Gene Symbol: Ak2
Description: adenylate kinase 2
Alias: Ak-2, D4Ertd220e, adenylate kinase 2, mitochondrial, AK 2, ATP-AMP transphosphorylase 2, ATP:AMP phosphotransferase, adenylate monophosphate kinase
Species: mouse
Products:     Ak2

Top Publications

  1. Tanabe T, Yamada M, Noma T, Kajii T, Nakazawa A. Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes. J Biochem. 1993;113:200-7 pubmed
    ..We isolated cDNAs for rat AK isozymes (AK1, AK2, and AK3), determined their mRNAs in rat tissues by Northern blot analysis, and measured the isozyme activities...
  2. Cao W, Haig Ladewig L, Gerton G, Moss S. Adenylate kinases 1 and 2 are part of the accessory structures in the mouse sperm flagellum. Biol Reprod. 2006;75:492-500 pubmed
    ..We previously identified adenylate kinase 1 and 2 (AK1 and AK2) by mass spectrometry as part of a mouse SDS-insoluble flagellar preparation containing the accessory structures (..
  3. Aksu S, Koczan D, Renne U, Thiesen H, Brockmann G. Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. J Appl Genet. 2007;48:133-43 pubmed
    ..14 out of these genes, occur in QTL regions for body weight or abdominal fat weight. Further analyses are necessary to discriminate between genes directly causing QTL effects and indirectly regulated differentially expressed genes. ..
  4. Lagresle Peyrou C, Six E, Picard C, Rieux Laucat F, Michel V, Ditadi A, et al. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet. 2009;41:106-11 pubmed publisher
    ..In addition, affected newborns have bilateral sensorineural deafness. Here we identify biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis...
  5. Francke U, Lalley P, Moss W, Ivy J, Minna J. Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19:57-84 pubmed
    ..Striking examples of norandom segregation of mouse chromosomes were observed in these hybrids with preferential retention of 15 and segregation of 11 and the Y chromosome. ..
  6. Lalley P, Francke U, Minna J. Homologous genes for enolase, phosphogluconate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome 1p. Proc Natl Acad Sci U S A. 1978;75:2382-6 pubmed
    ..Identification of such conserved regions will contribute to our understanding of the evolution of the mammalian genome and could suggest gene location by homology mapping. ..
  7. Lalley P, Minna J, Francke U. Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978;274:160-3 pubmed
  8. Etzion S, Etzion Y, DeBosch B, Crawford P, Muslin A. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial ?-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49:931-40 pubmed publisher
    ..This maladaptive response is associated with hypersensitivity of akt2(-/-) myocardium to ?-adrenergic stimulation. ..
  9. Burkart A, Shi X, Chouinard M, Corvera S. Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J Biol Chem. 2011;286:4081-9 pubmed publisher
    ..Here we find that adenylate kinase 2 (AK2), a mitochondrial enzyme that regulates adenine nucleotide interconversion within the intermembrane space, is ..

More Information


  1. Tanimura A, Horiguchi T, Miyoshi K, Hagita H, Noma T. Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS ONE. 2014;9:e89916 pubmed publisher
    ..In addition, two other studies reported that AK2 is a responsible gene for reticular dysgenesis (RD), a human disease that is characterized by severe combined ..
  2. Vadnais M, Cao W, Aghajanian H, Haig Ladewig L, Lin A, Al Alao O, et al. Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm. Biol Reprod. 2014;90:128 pubmed publisher
    ..In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm ..
  3. Kim H, Lee H, Oh Y, Choi S, Hong S, Kim H, et al. The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth. Nat Commun. 2014;5:3351 pubmed publisher
    Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-functional protein. Here we show that AK2 negatively regulates tumour cell growth...