Gene Symbol: Ahcyl1
Description: S-adenosylhomocysteine hydrolase-like 1
Alias: 1110034F20Rik, AA409031, AA414901, Ahcy-rs3, DCAL, Irbit, S-adenosylhomocysteine hydrolase-like protein 1, IP3R binding protein released with inositol 1,4,5-trisphosphate, S-adenosyl-L-homocysteine hydrolase 2, S-adenosylhomocysteine hydrolase, related sequence 3, adoHcyase 2
Species: mouse
Products:     Ahcyl1

Top Publications

  1. Devogelaere B, Nadif Kasri N, Derua R, Waelkens E, Callewaert G, Missiaen L, et al. Binding of IRBIT to the IP3 receptor: determinants and functional effects. Biochem Biophys Res Commun. 2006;343:49-56 pubmed
    b>IRBIT has previously been shown to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) in an IP3-sensitive way...
  2. Dekker J, Budhia S, Angel N, Cooper B, Clark G, Hart D, et al. Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. Immunogenetics. 2002;53:993-1001 pubmed
    ..Therefore, this molecule was termed DC-expressed AHCY-like molecule (DCAL)...
  3. Yang D, Shcheynikov N, Muallem S. IRBIT: it is everywhere. Neurochem Res. 2011;36:1166-74 pubmed publisher
    b>IRBIT (IP(3)Rs binding protein released with IP(3)) is a protein originally identified by the Mikoshiba group as an inhibitor of IP(3) receptors function...
  4. He P, Zhao L, No Y, Karvar S, Yun C. The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II. Am J Physiol Renal Physiol. 2016;311:F343-51 pubmed publisher
    ..shown that inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells...
  5. Martins J, Kongsuphol P, Sammels E, Dahimene S, Aldehni F, Clarke L, et al. F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis. Biochim Biophys Acta. 2011;1812:1385-92 pubmed publisher
    ..Moreover, F508del-CFTR could serve as a scavenger for inositol-1,4,5-trisphosphate [IP3] receptor binding protein released with IP(3) (IRBIT). Our data may explain how ER-localized F508del-CFTR controls intracellular Ca(2+) signaling.
  6. Park S, Shcheynikov N, Hong J, Zheng C, Suh S, Kawaai K, et al. Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013;145:232-241 pubmed publisher
    ..member 6 (Slc26a6(-/-) mice) and inositol 1,4,5-triphosphate (InsP3) receptor-binding protein released with InsP3 (Irbit(-/-)) mice...
  7. Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, et al. IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest. 2009;119:193-202 pubmed publisher
    ..Here we report that the protein IRBIT (inositol-1,4,5-trisphosphate [IP3] receptors binding protein released with IP3), a previously identified ..
  8. Ando H, Mizutani A, Mikoshiba K. An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. J Neurochem. 2009;109:539-50 pubmed publisher
    b>IRBIT is an inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-binding protein that inhibits the activation of IP(3)R by competing with IP(3) for the common binding site on IP(3)R...
  9. Yang D, Li Q, So I, Huang C, Ando H, Mizutani A, et al. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011;121:956-65 pubmed publisher
    ..of the NBCe1-B/CFTR activator inositol-1,4,5-trisphosphate (IP(3)) receptor-binding protein released with IP(3) (IRBIT) and by inhibition of protein phosphatase 1 (PP1)...

More Information


  1. Kiefer H, Mizutani A, Iemura S, Natsume T, Ando H, Kuroda Y, et al. Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. J Biol Chem. 2009;284:10694-705 pubmed publisher
    b>IRBIT is a recently identified protein that modulates the activities of both inositol 1,4,5-triphosphate receptor and pancreas-type Na(+)/HCO(3)(-) cotransporter 1, and the multisite phosphorylation of IRBIT is required for achieving ..
  2. Kawaai K, Mizutani A, Shoji H, Ogawa N, Ebisui E, Kuroda Y, et al. IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Proc Natl Acad Sci U S A. 2015;112:5515-20 pubmed publisher
    Inositol 1,4,5-trisphosphate receptor (IP3R) binding protein released with IP3 (IRBIT) contributes to various physiological events (electrolyte transport and fluid secretion, mRNA polyadenylation, and the maintenance of genomic integrity)..
  3. Ando H, Kawaai K, Mikoshiba K. IRBIT: a regulator of ion channels and ion transporters. Biochim Biophys Acta. 2014;1843:2195-204 pubmed publisher
    IRBIT (also called AHCYL1) was originally identified as a binding protein of the intracellular Ca(2+) channel inositol 1,4,5-trisphosphate (IP3) receptor and functions as an inhibitory regulator of this receptor...
  4. Gomi T, Takusagawa F, Nishizawa M, Agussalim B, Usui I, Sugiyama E, et al. Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney. Biochim Biophys Acta. 2008;1784:1786-94 pubmed publisher
    ..hydrolase (SAHase)-like protein 1 (SAH-L), also called inositol 1,4,5-triphosphate receptor-binding protein (IRBIT) is a novel protein involved in fish embryo development and calcium release in mammalian cells through protein-..
  5. Devogelaere B, Sammels E, De Smedt H. The IRBIT domain adds new functions to the AHCY family. Bioessays. 2008;30:642-52 pubmed publisher
    During the past few years, the IRBIT domain has emerged as an important add-on of S-adenosyl-L-homocystein hydrolase (AHCY), thereby creating the new family of AHCY-like proteins...
  6. Devogelaere B, Beullens M, Sammels E, Derua R, Waelkens E, Van Lint J, et al. Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor. Biochem J. 2007;407:303-11 pubmed
    b>IRBIT is an IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor]-binding protein that competes with IP3 for binding to the IP3R. Phosphorylation of IRBIT is essential for the interaction with the IP3R...
  7. Ando H, Mizutani A, Matsu ura T, Mikoshiba K. IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J Biol Chem. 2003;278:10602-12 pubmed
    ..Herein, we report a novel protein, termed IRBIT (IP(3)R binding protein released with inositol 1,4,5-trisphosphate), which interacts with type 1 IP(3)R (IP(3)R1) ..
  8. Shirakabe K, Priori G, Yamada H, Ando H, Horita S, Fujita T, et al. IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A. 2006;103:9542-7 pubmed
    ..We previously identified an IP(3)R binding protein, termed IP(3)R binding protein released with IP(3) (IRBIT)...
  9. Ando H, Hirose M, Gainche L, Kawaai K, Bonneau B, Ijuin T, et al. IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues. PLoS ONE. 2015;10:e0141569 pubmed publisher
    ..b>IRBIT (IP3R-binding protein released with inositol 1,4,5-trisphosphate) is a multifunctional protein that regulates ..