Agap2

Summary

Gene Symbol: Agap2
Description: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Alias: AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167, arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, centaurin, gamma 1, phosphatidylinositol 3-kinase enhancer
Species: mouse
Products:     Agap2

Top Publications

  1. Tang X, Feng Y, Ye K. Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Cell Death Differ. 2007;14:368-77 pubmed
    Phosphatidylinositol 3-kinase enhancer-activating Akt (PIKE-A) binds Akt and upregulates its kinase activity, preventing apoptosis...
  2. Tang X, Jang S, Okada M, Chan C, Feng Y, Liu Y, et al. Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nat Cell Biol. 2008;10:698-706 pubmed publisher
    ..Here we show that netrin-1 induces interaction of UNC5B with the brain-specific GTPase PIKE-L...
  3. Ye K, Hurt K, Wu F, Fang M, Luo H, Hong J, et al. Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell. 2000;103:919-30 pubmed
    ..A novel protein, PIKE (PI3Kinase Enhancer), interacts with nuclear PI3K to stimulate its lipid kinase activity...
  4. Chan C, Liu X, Jung D, Jun J, Luo H, Kim J, et al. Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes. 2010;59:883-93 pubmed publisher
    Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are unknown...
  5. Chan C, Liu X, Ensslin M, Dillehay D, Ormandy C, Sohn P, et al. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J. 2010;29:956-68 pubmed publisher
    PI 3-kinase enhancer A (PIKE-A) is critical for the activation of Akt signalling, and has an essential function in promoting cancer cell survival. However, its physiological functions are poorly understood...
  6. He K, Jang S, Joshi J, Yoo M, Ye K. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. Mol Biol Cell. 2011;22:1943-54 pubmed publisher
    ..UNC5B is a direct transcriptional target of p53 upon UV stimulation. Here we show that Akt phosphorylates PIKE-A and regulates its association with UNC5B and inhibits UNC5B-provoked apoptosis in a p53-dependent manner...
  7. Chan C, Liu X, He K, Qi Q, Jung D, Kim J, et al. The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep. 2011;12:847-54 pubmed publisher
    ..Here, we show that phosphoinositide 3-kinase enhancer A (PIKE-A) is a new insulin-dependent enhancer of hepatic IRTK...
  8. Chan C, Liu X, Zhao L, Liu G, Lee C, Feng Y, et al. PIKE is essential for oligodendroglia development and CNS myelination. Proc Natl Acad Sci U S A. 2014;111:1993-8 pubmed publisher
    ..Here, we report that phosphoinositide-3 kinase enhancer L (PIKE-L) is required for OL development and myelination...
  9. Gross C, Chang C, Kelly S, Bhattacharya A, McBride S, Danielson S, et al. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell Rep. 2015;11:727-36 pubmed publisher
    The PI3K enhancer PIKE links PI3K catalytic subunits to group 1 metabotropic glutamate receptors (mGlu1/5) and activates PI3K signaling. The roles of PIKE in synaptic plasticity and the etiology of mental disorders are unknown...

More Information

Publications16

  1. Tse M, Herlea Pana O, Brobst D, Yang X, Wood J, Hu X, et al. Tumor Necrosis Factor-? Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle. Diabetes. 2017;66:1858-1870 pubmed publisher
    ..We report in this study that phosphoinositide 3-kinase enhancer A (PIKE-A) is a novel effector of TNF-? to facilitate its metabolic modulation in the skeletal muscle...
  2. Liu Z, Jang S, Liu X, Cheng D, Peng J, Yepes M, et al. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol Cell. 2008;29:665-78 pubmed publisher
    ..under acidic condition, cuts SET, an inhibitor of DNase, and triggers DNA damage in brain, which is inhibited by PIKE-L. SET, a substrate of caspases, was cleaved by acidic cytosolic extract independent of caspase activation...
  3. Chan C, Liu X, Pradoldej S, Hao C, An J, Yepes M, et al. Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. J Neurosci. 2011;31:8083-92 pubmed publisher
    Phosphoinositide 3-kinase enhancer (PIKE) binds and enhances phosphatidylinositol 3-kinase (PI3K)/Akt activities. However, its physiological functions in brain have never been explored...
  4. Chan C, Chen Y, Liu X, Tang X, Lee C, Mei L, et al. PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression. EMBO J. 2011;30:4274-86 pubmed publisher
    ..Here, we show that PIKE (phosphoinositide 3-kinase enhancer) GTPases regulate neuronal AMPAR activity by promoting GluA2/GRIP1 association...
  5. Chan C, Chen Y, Liu X, Papale L, Escayg A, Mei L, et al. Essential role of PIKE GTPases in neuronal protection against excitotoxic insults. Adv Biol Regul. 2012;52:66-76 pubmed
  6. Tse M, Liu X, Yang S, Ye K, Chan C. Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction. Mol Cell Biol. 2013;33:1797-808 pubmed publisher
    ..transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A)...
  7. Kang S, Zhang Z, Liu X, Manfredsson F, He L, Iuvone P, et al. ?-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. Proc Natl Acad Sci U S A. 2017;114:1183-1188 pubmed publisher
    ..Here we show that ?-synuclein binds phosphoinositide-3 kinase enhancer L (PIKE-L) in a phosphorylation-dependent manner and sequesters it in Lewy bodies, leading to dopaminergic cell death via ..