Aldh2

Summary

Gene Symbol: Aldh2
Description: aldehyde dehydrogenase 2, mitochondrial
Alias: Ahd-5, Ahd5, AHD-M1, ALDH class 2, ALDH-E2, ALDHI, aldehyde dehydrogenase, mitochondrial
Species: mouse

Top Publications

  1. pmc AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol
    Wei Ge
    Department of Geriatrics, Fourth Military Medical University, Xi an, Shaan xi 710032, China
    Free Radic Biol Med 51:1736-48. 2011
  2. pmc Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases
    Heng Ma
    Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 China
    J Mol Cell Cardiol 49:322-9. 2010
  3. doi Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
    Juan I Garaycoechea
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 489:571-5. 2012
  4. ncbi Expression of the aldehyde dehydrogenase 2-like gene is controlled by BOB.1/OBF.1 in B lymphocytes
    Cornelia Brunner
    University of Ulm, Department of Physiological Chemistry, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Biol Chem 278:45231-9. 2003
  5. pmc Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems
    Boaz P Levi
    Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Blood 113:1670-80. 2009
  6. doi Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis
    Hiroko Hoshi
    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    J Bone Miner Res 27:2015-23. 2012
  7. pmc ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools
    Marilia Ioannou
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    Dev Biol 374:153-63. 2013
  8. pmc Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function
    Yingmei Zhang
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    BMC Med 10:40. 2012
  9. doi Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula
    Claudia Compagnucci
    Department of Craniofacial Development, King s College London, Floor 27, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Dev Biol 377:428-48. 2013
  10. doi Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase
    Martina Griesberger
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Graz, Austria
    Mol Pharmacol 79:541-8. 2011

Scientific Experts

  • Akiko Matsumoto
  • M Jamal
  • Toyohi Isse
  • Tsunehiro Oyama
  • Yuki Shimizu
  • Hyehun Choi
  • Toshihiro Kawamoto
  • Ikuroh Ohsawa
  • Jun Ren
  • Shigeo Ohta
  • Philip Wenzel
  • Matteo Beretta
  • Martina Griesberger
  • Frederic Langevin
  • Rui Guo
  • Vasilis Vasiliou
  • Kyoko Kitagawa
  • Keiichi I Nakayama
  • Elizabeth Fernandez
  • Kiyomi Nishimaki
  • Marilia Ioannou
  • Marc Estienne Roehrich
  • Claudia Compagnucci
  • Takuto Tsuchiya
  • Juan I Garaycoechea
  • Jianquan Liao
  • Margaret Chia Ying Wey
  • Yingmei Zhang
  • Hiroko Hoshi
  • Ketan J Patel
  • Bernd Mayer
  • Gerald Wölkart
  • Mark J Arends
  • Gerry P Crossan
  • Kurt Schmidt
  • Wei Ge
  • Zhongping Lu
  • Nan Hu
  • Motoaki Sano
  • Keiichi Fukuda
  • Heng Ma
  • Grant R Budas
  • Jin Endo
  • Hsu Sheng Yu
  • Boaz P Levi
  • Haruna Nagayoshi
  • Shi Yan Li
  • Randy Strong
  • Thomas Munzel
  • Johanna Müller
  • Andreas Daiber
  • Matthias Oelze
  • Eberhard Schulz
  • Swenja Schuhmacher
  • Sanjiv V Bhave
  • Yong Dae Kim
  • Zhiqiang Chen
  • Cornelia Brunner
  • Kouzin Kamino
  • Ujjwal Kumar Rout
  • Toshiharu Mori
  • Mélanie Debiais-Thibaud
  • Jennifer Fish
  • Véronique Borday-Birraux
  • Federica Bertocchini
  • Surendra Singh
  • Hajime Utsunomiya
  • Albert Spicher
  • Giuseppe Vassalli
  • Lori Sussel
  • Marion Coolen
  • Yoshinori Takeuchi
  • Kunitaka Menuki
  • Teppei Murai
  • Maryline Minoux
  • Filippo M Rijli
  • Michael J Depew
  • Giuseppina Milano
  • Luis Arnés
  • Shinkichi Kanoh
  • Ioannis Serafimidis
  • John N Griffin
  • Toshitaka Nakamura
  • Sylvie Mazan
  • Akinori Sakai
  • Anthony Gavalas
  • Didier Casane
  • Morio Matsumoto
  • Maria Daly
  • Kana Miyamoto

Detail Information

Publications54

  1. pmc AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol
    Wei Ge
    Department of Geriatrics, Fourth Military Medical University, Xi an, Shaan xi 710032, China
    Free Radic Biol Med 51:1736-48. 2011
    Mitochondrial aldehyde dehydrogenase-2 (ALDH2) alleviates ethanol toxicity although the precise mechanism is unclear. This study was designed to evaluate the effect of ALDH2 on ethanol-induced myocardial damage with a focus on autophagy...
  2. pmc Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases
    Heng Ma
    Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 China
    J Mol Cell Cardiol 49:322-9. 2010
    ..This study was designed to examine the influence of mitochondrial aldehyde dehydrogenase-2 (ALDH2) knockout (KO) on acute ethanol exposure-induced cardiomyocyte dysfunction...
  3. doi Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
    Juan I Garaycoechea
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 489:571-5. 2012
    ..Mice with combined inactivation of aldehyde catabolism (through Aldh2 knockout) and the Fanconi anaemia DNA-repair pathway (Fancd2 knockout) display developmental defects, a ..
  4. ncbi Expression of the aldehyde dehydrogenase 2-like gene is controlled by BOB.1/OBF.1 in B lymphocytes
    Cornelia Brunner
    University of Ulm, Department of Physiological Chemistry, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Biol Chem 278:45231-9. 2003
    ..Transient transfections confirm that this promoter is activated by BOB.1/OBF.1. Our observations suggest that by regulating genes in different functional pathways, BOB.1/OBF.1 has a widespread effect on B cell development and function...
  5. pmc Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems
    Boaz P Levi
    Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Blood 113:1670-80. 2009
    ..Finally, Aldh1a1 deficiency did not affect the function of stem cells from the adult central or peripheral nervous systems. Aldh1a1 is not a critical regulator of adult stem cell function or Aldefluor staining in mice...
  6. doi Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis
    Hiroko Hoshi
    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    J Bone Miner Res 27:2015-23. 2012
    ..Here we show that a dominant-negative form of aldehyde dehydrogenase 2 (ALDH2) protein, ALDH2*2, which is produced by a single nucleotide polymorphism (rs671), promotes osteoporosis due to ..
  7. pmc ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools
    Marilia Ioannou
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    Dev Biol 374:153-63. 2013
    ....
  8. pmc Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function
    Yingmei Zhang
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    BMC Med 10:40. 2012
    Mitochondrial aldehyde dehydrogenase (ALDH2) displays some promise in the protection against cardiovascular diseases although its role in diabetes has not been elucidated.
  9. doi Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula
    Claudia Compagnucci
    Department of Craniofacial Development, King s College London, Floor 27, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Dev Biol 377:428-48. 2013
    ....
  10. doi Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase
    Martina Griesberger
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Graz, Austria
    Mol Pharmacol 79:541-8. 2011
    Mitochondrial aldehyde dehydrogenase (ALDH2) contributes to vascular bioactivation of the antianginal drugs nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN), resulting in cGMP-mediated vasodilation...
  11. pmc Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity
    Marc Estienne Roehrich
    Department of Cardiology, Centre Hospitalier Universitaire Vaudois CHUV, avenue du Bugnon, 1011 Lausanne, Switzerland
    Biomed Res Int 2013:503047. 2013
    ..ALDH1A3 and ALDH2 expression was detectable in ALDH(very-br) and ALDH(br) cells, unlike ALDH(dim) cells, albeit at lower levels ..
  12. pmc SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
    Zhongping Lu
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, Maryland 20892, USA
    EMBO Rep 12:840-6. 2011
    ..Thus, protein deacetylation enhances xenobiotic liver injury by modulating the binding of a toxic metabolite to mitochondrial proteins...
  13. doi Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice
    Takuto Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Bone 53:358-68. 2013
    Aldehyde dehydrogenase 2 (ALDH2) degrades acetaldehyde produced by the metabolism of alcohol. The inactive ALDH2 phenotype is prevalent in East Asians, and an association between this ALDH2 polymorphism and osteoporosis has been reported...
  14. doi Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-2
    Matteo Beretta
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Austria
    Circ Res 110:385-93. 2012
    According to general view, aldehyde dehydrogenase-2 (ALDH2) catalyzes the high-affinity pathway of vascular nitroglycerin (GTN) bioactivation in smooth muscle mitochondria...
  15. doi High ethanol and acetaldehyde impair spatial memory in mouse models: opposite effects of aldehyde dehydrogenase 2 and apolipoprotein E on memory
    Mostofa Jamal
    Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki, Kita, Kagawa 761 0793, Japan
    Pharmacol Biochem Behav 101:443-9. 2012
    ..Apolipoprotein E has been suggested to be involved in the alteration of attention and memory. We have chosen Aldh2-knockout (Aldh2-KO), ApoE-KO, and their wild-type (WT) control mice to examine the effects of EtOH and AcH on ..
  16. pmc Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease
    Margaret Chia Ying Wey
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e31522. 2012
    ..To address this hypothesis, we generated mice null for Aldh1a1 and Aldh2, the two isoforms known to be expressed in substantia nigra dopamine neurons...
  17. pmc Aldehyde dehydrogenase-2 deficiency aggravates cardiac dysfunction elicited by endoplasmic reticulum stress induction
    Jianquan Liao
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
    Mol Med 18:785-93. 2012
    Mitochondrial aldehyde dehydrogenase-2 (ALDH2) has been characterized as an important mediator of endogenous cytoprotection in the heart...
  18. doi Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
    Frederic Langevin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 475:53-8. 2011
    ..Our results show that the acetaldehyde-catabolising enzyme Aldh2 is essential for the development of Fancd2(-/-) embryos...
  19. doi Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol
    Haruna Nagayoshi
    Osaka Prefectural Institute of Public Health, Osaka 537 0025, Japan
    Mutat Res 673:74-7. 2009
    ..dehydrogenase (Aldh)-2-knockout mice that were fed with alcohol to determine effects of alcohol consumption and Aldh2 genotype on the level of DNA damage in stomach...
  20. doi Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver
    Rui Guo
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming School of Pharmacy, Laramie, WY 82071, USA
    Clin Exp Pharmacol Physiol 36:463-8. 2009
    ..to examine the impact of facilitated acetaldehyde metabolism via overexpression of aldehyde dehydrogenase-2 (ALDH2) on chronic alcohol ingestion-induced hepatic damage...
  21. pmc Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress
    Shi Yan Li
    Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    J Mol Cell Cardiol 47:247-55. 2009
    ..This study was designed to examine the impact of aldehyde dehydrogenase-2 (ALDH2) transgenic overexpression on alcohol-induced insulin resistance and myocardial injury...
  22. doi Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models
    Mostofa Jamal
    Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki, Kita, Kagawa 761 0793, Japan
    Brain Res 1295:37-43. 2009
    ..acetaldehyde (ACe) on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the frontal cortex of Aldh2-/- (KO) mice. KO mice were used as models of Aldh2-deficient humans to examine ACe effects...
  23. doi Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart
    Jin Endo
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Circ Res 105:1118-27. 2009
    ..Aldehyde accumulation is regarded as a pathognomonic feature of oxidative stress-associated cardiovascular disease...
  24. doi Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice
    Hsu Sheng Yu
    Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Toxicol Mech Methods 19:535-40. 2009
    ..It covalently binds to DNA, and is known as a carcinogen. Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde...
  25. pmc Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice
    Grant R Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 48:757-64. 2010
    ..We recently identified aldehyde dehydrogenase 2 (ALDH2) as a PKCvarepsilon substrate, whose activation is necessary and sufficient to confer cardioprotection in vivo...
  26. ncbi Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate
    X Wang
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 271:16288-93. 1996
    ..These data support a function for RalDH(II) in the pathway of retinoic acid biogenesis...
  27. doi Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice
    Yuki Shimizu
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Bone 48:1075-86. 2011
    ..Approximately 45% of Chinese and Japanese individuals have the inactive aldehyde dehydrogenase 2 (Aldh2) phenotype. The absence of the ALDH2*2 allele is found to adversely influence the risk of osteoporosis...
  28. pmc Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice
    Hyehun Choi
    Department of Physiology, Georgia Health Sciences University, Augusta, Georgia 30912 3000, USA
    J Am Soc Hypertens 5:154-60. 2011
    Mitochondrial aldehyde dehydrogenase (ALDH2) is an enzyme that detoxifies aldehydes to carboxylic acids...
  29. doi Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice
    Akiko Matsumoto
    Departments of Social and Environmental Medicine, Saga Medical School, Saga, Japan
    Pharmacogenet Genomics 18:847-52. 2008
    The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian countries, and the mutated ALDH2 protein derived from ALDH2*2 lacks the ability of acetaldehyde metabolization...
  30. ncbi Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, 1 396 Kosugi cho, Nahakara ku, Kawasaki 211 8533, Japan
    J Neurochem 84:1110-7. 2003
    Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in acetaldehyde detoxification. The alcohol sensitivity is associated with a genetic deficiency of ALDH2...
  31. ncbi Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos
    Ujjwal Kumar Rout
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 East Hancock, Detroit, MI 48201, USA
    Reprod Toxicol 16:253-8. 2002
    ..The absence of enzymes to convert ethanol to acetaldehyde, coupled with oocyte expression of the acetaldehyde-degrading enzyme, Ahd-5, may be protective for the early embryo...
  32. ncbi Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse
    K Kitagawa
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan
    FEBS Lett 476:306-11. 2000
    ..MALD oxidation was examined with liver subcellular fractions from Japanese subjects who carried three different ALDH2 genotypes and Aldh2 knockout mice, which were generated in this study...
  33. ncbi Assignment of the mitochondrial aldehyde dehydrogenase gene (Aldh2) to mouse chromosome 5 by fluorescence in situ hybridization
    K Jeong
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Cytogenet Cell Genet 89:54-5. 2000
  34. ncbi Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice
    A Wallen
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, S 171 77, Sweden
    Exp Cell Res 253:737-46. 1999
    ..We conclude that NURR1 plays a critical role in the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic DA cells...
  35. pmc The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development
    W K Greene
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Cell Biol 18:7030-7. 1998
    ..This result suggests that expression of Aldh1 protein is negatively regulated by Hox11 and that abnormal expression of Aldh1 in Hox11 null mice may cause loss of splenic precursor cells by aberrant retinoic acid metabolism...
  36. ncbi Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11
    K Huppi
    Laboratory of Genetics, NCI NIH, Bethesda, MD 20892
    Immunogenetics 37:288-91. 1993
  37. ncbi Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases
    M Chen
    Department of Pharmacology, Cornell University Medical College, New York, New York 10021
    Mol Pharmacol 46:88-96. 1994
    ..AHD-2 is more active than AHD-M1 in this conversion, but AHD-2 is not the enzyme responsible for this conversion in F9 embryonic stem cells...
  38. ncbi Cloning and characterization of the gene encoding mouse mitochondrial aldehyde dehydrogenase
    C Chang
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Gene 148:331-6. 1994
    The mitochondrial (mt) aldehyde dehydrogenase (ALDH2) in liver has been considered to play a major role in the detoxification of alcohol in humans...
  39. pmc Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor
    J Caubín
    Departamento de Investigacion, Pharmacia Antibióticos Farma S A, Madrid, Spain
    Nucleic Acids Res 22:4132-8. 1994
    ..This method, extensive to other ligand-modulated transcription factors, might be useful to all transcription factors with slight modifications...
  40. ncbi A gene for susceptibility to small intestinal cancer, ssic1, maps to the distal part of mouse chromosome 4
    R J Fijneman
    The Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam, The Netherlands
    Cancer Res 55:3179-82. 1995
    ..This difference is highly significant (chi 2 = 31 for D4Mit158). Therefore, one of the genes that influence susceptibility to small intestinal cancer, ssic1, maps to the distal part of chromosome 4...
  41. ncbi Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki 211 8533, Japan
    J Hum Genet 48:404-9. 2003
    Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in acetaldehyde detoxification. The alcohol sensitivity is associated with a genetic deficiency of ALDH2...
  42. ncbi Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism
    Tsunehiro Oyama
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 10:951-60. 2005
    ..that may cause cellular and DNA damages, is converted to acetate by mitochondrial aldehyde dehydrogenase ALDH2. Although the majority of ingested alcohol is eliminated in the liver, the first-pass metabolism of ethanol in the ..
  43. doi Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction
    Philip Wenzel
    Second Medical Clinic, Department of Cardiology, Johannes Gutenberg University, Mainz, Germany
    Cardiovasc Res 80:280-9. 2008
    ..In the present study, mitochondria as a source of reactive oxygen species (ROS) and the contribution of manganese superoxide dismutase (MnSOD, SOD-2) and aldehyde dehydrogenase (ALDH-2) were investigated...
  44. doi Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 211 8533, Japan
    J Neurosci 28:6239-49. 2008
    ..We have previously shown that mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies HNE by oxidizing its aldehyde group...
  45. ncbi ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties
    Philip Wenzel
    II Medizinische Klinik, Labor für Molekulare Kardiologie, Johannes Gutenberg Universitat Mainz, Langenbeck Str 1, 55131 Mainz, Germany
    Biochem Biophys Res Commun 367:137-43. 2008
    ..Our results suggest that ALDH-2 has an indirect antioxidative property independent of its thiol-moiety in disease states of cardiovascular oxidative stress...
  46. ncbi Single-dose ethanol administration downregulates expression of cytochrome p450 2E1 mRNA in aldehyde dehydrogenase 2 knockout mice
    Akiko Matsumoto
    Department of Social and Environmental Medicine, Saga Medical School, Saga 849 8501, Japan
    Alcohol 41:587-9. 2007
    The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian origin...
  47. ncbi Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver
    Akiko Matsumoto
    Department of Social and Environmental Medicine, Saga Medical School, Saga 849 8501, Japan
    Alcohol 41:57-9. 2007
    Polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is far more common in East Asian countries...
  48. ncbi Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
    Alcohol Clin Exp Res 30:1659-69. 2006
    ..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains...
  49. ncbi Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice
    Elizabeth Fernandez
    Research Service and Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, USA
    Alcohol Clin Exp Res 30:1650-8. 2006
    ..addition to removing acetaldehyde produced during the metabolism of ethanol, mitochondrial aldehyde dehydrogenase (ALDH2) functions in the pathway by which aldehyde metabolites of the monoamines dopamine (DA) and serotonin (5-HT) are ..
  50. ncbi Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice
    Toyohi Isse
    Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Toxicol Sci 30:329-37. 2005
    Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde...
  51. ncbi Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality
    Toyohi Isse
    Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Toxicol Sci 30:315-28. 2005
    Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde...
  52. pmc An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation
    Zhiqiang Chen
    Department of Medicine and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:12159-64. 2005
    ....
  53. ncbi Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study
    Yong Dae Kim
    Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, 48 San Kaeshin dong, Hungdok gu, Cheongju, Chungbuk, 361 763, South Korea
    Arch Toxicol 79:192-5. 2005
    ..expression levels of hepatic cytochrome P450 (CYP) 2E1, 2B1/2 and 4B1 enzymes in aldehyde dehydrogenase 2 (Aldh2) +/+ and Aldh2 -/- mice by immunoblotting assay following subchronic ethanol exposure for eight days...
  54. ncbi Aldehyde dehydrogenase is a positional marker in the retina
    P McCaffery
    Department of Neurobiology, Harvard Medical School Boston, MA 02115
    Development 112:693-702. 1991
    ....