Gene Symbol: Ahcy
Description: S-adenosylhomocysteine hydrolase
Alias: AA987153, AL024110, CuBP, SAHH, adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, adoHcyase, liver copper-binding protein
Species: mouse
Products:     Ahcy

Top Publications

  1. Bethin K, Petrovic N, Ettinger M. Identification of a major hepatic copper binding protein as S-adenosylhomocysteine hydrolase. J Biol Chem. 1995;270:20698-702 pubmed
    The properties of a mouse liver copper binding protein (CuBP) and human placental S-adenosylhomocysteine hydrolase (SAHH) were compared to test the hypothesis that CuBP is SAHH...
  2. Miller M, Duhl D, Winkes B, Arredondo Vega F, Saxon P, Wolff G, et al. The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. EMBO J. 1994;13:1806-16 pubmed
    ..The Ahcy gene, which codes for the enzyme S-adenosylhomocysteine hydrolase (SAHase), is contained within a 20 kb region ..
  3. Seo H, Ettinger M. Purification and properties of a self-associating, 50-kDa copper-binding protein from brindled mouse livers. J Biol Chem. 1993;268:1160-5 pubmed
    ..A self-associating, 50-kDa copper-binding protein (CuBP) was purified from brindled mouse hepatic cytosols, and some of its properties were determined...
  4. Farrar C, Clarke S. Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. J Biol Chem. 2002;277:27856-63 pubmed
    ..Because changes in the AdoMet/AdoHcy ratio could potentially alter the overall excitatory state of the brain, this effect may play a role in the progressive epilepsy seen in the Pcmt1-/- mice. ..
  5. Liu S, Li Y, Chen Y, Chiang E, Li A, Lee Y, et al. Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 2007;46:1413-25 pubmed
    ..metabolism pathway revealed that 5,10-methylenetetrahydrofolate reductase, S-adenosylhomocysteine hydrolase (Ahcy), and formiminotransferase cyclodeaminase (Ftcd) were significantly down-regulated in Gnmt-/- mice...
  6. Pawlowski T, Heringer Walther S, Cheng C, Archie J, Chen C, Walther T, et al. Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice. Genomics. 2009;94:188-95 pubmed publisher
    ..This study provides insight into Agtr2 influenced candidate genes and suggests that expression dysregulation of these genes may modulate Agtr2 actions in the brain that influences learning and memory. ..
  7. Fernandez Sanchez M, Gonatopoulos Pournatzis T, Preston G, Lawlor M, Cowling V. S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation. Mol Cell Biol. 2009;29:6182-91 pubmed publisher
    ..Here we report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase (SAHH), an enzyme which hydrolyzes S-adenosyl homocysteine, thus neutralizing its inhibitory effects, and this is ..
  8. Tryndyak V, Han T, Muskhelishvili L, Fuscoe J, Ross S, Beland F, et al. Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet. Mol Nutr Food Res. 2011;55:411-8 pubmed publisher
  9. Zhou J, Yang L, Zhong T, Mueller M, Men Y, Zhang N, et al. H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase. Nat Commun. 2015;6:10221 pubmed publisher
    ..we report that the developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S-adenosylhomocysteine (SAH)...

More Information


  1. Pilz A, Le Tissier P, Moseley H, Peters J, Abbott C. Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse chromosome 2, and related sequences to chromosomes 8 and X. Mamm Genome. 1992;3:633-6 pubmed
    ..The structural locus for S-adenosyl-L-homocysteine hydrolase (EC in human, AHCY, maps to 20 qter-->q13...
  2. Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, et al. Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha. Am J Physiol Endocrinol Metab. 2009;296:E543-8 pubmed publisher
    ..These results define a novel role for the PGC-1alpha coactivator pathway in the regulation of Hcy homeostasis and suggest a potential pathogenic mechanism that contributes to hyperhomocysteinemia. ..
  3. Ishihara M, Kusakabe Y, Ohsumichi T, Tanaka N, Nakanishi M, Kitade Y, et al. Crystallization of mouse S-adenosyl-L-homocysteine hydrolase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:313-5 pubmed publisher
    S-adenosyl-L-homocysteine hydrolase (SAHH; EC catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine to adenosine and L-homocysteine...