Gene Symbol: Akap3
Description: A kinase (PRKA) anchor protein 3
Alias: Prka3, A-kinase anchor protein 3, A-kinase anchor protein 110 kDa, AKAP 110, AKAP-3, Protein kinase A-anchoring protein 3
Species: mouse
Products:     Akap3

Top Publications

  1. Vijayaraghavan S, Liberty G, Mohan J, Winfrey V, Olson G, Carr D. Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Mol Endocrinol. 1999;13:705-17 pubmed
    ..These data suggest that AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. ..
  2. Carr D, Fujita A, Stentz C, Liberty G, Olson G, Narumiya S. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. J Biol Chem. 2001;276:17332-8 pubmed
    ..These data suggest that sperm contains several proteins that bind to AKAPs in a manner similar to RII and imply that AKAPs may have additional and perhaps unique functions in spermatozoa. ..
  3. Brown P, Miki K, Harper D, Eddy E. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Biol Reprod. 2003;68:2241-8 pubmed
    ..We found that AKAP4 binds AKAP3 and two novel spermatogenic cell-specific proteins, Fibrous Sheath Interacting Proteins 1 and 2 (FSIP1, FSIP2)...
  4. Lea I, Widgren E, O Rand M. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. Reprod Biol Endocrinol. 2004;2:57 pubmed
    ..This study demonstrates that Sp17 from spermatozoa binds A-kinase anchoring protein 3 (AKAP3), confirming the functionality of the N-terminal domain...
  5. Krisfalusi M, Miki K, Magyar P, O Brien D. Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol Reprod. 2006;75:270-8 pubmed
    ..These data support a role for the fibrous sheath as a scaffold for anchoring multiple glycolytic enzymes along the length of the flagellum to provide a localized source of ATP that is essential for sperm motility. ..
  6. Li Y, He W, Kim Y, Mandal A, Digilio L, Klotz K, et al. CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Reprod Biol Endocrinol. 2010;8:101 pubmed publisher
    ..Deletion of the CABYR RII domain abolished the interaction between CABYR and AKAP3/AKAP4 but did not abolish the interaction between CABYR and ropporin suggesting that CABYR binds to AKAP3/AKAP4 by ..
  7. Xu K, Yang L, Zhao D, Wu Y, Qi H. AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis. Biol Reprod. 2014;90:119 pubmed publisher
    ..A-kinase anchoring protein 3 (AKAP3) is one of the major components of the fibrous sheath of the sperm tail that is formed during spermiogenesis...
  8. Xu K, Qi H. Sperm-specific AKAP3 is a dual-specificity anchoring protein that interacts with both protein kinase a regulatory subunits via conserved N-terminal amphipathic peptides. Mol Reprod Dev. 2014;81:595-607 pubmed publisher
    ..Among several A kinase anchoring proteins (AKAPs) expressed in the testis, sperm-specific AKAP3 can be found in the cytoplasm of elongating spermatids and interacts with RI?, as demonstrated by both in vivo and ..
  9. Fatima S, Wagstaff K, Loveland K, Jans D. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Sci Rep. 2015;5:9459 pubmed publisher
    ..with three of these, PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), A-Kinase anchor protein (AKAP3) and DNA methyl transferase 1 (DNMT1), was confirmed by coimmunoprecipitation assays...

More Information


  1. Weidemann M, Schuster Gossler K, Stauber M, Wrede C, Hegermann J, Ott T, et al. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development. 2016;143:4736-4748 pubmed