Ahr

Summary

Gene Symbol: Ahr
Description: aryl-hydrocarbon receptor
Alias: Ahh, Ahre, bHLHe76, aryl hydrocarbon receptor, ah receptor, dioxin receptor
Species: mouse
Products:     Ahr

Top Publications

  1. Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, et al. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J Exp Med. 2009;206:2027-35 pubmed publisher
    ..In this study, we found that the aryl hydrocarbon receptor (Ahr) negatively regulates inflammatory responses mediated by lipopolysaccharide (LPS) in macrophages...
  2. Jux B, Kadow S, Esser C. Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice. J Immunol. 2009;182:6709-17 pubmed publisher
    ..The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is involved in low molecular mass chemical metabolism ..
  3. Rico De Souza A, Zago M, Pollock S, Sime P, Phipps R, Baglole C. Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis. J Biol Chem. 2011;286:43214-28 pubmed publisher
    ..Fibroblasts express the aryl hydrocarbon receptor (AhR), a transcription factor that attenuates pulmonary inflammation and may also regulate apoptosis...
  4. Vogel C, Khan E, Leung P, Gershwin M, Chang W, Wu D, et al. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-?B. J Biol Chem. 2014;289:1866-75 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is involved in the regulation of immune responses, T-cell differentiation, and immunity...
  5. Marlowe J, Fan Y, Chang X, Peng L, Knudsen E, Xia Y, et al. The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol Biol Cell. 2008;19:3263-71 pubmed publisher
    ..These results point to a proproliferative, antiapoptotic function of the Ah receptor that likely plays a role in tumor progression.
  6. Sibilano R, Frossi B, Calvaruso M, Danelli L, Betto E, Dall Agnese A, et al. The aryl hydrocarbon receptor modulates acute and late mast cell responses. J Immunol. 2012;189:120-7 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activity is modulated by xenobiotics as well as physiological ligands...
  7. Mezrich J, Fechner J, Zhang X, Johnson B, Burlingham W, Bradfield C. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol. 2010;185:3190-8 pubmed publisher
    The aryl hydrocarbon receptor (AHR) has been known to cause immunosuppression after binding dioxin...
  8. Camacho I, Singh N, Hegde V, Nagarkatti M, Nagarkatti P. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. J Immunol. 2005;175:90-103 pubmed
    We investigated the role of aryl hydrocarbon receptor (AhR) in the regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced apoptosis in thymic T cells...
  9. Lee J, Cella M, McDonald K, Garlanda C, Kennedy G, Nukaya M, et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol. 2011;13:144-51 pubmed publisher
    ..ILC22 cells include NKp46(+) and lymphoid tissue-inducer (LTi)-like subsets that express the aryl hydrocarbon receptor (AHR)...

More Information

Publications88

  1. Ma Q, Baldwin K. 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway. Role of the transcription activaton and DNA binding of AhR. J Biol Chem. 2000;275:8432-8 pubmed
    Activation of the aryl hydrocarbon receptor (AhR) by 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), a potent agonist of AhR, induces a marked reduction in steady state AhR...
  2. Schmidt J, Carver L, Bradfield C. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem. 1993;268:22203-9 pubmed
    The AH receptor is a ligand-activated transcription factor that mediates the biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin...
  3. Andreola F, Fernandez Salguero P, Chiantore M, Petkovich M, Gonzalez F, De Luca L. Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res. 1997;57:2835-8 pubmed
    Livers from aryl hydrocarbon receptor-null mice showed a 3-fold increase in retinoids and a 65% decrease in retinoic acid metabolism...
  4. Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, et al. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature. 2003;423:545-50 pubmed
    ..A heterodimer of the dioxin receptor (AhR) and Arnt, which are basic helix-loop-helix/PAS-family transcription factors, mediates most of the toxic ..
  5. Funatake C, Marshall N, Steppan L, Mourich D, Kerkvliet N. Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells. J Immunol. 2005;175:4184-8 pubmed
    Activation of the aryl hydrocarbon receptor (AhR) by its most potent ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), leads to immune suppression in mice...
  6. Tanos R, Murray I, Smith P, Patterson A, Perdew G. Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver. Toxicol Sci. 2012;129:372-9 pubmed publisher
    We have previously demonstrated a role for the aryl hydrocarbon receptor (AHR) in the attenuation of the cholesterol biosynthesis pathway. This regulation did not require that the AHR binds to its cognate response element...
  7. Vogel C, Goth S, Dong B, Pessah I, Matsumura F. Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun. 2008;375:331-5 pubmed publisher
    b>Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to immune suppression associated with the induction of regulatory T cells (T(reg)) expressing the transcription factor Foxp3...
  8. Esser C, Rannug A, Stockinger B. The aryl hydrocarbon receptor in immunity. Trends Immunol. 2009;30:447-54 pubmed publisher
    ..Certain chemicals can alter immune responses via their action on the cytosolic transcription factor aryl hydrocarbon receptor (AhR)...
  9. Baglole C, Maggirwar S, Gasiewicz T, Thatcher T, Phipps R, Sime P. The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. J Biol Chem. 2008;283:28944-57 pubmed publisher
    ..The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that influences responses to certain environmental ..
  10. Wu D, Nishimura N, Kuo V, Fiehn O, Shahbaz S, VAN WINKLE L, et al. Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol. 2011;31:1260-7 pubmed publisher
    ..we showed that treatment of macrophages with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to aryl hydrocarbon receptor (AhR)-dependent activation of inflammatory mediators and the formation of cholesterol-laden foam cells...
  11. Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, et al. Evidence for a novel anti-apoptotic pathway in human keratinocytes involving the aryl hydrocarbon receptor, E2F1, and checkpoint kinase 1. Cell Death Differ. 2013;20:1425-34 pubmed publisher
    ..We have discovered that the aryl hydrocarbon receptor (AHR), a key regulator of drug metabolism and an UVB-sensitive transcription factor, serves an anti-..
  12. Benedict J, Miller K, Lin T, Greenfeld C, Babus J, Peterson R, et al. Aryl hydrocarbon receptor regulates growth, but not atresia, of mouse preantral and antral follicles. Biol Reprod. 2003;68:1511-7 pubmed
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds various environmental contaminants...
  13. Vorderstrasse B, Lawrence B. Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response. Infect Immun. 2006;74:5679-86 pubmed
    ..In the studies presented here, we sought to determine whether activation of the aryl hydrocarbon receptor (AhR) would protect mice from an otherwise lethal infection with S. pneumoniae...
  14. Patel R, Murray I, Flaveny C, Kusnadi A, Perdew G. Ah receptor represses acute-phase response gene expression without binding to its cognate response element. Lab Invest. 2009;89:695-707 pubmed publisher
    ..We investigated the potential of the aryl hydrocarbon receptor (AHR) to suppress NF-kappaB regulated-gene expression, especially acute-phase genes, such as serum ..
  15. Fernandez Salguero P, Ward J, Sundberg J, Gonzalez F. Lesions of aryl-hydrocarbon receptor-deficient mice. Vet Pathol. 1997;34:605-14 pubmed
    We have analyzed the possible role of the aryl-hydrocarbon receptor (AHR) in the aging process of mice using a homozygous null mouse (Ahr-/-) line as a model. We studied 52 male and female Ahr-/- mice aged from 6-13 months...
  16. Quintana F, Basso A, Iglesias A, Korn T, Farez M, Bettelli E, et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature. 2008;453:65-71 pubmed publisher
    ..Here we report the identification of the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) as a regulator of T(reg) and T(H)17 cell differentiation in mice...
  17. Lund A, Goens M, Kanagy N, Walker M. Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure. Toxicol Appl Pharmacol. 2003;193:177-87 pubmed
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicity of xenobiotics, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin...
  18. Kudo K, Takeuchi T, Murakami Y, Ebina M, Kikuchi H. Characterization of the region of the aryl hydrocarbon receptor required for ligand dependency of transactivation using chimeric receptor between Drosophila and Mus musculus. Biochim Biophys Acta. 2009;1789:477-86 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor...
  19. Ikuta T, Ohba M, Zouboulis C, Fujii Kuriyama Y, Kawajiri K. B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor. J Dermatol Sci. 2010;58:211-6 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor...
  20. Kiss E, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. 2011;334:1561-5 pubmed publisher
    ..ROR?t(+) ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of ..
  21. Ichihara S, Yamada Y, Ichihara G, Nakajima T, Li P, Kondo T, et al. A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2007;27:1297-304 pubmed
    The aryl hydrocarbon receptor (AHR) is a transcription factor that binds to DNA as a heterodimer with the AHR nuclear translocator (ARNT) after interaction with ligands such as polycyclic and halogenated aromatic hydrocarbons found in ..
  22. Negishi T, Kato Y, Ooneda O, Mimura J, Takada T, Mochizuki H, et al. Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance. J Immunol. 2005;175:7348-56 pubmed
    ..In this report, we determined that M50354 (an active metabolite of M50367) was a ligand for the aryl hydrocarbon receptor (AhR); the immunological effects of this compound on in vitro Th1/Th2 differentiation from naive Th ..
  23. Zhang N, Agbor L, Scott J, Zalobowski T, Elased K, Trujillo A, et al. An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice. Biochem Pharmacol. 2010;80:197-204 pubmed publisher
    It has been postulated that fetal vascular abnormalities in aryl hydrocarbon receptor null (ahr(-/-)) mice may alter cardiovascular homeostasis in adulthood...
  24. Chang C, Smith D, Prasad V, Sidman C, Nebert D, Puga A. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics. 1993;3:312-21 pubmed
    ..and nucleotide sequencing the cDNAs of the Ahrb-1 and Ahrd allelic forms of the aromatic hydrocarbon receptor (AhR) present in inbred strains of mice...
  25. Gomez Duran A, Carvajal Gonzalez J, Mulero Navarro S, Santiago Josefat B, Puga A, Fernandez Salguero P. Fitting a xenobiotic receptor into cell homeostasis: how the dioxin receptor interacts with TGFbeta signaling. Biochem Pharmacol. 2009;77:700-12 pubmed publisher
    ..The dioxin receptor (AhR) is a unique intracellular protein long studied because of its critical role in xenobiotic-induced ..
  26. Shi L, Faith N, Nakayama Y, Suresh M, Steinberg H, Czuprynski C. The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice. J Immunol. 2007;179:6952-62 pubmed
    The aryl hydrocarbon receptor (AhR) is part of a powerful signaling system that is triggered by xenobiotic agents such as polychlorinated hydrocarbons and polycyclic aromatic hydrocarbons...
  27. Sanchez Y, Rosado J, Vega L, Elizondo G, Estrada Muñiz E, Saavedra R, et al. The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. J Biomed Biotechnol. 2010;2010:505694 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is part of a signaling system that is mainly triggered by xenobiotic agents. Increasing evidence suggests that AhR may regulate immunity to infections...
  28. Fritsche E, Schafer C, Calles C, Bernsmann T, Bernshausen T, Wurm M, et al. Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci U S A. 2007;104:8851-6 pubmed
    ..We show that through the intracellular generation of photoproducts, such as the arylhydrocarbon receptor (AhR) ligand 6-formylindolo[3,2-b]carbazole, signaling events are initiated, which are transferred to the nucleus and ..
  29. Bunger M, Moran S, Glover E, Thomae T, Lahvis G, Lin B, et al. Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem. 2003;278:17767-74 pubmed
    The Ah receptor (AHR) mediates the metabolic adaptation to a number of planar aromatic chemicals...
  30. Walisser J, Glover E, Pande K, Liss A, Bradfield C. Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A. 2005;102:17858-63 pubmed
    The aryl hydrocarbon receptor (AHR) plays a role in three areas of biology that include the adaptive metabolism of xenobiotics, the toxic responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), and vascular ..
  31. Butler R, Kelley M, Powell W, Hahn M, Van Beneden R. An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding. Gene. 2001;278:223-34 pubmed
    The aryl hydrocarbon receptor (AHR) mediates numerous toxic effects following exposure of vertebrate animals to certain aromatic environmental contaminants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  32. Barnett K, Tomic D, Gupta R, Miller K, Meachum S, Paulose T, et al. The aryl hydrocarbon receptor affects mouse ovarian follicle growth via mechanisms involving estradiol regulation and responsiveness. Biol Reprod. 2007;76:1062-70 pubmed
    The aryl hydrocarbon receptor (AHR) is a known transcription factor. Although studies indicate that Ahr-deficient (AhRKO) mice have defects in female reproduction, only a few studies have examined the role of AHR in the ovary...
  33. Gonzalez F, Fernandez Salguero P. The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metab Dispos. 1998;26:1194-8 pubmed
    The aryl hydrocarbon receptor (AHR) is believed to mediate the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyls, and polycyclic aromatic hydrocarbons...
  34. Carvajal Gonzalez J, Roman A, Cerezo Guisado M, Rico Leo E, Martin Partido G, Fernandez Salguero P. Loss of dioxin-receptor expression accelerates wound healing in vivo by a mechanism involving TGFbeta. J Cell Sci. 2009;122:1823-33 pubmed publisher
    ..The dioxin receptor (AhR) modulates cell plasticity and migration and its activation by occupational polycyclic aromatic ..
  35. Bunger M, Glover E, Moran S, Walisser J, Lahvis G, Hsu E, et al. Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor. Toxicol Sci. 2008;106:83-92 pubmed publisher
    The aryl hydrocarbon receptor (AHR) is known for its role in the adaptive and toxic responses to a large number of environmental contaminants, as well as its role in hepatovascular development...
  36. Sekine H, Mimura J, Oshima M, Okawa H, Kanno J, Igarashi K, et al. Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol Cell Biol. 2009;29:6391-400 pubmed publisher
    b>Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic hydrocarbons...
  37. Nebert D, Dalton T, Okey A, Gonzalez F. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem. 2004;279:23847-50 pubmed
    ..encoding cytochromes P450 1A1, 1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR)...
  38. Abbott B, Probst M. Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo. Dev Dyn. 1995;204:144-55 pubmed
    The aryl hydrocarbon receptor (AhR) and the AhR nuclear translocator protein (ARNT) are basic-helix-loop-helix (bHLH) proteins involved in transcriptional regulation. The AhR is a ligand-activated partner of the ARNT protein...
  39. Mulero Navarro S, Pozo Guisado E, Perez Mancera P, Alvarez Barrientos A, Catalina Fernandez I, Hernández Nieto E, et al. Immortalized mouse mammary fibroblasts lacking dioxin receptor have impaired tumorigenicity in a subcutaneous mouse xenograft model. J Biol Chem. 2005;280:28731-41 pubmed
    Although the dioxin receptor, the aryl hydrocarbon receptor (AhR), is considered a major regulator of xenobiotic-induced carcinogenesis, its role in tumor formation in the absence of xenobiotics is still largely unknown...
  40. Gohlke J, Stockton P, Sieber S, Foley J, Portier C. AhR-mediated gene expression in the developing mouse telencephalon. Reprod Toxicol. 2009;28:321-8 pubmed publisher
    We hypothesize that TCDD-induced developmental neurotoxicity is modulated through an AhR-dependent interaction with key regulatory neuronal differentiation pathways during telencephalon development...
  41. Kerkvliet N, Shepherd D, Baecher Steppan L. T lymphocytes are direct, aryl hydrocarbon receptor (AhR)-dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): AhR expression in both CD4+ and CD8+ T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD. Toxicol Appl Pharmacol. 2002;185:146-52 pubmed
    ..Although activation of the aryl hydrocarbon receptor (AhR) is required, the specific AhR+ cells that transduce the suppression have been difficult to ..
  42. Soshilov A, Denison M. Role of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor. J Biol Chem. 2008;283:32995-3005 pubmed publisher
    The aryl hydrocarbon receptor (AhR) mediates the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds...
  43. Hu P, Herrmann R, Bednar A, Saloupis P, Dwyer M, Yang P, et al. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proc Natl Acad Sci U S A. 2013;110:E4069-78 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is a nuclear receptor that regulates xenobiotic metabolism and detoxification...
  44. Li Y, Innocentin S, Withers D, Roberts N, Gallagher A, Grigorieva E, et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell. 2011;147:629-40 pubmed publisher
    ..We show here that the aryl hydrocarbon receptor (AhR) is a crucial regulator in maintaining IEL numbers in both the skin and the intestine...
  45. Thomas R, Penn S, Holden K, Bradfield C, Rank D. Sequence variation and phylogenetic history of the mouse Ahr gene. Pharmacogenetics. 2002;12:151-63 pubmed
    The Ahr locus encodes for the aryl hydrocarbon receptor (AHR), which plays an important toxicological and developmental role...
  46. Hernandez Ochoa I, Barnett Ringgold K, Dehlinger S, Gupta R, Leslie T, Roby K, et al. The ability of the aryl hydrocarbon receptor to regulate ovarian follicle growth and estradiol biosynthesis in mice depends on stage of sexual maturity. Biol Reprod. 2010;83:698-706 pubmed publisher
    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of environmental chemicals and regulates many physiological functions, including processes in female reproduction...
  47. Lund A, Goens M, Nuñez B, Walker M. Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (AhR) null mice. Toxicol Appl Pharmacol. 2006;212:127-35 pubmed
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor characterized to play a role in detection and adaptation to environmental stimuli...
  48. Kadow S, Jux B, Zahner S, Wingerath B, Chmill S, Clausen B, et al. Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis. J Immunol. 2011;187:3104-10 pubmed publisher
    An immunoregulatory role of aryl hydrocarbon receptor (AhR) has been shown in conventional ?? and ?? T cells, but its function in skin ?? T cells (dendritic epidermal T cells [DETC]) is unknown...
  49. Tauchi M, Hida A, Negishi T, Katsuoka F, Noda S, Mimura J, et al. Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Mol Cell Biol. 2005;25:9360-8 pubmed
    ..It is also possible that PAHs contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription, since PAHs are potent inducers of the AhR...
  50. Moriguchi T, Motohashi H, Hosoya T, Nakajima O, Takahashi S, Ohsako S, et al. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc Natl Acad Sci U S A. 2003;100:5652-7 pubmed
    ..responses of mammals to dioxin are strongly influenced by functional polymorphisms of the arylhydrocarbon receptor (AHR)...
  51. Kimura A, Naka T, Nohara K, Fujii Kuriyama Y, Kishimoto T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U S A. 2008;105:9721-6 pubmed publisher
    ..Here, we demonstrate that aryl hydrocarbon receptor (Ahr) has an important regulatory function in the commitment of Th17 cells...
  52. Abbott B, Birnbaum L, Perdew G. Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo. Dev Dyn. 1995;204:133-43 pubmed
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with a basic region/helix-loop-helix (bHLH) motif...
  53. Fritz W, Lin T, Peterson R. The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates. Carcinogenesis. 2008;29:1077-82 pubmed publisher
    Hypoxia-inducible factor-1 alpha (HIF-1alpha) and aryl hydrocarbon receptor nuclear translocator (ARNT) are basic helix-loop-helix/per-arnt-sim (PAS) family transcription factors...
  54. Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, et al. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A. 2000;97:779-82 pubmed
    The contribution of the aryl hydrocarbon receptor (AhR) in induction of a battery of xenobiotic-metabolizing enzymes has been studied extensively...
  55. Veldhoen M, Hirota K, Christensen J, O GARRA A, Stockinger B. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med. 2009;206:43-9 pubmed publisher
    ..interleukin (IL)-6 and transforming growth factor (TGF)-beta, and it is modulated by activation of the aryl hydrocarbon receptor (AhR)...
  56. Zhou Y, Tung H, Tsai Y, Hsu S, Chang H, Kawasaki H, et al. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood. 2013;121:3195-204 pubmed publisher
    We propose that the aryl hydrocarbon receptor (AhR), a unique chemical sensor, is critical in controlling mast cell differentiation, growth, and function in vitro and in vivo...
  57. Fernandez Salguero P, Hilbert D, Rudikoff S, Ward J, Gonzalez F. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharmacol. 1996;140:173-9 pubmed
    ..in vitro and correlative studies have indicated the involvement of a transcription factor known as the aryl hydrocarbon receptor (AHR)...
  58. Petrulis J, Kusnadi A, Ramadoss P, Hollingshead B, Perdew G. The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity. J Biol Chem. 2003;278:2677-85 pubmed
    The mouse aryl hydrocarbon receptor (mAhR) is a ligand-activated transcription factor that exists in a tetrameric, core complex with a dimer of the 90-kDa heat shock protein, and the hepatitis B virus X-associated protein 2 (XAP2)...
  59. Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, Miki H, et al. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature. 2007;446:562-6 pubmed
    ..Here we characterize a fat-soluble ligand-dependent ubiquitin ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B(AhR)...
  60. Baba T, Mimura J, Nakamura N, Harada N, Yamamoto M, Morohashi K, et al. Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. Mol Cell Biol. 2005;25:10040-51 pubmed
    ..Studies using aryl hydrocarbon receptor (AhR)-deficient mice suggest that the majority of these toxic effects are mediated by the AhR...
  61. Chang X, Fan Y, Karyala S, Schwemberger S, Tomlinson C, Sartor M, et al. Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor. Mol Cell Biol. 2007;27:6127-39 pubmed
    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects of its xenobiotic ligands and acts as an environmental checkpoint during the cell cycle...
  62. Yu T, Kondo T, Matsumoto T, Fujii Kuriyama Y, Imai Y. Aryl hydrocarbon receptor catabolic activity in bone metabolism is osteoclast dependent in vivo. Biochem Biophys Res Commun. 2014;450:416-22 pubmed publisher
    ..b>Aryl hydrocarbon receptor (AhR) is known as a dioxin receptor and is responsible for various pathological and physiological ..
  63. Simonian P, Wehrmann F, Roark C, Born W, O Brien R, Fontenot A. ?? T cells protect against lung fibrosis via IL-22. J Exp Med. 2010;207:2239-53 pubmed publisher
    ..Preventing expression of IL-22, either by mutating the aryl hydrocarbon receptor (AhR) or inhibiting AhR signaling, accelerated lung fibrosis...
  64. Nukaya M, Moran S, Bradfield C. The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A. 2009;106:4923-8 pubmed publisher
    The aryl hydrocarbon receptor (AHR) plays a central role in 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) hepatotoxicity, regulation of xenobiotic metabolism, and hepatovascular development...
  65. Sánchez Martín F, Fernandez Salguero P, Merino J. Aryl hydrocarbon receptor-dependent induction of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in cerebellar granule cells from mouse. J Neurochem. 2011;118:153-62 pubmed publisher
    ..TCDD is a ligand of the aryl hydrocarbon receptor (AhR), which is a key signaling molecule to fully understand the toxic and carcinogenic properties of ..
  66. Aragon A, Kopf P, Campen M, Huwe J, Walker M. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicol Sci. 2008;101:321-30 pubmed
    ..cardiac hypertrophy (atrial natriuretic peptide, beta-myosin heavy chain, osteopontin), and aryl hydrocarbon receptor (AHR) activation (cytochrome P4501A1, AHR repressor)...
  67. Lahvis G, Bradfield C. Ahr null alleles: distinctive or different?. Biochem Pharmacol. 1998;56:781-7 pubmed
    Two independent laboratories have generated Ahr "null" or "knockout" mice that share some common characteristics but also have distinct phenotypes...
  68. Mimura J, Yamashita K, Nakamura K, Morita M, Takagi T, Nakao K, et al. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells. 1997;2:645-54 pubmed
    The aryl hydrocarbon receptor (AhR or dioxin receptor) is a ligand-activated transcription factor that is considered to mediate pleiotropic biological responses such as teratogenesis, tumour promotion, epithelial hyperplasia and the ..
  69. Jain S, Maltepe E, Lu M, Simon C, Bradfield C. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech Dev. 1998;73:117-23 pubmed
    The basic helix-loop-helix-PAS (bHLH-PAS) protein ARNT is a dimeric partner of the Ah receptor (AHR) and hypoxia inducible factor 1 alpha(HIF1 alpha)...
  70. Benedict J, Lin T, Loeffler I, Peterson R, Flaws J. Physiological role of the aryl hydrocarbon receptor in mouse ovary development. Toxicol Sci. 2000;56:382-8 pubmed
    The aryl hydrocarbon receptor (AhR) regulates the toxicity of environmental contaminants such as 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)...
  71. Contador Troca M, Alvarez Barrientos A, Barrasa E, Rico Leo E, Catalina Fernandez I, Menacho Márquez M, et al. The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis. Carcinogenesis. 2013;34:2683-93 pubmed publisher
    ..The dioxin receptor (AhR) is required for xenobiotic-induced toxicity and carcinogenesis and for cell physiology and organ ..
  72. Lahvis G, Pyzalski R, Glover E, Pitot H, McElwee M, Bradfield C. The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse. Mol Pharmacol. 2005;67:714-20 pubmed
    A developmental role for the Ahr locus has been indicated by the observation that mice harboring a null allele display a portocaval vascular shunt throughout life...
  73. MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 2013;41:1604-21 pubmed publisher
    ..poly(ADP-ribose) polymerase (TiPARP/ARTD14) is a member of the PARP family and is regulated by the aryl hydrocarbon receptor (AHR); however, little is known about TiPARP function...
  74. Rodriguez Sosa M, Elizondo G, López Durán R, Rivera I, Gonzalez F, Vega L. Over-production of IFN-gamma and IL-12 in AhR-null mice. FEBS Lett. 2005;579:6403-10 pubmed
    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicity of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin...
  75. Qiu J, Heller J, Guo X, Chen Z, Fish K, Fu Y, et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity. 2012;36:92-104 pubmed publisher
    ..Here, we have shown that the aryl hydrocarbon receptor (Ahr) plays an essential role in ROR?t(+) ILC maintenance and function...
  76. Veldhoen M, Hirota K, Westendorf A, Buer J, Dumoutier L, Renauld J, et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature. 2008;453:106-9 pubmed publisher
    The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor best known for mediating the toxicity of dioxin...
  77. Curran C, Miller K, Dalton T, Vorhees C, Miller M, Shertzer H, et al. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci. 2006;89:454-64 pubmed
    ..Coplanar PBBs bind to the aryl hydrocarbon receptor (AHR) in vertebrates...
  78. Duarte J, Di Meglio P, Hirota K, Ahlfors H, Stockinger B. Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo. PLoS ONE. 2013;8:e79819 pubmed publisher
    The aryl hydrocarbon receptor (AhR) has been attributed with anti-inflammatory effects in the development of pathological immune responses leading to experimental autoimmune encephalomyelitis (EAE) via the induction of regulatory T cells...
  79. Chiaro C, Morales J, Prabhu K, Perdew G. Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry. 2008;47:8445-55 pubmed publisher
    In addition to orchestrating an adaptive metabolic response to xenobiotic compounds, the aryl hydrocarbon receptor (AHR) also plays a necessary role in the normal physiology of mice...