Agtr1a

Summary

Gene Symbol: Agtr1a
Description: angiotensin II receptor, type 1a
Alias: 1810074K20Rik, AG2S, AI551199, AT1, AT1a, AT2R1, AT2R1A, Agtr-1a, Agtr1, Angtr-1a, type-1A angiotensin II receptor, angiotensin II type-1A receptor, angiotensin receptor 1, angiotensin receptor 1a
Species: mouse
Products:     Agtr1a

Top Publications

  1. Nagashio Y, Asaumi H, Watanabe S, Nomiyama Y, Taguchi M, Tashiro M, et al. Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G170-7 pubmed
  2. Zhou Y, Dirksen W, Chen Y, Morris M, Zweier J, Periasamy M. A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues. J Mol Cell Cardiol. 2005;38:693-6 pubmed
    In mice, angiotensin (Ang) II type-1 (AT(1)) receptors exist as AT1a, and AT(1b) subtypes...
  3. Kato H, Ishida J, Nagano K, Honjo K, Sugaya T, Takeda N, et al. Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells. Lab Invest. 2008;88:731-9 pubmed publisher
    ..in the extent of kidney damage between mice receiving BM transplants from mutant mice lacking the angiotensin II type 1a receptor (AT1a) gene and mice receiving transplants from wild-type (WT) mice...
  4. Sparks M, Parsons K, Stegbauer J, Gurley S, Vivekanandan Giri A, Fortner C, et al. Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension. 2011;57:577-85 pubmed publisher
    ..mouse line expressing Cre recombinase in smooth muscle cells with a mouse line bearing a conditional allele of the Agtr1a gene (Agtr1a (flox)), encoding the major murine AT(1) receptor isoform (AT(1A))...
  5. van Esch J, Gembardt F, Sterner Kock A, Heringer Walther S, Le T, Lassner D, et al. Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. Cardiovasc Res. 2010;86:401-9 pubmed publisher
    ..Renal Ang II levels largely depend on AT(1) binding of extracellularly generated Ang II, and in the absence of all three Ang II receptors, renal Ang II is only located extracellularly. ..
  6. Koga J, Egashira K, Matoba T, Kubo M, Ihara Y, Iwai M, et al. Essential role of angiotensin II type 1a receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis. Hypertens Res. 2008;31:1791-800 pubmed publisher
    The angiotensin II (Ang II) type 1a (AT1a) receptor is expressed on multiple cell types in atherosclerotic lesions, including bone marrow-derived cells and vascular wall cells, and mediates inflammatory and proliferative responses...
  7. Nataraj C, Oliverio M, Mannon R, Mannon P, Audoly L, Amuchastegui C, et al. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest. 1999;104:1693-701 pubmed
    ..Using Agtr1a(-/-) mice, which lack AT(1A) receptors for angiotensin II, we have identified a novel function of the RAS to ..
  8. Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436:112-6 pubmed
    ..However, other components of the renin-angiotensin system, including ACE, angiotensin II and the angiotensin II type 1a receptor (AT1a), promote disease pathogenesis, induce lung oedemas and impair lung function...
  9. Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, et al. Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart. Circulation. 2002;106:1722-8 pubmed
    ..Angiotensin II (Ang II) type 1A (AT1A), an Ang II receptor, regulates cardiovascular homeostasis oppositely...
  10. Lu Y, Chen Y, Kao Y, Wu T, Chen S, Chen Y. Extracellular matrix of collagen modulates intracellular calcium handling and electrophysiological characteristics of HL-1 cardiomyocytes with activation of angiotensin II type 1 receptor. J Card Fail. 2011;17:82-90 pubmed publisher
    ..These findings suggest a critical role of collagen in electrical remodeling during fibrosis. ..

Detail Information

Publications78

  1. Nagashio Y, Asaumi H, Watanabe S, Nomiyama Y, Taguchi M, Tashiro M, et al. Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G170-7 pubmed
  2. Zhou Y, Dirksen W, Chen Y, Morris M, Zweier J, Periasamy M. A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues. J Mol Cell Cardiol. 2005;38:693-6 pubmed
    In mice, angiotensin (Ang) II type-1 (AT(1)) receptors exist as AT1a, and AT(1b) subtypes...
  3. Kato H, Ishida J, Nagano K, Honjo K, Sugaya T, Takeda N, et al. Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells. Lab Invest. 2008;88:731-9 pubmed publisher
    ..in the extent of kidney damage between mice receiving BM transplants from mutant mice lacking the angiotensin II type 1a receptor (AT1a) gene and mice receiving transplants from wild-type (WT) mice...
  4. Sparks M, Parsons K, Stegbauer J, Gurley S, Vivekanandan Giri A, Fortner C, et al. Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension. 2011;57:577-85 pubmed publisher
    ..mouse line expressing Cre recombinase in smooth muscle cells with a mouse line bearing a conditional allele of the Agtr1a gene (Agtr1a (flox)), encoding the major murine AT(1) receptor isoform (AT(1A))...
  5. van Esch J, Gembardt F, Sterner Kock A, Heringer Walther S, Le T, Lassner D, et al. Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. Cardiovasc Res. 2010;86:401-9 pubmed publisher
    ..Renal Ang II levels largely depend on AT(1) binding of extracellularly generated Ang II, and in the absence of all three Ang II receptors, renal Ang II is only located extracellularly. ..
  6. Koga J, Egashira K, Matoba T, Kubo M, Ihara Y, Iwai M, et al. Essential role of angiotensin II type 1a receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis. Hypertens Res. 2008;31:1791-800 pubmed publisher
    The angiotensin II (Ang II) type 1a (AT1a) receptor is expressed on multiple cell types in atherosclerotic lesions, including bone marrow-derived cells and vascular wall cells, and mediates inflammatory and proliferative responses...
  7. Nataraj C, Oliverio M, Mannon R, Mannon P, Audoly L, Amuchastegui C, et al. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest. 1999;104:1693-701 pubmed
    ..Using Agtr1a(-/-) mice, which lack AT(1A) receptors for angiotensin II, we have identified a novel function of the RAS to ..
  8. Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436:112-6 pubmed
    ..However, other components of the renin-angiotensin system, including ACE, angiotensin II and the angiotensin II type 1a receptor (AT1a), promote disease pathogenesis, induce lung oedemas and impair lung function...
  9. Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, et al. Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart. Circulation. 2002;106:1722-8 pubmed
    ..Angiotensin II (Ang II) type 1A (AT1A), an Ang II receptor, regulates cardiovascular homeostasis oppositely...
  10. Lu Y, Chen Y, Kao Y, Wu T, Chen S, Chen Y. Extracellular matrix of collagen modulates intracellular calcium handling and electrophysiological characteristics of HL-1 cardiomyocytes with activation of angiotensin II type 1 receptor. J Card Fail. 2011;17:82-90 pubmed publisher
    ..These findings suggest a critical role of collagen in electrical remodeling during fibrosis. ..
  11. Owens A, Subramanian V, Moorleghen J, Guo Z, McNamara C, Cassis L, et al. Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3. Circ Res. 2010;106:611-9 pubmed publisher
    ..In conclusion, Ang II promotes both aortic medial hypertrophy and hyperplasia in a region-specific manner via an oxidant mechanism. The ascending aortic hyperplasia is dependent on Id3. ..
  12. Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo Sakamoto Y, Yabumoto C, et al. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice. Hypertension. 2012;59:627-33 pubmed publisher
    ..Our results demonstrate that constitutive activity of the AT(1) receptor under basal conditions contributes to the cardiac remodeling even in the absence of Ang II, when the AT(1) receptor is upregulated in the heart. ..
  13. Katada J, Meguro T, Saito H, Ohashi A, Anzai T, Ogawa S, et al. Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction. Circulation. 2005;111:2157-64 pubmed
    ..Acute MI was induced by coronary ligation in wild-type (WT) and angiotensin II type IA receptor-knockout (AT1A-KO) mice. Left ventricular (LV) geometry, hemodynamics, and cardiac gene expression were evaluated on day 28...
  14. Tsurumi Y, Tamura K, Tanaka Y, Koide Y, Sakai M, Yabana M, et al. Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules. Kidney Int. 2006;69:488-94 pubmed
    ..hemodynamics and sodium handling through the activation of vascular, glomerular and tubular angiotensin II type 1 (AT1) receptor-mediated signaling...
  15. Zhu Z, Zhang S, Wagner C, Kurtz A, Maeda N, Coffman T, et al. Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. Hypertension. 1998;31:1171-7 pubmed
    Our studies on angiotensin II receptor subtype 1A (AT1A) knockout mice define how endogenous receptors other than AT1A receptors stimulate changes in cytosolic calcium concentration ([Ca2+]i) in cultured aortic vascular smooth muscle ..
  16. Eto H, Miyata M, Shirasawa T, Akasaki Y, Hamada N, Nagaki A, et al. The long-term effect of angiotensin II type 1a receptor deficiency on hypercholesterolemia-induced atherosclerosis. Hypertens Res. 2008;31:1631-42 pubmed publisher
    ..In the present study, we investigated the long-term effect of angiotensin II type 1a receptor (AT1a) deficiency on hypercholesterolemia-induced atherosclerosis by the use of AT1a-knockout (AT1a-..
  17. Ito M, Oliverio M, Mannon P, Best C, Maeda N, Smithies O, et al. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A. 1995;92:3521-5 pubmed
    ..These studies demonstrate that type 1A angiotensin II receptor function is required for vascular and hemodynamic responses to angiotensin II and that altered ..
  18. Yoshida H, Kakuchi J, Guo D, Furuta H, Iwai N, van der Meer de Jong R, et al. Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human). Biochem Biophys Res Commun. 1992;186:1042-9 pubmed
    ..This conclusion was consistent with the results of genomic Southern blot analyses, which revealed that the mouse and rat possess 2 similar but separate genes, whereas the bovine and human have only a single class gene. ..
  19. Zhou N, Li L, Wu J, Gong H, Niu Y, Sun A, et al. Mechanical stress-evoked but angiotensin II-independent activation of angiotensin II type 1 receptor induces cardiac hypertrophy through calcineurin pathway. Biochem Biophys Res Commun. 2010;397:263-9 pubmed publisher
    ..These findings collectively suggest that mechanical stress-evoked but AngII-independent activation of AT(1) receptor induces cardiac hypertrophy through calcineurin pathway. ..
  20. Cassis L, Rateri D, Lu H, Daugherty A. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol. 2007;27:380-6 pubmed
    ..Male LDL receptor -/- mice, that were either AT1a receptor +/+ or -/-, were fed a fat enriched diet and infused with either saline or AngII...
  21. Henriques T, Zhang X, Yiannikouris F, Daugherty A, Cassis L. Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2008;28:1251-6 pubmed publisher
    ..Androgen promotes AT1aR mRNA abundance in abdominal aortas associated with increased Ang II-induced AAAs. ..
  22. Gurley S, Riquier Brison A, Schnermann J, Sparks M, Allen A, Haase V, et al. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011;13:469-475 pubmed publisher
    ..Thus, effectively targeting epithelial functions of the proximal tubule of the kidney should be a useful therapeutic strategy in hypertension. ..
  23. Yamamoto S, Yancey P, Zuo Y, Ma L, Kaseda R, Fogo A, et al. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Arterioscler Thromb Vasc Biol. 2011;31:2856-64 pubmed publisher
    ..macrophages are the most abundant cells in atherosclerotic plaques and express angiotensin II type 1 receptor (AT1), the pathophysiologic role of macrophage AT1 in atherogenesis remains uncertain...
  24. Yoshida T, Semprun Prieto L, Wainford R, Sukhanov S, Kapusta D, Delafontaine P. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology. 2012;153:1411-20 pubmed publisher
    ..These findings have major implications for understanding mechanisms of cachexia in chronic disease states such as congestive heart failure and end-stage renal disease, in which the renin-angiotensin system is activated. ..
  25. Abadir P, Foster D, Crow M, Cooke C, Rucker J, Jain A, et al. Identification and characterization of a functional mitochondrial angiotensin system. Proc Natl Acad Sci U S A. 2011;108:14849-54 pubmed publisher
  26. Sugaya T, Nishimatsu S, Tanimoto K, Takimoto E, Yamagishi T, Imamura K, et al. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem. 1995;270:18719-22 pubmed
    ..a key role in cardiovascular homeostasis, exerts its multiple effects through the different types of AT receptors, AT1a, AT1b, and AT2...
  27. Wassmann S, Czech T, van Eickels M, Fleming I, Bohm M, Nickenig G. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation. 2004;110:3062-7 pubmed
    ..Apolipoprotein E-deficient (ApoE-/-) mice were crossed with AT1A receptor-deficient (AT1-/-) mice to obtain homozygous double-knockout animals (ApoE-/--AT1-/- mice)...
  28. Poduri A, Owens A, Howatt D, Moorleghen J, Balakrishnan A, Cassis L, et al. Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS ONE. 2012;7:e48462 pubmed publisher
    ..This receptor is expressed as 2 structurally similar subtypes in rodents, termed AT1a and AT1b...
  29. Ichihara A, Suzuki F, Nakagawa T, Kaneshiro Y, Takemitsu T, Sakoda M, et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol. 2006;17:1950-61 pubmed
    ..It is not only AngII but also intraglomerular activation of MAPK by the receptor-associated prorenin that plays a pivotal role in diabetic nephropathy. ..
  30. Crowley S, Gurley S, Oliverio M, Pazmino A, Griffiths R, Flannery P, et al. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest. 2005;115:1092-9 pubmed
    ..Thus, the regulation of blood pressure by the RAS is mediated by AT(1) receptors both within and outside the kidney. ..
  31. Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 2012;487:477-81 pubmed publisher
    ..These results provide a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea. ..
  32. Yahata Y, Shirakata Y, Tokumaru S, Yang L, Dai X, Tohyama M, et al. A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation. J Biol Chem. 2006;281:13209-16 pubmed
  33. Oliverio M, Kim H, Ito M, Le T, Audoly L, Best C, et al. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A. 1998;95:15496-501 pubmed
    ..AT1 receptor, there are two AT1 receptor isoforms in rodents (AT1A and AT1B) that are products of separate genes (Agtr1a and Agtr1b)...
  34. Zhang X, Thatcher S, Rateri D, Bruemmer D, Charnigo R, Daugherty A, et al. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res. 2012;110:e73-85 pubmed publisher
    ..These data reveal an unrecognized role of transient sex hormone exposures during neonatal development as long-lasting mediators of regional aortic AT1aR expression and sexual dimorphism of AAAs. ..
  35. Lu H, Rateri D, Feldman D, Charnigo R, Fukamizu A, Ishida J, et al. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest. 2008;118:984-93 pubmed publisher
    ..Therefore, although previous work suggests that angiotensin peptides have conflicting effects on atherogenesis, we found that renin inhibition profoundly decreased lesion development in mice. ..
  36. Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, et al. Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. Br J Pharmacol. 2013;170:1384-95 pubmed publisher
    ..We induced cardiac hypertrophy in wild-type (WT) and angiotensin II type 1a receptor knockout (AT1aR-KO) mice by transverse aortic constriction (TAC)...
  37. Harada K, Komuro I, Shiojima I, Hayashi D, Kudoh S, Mizuno T, et al. Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation. 1998;97:1952-9 pubmed
    ..overload-induced cardiac hypertrophy, pressure overload was produced by constricting the abdominal aorta of AT1A knockout (KO) mice...
  38. Rateri D, Moorleghen J, Balakrishnan A, Owens A, Howatt D, Subramanian V, et al. Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res. 2011;108:574-81 pubmed publisher
    ..In contrast, endothelial-specific depletion attenuated this pathology. Ang II infusion promotes aneurysms in the ascending aorta via stimulation of AT(1a) receptors that are expressed on endothelial cells. ..
  39. Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, et al. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol. 2004;6:499-506 pubmed
    The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism...
  40. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, et al. (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system. Am J Pathol. 2008;173:1911-8 pubmed publisher
    ..Although we found significant involvement of angiotensin II type 1 receptor (AT1-R)-mediated inflammation in choroidal neovascularization (CNV), a central abnormality of vision-threatening age-..
  41. Tanaka Y, Tamura K, Koide Y, Sakai M, Tsurumi Y, Noda Y, et al. The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy. FEBS Lett. 2005;579:1579-86 pubmed
    ..These results indicate that ATRAP significantly promotes downregulation of the AT1R and further attenuates certain Ang II-mediated hypertrophic responses in cardiomyocytes. ..
  42. Daugherty A, Rateri D, Lu H, Inagami T, Cassis L. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation. 2004;110:3849-57 pubmed
    Hypercholesterolemia-induced atherosclerosis is attenuated by either pharmacological antagonism of AT1 receptors or AT1A receptor deficiency...
  43. Zhou Y, Chen Y, Dirksen W, Morris M, Periasamy M. AT1b receptor predominantly mediates contractions in major mouse blood vessels. Circ Res. 2003;93:1089-94 pubmed
    In rodents, angiotensin (Ang) II type-1 (AT1) receptors exist as two pharmacologically identical subtypes: AT1a and AT1b...
  44. Sasamura H, Hein L, Krieger J, Pratt R, Kobilka B, Dzau V. Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun. 1992;185:253-9 pubmed
    ..Because many of the structural differences were in the carboxy terminal putative intracellular domain, we speculate that these isoforms may differ in their regulation, signal transduction, or desensitization mechanisms. ..
  45. Burson J, Aguilera G, Gross K, Sigmund C. Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol. 1994;267:E260-7 pubmed
    At least two distinct genes (AT1A and AT1B) encode type 1 angiotensin II (AT1) receptors in rodents...
  46. Tanaka M, Tsuchida S, Imai T, Fujii N, Miyazaki H, Ichiki T, et al. Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout mice. Biochem Biophys Res Commun. 1999;258:194-8 pubmed
    ..Ang II was significantly greater in the AT2 gene-deleted mice than the control, which was completely abolished by AT1 antagonist losartan. The aortic content of AT1 receptor was significantly increased (P < 0...
  47. Crowley S, Gurley S, Herrera M, Ruiz P, Griffiths R, Kumar A, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006;103:17985-90 pubmed
    ..Based on the critical role of the renin-angiotensin system (RAS) and the type I (AT1) angiotensin receptor in essential hypertension, we developed an experimental model to separate AT1 receptor pools ..
  48. Stegbauer J, Lee D, Seubert S, Ellrichmann G, Manzel A, Kvakan H, et al. Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system. Proc Natl Acad Sci U S A. 2009;106:14942-7 pubmed publisher
    ..Our findings suggest a pivotal role of the RAS in autoimmune inflammation of the central nervous system and identify RAS blockade as a potential new target for multiple sclerosis therapy. ..
  49. Itoh S, Ding B, Shishido T, Lerner Marmarosh N, Wang N, Maekawa N, et al. Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation. 2006;113:1787-98 pubmed
  50. Brown N, Bradford J, Wang Z, Lea W, Ma L, Ma J, et al. Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency. Kidney Int. 2007;72:72-81 pubmed
    ..We conclude that Ang II stimulates PAI-1 expression in part through the AT(1b) receptor in the kidney and liver. Further, norepinephrine induces PAI-1 expression in vivo with AT(1a) receptor deficiency modulating the effect. ..
  51. Mededovic S, Fraser L. Angiotensin II stimulates cAMP production and protein tyrosine phosphorylation in mouse spermatozoa. Reproduction. 2004;127:601-12 pubmed
    ..The present study investigated the location of AII receptors on spermatozoa and AII's mechanism of action. AT1 type receptors for AII are present on the acrosomal cap region and along the whole of the flagellum of both mouse ..
  52. Keidar S, Kaplan M, Pavlotzky E, Coleman R, Hayek T, Hamoud S, et al. Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. Circulation. 2004;109:2213-20 pubmed
    ..Blocking of the mineralocorticoid receptor and inhibition of tissue ACE and/or the angiotensin receptor-1 reduced aldosterone deleterious pro-oxidative and proatherogenic effects. ..
  53. Zhou C, Ahmad S, Mi T, Abbasi S, Xia L, Day M, et al. Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension. 2008;51:1010-9 pubmed publisher
    ..These autoantibodies represent potentially important targets for diagnosis and therapeutic intervention. ..
  54. Hisada Y, Sugaya T, Yamanouchi M, Uchida H, Fujimura H, Sakurai H, et al. Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice. J Clin Invest. 1999;103:627-35 pubmed
    ..immune-mediated renal injury, we studied anti-glomerular basement membrane (GBM) nephritis in AII type 1a receptor (AT1a)-deficient homozygous (AT1a-/-) and wild-type (AT1a+/+) mice...
  55. Nakamura Y, Yoshiyama M, Omura T, Yoshida K, Kim S, Takeuchi K, et al. Transmitral inflow pattern assessed by Doppler echocardiography in angiotensin II type 1A receptor knockout mice with myocardial infarction. Circ J. 2002;66:192-6 pubmed
    ..Although angiotensin II type IA (AT1A) receptor knockout (KO) mice are reported to display less LV remodeling after MI, diastolic dysfunction has not ..
  56. Sakaue T, Suzuki J, Hamaguchi M, Suehiro C, Tanino A, Nagao T, et al. Perivascular Adipose Tissue Angiotensin II Type 1 Receptor Promotes Vascular Inflammation and Aneurysm Formation. Hypertension. 2017;70:780-789 pubmed publisher
    ..Our findings indicate a previously unrecognized effect of AT1a receptor in perivascular VAT on the pathogenesis of abdominal aortic aneurysm. ..
  57. Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, et al. Bone marrow AT1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1{alpha}. Arterioscler Thromb Vasc Biol. 2010;30:60-7 pubmed publisher
    ..injury was performed in the femoral artery of BM-chimeric mice whose BM was repopulated with AT(1)-deficient (BM-Agtr1(-/-)) or wild-type (BM-Agtr1(+/+)) cells. Neointima formation was profoundly reduced by 38% in BM-Agtr1(-/-) mice...
  58. Morris M, Means S, Oliverio M, Coffman T. Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1177-84 pubmed
    ..The results illustrate the importance of ANG AT(1a) receptors in the regulation of osmotic and endocrine balance...
  59. Tsuchida S, Miyazaki Y, Matsusaka T, Hunley T, Inagami T, Fogo A, et al. Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature. Kidney Int. 1999;56:509-16 pubmed
    Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening...
  60. Ryan M, Didion S, Mathur S, Faraci F, Sigmund C. Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension. 2004;43:1074-9 pubmed
    ..mediated by angiotensin type 1 receptors (AT1), of which there are 2 pharmacologically indistinguishable subtypes (AT1A and AT1B)...
  61. Amano H, Ito Y, Ogawa F, Eshima K, Suzuki T, Oba K, et al. Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. Am J Pathol. 2013;182:553-64 pubmed publisher
    ..B16F1 melanoma cells were intravenously injected into Agtr1a knockout mice (AT1a(-/-)) and wild-type littermates (WT); the AT1a(-/-) mice exhibited a reduction in lung ..
  62. Lin Z, Chen Y, Zhang W, Chen A, Lin S, Morris M. RNA interference shows interactions between mouse brainstem angiotensin AT1 receptors and angiotensin-converting enzyme 2. Exp Physiol. 2008;93:676-84 pubmed publisher
    ..0 x 10(9) c.f.u. ml(-1), 200 nl) carrying interference small hairpin RNA (shRNA) for either AngAT1a (Ad-AT1a-shRNA) or AngAT1b (Ad-AT1b-shRNA) were microinjected into the right side of the brainstem DVC...
  63. Alfarano C, Sartiani L, Nediani C, Mannucci E, Mugelli A, Cerbai E, et al. Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells). Br J Pharmacol. 2008;153:907-14 pubmed
    ..Angiotensin II is a candidate for increasing insulin resistance in cardiomyocytes. Our results suggest a further mechanism for the cardiovascular protection offered by the angiotensin II type 1 receptor blockers. ..
  64. Chang K, Nayak R, Roy S, Perumbeti A, Wellendorf A, Bezold K, et al. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nat Commun. 2015;6:5914 pubmed publisher
    ..Our data define for the first time the role of Ang-II HSC/P traffic regulation and redefine the haematopoietic consequences of anti-angiotensin therapy in SCD. ..
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    ..Enhanced NO generation may contribute to the reduced renal vascular tone and blood pressure observed with blockade of the renin-angiotensin system. ..
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    ..T cells might represent a novel therapeutic target for the treatment of high blood pressure. ..
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    ..We conclude that losartan inhibits LDL lipid peroxidation in the apo E deficient mice and this effect may have an important role in the attenuation of the accelerated atherosclerosis. ..
  68. Billet S, Bardin S, Verp S, Baudrie V, Michaud A, Conchon S, et al. Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice. J Clin Invest. 2007;117:1914-25 pubmed
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    ..In the basal state, plasma vasopressin levels are similar in wild-type controls and Agtr1a -/- mice...
  70. von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice. Regul Pept. 2001;99:209-16 pubmed
    ..Different high-affinity Ang II receptor subtypes (AT1A, AT1B and AT2) have been cloned. They are expressed in various brain structures...
  71. Morales M, Abrigo J, Meneses C, Simon F, Cisternas F, Rivera J, et al. The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-?1 induced by AngII in mouse skeletal muscle. Clin Sci (Lond). 2014;127:251-64 pubmed publisher
    ..In conclusion, our findings support the hypothesis that Ang-(1-7) decreases the expression and further biological activity of TGF-?1 induced by AngII in vitro and in vivo. ..
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    ..However, the magnitude of the increment of plantaris weight was not different between the two strains. Agtr1a mRNA expression did not change after OL in WT muscle...
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    ..Similarly, Agtr1a(-/-);Agtr1b(-/-) mouse kidneys had decreased angiopoietin-1, angiopoietin-2, and Tie-2 mRNAs at postnatal day 14...