Agtr1a

Summary

Gene Symbol: Agtr1a
Description: angiotensin II receptor, type 1a
Alias: 1810074K20Rik, AG2S, AI551199, AT1, AT1a, AT2R1, AT2R1A, Agtr-1a, Agtr1, Angtr-1a, type-1A angiotensin II receptor, angiotensin II type-1A receptor, angiotensin receptor 1, angiotensin receptor 1a
Species: mouse

Top Publications

  1. pmc Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
    H F Cheng
    Vanderbilt George M O Brien Kidney and Urologic Diseases Center, Nashville, TN 37232, USA
    J Clin Invest 103:953-61. 1999
  2. ncbi Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice
    Yoshikuni Nagashio
    Third Dept of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Physiol Gastrointest Liver Physiol 287:G170-7. 2004
  3. ncbi A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues
    Yingbi Zhou
    Davis Heart and Lung Research Institute, College of Medicine and Public Health, The Ohio State University, 375 W12th Avenue, Columbus, OH 43210, USA
    J Mol Cell Cardiol 38:693-6. 2005
  4. pmc Disruption of the Ang II type 1 receptor promotes longevity in mice
    Ariela Benigni
    Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, Bergamo, Italy
    J Clin Invest 119:524-30. 2009
  5. ncbi Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo
    Junji Ishida
    Center for Tsukuba Advanced Research Alliance, Institute of Applied Biochemistry, Institute of Basic Medical Sciences, Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 279:26274-9. 2004
  6. pmc Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons
    Amit K Mitra
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Physiol Cell Physiol 299:C561-9. 2010
  7. pmc Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
    Huijing Xia
    Louisiana State University Health Sciences Center, School of Medicine, Department of Pharmacology and Experimental Therapeutics, 1901 Perdido St, P7 1, New Orleans, LA 70112, USA
    Hypertension 53:210-6. 2009
  8. ncbi Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice
    K Tamura
    Department of Dermatology, Yokohama City University School of Medicine, Yokohama 236, Japan
    J Endocrinol 160:401-8. 1999
  9. ncbi Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling
    Minako Ishibashi
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circ Res 94:1203-10. 2004
  10. ncbi Angiotensin II type 1 receptors and the intestinal microvascular dysfunction induced by ischemia and reperfusion
    Thomas Petnehazy
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1203-10. 2006

Research Grants

Scientific Experts

Detail Information

Publications150 found, 100 shown here

  1. pmc Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
    H F Cheng
    Vanderbilt George M O Brien Kidney and Urologic Diseases Center, Nashville, TN 37232, USA
    J Clin Invest 103:953-61. 1999
    ..Mutant mice homozygous for both Agtr1a and Agtr1b null mutations (Agtr1a-/-,Agtr1b-/-) demonstrated large increases in immunoreactive COX-2 expression ..
  2. ncbi Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice
    Yoshikuni Nagashio
    Third Dept of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Physiol Gastrointest Liver Physiol 287:G170-7. 2004
    ....
  3. ncbi A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues
    Yingbi Zhou
    Davis Heart and Lung Research Institute, College of Medicine and Public Health, The Ohio State University, 375 W12th Avenue, Columbus, OH 43210, USA
    J Mol Cell Cardiol 38:693-6. 2005
    In mice, angiotensin (Ang) II type-1 (AT(1)) receptors exist as AT1a, and AT(1b) subtypes...
  4. pmc Disruption of the Ang II type 1 receptor promotes longevity in mice
    Ariela Benigni
    Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, Bergamo, Italy
    J Clin Invest 119:524-30. 2009
    ..Here, we show that targeted disruption of the Agtr1a gene that encodes AT1A results in marked prolongation of life span in mice...
  5. ncbi Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo
    Junji Ishida
    Center for Tsukuba Advanced Research Alliance, Institute of Applied Biochemistry, Institute of Basic Medical Sciences, Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 279:26274-9. 2004
    ..These results demonstrate that APJ exerts the hypotensive effect in vivo and plays a counterregulatory role against the pressor action of angiotensin II...
  6. pmc Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons
    Amit K Mitra
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Physiol Cell Physiol 299:C561-9. 2010
    ..a cell neuronal model. These data imply a positive feedback mechanism that may impact neuronal discharge sensitivity in response to ANG II...
  7. pmc Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
    Huijing Xia
    Louisiana State University Health Sciences Center, School of Medicine, Department of Pharmacology and Experimental Therapeutics, 1901 Perdido St, P7 1, New Orleans, LA 70112, USA
    Hypertension 53:210-6. 2009
    ..Together, our data suggest that angiotensin II type 1 receptor-mediated ACE2 inhibition impairs baroreflex function and support a critical role for ACE2 in the central regulation of BP and the development of hypertension...
  8. ncbi Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice
    K Tamura
    Department of Dermatology, Yokohama City University School of Medicine, Yokohama 236, Japan
    J Endocrinol 160:401-8. 1999
    This study examined whether type 1 angiotensin II receptor (AT1) and angiotensin-converting enzyme (ACE) mRNAs are regulated during dietary salt loading in angiotensinogen gene-knockout (Atg-/-) mice which are genetically deficient in ..
  9. ncbi Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling
    Minako Ishibashi
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circ Res 94:1203-10. 2004
    ..wild-type mice, Ang II increased CCR2 intensity in circulating monocytes, which was prevented by an Ang II type-1 (AT1) receptor blocker or blunted in AT1 receptor-deficient mice...
  10. ncbi Angiotensin II type 1 receptors and the intestinal microvascular dysfunction induced by ischemia and reperfusion
    Thomas Petnehazy
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1203-10. 2006
    ..Upregulation of angiotensin II type 1 receptors (AT1-R) has been implicated in the pathogenesis of conditions associated with oxidative stress...
  11. ncbi Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis
    Ihor V Yosypiv
    Department of Pediatrics, Tulane University Health Sciences Center, SL 37, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Am Soc Nephrol 17:1005-14. 2006
    ..This process depends on tyrosine phosphorylation of the EGFR. Cooperation of AT(1)R and EGFR signaling therefore is important in the development of the renal collecting system...
  12. ncbi Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature
    Mami Ishikawa
    Department of Neurosurgery, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi, 329 0498 Japan
    Am J Physiol Heart Circ Physiol 292:H2306-15. 2007
    ....
  13. ncbi Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice
    Daiju Fukuda
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 28:90-6. 2008
    ..Recently, bone marrow (BM) cells were reported to express AT1R. Here, we investigated the role of AT1R in BM in the pathogenesis of atherosclerosis...
  14. pmc Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells)
    C Alfarano
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Br J Pharmacol 153:907-14. 2008
    ..To determine whether angiotensin II increases insulin resistance in cardiomyocytes, we studied the effect of angiotensin II on basal and insulin-stimulated transport rate of energy substrates in immortalized cardiomyocytes (HL-1 cells)...
  15. pmc Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation
    Vanesa Esteban
    Cellular Biology in Renal Diseases Laboratory, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, Spain
    PLoS ONE 4:e5406. 2009
    ..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney...
  16. ncbi Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor
    L Daviet
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 274:17058-62. 1999
    ..two-hybrid screening of a mouse kidney cDNA library with the carboxyl-terminal cytoplasmic domain of the murine AT1a receptor as a bait, we have isolated a novel protein with a predicted molecular mass of 18 kDa, which we have named ..
  17. pmc Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis
    Ken Sasaki
    The Cardiovascular Research Institute, and Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    J Clin Invest 109:603-11. 2002
    ..WT) mice in response to hindlimb ischemia, whereas these responses were reduced in ATII type 1a receptor knockout (AT1a(-/-)) mice...
  18. ncbi Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 94:534-41. 2004
    ..These effects were completely omitted in AT1 receptor knockout mice (AT1A-/- mice)...
  19. ncbi Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis
    Nozomi Imai
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Kanagawa, Japan
    Lab Invest 87:189-98. 2007
    ..in cancer progression using murine Lewis lung carcinoma (LLC) cells, which express AT1 receptor, and AT1a receptor gene-deficient (AT1a-/-) mice...
  20. pmc Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, United Kingdom
    Hypertension 51:1010-9. 2008
    ..These autoantibodies represent potentially important targets for diagnosis and therapeutic intervention...
  21. pmc Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 57:2191-8. 2008
    ..The aim of the present study was to show the relationship of the renin-angiotensin system (RAS) with the synaptic vesicle protein synaptophysin and neuronal activity in the diabetic retina...
  22. pmc Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Kidney Int 74:1287-93. 2008
    ..Enhanced Wnt11 expression induces GDNF in adjacent mesenchyme causing focal bursts of ureteric bud tip cell proliferation, decreased tip cell apoptosis and branching...
  23. doi Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria
    Sérgio V B Pinheiro
    Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Kidney Int 75:1184-93. 2009
    ..changes and the renal dysfunction of the knockout mice were associated with an upregulation of angiotensin II AT1 receptor and transforming growth factor-beta mRNA...
  24. pmc Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis
    Steven D Crowley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, and Durham VA Medical Center, Durham, North Carolina 27705, USA
    J Clin Invest 119:943-53. 2009
    ..autoimmune disease, we generated MRL-Faslpr/lpr (lpr) mice lacking the major murine type 1 angiotensin receptor (AT1A); lpr mice develop a generalized autoimmune disease with glomerulonephritis that resembles SLE...
  25. pmc Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy
    Hong Yue
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cardiovasc Res 85:90-9. 2010
    ..This study was aimed at discovering a novel gene expression mechanism in heart failure...
  26. ncbi Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome
    H Sasamura
    Falk Cardiovascular Research Center, Stanford University School of Medicine, California 94305
    Biochem Biophys Res Commun 185:253-9. 1992
    ..Because many of the structural differences were in the carboxy terminal putative intracellular domain, we speculate that these isoforms may differ in their regulation, signal transduction, or desensitization mechanisms...
  27. ncbi Differential expression of angiotensin receptor 1A and 1B in mouse
    J M Burson
    Department of Medicine, University of Iowa College of Medicine, Iowa City 52242
    Am J Physiol 267:E260-7. 1994
    At least two distinct genes (AT1A and AT1B) encode type 1 angiotensin II (AT1) receptors in rodents...
  28. ncbi Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice
    Z Zhu
    Department of Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
    Hypertension 31:1171-7. 1998
    Our studies on angiotensin II receptor subtype 1A (AT1A) knockout mice define how endogenous receptors other than AT1A receptors stimulate changes in cytosolic calcium concentration ([Ca2+]i) in cultured aortic vascular smooth muscle ..
  29. ncbi Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice
    K Harada
    Department of Medicine III, University of Tokyo School of Medicine, Japan
    Circulation 97:1952-9. 1998
    ..in response to mechanical stretch and induces cardiomyocyte hypertrophy through the Ang II type 1 receptor (AT1) in vitro...
  30. pmc Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II
    M I Oliverio
    Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    Proc Natl Acad Sci U S A 95:15496-501. 1998
    ..AT1 receptor, there are two AT1 receptor isoforms in rodents (AT1A and AT1B) that are products of separate genes (Agtr1a and Agtr1b)...
  31. ncbi Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart
    Yuhao Li
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 106:1722-8. 2002
    ..Angiotensin II (Ang II) type 1A (AT1A), an Ang II receptor, regulates cardiovascular homeostasis oppositely...
  32. ncbi Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
    Yunzeng Zou
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Nat Cell Biol 6:499-506. 2004
    The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism...
  33. ncbi Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice
    Sven Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 110:3062-7. 2004
    Angiotensin II type 1 (AT1) receptor activation is potentially involved in the multifactorial pathogenesis of atherosclerosis.
  34. ncbi Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    Alan Daugherty
    Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Circulation 110:3849-57. 2004
    Hypercholesterolemia-induced atherosclerosis is attenuated by either pharmacological antagonism of AT1 receptors or AT1A receptor deficiency...
  35. ncbi The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy
    Yutaka Tanaka
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    FEBS Lett 579:1579-86. 2005
    ..These results indicate that ATRAP significantly promotes downregulation of the AT1R and further attenuates certain Ang II-mediated hypertrophic responses in cardiomyocytes...
  36. pmc Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 115:1092-9. 2005
    ..Thus, the regulation of blood pressure by the RAS is mediated by AT(1) receptors both within and outside the kidney...
  37. ncbi Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction
    Jun Katada
    Pfizer KEIO Research Laboratory, Tokyo, Japan
    Circulation 111:2157-64. 2005
    ..The molecular basis underlying this Ang II-independent remodeling is unclear...
  38. ncbi Angiotensin-converting enzyme 2 protects from severe acute lung failure
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A 1030, Austria
    Nature 436:112-6. 2005
    ..However, other components of the renin-angiotensin system, including ACE, angiotensin II and the angiotensin II type 1a receptor (AT1a), promote disease pathogenesis, induce lung oedemas and impair lung function...
  39. ncbi Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules
    Y Tsurumi
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Kidney Int 69:488-94. 2006
    ..hemodynamics and sodium handling through the activation of vascular, glomerular and tubular angiotensin II type 1 (AT1) receptor-mediated signaling...
  40. ncbi Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:1950-61. 2006
    ..It is not only AngII but also intraglomerular activation of MAPK by the receptor-associated prorenin that plays a pivotal role in diabetic nephropathy...
  41. pmc Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    Steven D Crowley
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17985-90. 2006
    ..Based on the critical role of the renin-angiotensin system (RAS) and the type I (AT1) angiotensin receptor in essential hypertension, we developed an experimental model to separate AT1 receptor pools ..
  42. ncbi Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms
    Lisa A Cassis
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 27:380-6. 2007
    ..The purpose of this study was to define whether AngII interacts with receptors on infiltrating versus resident cells in promoting vascular pathologies...
  43. pmc Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
    Hong Lu
    Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA
    J Clin Invest 118:984-93. 2008
    ..Therefore, although previous work suggests that angiotensin peptides have conflicting effects on atherogenesis, we found that renin inhibition profoundly decreased lesion development in mice...
  44. pmc Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice
    Tracy Henriques
    Graduate Center for Nutritional Sciences, Room 521b, Wethington Building, 900 S Limestone, University of Kentucky, Lexington, KY 40536 0200, USA
    Arterioscler Thromb Vasc Biol 28:1251-6. 2008
    ..The purpose of this study was to determine whether this reduction is attributable to androgen-mediated regulation of aortic Ang II type 1A receptors (AT1aR)...
  45. doi Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells
    Hideki Kato
    Center for Tsukuba Advanced Research Alliance TARA, University of Tsukuba, Ibaraki, Japan
    Lab Invest 88:731-9. 2008
    ..in the extent of kidney damage between mice receiving BM transplants from mutant mice lacking the angiotensin II type 1a receptor (AT1a) gene and mice receiving transplants from wild-type (WT) mice...
  46. doi The long-term effect of angiotensin II type 1a receptor deficiency on hypercholesterolemia-induced atherosclerosis
    Hideyuki Eto
    Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
    Hypertens Res 31:1631-42. 2008
    ..In the present study, we investigated the long-term effect of angiotensin II type 1a receptor (AT1a) deficiency on hypercholesterolemia-induced atherosclerosis by the use of AT1a-knockout (AT1a-..
  47. doi Essential role of angiotensin II type 1a receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis
    Jun ichiro Koga
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Hypertens Res 31:1791-800. 2008
    The angiotensin II (Ang II) type 1a (AT1a) receptor is expressed on multiple cell types in atherosclerotic lesions, including bone marrow-derived cells and vascular wall cells, and mediates inflammatory and proliferative responses...
  48. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..Although we found significant involvement of angiotensin II type 1 receptor (AT1-R)-mediated inflammation in choroidal neovascularization (CNV), a central abnormality of vision-threatening age-..
  49. pmc Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3
    A Phillip Owens
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 106:611-9. 2010
    ..Angiotensin II (Ang II) has diverse effects on smooth muscle cells (SMCs). The diversity of effects may relate to the regional location of this cell type...
  50. pmc Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts
    Joep H M van Esch
    Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Cardiovasc Res 86:401-9. 2010
    ....
  51. doi Mechanical stress-evoked but angiotensin II-independent activation of angiotensin II type 1 receptor induces cardiac hypertrophy through calcineurin pathway
    Ning Zhou
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China
    Biochem Biophys Res Commun 397:263-9. 2010
    ..These findings collectively suggest that mechanical stress-evoked but AngII-independent activation of AT(1) receptor induces cardiac hypertrophy through calcineurin pathway...
  52. pmc Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension
    Matthew A Sparks
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Room 2028 MSRB2, 106 Research Dr, Durham, NC 27710, USA
    Hypertension 57:577-85. 2011
    ..mouse line expressing Cre recombinase in smooth muscle cells with a mouse line bearing a conditional allele of the Agtr1a gene (Agtr1a (flox)), encoding the major murine AT(1) receptor isoform (AT(1A))...
  53. pmc Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice
    Debra L Rateri
    Saha Cardiovascular Research Center, BBSRB, Room 243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 108:574-81. 2011
    ..In agreement with this associative evidence, we have published recently that Ang II infusion induces aneurysmal pathology in the ascending aorta...
  54. pmc AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University and Durham, VA Medical Centers, Durham, NC 27710, USA
    Cell Metab 13:469-75. 2011
    ..Thus, effectively targeting epithelial functions of the proximal tubule of the kidney should be a useful therapeutic strategy in hypertension...
  55. pmc Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis
    Suguru Yamamoto
    Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, C 4204 Medical Center North, Nashville, TN 37232 2584, USA
    Arterioscler Thromb Vasc Biol 31:2856-64. 2011
    ..macrophages are the most abundant cells in atherosclerotic plaques and express angiotensin II type 1 receptor (AT1), the pathophysiologic role of macrophage AT1 in atherogenesis remains uncertain...
  56. pmc Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms
    Xuan Zhang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0200, USA
    Circ Res 110:e73-85. 2012
    ..However, mechanisms for sexual dimorphism of regional aortic angiotensin receptor expression and AAA formation are unknown...
  57. doi ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    Tatsuo Hashimoto
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    Nature 487:477-81. 2012
    ..These results provide a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea...
  58. pmc Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms
    Aruna Poduri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, United States of America
    PLoS ONE 7:e48462. 2012
    ..This receptor is expressed as 2 structurally similar subtypes in rodents, termed AT1a and AT1b...
  59. pmc Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy
    Shinji Yasuno
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Br J Pharmacol 170:1384-95. 2013
    ....
  60. ncbi Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)
    H Yoshida
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 186:1042-9. 1992
    ..This conclusion was consistent with the results of genomic Southern blot analyses, which revealed that the mouse and rat possess 2 similar but separate genes, whereas the bovine and human have only a single class gene...
  61. ncbi AT1b receptor predominantly mediates contractions in major mouse blood vessels
    Yingbi Zhou
    Department of Physiology and Cell Biology, College of Medicine and Public Health, Ohio State University, 304 Hamilton Hall, 1645 Neil Ave, Columbus, Ohio 43210, USA
    Circ Res 93:1089-94. 2003
    In rodents, angiotensin (Ang) II type-1 (AT1) receptors exist as two pharmacologically identical subtypes: AT1a and AT1b...
  62. ncbi Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia
    T Sugaya
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    J Biol Chem 270:18719-22. 1995
    ..a key role in cardiovascular homeostasis, exerts its multiple effects through the different types of AT receptors, AT1a, AT1b, and AT2...
  63. pmc Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway
    C Nataraj
    Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 104:1693-701. 1999
    ..Using Agtr1a(-/-) mice, which lack AT(1A) receptors for angiotensin II, we have identified a novel function of the RAS to ..
  64. pmc Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation
    Yumei Feng
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, Tulane University, New Orleans, LA 70112, USA
    Circ Res 102:729-36. 2008
    ..Taken together, our results show that ACE2 plays a pivotal role in the central regulation of blood pressure and volume homeostasis, offering a new target for the treatment of hypertension and other cardiovascular diseases...
  65. ncbi Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice
    A Leri
    Department of Medicine, New York Medical College, Valhalla, NY, USA
    Circ Res 84:752-62. 1999
    ..On this basis, p53 DNA binding activity to angiotensinogen (Aogen), bax, and the AT1 receptor was determined in left ventricular myocytes from FVB.Igf-/- and FVB.Igf+/- mice...
  66. ncbi Micropuncture analysis of tubuloglomerular feedback regulation in transgenic mice
    J Schnermann
    National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1370, USA
    J Am Soc Nephrol 10:2614-9. 1999
    ..In contrast, changes in loop flow did not alter stop-flow pressure in angiotensin II type 1A receptor and angiotensin-converting enzyme knockout mice...
  67. ncbi Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice
    O von Bohlen und Halbach
    Johannes Müller Institute of Physiology Charité, Humboldt University, Tucholskystrasse 2, D 10117, Berlin, Germany
    Regul Pept 99:209-16. 2001
    ..Different high-affinity Ang II receptor subtypes (AT1A, AT1B and AT2) have been cloned. They are expressed in various brain structures...
  68. ncbi Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors
    R E Mistlberger
    Department of Psychology, Simon Fraser University, 8888 University Drive, V5A 1S6, Burnaby, BC, Canada
    Physiol Behav 74:457-64. 2001
    ..The modestly shorter tau and increased rhythm amplitude in KO mice may be secondary to an effect of the mutation on the level of running and drinking activity...
  69. ncbi Renal segmental microvascular responses to ANG II in AT1A receptor null mice
    Lisa M Harrison-Bernard
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 284:F538-45. 2003
    ....
  70. ncbi Differential vasoconstrictions induced by angiotensin II: role of AT1 and AT2 receptors in isolated C57BL/6J mouse blood vessels
    Yingbi Zhou
    Department of Physiology and Cell Biology, Ohio State Univ College of Medicine and Public Health, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 285:H2797-803. 2003
    ..However, an AT1 antagonist, losartan (10 microM), completely inhibited ANG II (100 nM) response in abdominal aorta and carotid ..
  71. ncbi Efferent arterioles exclusively express the subtype 1A angiotensin receptor: functional insights from genetic mouse models
    Lisa M Harrison-Bernard
    Dept of Physiology, Box P7 3, Louisiana State Univ Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 290:F1177-86. 2006
    ..Therefore, we conclude that AT(1A) and AT(1B) receptors are functionally expressed on the AA, whereas the EA exclusively expresses the AT(1A) receptor...
  72. ncbi Salt consumption increases blood pressure and abolishes the light/dark rhythm in angiotensin AT1a receptor deficient mice
    Yanfang Chen
    Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University School, Dayton, OH 45450, USA
    Physiol Behav 88:95-100. 2006
    Experiments were performed to study the role of angiotensin (Ang) AT1a receptors in dietary sodium-induced changes in blood pressure (BP)...
  73. pmc Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 293:F586-93. 2007
    ..We tested the hypothesis that AT(1a) receptor-deficient mice (Agtr1a-/-) are unable to accumulate ANG II intracellularly in the kidney because of the absence of AT(1a) receptor-..
  74. pmc In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice
    Xiao C Li
    Am J Physiol Renal Physiol 294:F293-302. 2008
    Using type 1a angiotensin receptor (AT1a) receptor-deficient (Agtr1a-/-) mice and in vivo autoradiography, we tested the hypothesis that intracellular uptake of ANG II in the kidney and adrenal glands is primarily mediated by AT1a ..
  75. pmc AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Kidney Int 76:169-77. 2009
    ..We suggest that AT(1a) receptor deletion causes polyuria and urine concentration defects by decreasing basal AVP release and impairing AVP-induced receptor signaling in the inner medulla...
  76. doi Role of angiotensin II Type 1A receptors in cardiovascular reactivity and neuronal activation after aversive stress in mice
    Pamela J Davern
    Baker IDI Heart and Diabetes Institute, Commercial Rd, Prahran, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 54:1262-8. 2009
    ....
  77. ncbi [Role of angiotensin II type 1 receptor in activation of nuclear factor-kappaB and activator protein-1 in lung of mice with acute lung injury]
    Fei Wang
    Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
    Zhonghua Shao Shang Za Zhi 26:113-6. 2010
    To explore the role of angiotensin II type 1 (AT1) receptor in activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) in lung of mice with LPS-induced acute lung injury (ALI).
  78. pmc Transgenic expression of an altered angiotensin type I AT1 receptor resulting in marked modulation of vascular type I collagen
    Jun Yu
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    J Cell Physiol 227:2013-21. 2012
    The angiotensin II (AngII) type I receptor (AT1) was modified by replacing its third intracellular loop and C-terminal tail with the corresponding regions from the bradykinin B2 receptor...
  79. pmc Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin
    Jill W Verlander
    Renal Division, Emory University School of Medicine, 1639 Pierce Dr NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 301:F1314-25. 2011
    ..in this response, pendrin abundance and subcellular distribution were examined in wild-type, angiotensin type 1a (Agtr1a) and type 2 receptor (Agtr2) null mice given 7 days of a NaCl-restricted diet (< 0.02% NaCl)...
  80. doi Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress
    Daian Chen
    Department of Physiology, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Neurosci 32:2051-61. 2012
    ..This study demonstrates that AT(1A)R expression by C1 neurons is essential for the pressor response to angiotensin II and that this pathway plays an important role in the pressor response to aversive stress...
  81. pmc A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension
    Jian Dong Zhang
    Division of Nephrology, Departments of Medicine, Duke University Medical Center and Durham VA Medical Center, Durham, NC 27710, USA
    Circ Res 110:1604-17. 2012
    ..However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hypertension...
  82. ncbi Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Japan
    J Pharmacol Sci 123:185-94. 2013
    ..Imidapril (10 mg/kg per day) was administered to wild-type or angiotensin II type 1 (AT1) receptor knockout mice...
  83. pmc Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control
    Masanori Mitsuishi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:710-7. 2009
    ..Blockade of angiotensin (Ang) II has been shown to prevent new-onset type 2 diabetes. We focused on the effects of AngII on muscle mitochondria, especially on their biogenesis, as an underlining mechanism of type 2 diabetes...
  84. ncbi Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization
    H Qian
    Molecular Endocrinology Laboratory, Baker Medical Research Institute, Melbourne 8008, Australia
    Mol Endocrinol 15:1706-19. 2001
    ....
  85. doi The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Innere Medizin, Universitatsklinikum Bonn, Bonn, Germany
    Arch Biochem Biophys 488:76-82. 2009
    The AT1 receptor plays an essential role in the pathogenesis of atherosclerosis. AT1 receptor expression is predominately mediated via mRNA destabilization by mRNA binding proteins...
  86. pmc Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development
    Nicola J A Scott
    Department of Medicine, University of Otago Christchurch, P O Box 4345, Christchurch, New Zealand
    Biochim Biophys Acta 1792:1175-84. 2009
    ..The decreased viability of Npr1(-/-)embryos may result from a combination of cardiomegaly and dysregulated Cx43 protein affecting cardiac contractility...
  87. doi Blockage of angiotensin II type 1 receptor regulates TNF-alpha-induced MAdCAM-1 expression via inhibition of NF-kappaB translocation to the nucleus and ameliorates colitis
    Takashi Mizushima
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 298:G255-66. 2010
    ..Furthermore, inhibition of AT1R ameliorates colitis in a mouse colitis model. Therefore, AT1R might be one of new therapeutic target of IBD via regulation of MAdCAM-1...
  88. pmc A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Box 103015, Duke University Medical Center, Durham, NC 27710, USA
    Hypertension 55:99-108. 2010
    ....
  89. pmc Identification and characterization of a functional mitochondrial angiotensin system
    Peter M Abadir
    Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 108:14849-54. 2011
    ....
  90. doi Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice
    Noritaka Yasuda
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Hypertension 59:627-33. 2012
    ..Our results demonstrate that constitutive activity of the AT(1) receptor under basal conditions contributes to the cardiac remodeling even in the absence of Ang II, when the AT(1) receptor is upregulated in the heart...
  91. pmc Deletion of angiotensin II type 1 receptor gene or scavenge of superoxide prevents chronic alcohol-induced aortic damage and remodelling
    Yang Bai
    The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China
    J Cell Mol Med 16:2530-8. 2012
    To investigate whether chronic alcohol consumption induces vascular injury via angiotensin II (Ang II) type 1 (AT1) receptor-dependent superoxide generation, male transgenic mice with knockout of AT1 gene (AT1-KO) and age-matched wild-..
  92. ncbi Developmental expression of renal angiotensin II receptor genes in the mouse
    J Kakuchi
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Kidney Int 47:140-7. 1995
    The cellular distribution of angiotensin II type 1 (AT1) and type 2 (AT2) receptor mRNA was examined in mouse kidneys at several embryonic stages (12 to 18 days; 19 days = full term) and up to three weeks after birth by in situ ..
  93. ncbi Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice
    S Kudoh
    Department of Cardiovascular Medicine, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
    J Biol Chem 273:24037-43. 1998
    ..family and the expression of the c-fos gene as hypertrophic responses after stretching cultured cardiac myocytes of AT1a knockout (KO) mice...
  94. ncbi Angiotensin II maintains the structure and function of glomerular mesangium via type 1a receptor. What we have learned from null mutant mice minus the angiotensin II type 1a receptor gene
    S Inokuchi
    Department of Anatomy, Juntendo University, School of Medicine, Tokyo, Japan
    Virchows Arch 433:349-57. 1998
    The angiotensin II type 1a (AT1a) receptor is the major receptor effecting the multiple actions of angiotensin II on the cardiovascular system. It is expressed abundantly in the glomerular mesangial cells of the kidney...
  95. pmc Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice
    T Matsusaka
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2584, USA
    J Clin Invest 103:1451-8. 1999
    ..in cardiac remodeling, we generated chimeric mice that are made of both homozygous Ang II receptor type 1A gene (Agtr1a) null mutant cells and Agtr1a intact cells expressing the lacZ gene (ROSA26)...
  96. ncbi Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature
    S Tsuchida
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Kidney Int 56:509-16. 1999
    Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening...
  97. ncbi Ischemic injury in experimental stroke depends on angiotensin II
    Thomas Walther
    Max Planck Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany
    FASEB J 16:169-76. 2002
    ..significantly, we examined the effect of elevated levels of angiotensin II and the role of its receptor subtype AT1 in brain infarction in transgenic mice after focal cerebral ischemia...
  98. ncbi Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake
    Amy J Mangrum
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Renal Physiol 283:F447-53. 2002
    ....
  99. ncbi Essential role of AT1A receptor in the development of 2K1C hypertension
    Ludek Cervenka
    Center for Experimental Cardiovascular Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Hypertension 40:735-41. 2002
    The aims of this study were to delineate the relative contribution of angiotensin II (ANG II) subtype 1A (AT1A) and 1B (AT1B) receptors to the development of two-kidney, one-clip (2K1C) Goldblatt hypertension in mice, to examine if ..
  100. ncbi Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive
    Tom R Hollon
    Molecular Neuropharmacology Section and Basic Neurosciences Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
    J Neurosci 22:10801-10. 2002
    ....
  101. ncbi The role of ACE2 in cardiovascular physiology
    Gavin Y Oudit
    Department of Medical Biophysics and Richard Lewar Heart and Stroke Center of Excellence, University of Toronto, Toronto, Canada
    Trends Cardiovasc Med 13:93-101. 2003
    ....

Research Grants8

  1. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2005
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  2. Angiotensin Receptors in Central Osmonsensitivity
    Mariana Morris; Fiscal Year: 2005
    ..AT1 receptors exist in two forms, AT1a and AT1b, which are homologous in gene and protein structure, making it impossible to distinguish pharmacologically...
  3. AT1 Receptors in Renal Microvascular Physiology
    LISA HARRISON BERNARD; Fiscal Year: 2007
    ..There are 2 unique AT1 receptor subtypes in rodents, AT1A and AT1B, which cannot be distinguished using pharmacological antagonists...
  4. Estrogen in pathogenesis of tubulointerstitial disease
    Christine Maric; Fiscal Year: 2003
    ..abstract_text> ..
  5. ANGIOTENSIN TYPE IA RECEPTOR IN PRESSURE NATRIURESIS
    AMY MANGRUM; Fiscal Year: 2004
    ..plan is to understand the mechanisms underlying long-term control of blood pressure in angiotensin type IA (AT1A) receptor deficient mice...
  6. Vanderbilt Mentored Clinical Research Scholar Program
    Nancy Brown; Fiscal Year: 2006
    ..The VCRS program will train successful new clinical investigators who will serve as leaders role in the post-genomic era. [unreadable] [unreadable] [unreadable]..
  7. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    ..abstract_text> ..
  8. PAI-1 and The Vascular Toxicity of Aldosterone
    Nancy Brown; Fiscal Year: 2005
    ..This multi-disciplinary approach will generate new information regarding the role of aldosterone in vascular toxicity and, thus, improve our ability to prevent and treat cardiovascular disease. ..