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Genomes and Genes
| Adrb2SummaryGene Symbol: Adrb2 Description: adrenergic receptor, beta 2 Alias: Adrb-2, Badm, Gpcr7, beta 2-AR, beta 2-adrenoceptor, beta-2 adrenergic receptor, beta-2 adrenoceptor, beta-2 adrenoreceptor Species: mouse Top Publications
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Publications
Response to cardiac sympathetic activation in transgenic mice overexpressing beta 2-adrenergic receptorX J Du
Baker Medical Research Institute, Melbourne, Victoria, Australia
Am J Physiol 271:H630-6. 1996..Thus overexpression of cardiac beta 2-receptors modifies beta-adrenergic activity, but the responses to endogenous and exogenous adrenergic stimulation are affected differently...
Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytesChristopher J Hupfeld
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla 92093, USA
Proc Natl Acad Sci U S A 100:161-6. 2003....- Down-regulation of beta2-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulationChoh Ei Itoh
Department of Molecular Predictive Medicine and Sport Science, School of Medicine, Kyorin University, Mitaka, Tokyo 181 8611, Japan
Biochem Biophys Res Commun 322:979-84. 2004.... - Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotensionLin Chang
Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48105, USA
Circulation 119:2161-9. 2009..Little evidence is available on the molecular mechanisms underlying the role of vascular smooth muscle cell-specific PPARgamma in basal vascular tone... - Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytesRuijie Liu
Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
J Biol Chem 284:32279-87. 2009.... - Targeted disruption of the beta2 adrenergic receptor geneA J Chruscinski
Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
J Biol Chem 274:16694-700. 1999..In summary, the primary physiologic consequences of the beta2-AR gene disruption are observed only during the stress of exercise and are the result of alterations in both vascular tone and energy metabolism... 
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesityRuben Nogueiras
Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
J Neurosci 29:5916-25. 2009..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...- Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosisH Kiriazis
Department of Experimental Cardiology, Baker Heart Research Institute, Melbourne, Victoria, Australia
Br J Pharmacol 153:684-92. 2008..We investigated the effect of beta-adrenoceptors on cardiac hypertrophic growth using beta(1)- and beta(2)-adrenoreceptor knockout and wild-type (WT) mice... - The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivityEiichi Hinoi
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Cell Biol 183:1235-42. 2008..By showing that leptin inhibits insulin secretion by decreasing osteocalcin bioactivity, this study illustrates the importance of the relationship existing between fat and skeleton for the regulation of glucose homeostasis... - Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout miceE Devic
Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA
Mol Pharmacol 60:577-83. 2001..These studies show that all three beta AR subtypes are expressed in neonatal cardiac myocytes, and the beta(1)AR and beta(2)AR couple to distinct signaling pathways... - Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptorsD K Rohrer
Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, California 94304, USA
J Biol Chem 274:16701-8. 1999.... - Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fastingMaria Jimenez
Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
FEBS Lett 530:37-40. 2002..Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting... - Leptin regulation of bone resorption by the sympathetic nervous system and CARTFlorent Elefteriou
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 434:514-20. 2005..Sympathetic signalling via beta2-adrenergic receptors (Adrb2) present on osteoblasts controls bone formation downstream of leptin... - The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytesYang Xiang
Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA 94305, USA
Proc Natl Acad Sci U S A 100:10776-81. 2003.... - Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypesDaniel Bernstein
Dept of Pediatrics, 750 Welch Rd, Suite 305, Palo Alto, CA 94304, USA
Am J Physiol Heart Circ Physiol 289:H2441-9. 2005.... - Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effectsD K Rohrer
Department of Pediatrics, Stanford University, CA 94305, USA
Proc Natl Acad Sci U S A 93:7375-80. 1996..These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes... - Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancerJindan Yu
Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Cell 12:419-31. 2007..One of the candidates identified was ADRB2 (Adrenergic Receptor, Beta-2), a critical mediator of beta-adrenergic signaling... - beta2-Adrenoceptor blockade partially restores ex vivo TNF production following hemorrhagic shockKarim Asehnoune
AP HP, Univ Paris Sud, Hopital Bicetre, Departement d Anesthesie Reanimation, EA3540, F 94275 Le Kremlin Bicetre, France
Cytokine 34:212-8. 2006..Finally, this study demonstrates that beta(2)-adrenoceptor ligands play an important role in blood leukocyte deactivation to LPS after hemorrhagic shock... - Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesisMartin Angers
Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Biochem J 416:347-55. 2008..The observed induction of Mfsd2a expression in cultured BAT cells by dibutyryl-cAMP is in agreement with this conclusion. The present study suggests that Mfsd2a plays a role in adaptive thermogenesis... - Endogenous beta-adrenergic receptors inhibit lipopolysaccharide-induced pulmonary cytokine release and coagulationIda A J Giebelen
Center for Infection and Immunity Amsterdam CINIMA, University of Amsterdam, Amsterdam, The Netherlands
Am J Respir Cell Mol Biol 39:373-9. 2008..This study suggests that beta-adrenergic receptors, which are widely expressed in the lungs, serve as negative regulators of pulmonary cytokine release and coagulation induced by LPS and less so during LTA-induced pulmonary inflammation... - Haematopoietic stem cell release is regulated by circadian oscillationsSimon Mendez-Ferrer
Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
Nature 452:442-7. 2008..These data indicate that a circadian, neurally driven release of HSC during the animal's resting period may promote the regeneration of the stem cell niche and possibly other tissues... - Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanismsKai Soo Tan
The Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
Cell Signal 19:251-60. 2007.... - Vagal tone dominates autonomic control of mouse heart rate at thermoneutralityS J Swoap
Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
Am J Physiol Heart Circ Physiol 294:H1581-8. 2008..These experiments conclusively demonstrate that in the absence of cold stress, regulation of vagal tone and modulation of intrinsic rate are important determinants of HR control in the mouse... - The beta2 adrenergic receptor regulates morphine tolerance and physical dependenceDe Yong Liang
Veterans Affairs Palo Alto Health Care System, Stanford University, Department of Anesthesiology, 3801 Miranda Ave, Palo Alto, CA 94304, USA
Behav Brain Res 181:118-26. 2007..Therefore, beta2-AR antagonists show some promise as agents to enhance chronic opioid analgesic therapy... - Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytesOlga G Shcherbakova
Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 95305, USA
J Cell Biol 176:521-33. 2007.... - Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4Wito Richter
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
EMBO J 27:384-93. 2008.... - Respiratory syncytial virus induces insensitivity to beta-adrenergic agonists in mouse lung epithelium in vivoIan C Davis
Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
Am J Physiol Lung Cell Mol Physiol 293:L281-9. 2007.... - An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activationShinji Miura
Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Endocrinology 148:3441-8. 2007..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise... - Central control of bone remodeling by neuromedin UShingo Sato
Department of Orthopaedic Surgery, Graduate School, 21st Century Center of Excellence Program, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
Nat Med 13:1234-40. 2007..Given the existence of inhibitors and activators of NMU action, our results may influence the treatment of diseases involving low bone mass, such as osteoporosis... - Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cellsYoshifumi Takahata
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
J Cell Physiol 218:268-75. 2009.... - Beta2-adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanismsSarah J Aitken
Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
Arch Biochem Biophys 482:96-103. 2009.... - Confinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolaeCathleen D Valentine
Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Mol Biol Cell 22:2970-82. 2011.... - Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor functionNeelakantan T Vasudevan
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Mol Cell 41:636-48. 2011..Our study provides the underpinnings of a PI3Kγ-mediated regulation of PP2A activity that has significant consequences on receptor function with broad implications in cellular signaling... - Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptorsBjörn Neubauer
Physiologisches Institut, Universitat Regensburg, D 93040 Regensburg, Germany
Am J Physiol Renal Physiol 301:F71-7. 2011..Furthermore, β-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development... - β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathwayLi Qian
North Carolina Oral Health Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Immunol 186:4443-54. 2011.... - Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neuronsMisty R Marshall
Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195 7280, USA
J Biol Chem 286:12627-39. 2011..2 channels in vivo: increased functional expression, anchoring of AKAP15 and PKA, and initiation of excitation-transcription coupling... - Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout miceStephanie L Catus
Department of Pharmacology, Monash University, Clayton, Victoria, Australia
Br J Pharmacol 162:1700-15. 2011..The aims of the present study are to identify which β-adrenoceptor subtypes are present in mouse astrocytes, the signal transduction mechanisms involved and whether β-adrenoceptor stimulation regulates glucose uptake... - Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclaseWayne C H Wang
Dept of Medicine, Univ of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Physiol Lung Cell Mol Physiol 300:L472-8. 2011..ERK1/2 inhibition had no effect on the phenotype. Thus perturbing the ratio of β(2)-AR to AC in ASM by increasing AC fails to improve (and actually decreases) β-agonist efficacy due to counterregulatory events... - FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytesShubai Liu
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Biochem Biophys Res Commun 404:581-6. 2011..Together, this new PKA activity biosensor provides a useful tool to directly visualize the dynamic regulation of PKA activity on the SR in cardiomyocytes under various physiological and clinical conditions... - Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a beta2-adrenoceptor-independent mechanismCecilia McCormick
Biomedical and Clinical Sciences Research Institute, School of Medicine, Health Policy and Practice, Univ of East Anglia, Norwich NR4 7TJ, UK
J Appl Physiol 109:1716-27. 2010.... - Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscleDawit A P Gonçalves
Departments of Physiology and Biochemistry and Immunology, School of Medicine, University of Sao Paulo, 14049 900 Ribeirao Preto, Brazil
Endocrinology 150:5395-404. 2009.... - Folic acid supplementation modifies beta-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) miceTsz Yan Lam
Li Ka Shing Institute of Health Sciences, University of Hong Kong, Shatin, N T, Hong Kong, PR China
Exp Biol Med (Maywood) 234:1047-55. 2009..We demonstrate that lipolysis elicited by beta-AR (beta(2)- and beta(3)-ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on beta-ARs protein expression and lipolysis... - Sympathetic control of bone mass regulated by osteopontinMasashi Nagao
Department of Molecular Pharmacology, Medical Research Institute, and Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8510 Tokyo, Japan
Proc Natl Acad Sci U S A 108:17767-72. 2011..Our results indicate that OPN plays a critical role in sympathetic tone regulation of bone mass and that this OPN regulation is taking place through modulation of the β2-adrenergic receptor/cAMP signaling system... - Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytesVania De Arcangelis
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Biol Chem 284:33824-32. 2009..Our data underscore the complex regulation of intracellular cAMP by beta(2)AR-associated phosphodiesterase enzymes to enforce the specificity of the receptor signaling for physiological responses... - Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signalingKeith Schutsky
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
J Neurosci 31:14172-81. 2011..These results demonstrate that the β(2) receptor can be a critical effector of acute stress, and that β(1) and β(2) receptors can have quite distinct roles in CNS signaling and cognition... - Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalizationJianyun Huang
Department of Physiology, Cornell University Weill Medical College, New York, NY 10021, USA
J Biol Chem 279:21637-42. 2004..In other words, our finding suggests that receptor internalization is not required for beta2-adrenergic receptor signaling to the MAPK pathway in MEF cells... - PKC-alpha regulates cardiac contractility and propensity toward heart failureJulian C Braz
Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Nat Med 10:248-54. 2004..Thus, PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca(2+) and signal transduction events, which can profoundly affect propensity toward heart failure... - betaAR signaling required for diet-induced thermogenesis and obesity resistanceEric S Bachman
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
Science 297:843-5. 2002..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity... - Erythrocyte G protein-coupled receptor signaling in malarial infectionTravis Harrison
Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 Chicago Avenue, Chicago, IL 60611, USA
Science 301:1734-6. 2003..berghei infections in an in vivo mouse model. Thus, signaling via the erythrocyte beta2-adrenergic receptor and Galphas may regulate malarial infection across parasite species... - Physiological consequences of beta-adrenergic receptor disruptionD K Rohrer
Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
J Mol Med (Berl) 76:764-72. 1998.... - A multipoint genetic linkage map of mouse chromosome 18K R Johnson
Jackson Laboratory, Bar Harbor, Maine 04609
Genomics 13:1143-9. 1992..An additional previously unmapped gene, Drd-1, predicted to be on mouse Chr 18 based on its human chromosomal location, was mapped to the middle region of mouse Chr 13... - Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptorC A Milano
Department of Surgery, Duke University Medical Center, Durham, NC 27710
Science 264:582-6. 1994..Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state... - Lower risk of postinfarct rupture in mouse heart overexpressing beta 2-adrenergic receptors: importance of collagen contentXiao Ming Gao
Baker Medical Research Institute, Melbourne, Victoria, Australia
J Cardiovasc Pharmacol 40:632-40. 2002.... - G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclaseNatalie Lavine
Centre for Addiction and Mental Health, Department of Pharmacology, Institute of Medical Science, University of Toronto, Ontario M5T 1R8, Canada
J Biol Chem 277:46010-9. 2002..The observation that several G protein-coupled receptors form stable complexes with their effectors suggests that this arrangement might be a general feature of G protein-coupled signal transduction... - A putative beta2-adrenoceptor from the rainbow trout (Oncorhynuchus mykiss). Molecular characterization and pharmacologyJ G Nickerson
Department of Biology, University of Ottawa, Ontario, Canada
Eur J Biochem 268:6465-72. 2001.... - Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signalingGokhan M Mutlu
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
Circ Res 94:1091-100. 2004..These findings indicate that betaAR signaling may not be necessary for basal AFC, and that beta2AR is essential for the adaptive physiological response needed to clear excess fluid from the alveolar airspace of normal and injured lungs... - Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytesYang Xiang
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford Medical Center, Palo Alto, CA 94305, USA
J Biol Chem 277:34280-6. 2002..These observations suggest that beta(2)ARs are normally restricted to caveolae in myocyte membranes and that this localization is essential for physiologic signaling of this receptor subtype... - Chromosomal organization of adrenergic receptor genesT L Yang-Feng
Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
Proc Natl Acad Sci U S A 87:1516-20. 1990..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules... - Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout miceGeneviève Tavernier
Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard IFR31, CHU Rangueil, Batiment L3, BP 84225, 31432 Toulouse Cedex 4, France
Mol Pharmacol 68:793-9. 2005..We conclude that the residual lipolytic effect observed in beta-less mice can be attributed to an unknown Gs-protein-coupled receptor with low affinity for catecholamines... - The role of beta-adrenergic receptor signaling in cardioprotectionHaiyan Tong
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
FASEB J 19:983-5. 2005..These data show an important role for beta2-AR in cardioprotection and support the novel hypothesis that preconditioning involves switching of beta2-AR coupling from Gs to Gi... - Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variabilityPhillip M Ecker
Dept of Pediatrics, Stanford University, Stanford, California, USA
Am J Physiol Heart Circ Physiol 290:H192-9. 2006..These results demonstrate the differential role of beta-AR subtypes in regulating autonomic signaling... - Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryosStefan Cikos
Institute of Animal Physiology, Slovak Academy of Sciences, Soltesovej 4, Kosice, Slovakia
Mol Reprod Dev 71:145-53. 2005..Thus, our results indicate that beta adrenergic receptors are expressed in mouse oocytes and preimplantation embryos and that ligands for the receptors can affect the mouse embryo even in the very early stages of development... - Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomesS Shafqat
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Pharmacol 48:219-29. 1995..These findings warrant the consideration of a synaptic regulatory role for this transporter and its presumed natural substrate, L-proline, in the mammalian central nervous system... - Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractilityWei Zhong Zhu
Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Circ Res 97:244-51. 2005.... - Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouseL Byrd
Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
Genomics 11:794-8. 1991..Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-(2+)-cmo/cmo indicated that the cmo gene resides on mouse Chromosome 18... - Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptorsA Chruscinski
Howard Hughes Medical Institute, Stanford University, Stanford, California, USA
Mol Pharmacol 60:955-62. 2001.... - Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine modelLong P Nguyen
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Science and Research Building 2, Houston, TX 77204, USA
Proc Natl Acad Sci U S A 106:2435-40. 2009.... - Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggersMark D Levin
Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 119:3420-36. 2009..These data suggest that dysfunction of melanocyte-like cells in the atrium and pulmonary veins may contribute to atrial arrhythmias... - B cell receptor- and beta 2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cellsAdam P Kohm
Department of Cell Biology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
J Immunol 168:6314-22. 2002..Thus, this study provides additional insight into the signaling intermediates and molecular mechanisms by which stimulation of the BCR and beta(2)AR may regulate B cell-associated B7-2 expression... - Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activityYu Shi
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Cell Metab 11:231-8. 2010..By showing that both arms of the autonomic nervous system affect bone remodeling, this study further underscores the importance of neuronal regulation of bone... - Genetic regulation of beta 2-adrenergic receptors in 3T3-L1 fibroblastsM T Nakada
Department of Pharmacology, University of Pennsylvania, Philadelphia 19104
Biochem J 260:53-9. 1989.... - Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytesK E Hadri
INSERM Unité 282, Hopital Henri Mondor, 94010 Creteil, France
J Biol Chem 272:24514-21. 1997..These findings demonstrate a differential modulation by TNF-alpha of the three beta-adrenoreceptor subtypes in adipocytes, which may contribute to metabolic disorders induced by the cytokine in the adipocyte... - Lysyl oxidase (Lox) maps between Grl-1 and Adrb-2 on mouse chromosome 18A C Lossie
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618
Mamm Genome 4:177-8. 1993 - A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2BU Klein
Department of Division of Cardiovascular Medicine, Stanford University Medical School, Stanford, California 94305, USA
J Biol Chem 272:19099-102. 1997..These observations suggest a new role for a previously identified guanine nucleotide exchange protein in membrane biology and cell signaling... - Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPKDavid Cervantes
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Circ Res 106:79-88. 2010..Despite extensive studies investigating the regulation of single GPCR signaling cascades, the effects of concomitant GPCR activation on downstream signaling and cellular function remain unclear... - Foxj1 is required for apical localization of ezrin in airway epithelial cellsTao Huang
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Cell Sci 116:4935-45. 2003..These findings indicate that Foxj1 regulates ERM proteins differentially to selectively direct the apical localization of ezrin for the organization of multi-protein complexes in apical membranes of airway epithelial cells... - Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathwaysBoyd R Rorabaugh
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, NB5, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Mol Cell Cardiol 39:777-84. 2005..However, alpha(1)-AR subtypes are coupled to different beta-AR mediated signaling pathways with the alpha(1B)-AR being pertussis toxin sensitive... - N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytesYongyu Wang
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, B523 Burrill Hall, MC 114, 407 S Goodwin Avenue, Urbana, IL 61801, USA
Mol Pharmacol 72:429-39. 2007.... - Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptorLorenz Lehr
Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
FEBS Lett 576:179-82. 2004..Our data are the first report of a regulation by the beta3-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis... - Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathyGiovanni Fajardo
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
J Mol Cell Cardiol 40:375-83. 2006..beta2-AR subtypes in knockout mice are recapitulated in myocytes isolated from these mice. beta2-ARs appear to play a cardioprotective role, whereas beta1-ARs a cardiotoxic role... - I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activitiesXiao Jun Du
Experimental Cardiology Laboratory, Baker Heart Research Institute, Commercial Road, Melbourne, Victoria 3004, Australia
Br J Pharmacol 142:107-12. 2004..This specific HR-reducing action of ivabradine is well preserved under conditions that are associated with significant activation of the sympathoadrenergic system... - Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2Takako Kizaki
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Japan
Immunology 124:348-56. 2008.... - Persistence of circadian variation in arterial blood pressure in beta1/beta2-adrenergic receptor-deficient miceSoo Mi Kim
National Institute of Digestive and Diabetes and Kidney Diseases, NIH, Bethesda, MD 20892, USA
Am J Physiol Regul Integr Comp Physiol 294:R1427-34. 2008..Our results also confirm that locomotor activity contributes strongly to circadian variation in blood pressure in mice... - cAMP-mediated beta-adrenergic signaling negatively regulates Gq-coupled receptor-mediated fetal gene response in cardiomyocytesMario Patrizio
Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
J Mol Cell Cardiol 45:761-9. 2008.... - Differential contribution of beta-adrenergic receptors expressed on radiosensitive versus radioresistant cells to protection against inflammation and mortality in murine endotoxemiaJill Walker-Brown
Departments of Medicine and Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
Shock 32:541-7. 2009..Finally, we determined that beta3-AR subtype does not play a significant role in regulating LPS-mediated mortality and inflammation by evaluating mice lacking the beta1- and beta2-AR subtypes only... - Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contractionDagoberto Soto
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
Circ Res 104:770-9. 2009..Together, our data have revealed insights into kinetics of PKA activities in signaling propagation under neurohormonal stimulation... - Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptorRu Quan Han
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
Anesth Analg 108:280-7. 2009..We used beta(2)AR knockout mice and a beta(2) selective antagonist to test the effect of loss of beta(2)ARs on outcome from transient focal cerebral ischemia... - Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic painIpek Yalcin
Institut des Neurosciences Cellulaires et Integratives, Centre National de Recherche Scientifique and Université de Strasbourg, Strasbourg, France
Neurobiol Dis 33:386-94. 2009..We also showed that the anticonvulsant gabapentin was still effective in beta(2)-AR deficient mice. Our results demonstrate that beta(2)-ARs are essential for the antiallodynic action of antidepressant drugs... - Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytesJaclyn W McAlees
Department of Molecular Virology, The Ohio State University, Columbus, Ohio 43210, USA
Mol Cell Biol 29:675-86. 2009..Thus, beta(2)AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release bound p38 MAPK, making more available for phosphorylation and subsequent IgE regulation... - Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytesYongyu Wang
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61822, USA
J Biol Chem 283:1799-807. 2008..This study not only helps us understand the endogenous agonist-dependent beta(2)AR signaling in animal heart but also offers an example of how G protein-coupled receptor signaling may be finely regulated by GRK in physiological settings... - Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptorsU Maskos
Unité Récepteurs et Cognition, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Nature 436:103-7. 2005..We thus demonstrate the sufficient role of the VTA in both nicotine reinforcement and endogenous cholinergic regulation of cognitive functions... - Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complexDennis W McGraw
Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Invest 116:1400-9. 2006..This mechanism may contribute to beta-agonist resistance found in asthma...
Research Grants
- Biomechanics of Vertebral Fracture: The Framingham QCT StudyMary Bouxsein; Fiscal Year: 2007....
- Training Program in Integrative ImmunobiologyVirginia Sanders; Fiscal Year: 2007..In summary, we will provide a multidisciplinary training environment unlike any other for studying the basic science and clinical applications of the immune system in health and disease. ..
- Stress response and HPA regulation in cocaine addictionJOHN MANTSCH; Fiscal Year: 2006..Negative feedback will be further analyzed at a functional level in experiments investigating dexamethasone-induced suppression and metyrapone-induced disinhibition of the HPA axis. ..
- ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYDaniel Bernstein; Fiscal Year: 2007..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
- CORE--Skeletal Phenotyping CoreMary Bouxsein; Fiscal Year: 2007..abstract_text> ..
- ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYDaniel Bernstein; Fiscal Year: 2009..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
- GCs, CRF and Stressor-Induced RelapseJohn R Mantsch; Fiscal Year: 2010..The ability of a rat model of excessive drug use to enhance CRF regulation of drug-seeking behavior in a manner that depends on secretion of glucocorticoid hormones will be tested. ..
- ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYDaniel Bernstein; Fiscal Year: 2010..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
- REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTINMary Bouxsein; Fiscal Year: 2007..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
- When Belief Becomes False Memory: A Processing AccountDaniel Bernstein; Fiscal Year: 2003..The proposed work will help clarify the relationship between belief and memory, thereby delineating some of the mechanisms responsible for false memory. ..
- ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYDaniel Bernstein; Fiscal Year: 2004..abstract_text> ..
- Microcomputed Tomography Device (Scanco UCT40)Mary Bouxsein; Fiscal Year: 2004..abstract_text> ..
- High Resolution Ultrasound Biomicroscopy SystemDaniel Bernstein; Fiscal Year: 2005....
- Biomechanics of Vertebral Fracture: The Framingham QCT StudyMary L Bouxsein; Fiscal Year: 2010....