Agt

Summary

Gene Symbol: Agt
Description: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Alias: AI265500, AngI, AngII, Aogen, Serpina8, angiotensinogen, angiotensin I, angiotensin ll, serpin A8
Species: mouse
Products:     Agt

Top Publications

  1. Hoch N, Guzik T, Chen W, Deans T, Maalouf S, Gratze P, et al. Regulation of T-cell function by endogenously produced angiotensin II. Am J Physiol Regul Integr Comp Physiol. 2009;296:R208-16 pubmed publisher
    ..We determined that T cells express angiotensinogen, the angiotensin I-converting enzyme, and renin and produce physiological levels of ANG II...
  2. Yoshida T, Semprun Prieto L, Wainford R, Sukhanov S, Kapusta D, Delafontaine P. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology. 2012;153:1411-20 pubmed publisher
    ..These findings have major implications for understanding mechanisms of cachexia in chronic disease states such as congestive heart failure and end-stage renal disease, in which the renin-angiotensin system is activated. ..
  3. Kim H, Krege J, Kluckman K, Hagaman J, Hodgin J, Best C, et al. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A. 1995;92:2735-9 pubmed
    Variants of the human angiotensinogen gene have been linked in some studies to increased circulating angiotensinogen levels and essential hypertension...
  4. Daubert D, Meadows G, Wang J, Sanchez P, Speth R. Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res. 1999;816:8-16 pubmed
    ..001). Ang II receptors were slightly, but not significantly increased in both young and old EtOH-consuming mice. ..
  5. van Esch J, Gembardt F, Sterner Kock A, Heringer Walther S, Le T, Lassner D, et al. Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. Cardiovasc Res. 2010;86:401-9 pubmed publisher
    ..Renal Ang II levels largely depend on AT(1) binding of extracellularly generated Ang II, and in the absence of all three Ang II receptors, renal Ang II is only located extracellularly. ..
  6. Shigemura N, Iwata S, Yasumatsu K, Ohkuri T, Horio N, Sanematsu K, et al. Angiotensin II modulates salty and sweet taste sensitivities. J Neurosci. 2013;33:6267-77 pubmed publisher
    ..Here, we show that Angiotensin II (AngII), a major mediator of body fluid and sodium homeostasis, modulates salty and sweet taste sensitivities, and that ..
  7. Tanimoto K, Sugiyama F, Goto Y, Ishida J, Takimoto E, Yagami K, et al. Angiotensinogen-deficient mice with hypotension. J Biol Chem. 1994;269:31334-7 pubmed
    ..II, through its physiologically inactive intermediate decapeptide angiotensin I, from their precursor angiotensinogen. In the present study, we generated angiotensinogen-deficient mice by homologous recombination in mouse ..
  8. Esteban V, Lorenzo O, Ruperez M, Suzuki Y, Mezzano S, Blanco J, et al. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. J Am Soc Nephrol. 2004;15:1514-29 pubmed
  9. Crowley S, Frey C, Gould S, Griffiths R, Ruiz P, Burchette J, et al. Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. Am J Physiol Renal Physiol. 2008;295:F515-24 pubmed publisher
    ..These proinflammatory actions of ANG II seem to have a proclivity for inducing kidney injury while having negligible actions in the pathogenesis of cardiac hypertrophy. ..

More Information

Publications107 found, 100 shown here

  1. Lundequist A, Tchougounova E, Abrink M, Pejler G. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. J Biol Chem. 2004;279:32339-44 pubmed
    ..Taken together, the results of this study indicate that mast cell chymase and CPA have key roles in both the generation and degradation of Ang II. ..
  2. Yang G, Gray T, Sigmund C, Cassell M. The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Res. 1999;817:123-31 pubmed
    Two transgenic mouse models were used to examine the cellular localization of angiotensinogen (AGT) in the brain...
  3. Hefler L, Tempfer C, Moreno R, O Brien W, Gregg A. Endothelial-derived nitric oxide and angiotensinogen: blood pressure and metabolism during mouse pregnancy. Am J Physiol Regul Integr Comp Physiol. 2001;280:R174-82 pubmed
    ..These included mice with a null mutation in the endothelial NOS (eNOS) gene (Nos3(-/-)), four copies of the angiotensinogen gene (Agt(2/2)), and mutations in both genes [four copies of Agt and heterozygous deficient for eNOS (Agt(2/2)..
  4. Itoh S, Ding B, Shishido T, Lerner Marmarosh N, Wang N, Maekawa N, et al. Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation. 2006;113:1787-98 pubmed
    ..mRNA induction of PRECE was confirmed with serial angiotensinogen protein reduction after perfusion in WT-p90RSK-Tg mice, suggesting an increase of angiotensinogen cleavage ..
  5. Qin Z, Gongora M, Ozumi K, Itoh S, Akram K, Ushio Fukai M, et al. Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function. Hypertension. 2008;52:945-51 pubmed publisher
  6. Meng Y, Chen C, Tian C, Du J, Li H. Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-? ligand 15d-PGJ? in macrophages. Cell Physiol Biochem. 2015;35:689-98 pubmed publisher
    ..Activation of PPAR-? by 15d-PGJ2 suppresses Egr-1-mediated proinflammatory response, and may be a novel therapeutic strategy for treatment of vascular inflammatory diseases. ..
  7. Catanzaro D, Chen R, Yan Y, Hu L, Sealey J, Laragh J. Appropriate regulation of renin and blood pressure in 45-kb human renin/human angiotensinogen transgenic mice. Hypertension. 1999;33:318-22 pubmed
    ..In most species, renin is rate limiting, and angiotensinogen circulates at a concentration close to the Km, so varying the concentration of either can affect the rate of ..
  8. Li X, Molina Molina M, Abdul Hafez A, Uhal V, Xaubet A, Uhal B. Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008;295:L178-85 pubmed publisher
  9. Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, et al. Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014;124:448-60 pubmed publisher
    ..Together, these data suggest that increased TGF-? signaling contributes to postnatal aneurysm progression in LDS. ..
  10. Gusev K, Domenighetti A, Delbridge L, Pedrazzini T, Niggli E, Egger M. Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling. Circ Res. 2009;105:42-50 pubmed publisher
    ..cardiac myocytes isolated from transgenic (TG1306/1R [TG]) mice exhibiting cardiac specific overexpression of angiotensinogen, which develop Ang II-mediated cardiac hypertrophy in the absence of hemodynamic overload...
  11. Zack M, Boyanovsky B, Shridas P, Bailey W, Forrest K, Howatt D, et al. Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis. 2011;214:58-64 pubmed publisher
    ..GX sPLA(2) promotes Ang II-induced pathological responses leading to AAA formation. ..
  12. Bernardi S, Burns W, Toffoli B, Pickering R, Sakoda M, Tsorotes D, et al. Angiotensin-converting enzyme 2 regulates renal atrial natriuretic peptide through angiotensin-(1-7). Clin Sci (Lond). 2012;123:29-37 pubmed publisher
    ..We also exposed renal tubular cells to AngII and Ang-(1-7) in the presence and absence of inhibitors and agonists of RAS (renin-angiotensin system) signalling...
  13. Matsusaka T, Niimura F, Pastan I, Shintani A, Nishiyama A, Ichikawa I. Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation. Kidney Int. 2014;85:1068-77 pubmed publisher
    ..For this, kidney- or liver-specific angiotensinogen gene (Agt) knockout was superimposed on the mouse model of inducible podocyte injury (NEP25)...
  14. Díaz Ruiz C, Rodriguez Perez A, Beiroa D, Rodriguez Pallares J, Labandeira Garcia J. Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration. Oncotarget. 2015;6:26675-89 pubmed publisher
    ..The present findings show that SIRT1 and the axis AII/AT1/NADPH-oxidase regulate each other. This is impaired in aged animals and may be mitigated with sirtuin-activating compounds. ..
  15. Kakinuma Y, Hama H, Sugiyama F, Goto K, Murakami K, Fukamizu A. Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett. 1997;232:167-70 pubmed
    The morphological analysis in a congenic line of angiotensinogen knock-out mice (AgKO) revealed the decreased density in granular layer cells of hippocampus and cerebellum, suggesting neuronal cells of AgKO susceptible to apoptotic cell ..
  16. Ohuchi J, Arai T, Kon Y, Asano A, Yamauchi H, Watanabe T. Characterization of a novel gene, sperm-tail-associated protein (Stap), in mouse post-meiotic testicular germ cells. Mol Reprod Dev. 2001;59:350-8 pubmed
    ..We are proposing the name, sperm-tail-associated protein (Stap), for the gene encoding F77 cDNA. Mol. Reprod. Dev. 59: 350-358, 2001. ..
  17. Iosipiv I, Schroeder M. A role for angiotensin II AT1 receptors in ureteric bud cell branching. Am J Physiol Renal Physiol. 2003;285:F199-207 pubmed
    ..Using immunohistochemistry, we demonstrated that UB-derived epithelia express angiotensinogen (Ao) and the AT1 receptor during murine metanephrogenesis...
  18. Takimoto Ohnishi E, Saito T, Ishida J, Ohnishi J, Sugiyama F, Yagami K, et al. Differential roles of renin and angiotensinogen in the feto-maternal interface in the development of complications of pregnancy. Mol Endocrinol. 2005;19:1361-72 pubmed
    ..hypertension (PAH) and intrauterine growth restriction (IUGR) by mating females expressing human angiotensinogen (hANG) with males expressing human renin (hRN)...
  19. Campbell D, Xiao H, Fuchs S, Bernstein K. Genetic models provide unique insight into angiotensin and bradykinin peptides in the extravascular compartment of the heart in vivo. Clin Exp Pharmacol Physiol. 2009;36:547-53 pubmed publisher
    ..3. Cardiac AngII levels of 8/8, 1/8, WT/8 and WT mice were higher than KO levels...
  20. Ulmasov B, Xu Z, Talkad V, Oshima K, Neuschwander Tetri B. Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse. Am J Physiol Gastrointest Liver Physiol. 2010;299:G70-80 pubmed publisher
    ..Our results demonstrate that AT1a and AT1b receptor pathways do not seem to be essential for the development of pancreatitis in the mouse model of pancreatitis induced by repetitive cerulein injury. ..
  21. Pagni E, Baragatti B, Scebba F, Coceani F. Functional closure of the ductus arteriosus at birth: evidence against an intermediary role of angiotensin II. Pharmacology. 2014;93:120-5 pubmed publisher
    ..Coincidentally, olmesartan promoted the Agtr2 transcript. We conclude that AT1R-based Ang II has no role in the functional closure of DA. Conversely, the compound may modulate this process through AT2R-mediated vasodilatation. ..
  22. Chang S, Lo C, Zhao X, Liao M, Chenier I, Bouley R, et al. Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2-HO-1 pathway in renal proximal tubular cells of transgenic mice. J Renin Angiotensin Aldosterone Syst. 2016;17: pubmed publisher
    We aimed to examine the regulation of aquaporin 1 expression in an angiotensinogen transgenic mouse model, focusing on underlying mechanisms...
  23. Nakajima T, Cheng T, Rohrwasser A, Bloem L, Pratt J, Inoue I, et al. Functional analysis of a mutation occurring between the two in-frame AUG codons of human angiotensinogen. J Biol Chem. 1999;274:35749-55 pubmed
    b>Angiotensinogen (ANG) is the specific substrate of the renin-angiotensin system, a major participant in blood pressure control...
  24. Weiss D, Taylor W. Deoxycorticosterone acetate salt hypertension in apolipoprotein E-/- mice results in accelerated atherosclerosis: the role of angiotensin II. Hypertension. 2008;51:218-24 pubmed
  25. Moran C, Cullen B, Campbell J, Golledge J. Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysm. J Vasc Res. 2009;46:209-17 pubmed publisher
    Osteoprotegerin (OPG) has been associated with abdominal aortic aneurysm (AAA) expansion. Angiotensin II (AngII) receptor blockade has been shown to reduce OPG expression in human AAA tissue...
  26. Cardoso C, Cabrini D, May M, Bhagat C, Eleno N, Cayla C, et al. Functional expression of angiotensinogen depends on splicing enhancers in exon 2. Mol Cell Endocrinol. 2011;332:228-33 pubmed publisher
    b>Angiotensinogen belongs to the family of serpins and is the only precursor of the potent cardiovascular peptide, angiotensin II, the main effector of the renin-angiotensin system...
  27. Cook J, Carta L, Benard L, Chemaly E, Chiu E, Rao S, et al. Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest. 2014;124:1329-39 pubmed publisher
    ..AT1R or ?-arrestin 2, but not in MFS mice treated with an angiotensin-converting enzyme inhibitor or lacking angiotensinogen. Conversely, DCM associated with abnormal AT1R and FAK signaling was the sole abnormality in mice that were ..
  28. Ni J, Shen Y, Wang Z, Shao D, Liu J, Fu L, et al. Inhibition of STAT3 acetylation is associated with angiotesin renal fibrosis in the obstructed kidney. Acta Pharmacol Sin. 2014;35:1045-54 pubmed publisher
    ..STAT3 acetylation plays an important role in activation of STAT3 signaling pathway and consequent renal fibrosis...
  29. Ren X, Tong Y, Ling L, Chen D, Sun H, Zhou H, et al. NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling. Cell Physiol Biochem. 2017;44:2269-2280 pubmed publisher
    ..NLRP3 inflammasome activation contributes to Ang II-induced VSMC phenotypic transformation and proliferation as well as vascular remodeling and hypertension. ..
  30. Clouston W, Fournier R, Richards R. The angiotensinogen gene is located on mouse chromosome 8. FEBS Lett. 1989;255:419-22 pubmed
    We have recently identified a cis-acting genetic lesion affecting angiotensinogen gene expression in testis and salivary gland...
  31. Miyazaki Y, Tsuchida S, Nishimura H, Pope J, Harris R, McKanna J, et al. Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest. 1998;102:1489-97 pubmed
    ..These results reveal a new role for angiotensin in the unique cellular adaptations of the mammalian kidney to the physiological stresses of postnatal life. ..
  32. Gembardt F, Heringer Walther S, van Esch J, Sterner Kock A, van Veghel R, Le T, et al. Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors. FASEB J. 2008;22:3068-77 pubmed publisher
  33. Cousin M, Custaud M, Baron Menguy C, Toutain B, Dumont O, Guihot A, et al. Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries. Hypertension. 2010;55:109-15 pubmed publisher
    ..Thus, a chronic rise in blood flow in resistance arteries induces a diameter enlargement involving NO and superoxide, whereas hypertrophy was associated with extracellular signal-regulated kinase 1/2 activation by angiotensin II. ..
  34. Mercure C, Lacombe M, Khazaie K, Reudelhuber T. Cathepsin B is not the processing enzyme for mouse prorenin. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1212-6 pubmed publisher
    ..In conclusion, CTSB-deficient mice exhibit no differences compared with controls in their ability to generate active renin, and our results do not support CTSB as the PPE in mice. ..
  35. Guo F, Chen X, Wang F. [Role of angiotensin II-angiotensin II type 1 receptor pathway in the production of proinflammatory cytokines in macrophage]. Zhonghua Shao Shang Za Zhi. 2011;27:88-91 pubmed
    To investigate the role of angiotensin II (AngII)-angiotensin II type 1 receptor (AT1R) pathway in the production of proinflammatory cytokines in macrophage, and to analyze its mechanisms. RAW264...
  36. van Bilsen M, Daniels A, Brouwers O, Janssen B, Derks W, Brouns A, et al. Hypertension is a conditional factor for the development of cardiac hypertrophy in type 2 diabetic mice. PLoS ONE. 2014;9:e85078 pubmed publisher
    ..Thereto, 14-wks-old male db/db mice and non-diabetic db/+ mice received vehicle or angiotensin II (AngII) for 4 wks to induce mild hypertension (n?=?9-10 per group)...
  37. Nemoto W, Ogata Y, Nakagawasai O, Yaoita F, Tadano T, Tan No K. Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice. Neuropharmacology. 2015;99:221-31 pubmed publisher
  38. Gaddam R, Ang A, Badiei A, Chambers S, Bhatia M. Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology. 2015;15:647-53 pubmed publisher
    ..These data suggest dysregulation of RAS in acute pancreatitis as evidenced by altered Ang II/Ang-(1-7) levels induced by the imbalance of ACE/ACE2 activity. ..
  39. Niimura F, Labosky P, Kakuchi J, Okubo S, Yoshida H, Oikawa T, et al. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest. 1995;96:2947-54 pubmed
    ..We have produced by gene targeting mice homozygous for a null mutation in the angiotensinogen gene (Atg-1-). Postnatally, Atg-1- animals show a modest delay in glomerular maturation...
  40. van Kats J, Methot D, Paradis P, Silversides D, Reudelhuber T. Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice. Direct and indirect effects of angiotensin II on the heart. J Biol Chem. 2001;276:44012-7 pubmed
    ..Our findings are the first to distinguish between local and systemic effects of angiotensin II on the heart and introduce a novel technique for studying tissue-specific peptide function. ..
  41. Oudit G, Crackower M, Backx P, Penninger J. The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med. 2003;13:93-101 pubmed
  42. Stacy L, Yu Q, Horak K, Larson D. Effect of angiotensin II on primary cardiac fibroblast matrix metalloproteinase activities. Perfusion. 2007;22:51-5 pubmed
    ..Thus, Ang II and AT1-R and AT2-R differentially affect the collagenase and gelatinase MMPs activities released by cardiac fibroblasts. ..
  43. Jia Z, Guo X, Zhang H, Wang M, Dong Z, Yang T. Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress. Hypertension. 2008;52:952-9 pubmed publisher
    ..These results suggest that mPGES-1-derived PGE(2) buffers Ang II-induced vasoconstriction via inhibition of NADPH oxidase-dependent reactive oxygen species production. ..
  44. Yiannikouris F, Karounos M, Charnigo R, English V, Rateri D, Daugherty A, et al. Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol. 2012;302:R244-51 pubmed publisher
    Previous studies demonstrated that overexpression of angiotensinogen (AGT) in adipose tissue increased blood pressure...
  45. Gao N, Wang H, Yin H, Yang Z. Angiotensin II induces calcium-mediated autophagy in podocytes through enhancing reactive oxygen species levels. Chem Biol Interact. 2017;277:110-118 pubmed publisher
    ..Improving TRPC6 channels and autophagy may become a new targeted therapy to relieve glomerular damage induced by Ang II. ..
  46. Schrader L, Kinzenbaw D, Johnson A, Faraci F, Didion S. IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy. Arterioscler Thromb Vasc Biol. 2007;27:2576-81 pubmed
    ..These data demonstrate that IL-6 is essential for Ang II-induced increases in superoxide, endothelial dysfunction, and vascular hypertrophy. ..
  47. Zheng J, Li G, Chen S, Bihl J, Buck J, Zhu Y, et al. Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction. Neuroscience. 2014;273:39-51 pubmed publisher
    We previously demonstrated that mice which overexpress human renin and angiotensinogen (R+A+) show enhanced cerebral damage in both in vivo and in vitro experimental ischemia models...
  48. Umemura S, Kihara M, Sumida Y, Yabana M, Ishigami T, Tamura K, et al. Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading. J Hypertens. 1998;16:285-9 pubmed
    Physiological roles of the renin-angiotensin system in maintaining blood pressure and sodium-water balance in angiotensinogen gene-knockout mice were evaluated with special reference to endogenous pressor substances...
  49. Rahmouni K, Mark A, Haynes W, Sigmund C. Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. Am J Physiol Endocrinol Metab. 2004;286:E891-5 pubmed
    Adipose tissue represents an important source of angiotensinogen (AGT)...
  50. Pellieux C, Aasum E, Larsen T, Montessuit C, Papageorgiou I, Pedrazzini T, et al. Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway. J Mol Cell Cardiol. 2006;41:459-66 pubmed
    ..II stimulation on the fatty acid oxidation pathway in transgenic (TG) mice with targeted overexpression of angiotensinogen in the myocardium (TG1306/1R mice). TG1306/R1 mice progressively developed left ventricular hypertrophy...
  51. Arise K, Pandey K. Inhibition and down-regulation of gene transcription and guanylyl cyclase activity of NPRA by angiotensin II involving protein kinase C. Biochem Biophys Res Commun. 2006;349:131-5 pubmed
    ..This is the first report to demonstrate that ANG II-dependent transcriptional repression of Npr1 gene promoter activity and down-regulation of GC activity of translated protein, NPRA is regulated by PKC pathways. ..
  52. Nomura M, Nishii H, Ozaki Y, Fujimoto N, Matsumoto T. An angiotensin II receptor blocker increases sexual behavior in type 2 diabetic mice. Physiol Behav. 2007;91:223-8 pubmed
  53. Qiao L, Gu Q, Dai Y, Shen Z, Liu X, Qi R, et al. XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells. Tumour Biol. 2008;29:122-9 pubmed publisher
    ..Our data suggest that XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect. ..
  54. Lagerqvist E, Finnin B, Pouton C, Haynes J. Endothelin-1 and angiotensin II modulate rate and contraction amplitude in a subpopulation of mouse embryonic stem cell-derived cardiomyocyte-containing bodies. Stem Cell Res. 2011;6:23-33 pubmed publisher
    ..These results indicate the presence of functional ET(A) and both AT? and AT? receptors in murine ESC-CMs, but their expression and or activity appears to be evident only in a limited set of BBs. ..
  55. Wang J, Chen W, Wang Y, Zhang S, Bi H, Hong B, et al. Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis. 2011;217:90-6 pubmed publisher
    ..We hypothesized that statins (rosuvastatin and atorvastatin) would attenuate angiotensin II (AngII)-induced atherosclerosis and AAA...
  56. Park S, Liu X, Davis D, Sigmund C. Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression. Hypertension. 2012;59:1212-9 pubmed publisher
    A single-nucleotide polymorphism (C/A) located within an E-box at the -20 position of the human angiotensinogen (AGT) promoter may regulate transcriptional activation through differential recruitment of the transcription factors upstream ..
  57. Mima A, Hiraoka Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, et al. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKC? activation in diabetes. Diabetes. 2012;61:2967-79 pubmed publisher
  58. Dang M, Zhao X, Lai S, Wang X, Wang L, Zhang Y, et al. Gene expression profile in the early stage of angiotensin II-induced cardiac remodeling: a time series microarray study in a mouse model. Cell Physiol Biochem. 2015;35:467-76 pubmed publisher
    ..Our results indicate that many genes are mainly involved in metabolism, inflammation, cardiac fibrosis and hypertrophy. Serpine1 may play a central role in the development of Ang II-induced cardiac remodeling at the early stage. ..
  59. Clouston W. The angiotensinogen gene of Swiss mice is closely linked to a retrovirus-like element. DNA Cell Biol. 1990;9:623-30 pubmed
    b>Angiotensinogen is cleaved by renin and angiotensin-converting enzyme to liberate the potent vasocontrictor peptide angiotensin II...
  60. Wollert K, Drexler H. The renin-angiotensin system and experimental heart failure. Cardiovasc Res. 1999;43:838-49 pubmed
    ..In this paper, we review recent experimental evidence suggesting a critical role for the RAS in cardiac hypertrophy and failure with special emphasis on the putative role of Ang II and Ang II-receptor signaling in cardiac myocytes. ..
  61. Cuffe J, Walton S, Steane S, Singh R, Simmons D, Moritz K. The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014;35:953-61 pubmed publisher
    ..Placentas were collected from male and female CD1 mouse fetuses at seven gestational ages for qPCR analysis of Agt, Ren1, Atp6ap2, Ace, Ace2, Agtr1a, Agtr2 and Mas1...
  62. Jiang T, Zhang Y, Zhou J, Zhu X, Tian Y, Zhao H, et al. Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer's Disease. Mol Neurobiol. 2016;53:2489-97 pubmed publisher
    ..All these findings suggested that Ang-(1-7), the main effector of brain ACE2/Ang-(1-7)/Mas axis, might be implicated in the etiology and progression of AD, possibly via modulation of tau hyperphosphorylation. ..
  63. Inaba S, Iwai M, Furuno M, Tomono Y, Kanno H, Senba I, et al. Continuous activation of renin-angiotensin system impairs cognitive function in renin/angiotensinogen transgenic mice. Hypertension. 2009;53:356-62 pubmed publisher
    ..of the human brain renin-angiotensin system causes cognitive impairment, using human renin (hRN) and human angiotensinogen (hANG) gene chimeric transgenic (Tg) mice...
  64. Akishita M, Yamada H, Dzau V, Horiuchi M. Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun. 1999;261:345-9 pubmed
    ..These data suggest that the AT2 receptor modulates vascular contractility, which may influence blood pressure. ..
  65. Kim S, Urs S, Massiera F, Wortmann P, Joshi R, Heo Y, et al. Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression. Horm Metab Res. 2002;34:721-5 pubmed
    To address the role of angiotensinogen (agt) in lipid metabolism and its potential endocrine effects in vivo, we studied the effects of high-fat diet (HFD) on adult, 28-week-old agt knockout (KO) mice compared to wild type (WT) mice...
  66. Davisson R. Physiological genomic analysis of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2003;285:R498-511 pubmed
    ..It also summarizes the principles, progress, and prospects for a better understanding of the brain RAS in health and disease. ..
  67. Walther T, Steendijk P, Westermann D, Hohmann C, Schulze K, Heringer Walther S, et al. Angiotensin deficiency in mice leads to dilated cardiomyopathy. Eur J Pharmacol. 2004;493:161-5 pubmed
    To explore the role of angiotensin II, we assessed hemodynamics and cardiac function in angiotensinogen-deficient mice in comparison to wild-type animals...
  68. Sherrod M, Davis D, Zhou X, Cassell M, Sigmund C. Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1763-9 pubmed
    b>Angiotensinogen (AGT) is mainly expressed in glial cells in close proximity to renin-expressing neurons in the brain. We previously reported that glial-specific overexpression of ANG II results in mild hypertension...
  69. Tanifuji C, Suzuki Y, Geot W, Horikoshi S, Sugaya T, Ruiz Ortega M, et al. Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells. Antioxid Redox Signal. 2005;7:1261-8 pubmed
    Angiotensin II (AngII) has pleiotropic effects, the most well known of which is the generation of reactive oxygen species (ROS) and chemokines in inflammatory lesions...
  70. Moon J, Tanimoto M, Gohda T, Hagiwara S, Yamazaki T, Ohara I, et al. Attenuating effect of angiotensin-(1-7) on angiotensin II-mediated NAD(P)H oxidase activation in type 2 diabetic nephropathy of KK-A(y)/Ta mice. Am J Physiol Renal Physiol. 2011;300:F1271-82 pubmed publisher
    ..The ACE2-ANG-(1-7)-Mas receptor axis should be investigated as a novel target for treatment of type 2 diabetic nephropathy. ..
  71. Konvalinka A, Zhou J, Dimitromanolakis A, Drabovich A, Fang F, Gurley S, et al. Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC). J Biol Chem. 2013;288:24834-47 pubmed publisher
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    ..of a selected Ang (1-7) antagonist (A779) to show the effect of ACE2 overexpression on MCP-1 level induced by AngII. AngII-induced MCP-1 expression increased obviously at 24 h and at the concentration of 10(-6) M...
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    NADPH oxidase-generated reactive oxygen species (ROS) are highly implicated in the development of angiotensin II (AngII)-dependent hypertension mediated in part through the hypothalamic paraventricular nucleus (PVN)...
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