Adrb1

Summary

Gene Symbol: Adrb1
Description: adrenergic receptor, beta 1
Alias: Adrb-1, beta-AR, beta 1-AR, beta-1 adrenergic receptor, beta-1 adrenoceptor, beta-1 adrenoreceptor, cardiac beta adrenergic receptor
Species: mouse

Top Publications

  1. ncbi Physiological consequences of beta-adrenergic receptor disruption
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
    J Mol Med (Berl) 76:764-72. 1998
  2. ncbi Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 94:1091-100. 2004
  3. pmc Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction
    Dagoberto Soto
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
    Circ Res 104:770-9. 2009
  4. pmc Confinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae
    Cathleen D Valentine
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 22:2970-82. 2011
  5. pmc Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects
    D K Rohrer
    Department of Pediatrics, Stanford University, CA 94305, USA
    Proc Natl Acad Sci U S A 93:7375-80. 1996
  6. ncbi Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes
    Daniel Bernstein
    Dept of Pediatrics, 750 Welch Rd, Suite 305, Palo Alto, CA 94304, USA
    Am J Physiol Heart Circ Physiol 289:H2441-9. 2005
  7. ncbi Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy
    S Lee
    Department III of Internal Medicine, University of Cologne, Cologne, Germany
    Physiol Res 59:679-89. 2010
  8. ncbi Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability
    Phillip M Ecker
    Dept of Pediatrics, Stanford University, Stanford, California, USA
    Am J Physiol Heart Circ Physiol 290:H192-9. 2006
  9. pmc Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors
    A Galindo-Tovar
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Br J Pharmacol 153:710-20. 2008
  10. ncbi Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, California 94304, USA
    J Biol Chem 274:16701-8. 1999

Scientific Experts

  • Lorenz Lehr
  • Florian Stöckigt
  • Ruben Nogueiras
  • Philip W Raake
  • Lesley A Schimanski
  • Geneviève Tavernier
  • Shinji Miura
  • C J Daly
  • IRA JAY GOLDBERG
  • Mary Bouxsein
  • Marika Charalambous
  • Daniel M Bernstein
  • Maria Jimenez
  • B Roozendaal
  • Ming Ouyang
  • Soo Mi Kim
  • Keith Schutsky
  • D K Rohrer
  • Yang Xiang
  • Mingming Zhao
  • Steven A Thomas
  • Wei Zhong Zhu
  • Jurgen Schnermann
  • Brian K Kobilka
  • Giovanni Fajardo
  • Jan Benes
  • Oliver Vranjkovic
  • Stephen B Liggett
  • Weizhi Zhang
  • Thomas Pulinilkunnil
  • Shubai Liu
  • Cathleen D Valentine
  • Qi Chen
  • Björn Neubauer
  • C F Murchison
  • Stephanie L Catus
  • Emilio P Mottillo
  • Wei Wang
  • S Lee
  • Jin Zhang
  • Santhosh K Mani
  • Dong Kong
  • Dagoberto Soto
  • Jill Walker-Brown
  • Yuejin Wu
  • ByungSu Yoo
  • Geertje Lewin
  • Mark D Levin
  • B K Kobilka
  • Vania De Arcangelis
  • H Kiriazis
  • A Galindo-Tovar
  • Wito Richter
  • S J Swoap
  • Yongyu Wang
  • Carley A E Shaut
  • Martin Angers
  • Mario Patrizio
  • Josephine P Briggs
  • Yuning Huang
  • Diane Mizel
  • W J Koch
  • Masaki Ieda
  • Rebecca T Emeny
  • Joan Heller Brown
  • N N Rocha
  • Phillip M Ecker
  • Shahab A Akhter
  • James J Crowley
  • Jennifer Powers
  • Benoit Boivin
  • Terence E Hebert
  • Catherine Lavoie
  • A Chruscinski
  • David A Lawrence
  • Stefan Cikos
  • Chihiro Hosoda
  • Brian Kobilka
  • Edward G Lakatta
  • Heping Cheng
  • Charles F Murchison
  • Julian C Braz
  • Gokhan M Mutlu
  • Dongmei Yang
  • Rui Ping Xiao
  • Khalid Chakir
  • Ling Cao
  • Dennis W McGraw
  • Eric Devic
  • Andrea D Eckhart

Detail Information

Publications86

  1. ncbi Physiological consequences of beta-adrenergic receptor disruption
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
    J Mol Med (Berl) 76:764-72. 1998
    ....
  2. ncbi Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 94:1091-100. 2004
    ..These findings indicate that betaAR signaling may not be necessary for basal AFC, and that beta2AR is essential for the adaptive physiological response needed to clear excess fluid from the alveolar airspace of normal and injured lungs...
  3. pmc Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction
    Dagoberto Soto
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
    Circ Res 104:770-9. 2009
    ..Together, our data have revealed insights into kinetics of PKA activities in signaling propagation under neurohormonal stimulation...
  4. pmc Confinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae
    Cathleen D Valentine
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 22:2970-82. 2011
    ....
  5. pmc Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects
    D K Rohrer
    Department of Pediatrics, Stanford University, CA 94305, USA
    Proc Natl Acad Sci U S A 93:7375-80. 1996
    ..These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes...
  6. ncbi Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes
    Daniel Bernstein
    Dept of Pediatrics, 750 Welch Rd, Suite 305, Palo Alto, CA 94304, USA
    Am J Physiol Heart Circ Physiol 289:H2441-9. 2005
    ....
  7. ncbi Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy
    S Lee
    Department III of Internal Medicine, University of Cologne, Cologne, Germany
    Physiol Res 59:679-89. 2010
    ..The decreased SERCA 2a activity following beta-adrenoceptor deficiency may be partly compensated by an increased myofibrillar calcium-sensitivity...
  8. ncbi Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability
    Phillip M Ecker
    Dept of Pediatrics, Stanford University, Stanford, California, USA
    Am J Physiol Heart Circ Physiol 290:H192-9. 2006
    ..These results demonstrate the differential role of beta-AR subtypes in regulating autonomic signaling...
  9. pmc Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors
    A Galindo-Tovar
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Br J Pharmacol 153:710-20. 2008
    ..We investigated the influence of the PDE3 inhibitor cilostamide and PDE4 inhibitor rolipram on the effects of (-)-adrenaline in three regions of murine heart...
  10. ncbi Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, California 94304, USA
    J Biol Chem 274:16701-8. 1999
    ....
  11. pmc Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II
    Wei Zhong Zhu
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Clin Invest 111:617-25. 2003
    ..These findings indicate that CaMKII constitutes a novel PKA-independent linkage of beta(1)AR stimulation to cardiomyocyte apoptosis that has been implicated in the overall process of chronic heart failure...
  12. ncbi Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice
    E Devic
    Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA
    Mol Pharmacol 60:577-83. 2001
    The sympathetic nervous system modulates cardiac contractility and rate by activating beta-adrenergic receptors (beta AR) expressed on cardiac myocytes and specialized cells in the sinoatrial node and the conduction system...
  13. ncbi Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
    Maria Jimenez
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    FEBS Lett 530:37-40. 2002
    ..Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting...
  14. pmc Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function
    M Jaber
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 93:12974-9. 1996
    ....
  15. ncbi The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes
    Yang Xiang
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institution, B157 Beckman Center, Stanford Medical Center, Palo Alto, CA 94043, USA
    J Biol Chem 277:33783-90. 2002
    ..These studies suggest that association of the beta(1)AR with PSD-95 or a related protein dictates signaling specificity by retaining the receptor at the cell surface and preventing interaction with G(i)...
  16. pmc Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes
    Mingming Zhao
    Department of Pediatrics, Stanford University, Stanford, California 94304, USA
    Am J Physiol Heart Circ Physiol 301:H1461-70. 2011
    ..Angiogenesis is not a prerequisite for compensated cardiac hypertrophy...
  17. doi Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  18. ncbi Primary structure of the mouse beta 1-adrenergic receptor gene
    J R Jasper
    Department of Pediatrics, Stanford University, CA 94305
    Biochim Biophys Acta 1178:307-9. 1993
    ..7% identical to the human sequence, 98.5% identical to the rat sequence, and contains a consensus site for N-linked glycosylation at Asn-15 and a cAMP-dependent protein kinase phosphorylation site at Ser-301...
  19. pmc β-Adrenergic receptor-PI3K signaling crosstalk in mouse heart: elucidation of immediate downstream signaling cascades
    Weizhi Zhang
    Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    PLoS ONE 6:e26581. 2011
    ....
  20. pmc Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis
    H Kiriazis
    Department of Experimental Cardiology, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Br J Pharmacol 153:684-92. 2008
    ..We investigated the effect of beta-adrenoceptors on cardiac hypertrophic growth using beta(1)- and beta(2)-adrenoreceptor knockout and wild-type (WT) mice...
  21. pmc Total beta-adrenoceptor knockout slows conduction and reduces inducible arrhythmias in the mouse heart
    Florian Stöckigt
    Department of Medicine Cardiology, University Hospital of Bonn, Bonn, Germany
    PLoS ONE 7:e49203. 2012
    ..TKO represents a unique mouse model mimicking total unselective medical β-blocker therapy in men. Electrophysiological characteristics of TKO have not yet been investigated in an animal model...
  22. doi Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M(2) KO animals
    Jan Benes
    Institute of Physiology, 1st Faculty of Medicine, Charles University, Albertov 5, 128 00, Prague, Czech Republic
    Naunyn Schmiedebergs Arch Pharmacol 385:1161-73. 2012
    ..As possible mechanisms of almost normal cardiac function, the decreases of both β(1)- and β(2)-adrenoceptor gene expression and receptor binding should be considered...
  23. pmc β-adrenergic receptor mediation of stress-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: roles for β1 and β2 adrenergic receptors
    Oliver Vranjkovic
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53201, USA
    J Pharmacol Exp Ther 342:541-51. 2012
    ..p.) induced reinstatement in wild-type, but not β- adrenergic receptor-deficient Adrb1/Adrb2 double-knockout, mice. In contrast, cocaine administration (15 mg/kg i.p...
  24. pmc Redundant catecholamine signaling consolidates fear memory via phospholipase C
    Ming Ouyang
    Department of Pharmacology and Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 32:1932-41. 2012
    ..The results support recent evidence indicating that blocking β-adrenergic receptors alone shortly after trauma may not be sufficient to prevent PTSD...
  25. pmc Norepinephrine and ß₁-adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval
    C F Murchison
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroscience 181:109-16. 2011
    ....
  26. pmc Intracellular fatty acids suppress β-adrenergic induction of PKA-targeted gene expression in white adipocytes
    Emilio P Mottillo
    Center for Integrative Metabolic and Endocrine Research, Department of Pathology and Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Endocrinol Metab 301:E122-31. 2011
    ..Overall, our results demonstrate that fatty acids limit the upregulation of β-AR-responsive genes in white adipocytes and suggest that limiting lipolysis may be a novel means of enhancing β-AR signaling...
  27. pmc Chromosomal organization of adrenergic receptor genes
    T L Yang-Feng
    Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 87:1516-20. 1990
    ..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules...
  28. pmc Calmodulin kinase II is required for fight or flight sinoatrial node physiology
    Yuejin Wu
    Departments of Internal Medicine and Molecular Physiology and Biophysics, University of Iowa, 2256 CBRB, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:5972-7. 2009
    ....
  29. doi Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction
    Geertje Lewin
    Institute of Pharmacology and Toxicology, University of Munster, Munster, Germany
    Circulation 119:79-88. 2009
    ....
  30. doi cAMP-mediated beta-adrenergic signaling negatively regulates Gq-coupled receptor-mediated fetal gene response in cardiomyocytes
    Mario Patrizio
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Mol Cell Cardiol 45:761-9. 2008
    ....
  31. pmc Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 150:144-52. 2009
    ..Our findings also suggest direct positive effects of weight and/or leptin on bone turnover and cortical bone structure, independent of adrenergic signaling...
  32. pmc Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    J Neurosci 28:6642-51. 2008
    ....
  33. pmc HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification
    Carley A E Shaut
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 4:e1000073. 2008
    ....
  34. pmc Persistence of circadian variation in arterial blood pressure in beta1/beta2-adrenergic receptor-deficient mice
    Soo Mi Kim
    National Institute of Digestive and Diabetes and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1427-34. 2008
    ..Our results also confirm that locomotor activity contributes strongly to circadian variation in blood pressure in mice...
  35. doi Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
    S J Swoap
    Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
    Am J Physiol Heart Circ Physiol 294:H1581-8. 2008
    ..These experiments conclusively demonstrate that in the absence of cold stress, regulation of vagal tone and modulation of intrinsic rate are important determinants of HR control in the mouse...
  36. pmc Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4
    Wito Richter
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    EMBO J 27:384-93. 2008
    ....
  37. ncbi Alterations in dynamic heart rate control in the beta 1-adrenergic receptor knockout mouse
    D K Rohrer
    Department of Pediatrics, Stanford University, California 94305, USA
    Am J Physiol 274:H1184-93. 1998
    ..Thus, in mice, the beta 1-AR is not essential for either maintenance of resting heart rate or for maximally stressed cardiovascular performance...
  38. ncbi Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes
    Yongyu Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61822, USA
    J Biol Chem 283:1799-807. 2008
    ..This study not only helps us understand the endogenous agonist-dependent beta(2)AR signaling in animal heart but also offers an example of how G protein-coupled receptor signaling may be finely regulated by GRK in physiological settings...
  39. pmc Differential contribution of beta-adrenergic receptors expressed on radiosensitive versus radioresistant cells to protection against inflammation and mortality in murine endotoxemia
    Jill Walker-Brown
    Departments of Medicine and Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Shock 32:541-7. 2009
    ..Finally, we determined that beta3-AR subtype does not play a significant role in regulating LPS-mediated mortality and inflammation by evaluating mice lacking the beta1- and beta2-AR subtypes only...
  40. ncbi Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes
    K E Hadri
    INSERM Unité 282, Hopital Henri Mondor, 94010 Creteil, France
    J Biol Chem 272:24514-21. 1997
    ..These findings demonstrate a differential modulation by TNF-alpha of the three beta-adrenoreceptor subtypes in adipocytes, which may contribute to metabolic disorders induced by the cytokine in the adipocyte...
  41. pmc beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes
    Santhosh K Mani
    Division of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty Street, Box 250773, Charleston, SC 29425, USA
    J Mol Cell Cardiol 48:342-51. 2010
    ..In conclusion, this work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart...
  42. ncbi Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus
    S A Keller
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618
    Genomics 23:309-20. 1994
    ..This deletion, Del(19)TgN8052Mm, will be useful for genetic and functional studies of this region of mouse Chromosome 19...
  43. pmc Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling
    Keith Schutsky
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 31:14172-81. 2011
    ..These results demonstrate that the β(2) receptor can be a critical effector of acute stress, and that β(1) and β(2) receptors can have quite distinct roles in CNS signaling and cognition...
  44. doi Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors
    Björn Neubauer
    Physiologisches Institut, Universitat Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 301:F71-7. 2011
    ..Furthermore, β-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development...
  45. ncbi Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2433-42. 2006
    ..those for vesicular monoamine transporter 2 (VMAT2, slc18a2), alpha 2A adrenergic receptor (adra2a), and beta 1 adrenergic receptor (adrb1)...
  46. pmc Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo
    Thomas Pulinilkunnil
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 286:8798-809. 2011
    ..Furthermore, AMPK α Ser(485/491) phosphorylation may be a novel mechanism to inhibit AMPK activity in vivo and alter its biological effects...
  47. pmc Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation
    Qi Chen
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 286:4349-56. 2011
    ..Abnormal β(2)-AR activation at early pregnancy provided a molecular clue in explaining how maternal stress at early stages could adversely affect the pregnancy outcome...
  48. pmc Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice
    Stephanie L Catus
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 162:1700-15. 2011
    ..The aims of the present study are to identify which β-adrenoceptor subtypes are present in mouse astrocytes, the signal transduction mechanisms involved and whether β-adrenoceptor stimulation regulates glucose uptake...
  49. pmc FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes
    Shubai Liu
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 404:581-6. 2011
    ..Together, this new PKA activity biosensor provides a useful tool to directly visualize the dynamic regulation of PKA activity on the SR in cardiomyocytes under various physiological and clinical conditions...
  50. pmc {beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways
    Wei Wang
    Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China
    Am J Physiol Heart Circ Physiol 299:H322-31. 2010
    ..Our results suggest that catecholamines induce myocyte necrosis primarily through beta(1)-AR-mediated increases in I(Ca-L), but other mechanisms are also involved in rodents...
  51. ncbi Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1
    T Nabika
    Department of Laboratory Medicine, Shimane Medical University, Izumo, 693, Japan
    Mamm Genome 8:215-7. 1997
  52. ncbi Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptors
    Soo Mi Kim
    National Institute of Digestive and Diabetes and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Hypertension 50:103-9. 2007
    ....
  53. ncbi An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Endocrinology 148:3441-8. 2007
    ..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise...
  54. ncbi Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice
    Geneviève Tavernier
    Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard IFR31, CHU Rangueil, Batiment L3, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Pharmacol 68:793-9. 2005
    ..We conclude that the residual lipolytic effect observed in beta-less mice can be attributed to an unknown Gs-protein-coupled receptor with low affinity for catecholamines...
  55. ncbi Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos
    Stefan Cikos
    Institute of Animal Physiology, Slovak Academy of Sciences, Soltesovej 4, Kosice, Slovakia
    Mol Reprod Dev 71:145-53. 2005
    ..Thus, our results indicate that beta adrenergic receptors are expressed in mouse oocytes and preimplantation embryos and that ligands for the receptors can affect the mouse embryo even in the very early stages of development...
  56. ncbi betaAR signaling required for diet-induced thermogenesis and obesity resistance
    Eric S Bachman
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 297:843-5. 2002
    ..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity...
  57. ncbi A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus
    J M Rochelle
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 14:26-31. 1992
    ....
  58. ncbi Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor
    Lorenz Lehr
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    FEBS Lett 576:179-82. 2004
    ..Our data are the first report of a regulation by the beta3-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis...
  59. ncbi Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice
    W J Koch
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Trends Cardiovasc Med 9:77-81. 1999
    ..Signaling through beta ARs can be dampened by the actions of the beta AR kinase, a kinase whose expression and activity are elevated in chronic human heart failure...
  60. ncbi PKC-alpha regulates cardiac contractility and propensity toward heart failure
    Julian C Braz
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Nat Med 10:248-54. 2004
    ..Thus, PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca(2+) and signal transduction events, which can profoundly affect propensity toward heart failure...
  61. ncbi Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility
    Wei Zhong Zhu
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Circ Res 97:244-51. 2005
    ....
  62. ncbi Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors
    A Chruscinski
    Howard Hughes Medical Institute, Stanford University, Stanford, California, USA
    Mol Pharmacol 60:955-62. 2001
    ....
  63. ncbi Acute cold/restraint stress inhibits host resistance to Listeria monocytogenes via beta1-adrenergic receptors
    Ling Cao
    Wadsworth Center, New York State Department of Health, Empire State Plaza, 12201 0509, Albany, NY, USA
    Brain Behav Immun 17:121-33. 2003
    ....
  64. ncbi A putative beta2-adrenoceptor from the rainbow trout (Oncorhynuchus mykiss). Molecular characterization and pharmacology
    J G Nickerson
    Department of Biology, University of Ottawa, Ontario, Canada
    Eur J Biochem 268:6465-72. 2001
    ....
  65. ncbi Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes
    Benoit Boivin
    Centre de Recherche, Institut de Cardiologie de Montreal, Canada
    Cardiovasc Res 71:69-78. 2006
    ..We sought to determine if different beta-adrenergic receptor (betaAR) subtypes, and their associated signalling machinery, are functionally localized to nuclear membranes...
  66. ncbi Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury
    Shahab A Akhter
    Department of Surgery, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Heart Circ Physiol 290:H1427-32. 2006
    ..Thus genetic variation of the human beta(1)-AR may play a role in cardiac functional recovery after ischemic injury...
  67. pmc Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy
    Giovanni Fajardo
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    J Mol Cell Cardiol 40:375-83. 2006
    ..beta2-AR subtypes in knockout mice are recapitulated in myocytes isolated from these mice. beta2-ARs appear to play a cardioprotective role, whereas beta1-ARs a cardiotoxic role...
  68. ncbi A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse
    Craig J Daly
    Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland
    Physiol Genomics 9:85-91. 2002
    ....
  69. ncbi Sema3a maintains normal heart rhythm through sympathetic innervation patterning
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 13:604-12. 2007
    ..We conclude that appropriate cardiac Sema3a expression is needed for sympathetic innervation patterning and is critical for heart rate control...
  70. ncbi Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy
    Andrea D Eckhart
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 34:669-77. 2002
    ....
  71. ncbi Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection
    N N Rocha
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Parasitology 133:729-37. 2006
    ....
  72. ncbi Ontogeny of humoral heart rate regulation in the embryonic mouse
    G A Porter
    Division of Cardiology, Yale University School of Medicine, 464 Congress Ave, New Haven, CT 06520, USA
    Am J Physiol Regul Integr Comp Physiol 281:R401-7. 2001
    ..0. These results identify the adenosinergic system as the earliest and most potent regulator of embryonic cardiac function and show that prenatal responsiveness to catecholamines and acetylcholine develops at later embryonic stages...
  73. ncbi Genetic maps of polymorphic DNA loci on rat chromosome 1
    Y P Ding
    Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:320-7. 1996
    ..for five genes, gamma-aminobutyric acid receptor beta3 (Gabrb3), syntaxin 2 (Stx2), adrenergic receptor beta1 (Adrb1), carcinoembryonic antigen gene family member 1 (Cgm1), and lipogenic protein S14 (Lpgp), and 20 anonymous loci ..
  74. ncbi Corrected centromere orientation for mouse chromosome 19 MIT markers
    E M Eicher
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 4:223-5. 1993
  75. pmc Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers
    Mark D Levin
    Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:3420-36. 2009
    ..These data suggest that dysfunction of melanocyte-like cells in the atrium and pulmonary veins may contribute to atrial arrhythmias...
  76. pmc Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction
    ByungSu Yoo
    Departments of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 297:H1377-86. 2009
    ..Moreover, it appears that beta(1)AR signaling is detrimental to cardiac function following MI, possibly through activation of CaMKII...
  77. ncbi A distinct role for norepinephrine in memory retrieval
    Charles F Murchison
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 117:131-43. 2004
    ..These findings may be relevant to symptoms in several neuropsychiatric disorders as well as the treatment of cardiac failure with beta blockers...
  78. ncbi Beta1-adrenergic receptors on immune cells impair innate defenses against Listeria
    Rebecca T Emeny
    Laboratory of Clinical and Experimental Endocrinology and Immunology, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    J Immunol 178:4876-84. 2007
    ..In conclusion, beta1AR signaling has immunomodulatory effects on early cell-mediated immune responses; a lack of beta1AR signaling improves antilisterial defenses and cell-mediated immunity, in general...
  79. pmc Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox
    Dennis W McGraw
    University of Cincinnati College of Medicine, 231 Albert Sabin Way, Room G062, Cincinnati, Ohio 45267, USA
    J Clin Invest 112:619-26. 2003
    ..These results establish a mechanism of the beta-agonist paradox and identify a potential asthma modifier gene (phospholipase C-beta1), which may also be a therapeutic target in asthma when chronic beta-agonists are required...
  80. pmc Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse
    K Asai
    Weis Center for Research, Penn State College of Medicine, Danville, Pennsylvania 17822, USA
    J Clin Invest 104:551-8. 1999
    ..This study indicates that chronic sympathetic stimulation over an extended period is deleterious and results in cardiomyopathy. Conversely, beta-AR blockade is salutary in this situation and can prevent the development of cardiomyopathy...
  81. pmc Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
    Martin Angers
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem J 416:347-55. 2008
    ..The observed induction of Mfsd2a expression in cultured BAT cells by dibutyryl-cAMP is in agreement with this conclusion. The present study suggests that Mfsd2a plays a role in adaptive thermogenesis...
  82. ncbi Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor
    W J Koch
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Science 268:1350-3. 1995
    ..Because increased amounts of beta ARK1 and diminished cardiac beta-adrenergic responsiveness characterize heart failure, these animals may provide experimental models to study the role of beta ARK in heart disease...
  83. ncbi Molecular map of chromosome 19 including three genes affecting bleeding time: ep, ru, and bm
    E P O'Brien
    Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Buffalo, New York 14263
    Mamm Genome 5:356-60. 1994
    ..Several markers were found to be closely linked to the three genes and should be useful as entry points in their eventual molecular identification...
  84. pmc Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
    S Engelhardt
    Institut fur Pharmakologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 96:7059-64. 1999
    ..We conclude that overexpression of beta1-adrenergic receptors in the heart may lead to a short-lived improvement of cardiac function, but that increased beta1-adrenergic receptor signalling is ultimately detrimental...
  85. ncbi Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation
    Chihiro Hosoda
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Mol Pharmacol 67:912-22. 2005
    ..The study shows differential contributions of alpha1B- and alpha1D-ARs in BP regulation...
  86. ncbi Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution
    R J Oakey
    Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 10:338-44. 1991
    ..We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor...

Research Grants41

  1. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  2. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    IRA JAY GOLDBERG; Fiscal Year: 2010
    ..In addition, by understanding how fat regulates genes it is likely that better drugs can be developed for treatment of hypertriglyceridemia and insulin resistance. ..
  3. CORE--Skeletal Phenotyping Core
    Mary Bouxsein; Fiscal Year: 2007
    ..abstract_text> ..
  4. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2007
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  5. Creating Glucose Responsive Cardiovascular Complications
    Ira Goldberg; Fiscal Year: 2007
    ..Both processes will be studied in vivo and mechanistic information obtained by studying gene and protein expression. ..
  6. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary Bouxsein; Fiscal Year: 2007
    ....
  7. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    Ira Goldberg; Fiscal Year: 2007
    ..abstract_text> ..
  8. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary L Bouxsein; Fiscal Year: 2010
    ....
  9. Mechanisms of fatty acid uptake by cardiac muscle
    IRA JAY GOLDBERG; Fiscal Year: 2010
    ..The experiments in this application seek to understand how fats, including dietary fat, enter the heart and to determine which of these fats are responsible for heart failure. ..
  10. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2010
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  11. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2009
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  12. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2007
    ..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
  13. Mechanisms of fatty acid uptake by cardiac muscle
    Ira Goldberg; Fiscal Year: 2007
    ..Our overall objective is to understand how the heart derived energy from fat, how it compensates for a defect in fat uptake, and how excess fat leads to cardiac dysfunction and premature death. ..
  14. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
  15. When Belief Becomes False Memory: A Processing Account
    Daniel Bernstein; Fiscal Year: 2003
    ..The proposed work will help clarify the relationship between belief and memory, thereby delineating some of the mechanisms responsible for false memory. ..
  16. High Resolution Ultrasound Biomicroscopy System
    Daniel Bernstein; Fiscal Year: 2005
    ....
  17. Microcomputed Tomography Device (Scanco UCT40)
    Mary Bouxsein; Fiscal Year: 2004
    ..abstract_text> ..
  18. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2004
    ..abstract_text> ..