:331-6. 1994The mitochondrial (mt) aldehyde dehydrogenase (ALDH2) in liver has been considered to play a major role in the detoxification of alcohol in humans... - Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factorJ Caubín
Departamento de Investigacion, Pharmacia Antibióticos Farma S A, Madrid, Spain
Nucleic Acids Res 22:4132-8. 1994..This method, extensive to other ligand-modulated transcription factors, might be useful to all transcription factors with slight modifications... - A gene for susceptibility to small intestinal cancer, ssic1, maps to the distal part of mouse chromosome 4R J Fijneman
The Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam, The Netherlands
Cancer Res 55:3179-82. 1995..This difference is highly significant (chi 2 = 31 for D4Mit158). Therefore, one of the genes that influence susceptibility to small intestinal cancer, ssic1, maps to the distal part of chromosome 4... - Assignment of the mitochondrial aldehyde dehydrogenase gene (Aldh2) to mouse chromosome 5 by fluorescence in situ hybridizationK Jeong
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Cytogenet Cell Genet 89:54-5. 2000 - Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive miceHyehun Choi
Department of Physiology, Georgia Health Sciences University, Augusta, Georgia 30912 3000, USA
J Am Soc Hypertens 5:154-60. 2011Mitochondrial aldehyde dehydrogenase (ALDH2) is an enzyme that detoxifies aldehydes to carboxylic acids... - An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivationZhiqiang Chen
Department of Medicine and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 102:12159-64. 2005.... - Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot studyYong Dae Kim
Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, 48 San Kaeshin dong, Hungdok gu, Cheongju, Chungbuk, 361 763, South Korea
Arch Toxicol 79:192-5. 2005..expression levels of hepatic cytochrome P450 (CYP) 2E1, 2B1/2 and 4B1 enzymes in aldehyde dehydrogenase 2 (Aldh2) +/+ and Aldh2 -/- mice by immunoblotting assay following subchronic ethanol exposure for eight days... - Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolismTsunehiro Oyama
Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
Front Biosci 10:951-60. 2005..that may cause cellular and DNA damages, is converted to acetate by mitochondrial aldehyde dehydrogenase ALDH2. Although the majority of ingested alcohol is eliminated in the liver, the first-pass metabolism of ethanol in the .. - Expression of the aldehyde dehydrogenase 2-like gene is controlled by BOB.1/OBF.1 in B lymphocytesCornelia Brunner
University of Ulm, Department of Physiological Chemistry, Albert Einstein Allee 11, D 89081 Ulm, Germany
J Biol Chem 278:45231-9. 2003..Transient transfections confirm that this promoter is activated by BOB.1/OBF.1. Our observations suggest that by regulating genes in different functional pathways, BOB.1/OBF.1 has a widespread effect on B cell development and function... - Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling femalesIkuroh Ohsawa
Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki 211 8533, Japan
J Hum Genet 48:404-9. 2003Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in acetaldehyde detoxification. The alcohol sensitivity is associated with a genetic deficiency of ALDH2... - Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cellsIkuroh Ohsawa
Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, 1 396 Kosugi cho, Nahakara ku, Kawasaki 211 8533, Japan
J Neurochem 84:1110-7. 2003Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in acetaldehyde detoxification. The alcohol sensitivity is associated with a genetic deficiency of ALDH2... - Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryosUjjwal Kumar Rout
Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 East Hancock, Detroit, MI 48201, USA
Reprod Toxicol 16:253-8. 2002..The absence of enzymes to convert ethanol to acetaldehyde, coupled with oocyte expression of the acetaldehyde-degrading enzyme, Ahd-5, may be protective for the early embryo... - Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouseK Kitagawa
Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan
FEBS Lett 476:306-11. 2000..MALD oxidation was examined with liver subcellular fractions from Japanese subjects who carried three different ALDH2 genotypes and Aldh2 knockout mice, which were generated in this study... - Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systemsBoaz P Levi
Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
Blood 113:1670-80. 2009..Finally, Aldh1a1 deficiency did not affect the function of stem cells from the adult central or peripheral nervous systems. Aldh1a1 is not a critical regulator of adult stem cell function or Aldefluor staining in mice...