Agtr2

Summary

Gene Symbol: Agtr2
Description: angiotensin II receptor, type 2
Alias: AI316812, AW107640, type-2 angiotensin II receptor, AT2 receptor, angiotensin II type-2 receptor
Species: mouse
Products:     Agtr2

Top Publications

  1. Horiuchi M, Koike G, Yamada T, Mukoyama M, Nakajima M, Dzau V. The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. J Biol Chem. 1995;270:20225-30 pubmed
    ..To elucidate the molecular mechanism of growth-regulated AT2 receptor expression, we cloned the mouse AT2 receptor genomic DNA and studied its promoter function in mouse fibroblast-..
  2. Johansson M, Wickman A, Fitzgerald S, Gan L, Bergstrom G. Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice. J Hypertens. 2005;23:1541-9 pubmed
    ..To confirm and further explore this possibility, we studied the effect of AT2 receptor antagonism on Ang II-accelerated atherosclerosis. ApoE mice were fed a standard or high cholesterol diet (1...
  3. Tanaka M, Tsuchida S, Imai T, Fujii N, Miyazaki H, Ichiki T, et al. Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout mice. Biochem Biophys Res Commun. 1999;258:194-8 pubmed
  4. Silvestre J, Tamarat R, Senbonmatsu T, Icchiki T, Ebrahimian T, Iglarz M, et al. Antiangiogenic effect of angiotensin II type 2 receptor in ischemia-induced angiogenesis in mice hindlimb. Circ Res. 2002;90:1072-9 pubmed
    ..Ischemia was produced by femoral artery ligature in both wild-type and AT(2) gene-deleted mice (Agtr2(-)/Y)...
  5. Benndorf R, Krebs C, Hirsch Hoffmann B, Schwedhelm E, Cieslar G, Schmidt Haupt R, et al. Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice. Kidney Int. 2009;75:1039-49 pubmed publisher
    ..It is thought that the AT2 receptor counteracts these processes; however, recent studies have found proinflammatory and hypertrophic effects of ..
  6. Reinemund J, Seidel K, Steckelings U, Zaade D, Klare S, Rompe F, et al. Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes. Biochem Pharmacol. 2009;77:1795-805 pubmed publisher
    ..The angiotensin AT2 receptor (AT2R) seems to counteract the proinflammatory, prohypertrophic and profibrotic actions of the AT1 receptor...
  7. Yan X, Price R, Nakayama M, Ito K, Schuldt A, Manning W, et al. Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice. Am J Physiol Heart Circ Physiol. 2003;285:H2179-87 pubmed
    ..These data demonstrate that ventricular myocyte-specific expression of AT2 receptors promotes the development of dilated cardiomyopathy and heart failure in vivo. ..
  8. Ma J, Nishimura H, Fogo A, Kon V, Inagami T, Ichikawa I. Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int. 1998;53:937-44 pubmed
    ..role of angiotensin in renal remodeling that is specifically channeled through the angiotensin type 2 receptor (AT2 receptor)...
  9. Iwai M, Chen R, Li Z, Shiuchi T, Suzuki J, Ide A, et al. Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice. Circulation. 2005;112:1636-43 pubmed
    The role of angiotensin II (Ang II) type 2 (AT2) receptor in atherosclerosis was explored with the use of AT2 receptor/apolipoprotein E (ApoE)-double-knockout (AT2/ApoE-DKO) mice, with a focus on oxidative stress...

More Information

Publications84

  1. Senbonmatsu T, Saito T, Landon E, Watanabe O, Price E, Roberts R, et al. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J. 2003;22:6471-82 pubmed
    ..PLZF is expressed robustly in the heart in contrast to many other tissues. This cardiac selective pathway involving AT(2), PLZF and p85 alpha PI3K may explain the absence of a cardiac hypertrophic response in AT(2) gene-deleted mice. ..
  2. Lu H, Boustany Kari C, Daugherty A, Cassis L. Angiotensin II increases adipose angiotensinogen expression. Am J Physiol Endocrinol Metab. 2007;292:E1280-7 pubmed
    ..Chronic infusion of ANG II robustly stimulated AT(1a)R and AGT mRNA abundance in adipose tissue, suggesting that adipose tissue serves as a primary contributor to the activated systemic renin-angiotensin system. ..
  3. Senbonmatsu T, Ichihara S, Price E, Gaffney F, Inagami T. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest. 2000;106:R25-9 pubmed
    The pathophysiological roles of the angiotensin II type 2 receptor (AT(2)) in cardiac hypertrophy remain unclear...
  4. Armando I, Jezova M, Juorio A, Terrón J, Falcón Neri A, Semino Mora C, et al. Estrogen upregulates renal angiotensin II AT(2) receptors. Am J Physiol Renal Physiol. 2002;283:F934-43 pubmed
    ..We propose that the protective effects of estrogen may be partially mediated through enhancement of AT(2) receptor stimulation. ..
  5. Abadir P, Foster D, Crow M, Cooke C, Rucker J, Jain A, et al. Identification and characterization of a functional mitochondrial angiotensin system. Proc Natl Acad Sci U S A. 2011;108:14849-54 pubmed publisher
  6. Akishita M, Yamada H, Dzau V, Horiuchi M. Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun. 1999;261:345-9 pubmed
    ..In the mice lacking the gene encoding the AT2 receptor, the pressor response to Ang II was increased although the underlying mechanism is unknown...
  7. Masaki H, Kurihara T, Yamaki A, Inomata N, Nozawa Y, Mori Y, et al. Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest. 1998;101:527-35 pubmed
  8. Gross V, Milia A, Plehm R, Inagami T, Luft F. Long-term blood pressure telemetry in AT2 receptor-disrupted mice. J Hypertens. 2000;18:955-61 pubmed
    The hypertension in AT2 receptor knockout mice is imperfectly defined...
  9. Munk V, Sanchez de Miguel L, Petrimpol M, Butz N, Banfi A, Eriksson U, et al. Angiotensin II induces angiogenesis in the hypoxic adult mouse heart in vitro through an AT2-B2 receptor pathway. Hypertension. 2007;49:1178-85 pubmed
  10. Yan X, Schuldt A, Price R, Amende I, Liu F, Okoshi K, et al. Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2008;294:H1274-81 pubmed publisher
    ..iNOS was higher in AT2TG-AS than in NTG-AS mice but not significantly different. Our results indicate that AT2 receptor overexpression modified the pathological hypertrophic response to aortic banding in transgenic mice.
  11. Sales V, Sukhova G, Lopez Ilasaca M, Libby P, Dzau V, Pratt R. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation. 2005;112:3328-36 pubmed
    ..To test the consequences of this expression, male ApoE(-/-), angiotensin II type 2 receptor-deficient (Agtr2-), and ApoE(-/-), wild-type (Agtr2+) mice consumed a high-cholesterol diet from 4 ..
  12. Yayama K, Hiyoshi H, Imazu D, Okamoto H. Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor. Hypertension. 2006;48:958-64 pubmed
    ..To clarify mechanisms underlying the vascular AT2 receptor-dependent NO production, we measured aortic levels of endothelial NO synthase (eNOS), eNOS phosphorylated at ..
  13. Yvan Charvet L, Massiera F, Lamandé N, Ailhaud G, Teboul M, Moustaid Moussa N, et al. Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue. Endocrinology. 2009;150:1421-8 pubmed publisher
    ..Several studies have highlighted the importance of the angiotensin II type 2 receptor (AT2) in the regulation of blood pressure and fat mass, but the relevance of this transporter in a ..
  14. Yvan Charvet L, Even P, Bloch Faure M, Guerre Millo M, Moustaid Moussa N, Ferre P, et al. Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Diabetes. 2005;54:991-9 pubmed
    ..These data support the idea that AT2R-dependent Ang II signaling increases adipose cell mass and glucose intolerance and thus could participate to the deleterious effects of a high-fat diet. ..
  15. Ichihara S, Senbonmatsu T, Price E, Ichiki T, Gaffney F, Inagami T. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation. 2001;104:346-51 pubmed
    ..of left ventricular hypertrophy and cardiac fibrosis by Ang II infusion in mice lacking the AT(2) gene (Agtr2-/Y). Male Agtr2-/Y and age-matched wild-type (WT) mice were treated long-term with Ang II, infused at a rate of 4...
  16. Habashi J, Doyle J, Holm T, Aziz H, Schoenhoff F, Bedja D, et al. Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science. 2011;332:361-5 pubmed publisher
    ..These data highlight the protective nature of AT2 signaling and potentially inform the choice of therapies in MFS and related disorders...
  17. van Esch J, Gembardt F, Sterner Kock A, Heringer Walther S, Le T, Lassner D, et al. Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. Cardiovasc Res. 2010;86:401-9 pubmed publisher
    ..Renal Ang II levels largely depend on AT(1) binding of extracellularly generated Ang II, and in the absence of all three Ang II receptors, renal Ang II is only located extracellularly. ..
  18. Yvan Charvet L, Even P, Lamandé N, Ferre P, Quignard Boulange A. Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient mice. Endocrinology. 2006;147:5078-86 pubmed
    ..These data reveal an important physiological role of AT2R in metabolic adaptations to fasting. ..
  19. Hein L, Barsh G, Pratt R, Dzau V, Kobilka B. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 1995;377:744-7 pubmed
    ..To address this question, we have generated mice lacking the gene encoding the AT2 receptor. Mutant mice develop normally, but have an impaired drinking response to water deprivation as well as a ..
  20. Ichiki T, Labosky P, Shiota C, Okuyama S, Imagawa Y, Fogo A, et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995;377:748-50 pubmed
    ..Our results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemodynamic effects, and that AT2 regulates central nervous system functions, including behaviour. ..
  21. Iwanami J, Mogi M, Li J, Tsukuda K, Min L, Sakata A, et al. Deletion of angiotensin II type 2 receptor attenuates protective effects of bone marrow stromal cell treatment on ischemia-reperfusion brain injury in mice. Stroke. 2008;39:2554-9 pubmed publisher
    ..of AT(2) receptor could attenuate the cerebroprotective effects of MSC using AT(2) receptor-deficient mice (Agtr2 (-)) and the effect of selective AT(1) receptor blocker...
  22. Ichihara S, Senbonmatsu T, Price E, Ichiki T, Gaffney F, Inagami T. Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. Circulation. 2002;106:2244-9 pubmed
    ..fibrillar collagen accumulation at the infarcted and noninfarcted regions in male mice lacking the AT(2) receptor (Agtr2-/Y) and age-matched wild-type (WT) animals. Of the Agtr2-/Y mice, 63.6% died of cardiac rupture, whereas 23...
  23. Callera G, Antunes T, Correa J, Moorman D, Gutsol A, He Y, et al. Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis. Biosci Rep. 2016;36: pubmed
    ..These findings suggest novel mechanisms through the protective RAS axis, whereby candesartan may ameliorate diabetic nephropathy. Our findings also highlight potential injurious renal effects of ultra-high dose candesartan in diabetes. ..
  24. AbdAlla S, Lother H, el Missiry A, Langer A, Sergeev P, el Faramawy Y, et al. Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease. J Biol Chem. 2009;284:6554-65 pubmed publisher
    ..Thus, Abeta induces the formation of cross-linked AT2 oligomers that contribute to the dysfunction of Galphaq/11 in an animal model of Alzheimer disease. ..
  25. Füchtbauer L, Toft Hansen H, Khorooshi R, Owens T. Expression of astrocytic type 2 angiotensin receptor in central nervous system inflammation correlates with blood-brain barrier breakdown. J Mol Neurosci. 2010;42:89-98 pubmed publisher
    ..Our results suggest that AT(2) induction correlates with solute leakage rather than cellular infiltration. This points to a role for AT(2) in selective changes to the BBB. ..
  26. Nabeshima Y, Tazuma S, Kanno K, Hyogo H, Iwai M, Horiuchi M, et al. Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis. Biochem Biophys Res Commun. 2006;346:658-64 pubmed
    ..We therefore suggest that RAS-associated liver fibrogenesis may be determined by the balance between AT1 and AT2 signals. ..
  27. Yu L, Shao C, Gao L. Developmental expression patterns for angiotensin receptors in mouse skin and brain. J Renin Angiotensin Aldosterone Syst. 2014;15:139-49 pubmed publisher
    ..In other organs and tissues, adults express higher AT2R protein than does the fetus. ..
  28. Dadam F, Cisternas C, Macchione A, Godino A, Antunes Rodrigues J, Cambiasso M, et al. Sex chromosome complement involvement in angiotensin receptor sexual dimorphism. Mol Cell Endocrinol. 2017;447:98-105 pubmed publisher
    ..complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney...
  29. Ludwig M, Skorska A, Tolk A, Hopp H, Patejdl R, Li J, et al. Characterization of ion currents of murine CD117(pos) stem cells in vitro and their modulation under AT2 R stimulation. Acta Physiol (Oxf). 2013;208:274-87 pubmed publisher
    ..Activation of angiotensin II type 2 receptor (AT2 R) can lead to further cell differentiation and receptor auto-expression and might thus influence ..
  30. Voros S, Yang Z, Bove C, Gilson W, Epstein F, French B, et al. Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodeling. Am J Physiol Heart Circ Physiol. 2006;290:H1004-10 pubmed
    ..Pharmacological blockade of AT1-R is equivalent to AT2-R overexpression in attenuating post-MI remodeling. Genetic knockout of the AT1a-R is additive to AT2-R overexpression, due, at least in part, to blood pressure lowering. ..
  31. Akishita M, Horiuchi M, Yamada H, Zhang L, Shirakami G, Tamura K, et al. Inflammation influences vascular remodeling through AT2 receptor expression and signaling. Physiol Genomics. 2000;2:13-20 pubmed
    ..in vascular diseases, we developed a mouse model of vascular remodeling and compared the responses in wild-type (Agtr2(+)) and AT(2) receptor knockout (Agtr2(-)) mice...
  32. von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice. Regul Pept. 2001;99:209-16 pubmed
    ..pressor and mitogenic effects of Ang II, whereas physiological function and signaling mechanisms of the AT2 receptor remain poorly understood. Recent reports have shown that Ang II could mediate apoptosis through AT2 receptors...
  33. Mitsuishi M, Miyashita K, Muraki A, Itoh H. Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control. Diabetes. 2009;58:710-7 pubmed publisher
    ..AngII reduces mitochondrial content possibly through AT1R-dependent augmentation of their degradation and AT2R-dependent direct suppression of their biogenesis. ..
  34. Kljajic S, Widdop R, Vinh A, Welungoda I, Bosnyak S, Jones E, et al. Direct AT? receptor stimulation is athero-protective and stabilizes plaque in apolipoprotein E-deficient mice. Int J Cardiol. 2013;169:281-7 pubmed publisher
    The angiotensin II type 2 receptor (AT?R) has been suggested to have an athero-protective role, however no studies have investigated the effect of direct stimulation of this receptor in atherosclerosis...
  35. Fritz R, Radziwill G. The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor. Biochem Biophys Res Commun. 2005;338:1906-12 pubmed
    ..we report that CNK1 binds through the sterile alpha motif (SAM) and the conserved region in CNK (CRIC) to the AT2 receptor. The exchange of a conserved leucine residue with arginine in the CRIC domain increases the binding affinity of ..
  36. Daubert D, Meadows G, Wang J, Sanchez P, Speth R. Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res. 1999;816:8-16 pubmed
    ..The selective AT2 receptor subtype antagonist PD 123319 (10 microM) was used to inhibit 125I-SI Ang II binding to AT2 receptors to ..
  37. Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436:112-6 pubmed
    ..Here we report that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis...
  38. Kukida M, Mogi M, Ohshima K, Nakaoka H, Iwanami J, Kanno H, et al. Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPAR?. Am J Hypertens. 2016;29:727-36 pubmed publisher
    ..Previously, we reported that AT2 receptor stimulation ameliorated insulin resistance in diabetic mice accompanied by PPAR? activation which also plays a ..
  39. Mirabito K, Hilliard L, Kett M, Brown R, Booth S, Widdop R, et al. Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor. Am J Physiol Renal Physiol. 2014;307:F901-7 pubmed publisher
    ..Conversely, in males, angiotensin receptor expression did not vary significantly with age. In conclusion, the angiotensin type 2 receptor modulates the chronic pressure-natriuresis relationship in an age- and sex-dependent manner. ..
  40. Saavedra J, Armando I, Terron J, Falcón Neri A, Johren O, Hauser W, et al. Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice. Regul Pept. 2001;102:41-7 pubmed
  41. Isbell D, Voros S, Yang Z, DiMaria J, Berr S, French B, et al. Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling. Am J Physiol Heart Circ Physiol. 2007;293:H3372-8 pubmed
    b>Angiotensin II type 2 receptor (AT(2)R) overexpression (AT(2)TG) attenuates left ventricular remodeling in a mouse model of anterior myocardial infarction (MI)...
  42. Huang J, Yamashiro Y, Papke C, Ikeda Y, Lin Y, Patel M, et al. Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice. Sci Transl Med. 2013;5:183ra58, 1-11 pubmed publisher
    ..The therapeutic effects of losartan in Fbln4(SMKO) mice do not require the AngII receptor type 2 (Agtr2) but likely require both type 1a (Agtr1a) and 1b (Agtr1b) receptors...
  43. Hatta K, Carter A, Chen Z, Leno Durán E, Ruiz Ruiz C, Olivares E, et al. Expression of the vasoactive proteins AT1, AT2, and ANP by pregnancy-induced mouse uterine natural killer cells. Reprod Sci. 2011;18:383-90 pubmed publisher
    ..Expression of these molecules suggests that uNK cells have the potential to contribute to the changes in blood pressure that occur between days 5 and 12 of pregnancy in mice. ..
  44. Zhang M, Yao B, Cheng H, Wang S, Inagami T, Harris R. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A. 2006;103:16045-50 pubmed
  45. Siragy H, Inagami T, Ichiki T, Carey R. Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor. Proc Natl Acad Sci U S A. 1999;96:6506-10 pubmed
    ..We investigated the role of the AT2 receptor in the vascular and renal responses to physiological increases in angiotensin II (ANG II) in mice with targeted ..
  46. Gross V, Walther T, Milia A, Walter K, Schneider W, Luft F. Left ventricular function in mice lacking the AT2 receptor. J Hypertens. 2001;19:967-76 pubmed
    The role of the AT2 receptor in the heart is incompletely understood. We investigated left ventricular performance in AT2 receptor knockout mice, with and without deoxycorticosterone acetate (DOCA)-salt treatment...
  47. Pulgar V, Yamashiro H, Rose J, Moore L. Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation. J Renin Angiotensin Aldosterone Syst. 2011;12:176-83 pubmed publisher
    ..Ang-II responses were also greater during pregnancy, with an increased contraction in response to AT2 receptor blockade at mid-gestation. AT1 receptor blockade abolished the Ang-II response in all groups...
  48. Machura K, Steppan D, Neubauer B, Alenina N, Coffman T, Facemire C, et al. Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol. 2009;297:F1371-80 pubmed publisher
  49. Hunley T, Tamura M, Stoneking B, Nishimura H, Ichiki T, Inagami T, et al. The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice. Kidney Int. 2000;57:570-7 pubmed
    ..we used an high-performance liquid chromatography (HPLC)-based enzymatic assay in tissues from AT2 knockout mice (Agtr2-/y) and cultured cells. These studies were complimented by physiologic studies of pharmacologic inhibition of AT2...
  50. Dandapat A, Hu C, Chen J, Liu Y, Khan J, Remeo F, et al. Over-expression of angiotensin II type 2 receptor (agtr2) decreases collagen accumulation in atherosclerotic plaque. Biochem Biophys Res Commun. 2008;366:871-7 pubmed
    ..This study demonstrates that AT2R over-expression reduces enhanced collagen accumulation, MMP expression and activity in atherosclerotic regions via inhibition of pro-oxidant signals. ..
  51. Gross V, Plehm R, Tank J, Jordan J, Diedrich A, Obst M, et al. Heart rate variability and baroreflex function in AT2 receptor-disrupted mice. Hypertension. 2002;40:207-13 pubmed
    ..Mean arterial pressure leveled during the day at 101+/-1 mm Hg and during the night at 109+/-1 mm Hg in AT2 receptor-deleted mice, compared with 98+/-2 mm Hg (day) and 104+/-2 mm Hg (night) in wild-type mice...
  52. Abadir P, Carey R, Siragy H. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Hypertension. 2003;42:600-4 pubmed
    ..B2-null and wild-type mice (n=8 in each group) during low sodium intake alone or with the angiotensin AT1 or AT2 receptor blockers, valsartan (0.5 microg/min) or PD123319 (0.15 microg/min), or both...
  53. Hiyoshi H, Yayama K, Takano M, Okamoto H. Stimulation of cyclic GMP production via AT2 and B2 receptors in the pressure-overloaded aorta after banding. Hypertension. 2004;43:1258-63 pubmed
    ..was to use a mouse model to clarify the mechanisms by which the banding elicits upregulation of the aortic AT2 receptor and the subsequent attenuation of Ang II responsiveness...
  54. Mitchell E, Taylor D, Woods K, Davis M, Nelson A, Teasdale R, et al. Differential gene expression in the developing mouse ureter. Gene Expr Patterns. 2006;6:519-38 pubmed
    ..This study marks the first known report defining global gene expression of the developing mouse ureter and will provide insight into the molecular mechanisms underlying kidney and lower urinary tract malformations. ..
  55. Takasaki N, McIsaac R, Dean J. Gpbox (Psx2), a homeobox gene preferentially expressed in female germ cells at the onset of sexual dimorphism in mice. Dev Biol. 2000;223:181-93 pubmed
    ..The persistence of GPBOX transcripts in female germ cells until E15.5 and their virtual disappearance in males by E13.5 suggest that Gpbox may play a role in mammalian oogenesis. ..
  56. Ali Q, Dhande I, Samuel P, Hussain T. Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury. J Renin Angiotensin Aldosterone Syst. 2016;17: pubmed publisher
    ..Further, AT2KO mice are more susceptible to HFD-induced renal injury. ..
  57. Min L, Cui T, Yahata Y, Yamasaki K, Shiuchi T, Liu H, et al. Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes. Endocrinology. 2004;145:253-60 pubmed
    ..and these increases were inhibited by valsartan, an AT1 receptor blocker, but augmented by PD123319, an AT2 receptor antagonist...
  58. Wang L, Flannery P, Spurney R. Characterization of angiotensin II-receptor subtypes in podocytes. J Lab Clin Med. 2003;142:313-21 pubmed
    ..005). Glomerular podocytes expressed messenger RNA for AT1A, AT1B, and AT2 receptor subtypes, and competitive binding studies found that differentiated podocytes expressed mostly AT1 receptors (..
  59. Xu J, Carretero O, Zhu L, Shesely E, Rhaleb N, Dai X, et al. Protective role of AT(2) and B(1) receptors in kinin B(2)-receptor-knockout mice with myocardial infarction. Clin Sci (Lond). 2013;124:87-96 pubmed
  60. Daugherty A, Rateri D, Howatt D, Charnigo R, Cassis L. PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism. PLoS ONE. 2013;8:e61849 pubmed publisher
    ..function on development of abdominal aortic aneurysms (AAAs), although a pharmacological approach using the AT2 receptor antagonist PD123319 has implicated a role...
  61. Hu C, Dandapat A, Chen J, Liu Y, Hermonat P, Carey R, et al. Over-expression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression. Atherosclerosis. 2008;199:288-94 pubmed
    ..Since angiotensin II type 2 receptor (AT2R) activity is purported to oppose the effects of AT1R, we hypothesized that AT2R (agtr2) over-..
  62. Nakajima M, Mukoyama M, Pratt R, Horiuchi M, Dzau V. Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor. Biochem Biophys Res Commun. 1993;197:393-9 pubmed
    A cDNA clone encoding the mouse angiotensin receptor subtype 2 (AT2 receptor) was isolated from a mouse fetal cDNA library...
  63. Zhang S, Moini B, Ingelfinger J. Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J Am Soc Nephrol. 2004;15:1452-65 pubmed
  64. Hauser W, Johren O, Saavedra J. Characterization and distribution of angiotensin II receptor subtypes in the mouse brain. Eur J Pharmacol. 1998;348:101-14 pubmed
    ..Our data also form the basis for future studies of mouse models such as those with angiotensin receptor gene deficiencies. ..
  65. Mizoue S, Iwai M, Ide A, Suzuki J, Horiuchi M, Shiraishi A, et al. Role of angiotensin II receptor subtypes in conjunctival wound healing. Curr Eye Res. 2006;31:129-36 pubmed
    ..model was developed by subconjunctival blunt dissection in male wild-type, AT1a receptor-deficient (AT1aKO) and AT2 receptor-deficient (AT2KO) mice. Collagen deposition and cell infiltration were evaluated histologically...
  66. Painemal P, Acuña M, Riquelme C, Brandan E, Cabello Verrugio C. Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle. Biofactors. 2013;39:467-75 pubmed publisher
    ..This finding suggests that AT-2 might be involved in the physiopathology of fibrosis in dystrophic skeletal muscle. ..
  67. Donaldson D, Whitters M, Fitz L, Neben T, Finnerty H, Henderson S, et al. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J Immunol. 1998;161:2317-24 pubmed
    ..These results show that mIL-13R alpha 2 and mIL-13R alpha 1 are not functionally equivalent and predict distinct roles for each polypeptide in IL-13R complex formation and in the modulation of IL-13 signal transduction. ..
  68. Zuern C, Krenacs L, Starke S, Heimrich J, Palmetshofer A, Holtmann B, et al. Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease. Int J Oncol. 2012;40:1079-88 pubmed publisher
    ..has also been shown to act as an early component in the growth inhibitory signaling cascade of the angiotensin II type 2 receptor (AT2R)...
  69. Obst M, Gross V, Janke J, Wellner M, Schneider W, Luft F. Pressure natriuresis in AT(2) receptor-deficient mice with L-NAME hypertension. J Am Soc Nephrol. 2003;14:303-10 pubmed
    ..Changes in RBF, GFR, and tubular sodium and water reabsorption are involved and may be also responsible for the greater BP increase in L-NAME-treated AT(2) -/- mice. ..
  70. Hashikawa Hobara N, Hashikawa N. Angiotensin II AT2 receptors regulate NGF-mediated neurite outgrowth via the NO-cGMP pathway. Biochem Biophys Res Commun. 2016;478:970-5 pubmed publisher
    ..NGF-mediated neurite outgrowth in cultured dorsal root ganglia (DRG) cells was significantly inhibited by AT2 receptor antagonist (PD123,319) treatment. AT2 receptor knockdown also inhibited NGF-mediated neurite outgrowth...
  71. Wesseling S, Ishola D, Joles J, Bluyssen H, Koomans H, Braam B. Resistance to oxidative stress by chronic infusion of angiotensin II in mouse kidney is not mediated by the AT2 receptor. Am J Physiol Renal Physiol. 2005;288:F1191-200 pubmed
    ..The present study tested whether ANG II induces expression of antioxidative genes via the AT2 receptor in renal cortex and thereby counteracts prooxidative forces...
  72. Gormally E, Boyd Y. Faint lined (Fnl): a novel X-linked coat mutant in the mouse. Genet Res. 1998;72:211-6 pubmed
    ..Further genetic resolution of co-segregating markers flanking Fnl established that Fnl lies in a 7.6 +/- 2.6 cM interval between DXMit50 and DXMit82. ..
  73. Villar Cheda B, Rodriguez Pallares J, Valenzuela R, Munoz A, Guerra M, Baltatu O, et al. Nigral and striatal regulation of angiotensin receptor expression by dopamine and angiotensin in rodents: implications for progression of Parkinson's disease. Eur J Neurosci. 2010;32:1695-706 pubmed publisher
    ..The results reveal an important interaction between the dopaminergic and local renin-angiotensin system in the basal ganglia, which may be a major factor in the progression of Parkinson's disease. ..
  74. Okuyama S, Sakagawa T, Chaki S, Imagawa Y, Ichiki T, Inagami T. Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor. Brain Res. 1999;821:150-9 pubmed
    The main biological role of angiotensin II type 2 receptor (AT2) has not been established. We made use of targeted disruption of the mouse AT2 gene to examine the role of the AT2 receptor in the central nervous system (CNS)...
  75. Ulmasov B, Xu Z, Tetri L, Inagami T, Neuschwander Tetri B. Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2009;296:G284-94 pubmed publisher
    ..Our results demonstrate that, in contrast to AT1 receptor signaling, AT2 receptor signaling modulates protective antifibrogenic effects in a mouse model of cerulein-induced pancreatic ..