Gene Symbol: Agpat3
Description: 1-acylglycerol-3-phosphate O-acyltransferase 3
Alias: AW061257, AW493985, D10Jhu12e, lpaat3, 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma, 1-AGP acyltransferase 3, 1-AGPAT 3, LPAAT-gamma, lysophosphatidic acid acyltransferase 3, lysophosphatidic acid acyltransferase gamma
Lu B, Jiang Y, Zhou Y, Xu F, Hatch G, Choy P. Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. Biochem J. 2005;385:469-77 pubmed
..3-phosphate acyltransferase) exists in at least five isoforms in humans, termed as AGPAT1, AGPAT2, AGPAT3, AGPAT4 and AGPAT5...
Lu B, Jiang Y, Man M, Brown B, Elias P, Feingold K. Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis. J Lipid Res. 2005;46:2448-57 pubmed
..Because upregulation of mAGPAT mRNAs after tape-stripping could be partially reversed by artificial barrier restoration by occlusion, these studies suggest that an increase in the expression of AGPATs is linked to barrier requirements. ..
Cao J, Li J, Li D, Tobin J, Gimeno R. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. Proc Natl Acad Sci U S A. 2006;103:19695-700 pubmed
..These findings identify GPAT3 as a previously uncharacterized triacylglycerol biosynthetic enzyme. Similar to other lipogenic enzymes, GPAT3 may be useful as a target for the treatment of obesity. ..
Yuki K, Shindou H, Hishikawa D, Shimizu T. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. J Lipid Res. 2009;50:860-9 pubmed publisher
..Here, we demonstrated that mouse LPAAT3, previously known as mouse AGPAT3, possesses strong LPAAT activity and modest lysophosphatidylinositol acyltransferase activity with a clear ..
Koeberle A, Shindou H, Harayama T, Yuki K, Shimizu T. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2012;26:169-80 pubmed publisher
..correlated with an induced lysophosphatidic acid acyltransferase (LPAAT)3 mRNA expression, increased microsomal LPAAT3 activity, and shift of LPAAT specificity to PUFA-coenzyme A...
Iizuka Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, et al
. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J Biol Chem. 2017;292:12065-12076 pubmed publisher
..We found that lysophosphatidic acid acyltransferase 3 (LPAAT3) is required for producing DHA-containing phospholipids in various tissues, such as the ..
Shindou H, Koso H, Sasaki J, Nakanishi H, Sagara H, Nakagawa K, et al
. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J Biol Chem. 2017;292:12054-12064 pubmed publisher
..We previously identified lysophosphatidic acid acyltransferase 3 (LPAAT3) as a PL-DHA biosynthetic enzyme...