Adrb2

Summary

Gene Symbol: Adrb2
Description: adrenergic receptor, beta 2
Alias: Adrb-2, Badm, Gpcr7, beta 2-AR, beta-2 adrenergic receptor, beta-2 adrenoceptor, beta-2 adrenoreceptor
Species: mouse

Top Publications

  1. ncbi Response to cardiac sympathetic activation in transgenic mice overexpressing beta 2-adrenergic receptor
    X J Du
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Am J Physiol 271:H630-6. 1996
  2. pmc Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes
    Christopher J Hupfeld
    Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla 92093, USA
    Proc Natl Acad Sci U S A 100:161-6. 2003
  3. ncbi Down-regulation of beta2-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulation
    Choh Ei Itoh
    Department of Molecular Predictive Medicine and Sport Science, School of Medicine, Kyorin University, Mitaka, Tokyo 181 8611, Japan
    Biochem Biophys Res Commun 322:979-84. 2004
  4. pmc Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension
    Lin Chang
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48105, USA
    Circulation 119:2161-9. 2009
  5. pmc Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes
    Ruijie Liu
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 284:32279-87. 2009
  6. pmc Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects
    D K Rohrer
    Department of Pediatrics, Stanford University, CA 94305, USA
    Proc Natl Acad Sci U S A 93:7375-80. 1996
  7. ncbi Targeted disruption of the beta2 adrenergic receptor gene
    A J Chruscinski
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 274:16694-700. 1999
  8. pmc Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes
    Vania De Arcangelis
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 284:33824-32. 2009
  9. pmc Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4
    Wito Richter
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    EMBO J 27:384-93. 2008
  10. ncbi Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes
    Yongyu Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61822, USA
    J Biol Chem 283:1799-807. 2008

Research Grants

  1. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary Bouxsein; Fiscal Year: 2007
  2. Training Program in Integrative Immunobiology
    Virginia Sanders; Fiscal Year: 2007
  3. Stress response and HPA regulation in cocaine addiction
    JOHN MANTSCH; Fiscal Year: 2006
  4. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2007
  5. CORE--Skeletal Phenotyping Core
    Mary Bouxsein; Fiscal Year: 2007
  6. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2009
  7. GCs, CRF and Stressor-Induced Relapse
    John R Mantsch; Fiscal Year: 2010
  8. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2010
  9. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2007
  10. When Belief Becomes False Memory: A Processing Account
    Daniel Bernstein; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications107 found, 100 shown here

  1. ncbi Response to cardiac sympathetic activation in transgenic mice overexpressing beta 2-adrenergic receptor
    X J Du
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Am J Physiol 271:H630-6. 1996
    ..Thus overexpression of cardiac beta 2-receptors modifies beta-adrenergic activity, but the responses to endogenous and exogenous adrenergic stimulation are affected differently...
  2. pmc Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes
    Christopher J Hupfeld
    Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla 92093, USA
    Proc Natl Acad Sci U S A 100:161-6. 2003
    ....
  3. ncbi Down-regulation of beta2-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulation
    Choh Ei Itoh
    Department of Molecular Predictive Medicine and Sport Science, School of Medicine, Kyorin University, Mitaka, Tokyo 181 8611, Japan
    Biochem Biophys Res Commun 322:979-84. 2004
    ....
  4. pmc Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension
    Lin Chang
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48105, USA
    Circulation 119:2161-9. 2009
    ..Little evidence is available on the molecular mechanisms underlying the role of vascular smooth muscle cell-specific PPARgamma in basal vascular tone...
  5. pmc Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes
    Ruijie Liu
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 284:32279-87. 2009
    ....
  6. pmc Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects
    D K Rohrer
    Department of Pediatrics, Stanford University, CA 94305, USA
    Proc Natl Acad Sci U S A 93:7375-80. 1996
    ..These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes...
  7. ncbi Targeted disruption of the beta2 adrenergic receptor gene
    A J Chruscinski
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 274:16694-700. 1999
    ..In summary, the primary physiologic consequences of the beta2-AR gene disruption are observed only during the stress of exercise and are the result of alterations in both vascular tone and energy metabolism...
  8. pmc Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes
    Vania De Arcangelis
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 284:33824-32. 2009
    ..Our data underscore the complex regulation of intracellular cAMP by beta(2)AR-associated phosphodiesterase enzymes to enforce the specificity of the receptor signaling for physiological responses...
  9. pmc Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4
    Wito Richter
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    EMBO J 27:384-93. 2008
    ....
  10. ncbi Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes
    Yongyu Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61822, USA
    J Biol Chem 283:1799-807. 2008
    ..This study not only helps us understand the endogenous agonist-dependent beta(2)AR signaling in animal heart but also offers an example of how G protein-coupled receptor signaling may be finely regulated by GRK in physiological settings...
  11. ncbi Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes
    Daniel Bernstein
    Dept of Pediatrics, 750 Welch Rd, Suite 305, Palo Alto, CA 94304, USA
    Am J Physiol Heart Circ Physiol 289:H2441-9. 2005
    ....
  12. ncbi Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 94:1091-100. 2004
    ..These findings indicate that betaAR signaling may not be necessary for basal AFC, and that beta2AR is essential for the adaptive physiological response needed to clear excess fluid from the alveolar airspace of normal and injured lungs...
  13. pmc Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction
    Dagoberto Soto
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
    Circ Res 104:770-9. 2009
    ..Together, our data have revealed insights into kinetics of PKA activities in signaling propagation under neurohormonal stimulation...
  14. doi Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  15. pmc The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes
    Yang Xiang
    Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 100:10776-81. 2003
    ....
  16. ncbi Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy
    S Lee
    Department III of Internal Medicine, University of Cologne, Cologne, Germany
    Physiol Res 59:679-89. 2010
    ..The decreased SERCA 2a activity following beta-adrenoceptor deficiency may be partly compensated by an increased myofibrillar calcium-sensitivity...
  17. ncbi Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability
    Phillip M Ecker
    Dept of Pediatrics, Stanford University, Stanford, California, USA
    Am J Physiol Heart Circ Physiol 290:H192-9. 2006
    ..These results demonstrate the differential role of beta-AR subtypes in regulating autonomic signaling...
  18. ncbi Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, California 94304, USA
    J Biol Chem 274:16701-8. 1999
    ....
  19. ncbi Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes
    Yang Xiang
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford Medical Center, Palo Alto, CA 94305, USA
    J Biol Chem 277:34280-6. 2002
    ..These observations suggest that beta(2)ARs are normally restricted to caveolae in myocyte membranes and that this localization is essential for physiologic signaling of this receptor subtype...
  20. ncbi Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
    Maria Jimenez
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    FEBS Lett 530:37-40. 2002
    ..Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting...
  21. pmc Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis
    H Kiriazis
    Department of Experimental Cardiology, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Br J Pharmacol 153:684-92. 2008
    ..We investigated the effect of beta-adrenoceptors on cardiac hypertrophic growth using beta(1)- and beta(2)-adrenoreceptor knockout and wild-type (WT) mice...
  22. pmc The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity
    Eiichi Hinoi
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 183:1235-42. 2008
    ..By showing that leptin inhibits insulin secretion by decreasing osteocalcin bioactivity, this study illustrates the importance of the relationship existing between fat and skeleton for the regulation of glucose homeostasis...
  23. ncbi Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice
    E Devic
    Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA
    Mol Pharmacol 60:577-83. 2001
    ..These studies show that all three beta AR subtypes are expressed in neonatal cardiac myocytes, and the beta(1)AR and beta(2)AR couple to distinct signaling pathways...
  24. pmc β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation
    Mohsin Khan
    San Diego Heart Research Institute, San Diego State University, San Diego, CA 92182, USA
    Circ Res 112:476-86. 2013
    ..Endogenous cardiac progenitor cell (CPC) activation may partially offset cardiomyocyte losses, but consequences of long-term β-adrenergic drive on CPC survival and proliferation are unknown...
  25. doi Molecular and functional characteristics of β3-adrenoceptors in late pregnant mouse uterus: a comparison with β2-adrenoceptors
    Subhashree Parida
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, UP, India
    Eur J Pharmacol 700:74-9. 2013
    ..The predominance of β(2)- over β(3)-adrenoceptor expression may explain variable potency amongst the β-adrenoceptor agonists...
  26. pmc β2AR antagonists and β2AR gene deletion both promote skin wound repair processes
    Christine E Pullar
    Deparment of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK
    J Invest Dermatol 132:2076-84. 2012
    ..2AR antagonism promoted wound repair processes in the early stages of wound repair, revealing a possible new avenue for therapeutic intervention...
  27. pmc β-Adrenergic receptor-PI3K signaling crosstalk in mouse heart: elucidation of immediate downstream signaling cascades
    Weizhi Zhang
    Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    PLoS ONE 6:e26581. 2011
    ....
  28. doi Beta2-adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA-dependent manner
    Márcia G Guereschi
    Department of Microbiology, Immunology and Parasitology, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, Brazil
    Eur J Immunol 43:1001-12. 2013
    ..Our data suggest that sympathetic fibers are able to regulate Treg-cell suppressive activity in a positive manner through B2AR signaling...
  29. pmc Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA
    Xiaojie Ma
    Department of Urology and Prostate Disease Center, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 287:18925-36. 2012
    ..These results suggest that βArrestin2 may serve as a convergence point for non-G(12/13) and non-G(q) protein-coupled receptors to activate RhoA...
  30. doi Cardiac sympathetic neurons provide trophic signal to the heart via β2-adrenoceptor-dependent regulation of proteolysis
    Tania Zaglia
    Department of Biomedical Sciences, University of Padova, Viale G Colombo 3, Padova 35121, Italy
    Cardiovasc Res 97:240-50. 2013
    ..Whether continuous input from the SNs is required for the maintenance of the cardiomyocyte size has not been determined thus far...
  31. doi Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M(2) KO animals
    Jan Benes
    Institute of Physiology, 1st Faculty of Medicine, Charles University, Albertov 5, 128 00, Prague, Czech Republic
    Naunyn Schmiedebergs Arch Pharmacol 385:1161-73. 2012
    ..As possible mechanisms of almost normal cardiac function, the decreases of both β(1)- and β(2)-adrenoceptor gene expression and receptor binding should be considered...
  32. pmc Redundant catecholamine signaling consolidates fear memory via phospholipase C
    Ming Ouyang
    Department of Pharmacology and Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 32:1932-41. 2012
    ..The results support recent evidence indicating that blocking β-adrenergic receptors alone shortly after trauma may not be sufficient to prevent PTSD...
  33. pmc Total beta-adrenoceptor knockout slows conduction and reduces inducible arrhythmias in the mouse heart
    Florian Stöckigt
    Department of Medicine Cardiology, University Hospital of Bonn, Bonn, Germany
    PLoS ONE 7:e49203. 2012
    ..TKO represents a unique mouse model mimicking total unselective medical β-blocker therapy in men. Electrophysiological characteristics of TKO have not yet been investigated in an animal model...
  34. doi β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression
    Penghui Zhang
    Clinical Laboratory Center, Children s Hospital, Chongqing Medical University, Chongqing, PR China
    Oncol Rep 26:1471-7. 2011
    ..This study demonstrates that βArr2 is involved in prostate carcinogenesis induced by stress and provides potential therapeutic targets for cancer...
  35. pmc Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes
    Mingming Zhao
    Department of Pediatrics, Stanford University, Stanford, California 94304, USA
    Am J Physiol Heart Circ Physiol 301:H1461-70. 2011
    ..Angiogenesis is not a prerequisite for compensated cardiac hypertrophy...
  36. ncbi Leptin regulation of bone resorption by the sympathetic nervous system and CART
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 434:514-20. 2005
    ..Sympathetic signalling via beta2-adrenergic receptors (Adrb2) present on osteoblasts controls bone formation downstream of leptin...
  37. pmc Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes
    Ruijie Liu
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS ONE 7:e42658. 2012
    ..Our data reveal a novel function of palmitoylation in shaping subcellular cAMP-PKA signaling in cardiomyocytes via modulating the recruitment of β arrestin 2-PDE4D complexes to the agonist-stimulated β(2)AR...
  38. doi Role of β-adrenergic receptors in the anti-obesity and anti-diabetic effects of zinc-α2-glycoprotien (ZAG)
    Steven Thomas Russell
    Nutritional Biomedicine, School of Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochim Biophys Acta 1821:590-9. 2012
    ..The goal of the current study is to determine whether the β-adrenoreceptor (β-AR) plays a role in the anti-obesity and anti-diabetic effects of zinc-α2-glycoprotein (ZAG)...
  39. doi Haematopoietic stem cell release is regulated by circadian oscillations
    Simon Mendez-Ferrer
    Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
    Nature 452:442-7. 2008
    ..These data indicate that a circadian, neurally driven release of HSC during the animal's resting period may promote the regeneration of the stem cell niche and possibly other tissues...
  40. doi Endogenous beta-adrenergic receptors inhibit lipopolysaccharide-induced pulmonary cytokine release and coagulation
    Ida A J Giebelen
    Center for Infection and Immunity Amsterdam CINIMA, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Cell Mol Biol 39:373-9. 2008
    ..This study suggests that beta-adrenergic receptors, which are widely expressed in the lungs, serve as negative regulators of pulmonary cytokine release and coagulation induced by LPS and less so during LTA-induced pulmonary inflammation...
  41. doi Folic acid supplementation modifies beta-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice
    Tsz Yan Lam
    Li Ka Shing Institute of Health Sciences, University of Hong Kong, Shatin, N T, Hong Kong, PR China
    Exp Biol Med (Maywood) 234:1047-55. 2009
    ..We demonstrate that lipolysis elicited by beta-AR (beta(2)- and beta(3)-ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on beta-ARs protein expression and lipolysis...
  42. doi Beta2-adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms
    Sarah J Aitken
    Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Arch Biochem Biophys 482:96-103. 2009
    ....
  43. pmc β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway
    Li Qian
    North Carolina Oral Health Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 186:4443-54. 2011
    ....
  44. doi Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
    S J Swoap
    Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
    Am J Physiol Heart Circ Physiol 294:H1581-8. 2008
    ..These experiments conclusively demonstrate that in the absence of cold stress, regulation of vagal tone and modulation of intrinsic rate are important determinants of HR control in the mouse...
  45. pmc Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
    Martin Angers
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem J 416:347-55. 2008
    ..The observed induction of Mfsd2a expression in cultured BAT cells by dibutyryl-cAMP is in agreement with this conclusion. The present study suggests that Mfsd2a plays a role in adaptive thermogenesis...
  46. doi Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle
    Dawit A P Gonçalves
    Departments of Physiology and Biochemistry and Immunology, School of Medicine, University of Sao Paulo, 14049 900 Ribeirao Preto, Brazil
    Endocrinology 150:5395-404. 2009
    ....
  47. pmc Sympathetic control of bone mass regulated by osteopontin
    Masashi Nagao
    Department of Molecular Pharmacology, Medical Research Institute, and Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8510 Tokyo, Japan
    Proc Natl Acad Sci U S A 108:17767-72. 2011
    ..Our results indicate that OPN plays a critical role in sympathetic tone regulation of bone mass and that this OPN regulation is taking place through modulation of the β2-adrenergic receptor/cAMP signaling system...
  48. pmc Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling
    Keith Schutsky
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 31:14172-81. 2011
    ..These results demonstrate that the β(2) receptor can be a critical effector of acute stress, and that β(1) and β(2) receptors can have quite distinct roles in CNS signaling and cognition...
  49. pmc Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor function
    Neelakantan T Vasudevan
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Cell 41:636-48. 2011
    ..Our study provides the underpinnings of a PI3Kγ-mediated regulation of PP2A activity that has significant consequences on receptor function with broad implications in cellular signaling...
  50. doi Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors
    Björn Neubauer
    Physiologisches Institut, Universitat Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 301:F71-7. 2011
    ..Furthermore, β-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development...
  51. pmc Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons
    Misty R Marshall
    Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 286:12627-39. 2011
    ..2 channels in vivo: increased functional expression, anchoring of AKAP15 and PKA, and initiation of excitation-transcription coupling...
  52. pmc Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice
    Stephanie L Catus
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 162:1700-15. 2011
    ..The aims of the present study are to identify which β-adrenoceptor subtypes are present in mouse astrocytes, the signal transduction mechanisms involved and whether β-adrenoceptor stimulation regulates glucose uptake...
  53. pmc Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase
    Wayne C H Wang
    Dept of Medicine, Univ of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Lung Cell Mol Physiol 300:L472-8. 2011
    ..ERK1/2 inhibition had no effect on the phenotype. Thus perturbing the ratio of β(2)-AR to AC in ASM by increasing AC fails to improve (and actually decreases) β-agonist efficacy due to counterregulatory events...
  54. pmc FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes
    Shubai Liu
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 404:581-6. 2011
    ..Together, this new PKA activity biosensor provides a useful tool to directly visualize the dynamic regulation of PKA activity on the SR in cardiomyocytes under various physiological and clinical conditions...
  55. pmc Confinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae
    Cathleen D Valentine
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 22:2970-82. 2011
    ....
  56. doi Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a beta2-adrenoceptor-independent mechanism
    Cecilia McCormick
    Biomedical and Clinical Sciences Research Institute, School of Medicine, Health Policy and Practice, Univ of East Anglia, Norwich NR4 7TJ, UK
    J Appl Physiol (1985) 109:1716-27. 2010
    ....
  57. doi Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells
    Yoshifumi Takahata
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
    J Cell Physiol 218:268-75. 2009
    ....
  58. pmc Chromosomal organization of adrenergic receptor genes
    T L Yang-Feng
    Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 87:1516-20. 1990
    ..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules...
  59. ncbi Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility
    Wei Zhong Zhu
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Circ Res 97:244-51. 2005
    ....
  60. ncbi Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice
    Geneviève Tavernier
    Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard IFR31, CHU Rangueil, Batiment L3, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Pharmacol 68:793-9. 2005
    ..We conclude that the residual lipolytic effect observed in beta-less mice can be attributed to an unknown Gs-protein-coupled receptor with low affinity for catecholamines...
  61. ncbi The role of beta-adrenergic receptor signaling in cardioprotection
    Haiyan Tong
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    FASEB J 19:983-5. 2005
    ..These data show an important role for beta2-AR in cardioprotection and support the novel hypothesis that preconditioning involves switching of beta2-AR coupling from Gs to Gi...
  62. ncbi Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos
    Stefan Cikos
    Institute of Animal Physiology, Slovak Academy of Sciences, Soltesovej 4, Kosice, Slovakia
    Mol Reprod Dev 71:145-53. 2005
    ..Thus, our results indicate that beta adrenergic receptors are expressed in mouse oocytes and preimplantation embryos and that ligands for the receptors can affect the mouse embryo even in the very early stages of development...
  63. ncbi PKC-alpha regulates cardiac contractility and propensity toward heart failure
    Julian C Braz
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Nat Med 10:248-54. 2004
    ..Thus, PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca(2+) and signal transduction events, which can profoundly affect propensity toward heart failure...
  64. ncbi Erythrocyte G protein-coupled receptor signaling in malarial infection
    Travis Harrison
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 Chicago Avenue, Chicago, IL 60611, USA
    Science 301:1734-6. 2003
    ..berghei infections in an in vivo mouse model. Thus, signaling via the erythrocyte beta2-adrenergic receptor and Galphas may regulate malarial infection across parasite species...
  65. ncbi Lower risk of postinfarct rupture in mouse heart overexpressing beta 2-adrenergic receptors: importance of collagen content
    Xiao Ming Gao
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    J Cardiovasc Pharmacol 40:632-40. 2002
    ....
  66. ncbi G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase
    Natalie Lavine
    Centre for Addiction and Mental Health, Department of Pharmacology, Institute of Medical Science, University of Toronto, Ontario M5T 1R8, Canada
    J Biol Chem 277:46010-9. 2002
    ..The observation that several G protein-coupled receptors form stable complexes with their effectors suggests that this arrangement might be a general feature of G protein-coupled signal transduction...
  67. ncbi betaAR signaling required for diet-induced thermogenesis and obesity resistance
    Eric S Bachman
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 297:843-5. 2002
    ..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity...
  68. ncbi A putative beta2-adrenoceptor from the rainbow trout (Oncorhynuchus mykiss). Molecular characterization and pharmacology
    J G Nickerson
    Department of Biology, University of Ottawa, Ontario, Canada
    Eur J Biochem 268:6465-72. 2001
    ....
  69. ncbi Physiological consequences of beta-adrenergic receptor disruption
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
    J Mol Med (Berl) 76:764-72. 1998
    ....
  70. ncbi Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor
    C A Milano
    Department of Surgery, Duke University Medical Center, Durham, NC 27710
    Science 264:582-6. 1994
    ..Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state...
  71. ncbi Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes
    S Shafqat
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Pharmacol 48:219-29. 1995
    ..These findings warrant the consideration of a synaptic regulatory role for this transporter and its presumed natural substrate, L-proline, in the mammalian central nervous system...
  72. ncbi Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization
    Jianyun Huang
    Department of Physiology, Cornell University Weill Medical College, New York, NY 10021, USA
    J Biol Chem 279:21637-42. 2004
    ..In other words, our finding suggests that receptor internalization is not required for beta2-adrenergic receptor signaling to the MAPK pathway in MEF cells...
  73. ncbi beta2-Adrenoceptor blockade partially restores ex vivo TNF production following hemorrhagic shock
    Karim Asehnoune
    AP HP, Univ Paris Sud, Hopital Bicetre, Departement d Anesthesie Reanimation, EA3540, F 94275 Le Kremlin Bicetre, France
    Cytokine 34:212-8. 2006
    ..Finally, this study demonstrates that beta(2)-adrenoceptor ligands play an important role in blood leukocyte deactivation to LPS after hemorrhagic shock...
  74. pmc Respiratory syncytial virus induces insensitivity to beta-adrenergic agonists in mouse lung epithelium in vivo
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 293:L281-9. 2007
    ....
  75. pmc The beta2 adrenergic receptor regulates morphine tolerance and physical dependence
    De Yong Liang
    Veterans Affairs Palo Alto Health Care System, Stanford University, Department of Anesthesiology, 3801 Miranda Ave, Palo Alto, CA 94304, USA
    Behav Brain Res 181:118-26. 2007
    ..Therefore, beta2-AR antagonists show some promise as agents to enhance chronic opioid analgesic therapy...
  76. ncbi Central control of bone remodeling by neuromedin U
    Shingo Sato
    Department of Orthopaedic Surgery, Graduate School, 21st Century Center of Excellence Program, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Nat Med 13:1234-40. 2007
    ..Given the existence of inhibitors and activators of NMU action, our results may influence the treatment of diseases involving low bone mass, such as osteoporosis...
  77. pmc Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes
    Olga G Shcherbakova
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 95305, USA
    J Cell Biol 176:521-33. 2007
    ....
  78. ncbi An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Endocrinology 148:3441-8. 2007
    ..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise...
  79. ncbi Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms
    Kai Soo Tan
    The Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell Signal 19:251-60. 2007
    ....
  80. ncbi A multipoint genetic linkage map of mouse chromosome 18
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 13:1143-9. 1992
    ..An additional previously unmapped gene, Drd-1, predicted to be on mouse Chr 18 based on its human chromosomal location, was mapped to the middle region of mouse Chr 13...
  81. ncbi Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
    Jindan Yu
    Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 12:419-31. 2007
    ..One of the candidates identified was ADRB2 (Adrenergic Receptor, Beta-2), a critical mediator of beta-adrenergic signaling...
  82. ncbi Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse
    L Byrd
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 11:794-8. 1991
    ..Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-(2+)-cmo/cmo indicated that the cmo gene resides on mouse Chromosome 18...
  83. pmc Persistence of circadian variation in arterial blood pressure in beta1/beta2-adrenergic receptor-deficient mice
    Soo Mi Kim
    National Institute of Digestive and Diabetes and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1427-34. 2008
    ..Our results also confirm that locomotor activity contributes strongly to circadian variation in blood pressure in mice...
  84. ncbi B cell receptor- and beta 2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells
    Adam P Kohm
    Department of Cell Biology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
    J Immunol 168:6314-22. 2002
    ..Thus, this study provides additional insight into the signaling intermediates and molecular mechanisms by which stimulation of the BCR and beta(2)AR may regulate B cell-associated B7-2 expression...
  85. ncbi N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes
    Yongyu Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, B523 Burrill Hall, MC 114, 407 S Goodwin Avenue, Urbana, IL 61801, USA
    Mol Pharmacol 72:429-39. 2007
    ....
  86. ncbi Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors
    A Chruscinski
    Howard Hughes Medical Institute, Stanford University, Stanford, California, USA
    Mol Pharmacol 60:955-62. 2001
    ....
  87. ncbi Lysyl oxidase (Lox) maps between Grl-1 and Adrb-2 on mouse chromosome 18
    A C Lossie
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618
    Mamm Genome 4:177-8. 1993
  88. pmc Genetic regulation of beta 2-adrenergic receptors in 3T3-L1 fibroblasts
    M T Nakada
    Department of Pharmacology, University of Pennsylvania, Philadelphia 19104
    Biochem J 260:53-9. 1989
    ....
  89. ncbi Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes
    K E Hadri
    INSERM Unité 282, Hopital Henri Mondor, 94010 Creteil, France
    J Biol Chem 272:24514-21. 1997
    ..These findings demonstrate a differential modulation by TNF-alpha of the three beta-adrenoreceptor subtypes in adipocytes, which may contribute to metabolic disorders induced by the cytokine in the adipocyte...
  90. pmc Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2
    Takako Kizaki
    Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Japan
    Immunology 124:348-56. 2008
    ....
  91. ncbi A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B
    U Klein
    Department of Division of Cardiovascular Medicine, Stanford University Medical School, Stanford, California 94305, USA
    J Biol Chem 272:19099-102. 1997
    ..These observations suggest a new role for a previously identified guanine nucleotide exchange protein in membrane biology and cell signaling...
  92. pmc Differential contribution of beta-adrenergic receptors expressed on radiosensitive versus radioresistant cells to protection against inflammation and mortality in murine endotoxemia
    Jill Walker-Brown
    Departments of Medicine and Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Shock 32:541-7. 2009
    ..Finally, we determined that beta3-AR subtype does not play a significant role in regulating LPS-mediated mortality and inflammation by evaluating mice lacking the beta1- and beta2-AR subtypes only...
  93. pmc Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model
    Long P Nguyen
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Science and Research Building 2, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 106:2435-40. 2009
    ....
  94. ncbi Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways
    Boyd R Rorabaugh
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, NB5, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Mol Cell Cardiol 39:777-84. 2005
    ..However, alpha(1)-AR subtypes are coupled to different beta-AR mediated signaling pathways with the alpha(1B)-AR being pertussis toxin sensitive...
  95. pmc Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers
    Mark D Levin
    Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:3420-36. 2009
    ..These data suggest that dysfunction of melanocyte-like cells in the atrium and pulmonary veins may contribute to atrial arrhythmias...
  96. pmc Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPK
    David Cervantes
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Circ Res 106:79-88. 2010
    ..Despite extensive studies investigating the regulation of single GPCR signaling cascades, the effects of concomitant GPCR activation on downstream signaling and cellular function remain unclear...
  97. pmc Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor
    Ru Quan Han
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesth Analg 108:280-7. 2009
    ..We used beta(2)AR knockout mice and a beta(2) selective antagonist to test the effect of loss of beta(2)ARs on outcome from transient focal cerebral ischemia...
  98. doi Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain
    Ipek Yalcin
    Institut des Neurosciences Cellulaires et Integratives, Centre National de Recherche Scientifique and Université de Strasbourg, Strasbourg, France
    Neurobiol Dis 33:386-94. 2009
    ..We also showed that the anticonvulsant gabapentin was still effective in beta(2)-AR deficient mice. Our results demonstrate that beta(2)-ARs are essential for the antiallodynic action of antidepressant drugs...
  99. ncbi Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor
    Lorenz Lehr
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    FEBS Lett 576:179-82. 2004
    ..Our data are the first report of a regulation by the beta3-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis...
  100. pmc Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes
    Jaclyn W McAlees
    Department of Molecular Virology, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 29:675-86. 2009
    ..Thus, beta(2)AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release bound p38 MAPK, making more available for phosphorylation and subsequent IgE regulation...
  101. pmc I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker Heart Research Institute, Commercial Road, Melbourne, Victoria 3004, Australia
    Br J Pharmacol 142:107-12. 2004
    ..This specific HR-reducing action of ivabradine is well preserved under conditions that are associated with significant activation of the sympathoadrenergic system...

Research Grants30

  1. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary Bouxsein; Fiscal Year: 2007
    ....
  2. Training Program in Integrative Immunobiology
    Virginia Sanders; Fiscal Year: 2007
    ..In summary, we will provide a multidisciplinary training environment unlike any other for studying the basic science and clinical applications of the immune system in health and disease. ..
  3. Stress response and HPA regulation in cocaine addiction
    JOHN MANTSCH; Fiscal Year: 2006
    ..Negative feedback will be further analyzed at a functional level in experiments investigating dexamethasone-induced suppression and metyrapone-induced disinhibition of the HPA axis. ..
  4. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2007
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  5. CORE--Skeletal Phenotyping Core
    Mary Bouxsein; Fiscal Year: 2007
    ..abstract_text> ..
  6. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2009
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  7. GCs, CRF and Stressor-Induced Relapse
    John R Mantsch; Fiscal Year: 2010
    ..The ability of a rat model of excessive drug use to enhance CRF regulation of drug-seeking behavior in a manner that depends on secretion of glucocorticoid hormones will be tested. ..
  8. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2010
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  9. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2007
    ..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
  10. When Belief Becomes False Memory: A Processing Account
    Daniel Bernstein; Fiscal Year: 2003
    ..The proposed work will help clarify the relationship between belief and memory, thereby delineating some of the mechanisms responsible for false memory. ..
  11. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2004
    ..abstract_text> ..
  12. Microcomputed Tomography Device (Scanco UCT40)
    Mary Bouxsein; Fiscal Year: 2004
    ..abstract_text> ..
  13. High Resolution Ultrasound Biomicroscopy System
    Daniel Bernstein; Fiscal Year: 2005
    ....
  14. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary L Bouxsein; Fiscal Year: 2010
    ....