Gene Symbol: Agtr1b
Description: angiotensin II receptor, type 1b
Alias: AT1B, AT2R1B, Agtr-1b, Angtr-1b, type-1B angiotensin II receptor, AT3, angiotensin II type-1B receptor
Species: mouse
Products:     Agtr1b

Top Publications

  1. Sasamura H, Hein L, Krieger J, Pratt R, Kobilka B, Dzau V. Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun. 1992;185:253-9 pubmed
    ..Because many of the structural differences were in the carboxy terminal putative intracellular domain, we speculate that these isoforms may differ in their regulation, signal transduction, or desensitization mechanisms. ..
  2. Zhou Y, Chen Y, Dirksen W, Morris M, Periasamy M. AT1b receptor predominantly mediates contractions in major mouse blood vessels. Circ Res. 2003;93:1089-94 pubmed
    In rodents, angiotensin (Ang) II type-1 (AT1) receptors exist as two pharmacologically identical subtypes: AT1a and AT1b. Recent studies have utilized mouse models with specific subtype receptor deletions to differentiate the functional ..
  3. Oliverio M, Kim H, Ito M, Le T, Audoly L, Best C, et al. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A. 1998;95:15496-501 pubmed
    ..there are two AT1 receptor isoforms in rodents (AT1A and AT1B) that are products of separate genes (Agtr1a and Agtr1b). We have generated mice lacking AT1B (Agtr1b -/-) and both AT1A and AT1B receptors (Agtr1a -/-Agtr1b -/-)...
  4. Zhu Z, Zhang S, Wagner C, Kurtz A, Maeda N, Coffman T, et al. Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. Hypertension. 1998;31:1171-7 pubmed
    ..Wild-type cells have a 1.7 ratio of AT1A/AT1B receptor mRNA as determined by semiquantitative reverse transcriptase-polymerase chain reaction...
  5. Yoshida H, Kakuchi J, Guo D, Furuta H, Iwai N, van der Meer de Jong R, et al. Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human). Biochem Biophys Res Commun. 1992;186:1042-9 pubmed
    ..This conclusion was consistent with the results of genomic Southern blot analyses, which revealed that the mouse and rat possess 2 similar but separate genes, whereas the bovine and human have only a single class gene. ..
  6. Zhou Y, Dirksen W, Chen Y, Morris M, Zweier J, Periasamy M. A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues. J Mol Cell Cardiol. 2005;38:693-6 pubmed
    ..These results further underscore a tissue-specific role for AT(1b) receptor in mice. ..
  7. MacTaggart T, Ito M, Smithies O, John S. Mouse angiotensin receptor genes Agtr1a and Agtr1b map to chromosomes 13 and 3. Mamm Genome. 1997;8:294-5 pubmed
  8. Miyazaki Y, Tsuchida S, Nishimura H, Pope J, Harris R, McKanna J, et al. Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest. 1998;102:1489-97 pubmed
    ..These results reveal a new role for angiotensin in the unique cellular adaptations of the mammalian kidney to the physiological stresses of postnatal life. ..
  9. Hubert C, Gasc J, Berger S, Schutz G, Corvol P. Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice. Mol Endocrinol. 1999;13:297-306 pubmed
    ..Angiotensinogen and AT1 in the liver are also increased, but the other elements of the RAS are not affected. ..

More Information


  1. Yosypiv I, Schroeder M, El Dahr S. Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis. J Am Soc Nephrol. 2006;17:1005-14 pubmed
    ..This process depends on tyrosine phosphorylation of the EGFR. Cooperation of AT(1)R and EGFR signaling therefore is important in the development of the renal collecting system. ..
  2. Brede M, Hein L. Transgenic mouse models of angiotensin receptor subtype function in the cardiovascular system. Regul Pept. 2001;96:125-32 pubmed
  3. Tsuchida S, Miyazaki Y, Matsusaka T, Hunley T, Inagami T, Fogo A, et al. Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature. Kidney Int. 1999;56:509-16 pubmed
    Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening...
  4. Kakinuma Y, Hama H, Sugiyama F, Goto K, Murakami K, Fukamizu A. Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett. 1997;232:167-70 pubmed
    ..These results suggest that the renin-angiotensin system could play a critical role in central nervous system, preventing neuronal cells from apoptosis not only by AII but also AIV. ..
  5. Brown N, Bradford J, Wang Z, Lea W, Ma L, Ma J, et al. Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency. Kidney Int. 2007;72:72-81 pubmed
    ..We conclude that Ang II stimulates PAI-1 expression in part through the AT(1b) receptor in the kidney and liver. Further, norepinephrine induces PAI-1 expression in vivo with AT(1a) receptor deficiency modulating the effect. ..
  6. Burson J, Aguilera G, Gross K, Sigmund C. Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol. 1994;267:E260-7 pubmed
    At least two distinct genes (AT1A and AT1B) encode type 1 angiotensin II (AT1) receptors in rodents...
  7. Esteban V, Heringer Walther S, Sterner Kock A, de Bruin R, van den Engel S, Wang Y, et al. Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE. 2009;4:e5406 pubmed publisher
    ..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney. ..
  8. Park S, Harrison Bernard L. Augmented renal vascular nNOS and renin protein expression in angiotensin type 1 receptor null mice. J Histochem Cytochem. 2008;56:401-14 pubmed publisher
    ..Enhanced NO generation may contribute to the reduced renal vascular tone and blood pressure observed with blockade of the renin-angiotensin system. ..
  9. Park S, Bivona B, Harrison Bernard L. Compromised renal microvascular reactivity of angiotensin type 1 double null mice. Am J Physiol Renal Physiol. 2007;293:F60-7 pubmed
    ..We conclude that ANG II signaling via the AT(1) receptor plays a pivotal role in basal renal microvascular tone and effectiveness to respond to vasoconstrictor and vasodilator agonists. ..
  10. Sifi A, Adi Bessalem S, Laraba Djebari F. Role of angiotensin II and angiotensin type-1 receptor in scorpion venom-induced cardiac and aortic tissue inflammation. Exp Mol Pathol. 2017;102:32-40 pubmed publisher
    ..These results suggest the involvement of AngII, through its AT1R in the inflammation induced by Aah venom, in the heart and the aorta. ..
  11. Matsusaka T, Fogo A, Ichikawa I. Targeting the genes of angiotensin receptors. Semin Nephrol. 1997;17:396-403 pubmed
    ..Because renin and angiotensin (ANG) production is upregulated in AT1A null-mutant mice, it is conceivable that the AT1B receptor provides compensation for the lost functions of AT1A...
  12. Cheng H, Wang J, Zhang M, Miyazaki Y, Ichikawa I, McKanna J, et al. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. J Clin Invest. 1999;103:953-61 pubmed
    ..Mutant mice homozygous for both Agtr1a and Agtr1b null mutations (Agtr1a-/-,Agtr1b-/-) demonstrated large increases in immunoreactive COX-2 expression inthe cTALH/..
  13. Gao J, Chao J, Parbhu K, Yu L, Xiao L, Gao F, et al. Ontogeny of angiotensin type 2 and type 1 receptor expression in mice. J Renin Angiotensin Aldosterone Syst. 2012;13:341-52 pubmed publisher
    ..These data imply an involvement of AT1R in fetal development and of AT2R in adult function. ..
  14. Nagai N, Oike Y, Izumi Nagai K, Urano T, Kubota Y, Noda K, et al. Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2006;26:2252-9 pubmed
    ..AT1-R-mediated inflammation plays a pivotal role in the development of CNV, indicating the possibility of AT1-R blockade as a novel therapeutic strategy to inhibit CNV. ..
  15. Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, et al. Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. PLoS ONE. 2015;10:e0129484 pubmed publisher
    ..To genetically determine the responsible receptor subtype, we examined AT1a, AT1b, and AT2 knockout mice, but did not observe anemia in any of them...
  16. Tanaka M, Tsuchida S, Imai T, Fujii N, Miyazaki H, Ichiki T, et al. Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout mice. Biochem Biophys Res Commun. 1999;258:194-8 pubmed
  17. Keidar S, Kaplan M, Pavlotzky E, Coleman R, Hayek T, Hamoud S, et al. Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. Circulation. 2004;109:2213-20 pubmed
    ..Blocking of the mineralocorticoid receptor and inhibition of tissue ACE and/or the angiotensin receptor-1 reduced aldosterone deleterious pro-oxidative and proatherogenic effects. ..
  18. Miyazaki Y, Tsuchida S, Fogo A, Ichikawa I. The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy. Kidney Int. 1999;55:1683-95 pubmed
    ..The abnormal kidney structure that develops in neonates during angiotensin inhibition is attributed largely to "functional obstruction" of the urinary tract caused by the defective development of peristaltic machinery. ..
  19. Hoffmann A, Cool D. Angiotensin II receptor types 1A, 1B, and 2 in murine neuroblastoma Neuro-2a cells. J Recept Signal Transduct Res. 2003;23:111-21 pubmed
    ..chain reaction (RT-PCR) showed that Neuro-2a cells express mRNA of angiotensin II (AngII) receptor subtypes AT1A, AT1B, and AT2. Analysis of Neuro-2a cells by Western blotting revealed AT1 and AT2 receptor protein expression...
  20. Abraham D, Davis R, Warren C, Mao L, Wolska B, Solaro R, et al. β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility. Proc Natl Acad Sci U S A. 2016;113:14426-14431 pubmed
    ..Our data reveal β-arrestin 1, β-arrestin 2, and AT1R as key regulatory molecules in the Frank-Starling mechanism, which potentially can be targeted therapeutically with β-arrestin-biased AT1R ligands. ..
  21. Poduri A, Owens A, Howatt D, Moorleghen J, Balakrishnan A, Cassis L, et al. Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS ONE. 2012;7:e48462 pubmed publisher
    ..This receptor is expressed as 2 structurally similar subtypes in rodents, termed AT1a and AT1b. Although AT1a receptors have been studied comprehensively, roles of AT1b receptors in the aorta have not been ..
  22. Ulmasov B, Xu Z, Talkad V, Oshima K, Neuschwander Tetri B. Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse. Am J Physiol Gastrointest Liver Physiol. 2010;299:G70-80 pubmed publisher was to elucidate the effect of the AT1 signaling pathway in the development of pancreatitis using AT1a- and AT1b-deficient mice as well as the ARB losartan...
  23. van Esch J, Gembardt F, Sterner Kock A, Heringer Walther S, Le T, Lassner D, et al. Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. Cardiovasc Res. 2010;86:401-9 pubmed publisher
    ..Renal Ang II levels largely depend on AT(1) binding of extracellularly generated Ang II, and in the absence of all three Ang II receptors, renal Ang II is only located extracellularly. ..
  24. Chen Y, da Rocha M, Morris M. Osmotic regulation of angiotensin AT1 receptor subtypes in mouse brain. Brain Res. 2003;965:35-44 pubmed
    Experiments were performed to study angiotensin (Ang) AT1a and AT1b mRNA expression in mice, including, examination of brain distribution and the effect of salt loading...
  25. Harrison Bernard L, Cook A, Oliverio M, Coffman T. Renal segmental microvascular responses to ANG II in AT1A receptor null mice. Am J Physiol Renal Physiol. 2003;284:F538-45 pubmed
  26. Madsen K, Marcussen N, Pedersen M, Kjaersgaard G, Facemire C, Coffman T, et al. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. J Am Soc Nephrol. 2010;21:448-59 pubmed publisher
    ..Similarly, Agtr1a(-/-);Agtr1b(-/-) mouse kidneys had decreased angiopoietin-1, angiopoietin-2, and Tie-2 mRNAs at postnatal day 14...
  27. Rahman M, Nara H, Onoda T, Araki A, Li J, Hoshino T, et al. Cloning and characterization of an isoform of interleukin-21. FEBS Lett. 2007;581:4001-9 pubmed
    ..We also show that the secretion efficiency of hIL-21iso is much lower than that of hIL-21. These results may suggest there are some different regulatory mechanisms to produce IL-21 or IL-21iso in transcriptional and secretory steps. ..
  28. Chen X, Li W, Yoshida H, Tsuchida S, Nishimura H, Takemoto F, et al. Targeting deletion of angiotensin type 1B receptor gene in the mouse. Am J Physiol. 1997;272:F299-304 pubmed
    We null mutated the mouse angiotensin type 1B (AT1B) receptor gene (Agtr1b) by gene targeting...
  29. Machura K, Steppan D, Neubauer B, Alenina N, Coffman T, Facemire C, et al. Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol. 2009;297:F1371-80 pubmed publisher
    ..of renin expression, we studied the development of intrarenal renin expression in mice lacking ANG II AT1a, AT1b, or AT2 receptors and in animals with abolished circulating ANG II due to deletion of the gene for angiotensin I-..
  30. Takahashi N, Smithies O. Gene targeting approaches to analyzing hypertension. J Am Soc Nephrol. 1999;10:1598-605 pubmed
    ..These various gene targeting experiments help identify genes regulating BP, promote a better understanding of the pathophysiology of the condition, and help identify potential targets for therapies. ..
  31. Villar Cheda B, Dominguez Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira Garcia J. Aging-related dysregulation of dopamine and angiotensin receptor interaction. Neurobiol Aging. 2014;35:1726-38 pubmed publisher
    ..The results suggest that dopamine may play an important role in modulating oxidative stress and inflammation in the substantia nigra and striatum via the RAS, which is impaired by aging. ..
  32. Storch U, Blodow S, Gudermann T, Mederos y Schnitzler M. Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors-brief report. Arterioscler Thromb Vasc Biol. 2015;35:121-6 pubmed publisher
    ..Analyzing myogenic tone of isolated murine mesenteric arteries of AT1A and AT1B receptor double gene-deficient (AT1A/1B (-/-)) mice ex vivo, we observed a decreased myogenic tone at high ..
  33. Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, et al. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest. 1998;101:755-60 pubmed
    Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting, we produced double mutant mice ..
  34. Tamura K, Yokoyama N, Sumida Y, Fujita T, Chiba E, Tamura N, et al. Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. J Endocrinol. 1999;160:401-8 pubmed
    ..Thus, expression of AT1 and ACE is regulated by salt loading in a tissue-specific manner that appears to be mediated, at least partly, by a mechanism other than changes in the circulating or tissue levels of angiotensin peptides. ..
  35. Biggs W, Cavenee W, Arden K. Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome. 2001;12:416-25 pubmed
    ..Further characterization will provide insight into the roles of members of the FKHR subfamily of forkhead-related genes during both normal and neoplastic development. ..
  36. Le T, Oliverio M, Kim H, Salzler H, Dash R, Howell D, et al. A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiol Genomics. 2004;18:290-8 pubmed
    ..background and in mice with targeted disruption of one or both of the murine AT(1) receptor genes (Agtr1a and Agtr1b). On all three backgrounds, gammaGT-AT(1A) transgenic mice were healthy and viable...
  37. Wang G, Sarkar P, Peterson J, Anrather J, Pierce J, Moore J, et al. COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ. Am J Physiol Heart Circ Physiol. 2013;305:H1451-61 pubmed publisher
    ..Our findings provide the first evidence of a spatial and functional framework that underlies ANG-II signaling in the SFO and reveal novel targets for antihypertensive therapies. ..
  38. Yu L, Shao C, Gao L. Developmental expression patterns for angiotensin receptors in mouse skin and brain. J Renin Angiotensin Aldosterone Syst. 2014;15:139-49 pubmed publisher
    ..In other organs and tissues, adults express higher AT2R protein than does the fetus. ..
  39. Oudit G, Crackower M, Backx P, Penninger J. The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med. 2003;13:93-101 pubmed
  40. Alli C, Consalez G. Linkage mapping of Csrp to proximal mouse chromosome 3. Mamm Genome. 1998;9:172-3 pubmed
  41. Zhang C, Huang X, Lu H, Meng X, Liu D, Kim Y, et al. Up-regulation of the Ang II/AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice. Mol Cell Endocrinol. 2016;423:77-86 pubmed publisher
    ..ACE and AT1R up-regulation in the stomach may help compensate for ICC loss in STZ-induced diabetic mice. ..
  42. Gallego Delgado J, Basu Roy U, Ty M, Alique M, Fernandez Arias C, Movila A, et al. Angiotensin receptors and ?-catenin regulate brain endothelial integrity in malaria. J Clin Invest. 2016;126:4016-4029 pubmed publisher
    ..The interrelation of the ?-catenin and the angiotensin II signaling pathways opens immediate host-targeted therapeutic possibilities for cerebral malaria and other diseases in which brain endothelial integrity is compromised. ..
  43. Nahmod K, Walther T, Cambados N, Fernandez N, Meiss R, Tappenbeck N, et al. AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system. FASEB J. 2012;26:1982-94 pubmed publisher
    ..Taken together, these results strongly suggest that AngII, via the AT(1) receptor, plays a major role in mouse mammary gland involution identifying a novel role for the RAS. angiotensin system. ..
  44. Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, et al. Bone marrow AT1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1{alpha}. Arterioscler Thromb Vasc Biol. 2010;30:60-7 pubmed publisher
    ..The BM-AT(1) receptor promotes neointima formation by regulating the mobilization and homing of BM-derived VPCs in a platelet-derived SDF-1alpha-dependent manner without affecting EPC-mediated reendothelialization. ..
  45. Gembardt F, Heringer Walther S, van Esch J, Sterner Kock A, van Veghel R, Le T, et al. Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors. FASEB J. 2008;22:3068-77 pubmed publisher
  46. Chen Y, Chen H, Morris M. Enhanced osmotic responsiveness in angiotensin AT1a receptor deficient mice: evidence for a role for AT1b receptors. Exp Physiol. 2005;90:739-46 pubmed
    Experiments were performed to study the role of angiotensin (Ang) AT1a and AT1b receptor subtypes in osmotic regulation of blood pressure using gene deletion and pharmacological methods...
  47. Nagashio Y, Asaumi H, Watanabe S, Nomiyama Y, Taguchi M, Tashiro M, et al. Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G170-7 pubmed
  48. Davisson R. Physiological genomic analysis of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2003;285:R498-511 pubmed
    ..It also summarizes the principles, progress, and prospects for a better understanding of the brain RAS in health and disease. ..
  49. Davisson R, Oliverio M, Coffman T, Sigmund C. Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest. 2000;106:103-6 pubmed
    ..However, the drinking response requires the presence of AT(1B) receptors. To our knowledge, this is the first demonstration of a primary and nonredundant physiological function for AT(1B) receptors. ..
  50. Ma L, Corsa B, Zhou J, Yang H, Li H, Tang Y, et al. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. Am J Physiol Renal Physiol. 2011;300:F1203-13 pubmed publisher
    ..Our data suggest obesity accelerates kidney injury, linked to augmented inflammation in adipose and kidney tissues and a proinflammatory shift in macrophage and M1/M2 balance. ..
  51. Mazzolai L, Pedrazzini T, Nicoud F, Gabbiani G, Brunner H, Nussberger J. Increased cardiac angiotensin II levels induce right and left ventricular hypertrophy in normotensive mice. Hypertension. 2000;35:985-91 pubmed
    ..Blocking of the angiotensin II type 1 receptor rather than enhanced stimulation of the angiotensin II type 2 receptor may prevent remodeling and account for the beneficial effects of angiotensin antagonists. ..
  52. Gharavi A, Ahmad T, Wong R, Hooshyar R, Vaughn J, Oller S, et al. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci U S A. 2004;101:2488-93 pubmed
    ..These findings demonstrate a strong genetic influence on HIVAN and demonstrate a major renal disease susceptibility locus on mouse chromosome 3A1-3. ..