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Genomes and Genes | Adrb1SummaryGene Symbol: Adrb1 Description: adrenergic receptor, beta 1 Alias: Adrb-1, beta-AR, beta 1-AR, beta-1 adrenergic receptor, beta-1 adrenoceptor, beta-1 adrenoreceptor, cardiac beta adrenergic receptor Species: mouse Top Publications
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Publications
Physiological consequences of beta-adrenergic receptor disruptionD K Rohrer
Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
J Mol Med (Berl) 76:764-72. 1998....- Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signalingGokhan M Mutlu
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
Circ Res 94:1091-100. 2004..These findings indicate that betaAR signaling may not be necessary for basal AFC, and that beta2AR is essential for the adaptive physiological response needed to clear excess fluid from the alveolar airspace of normal and injured lungs... 
Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contractionDagoberto Soto
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
Circ Res 104:770-9. 2009..Together, our data have revealed insights into kinetics of PKA activities in signaling propagation under neurohormonal stimulation...- Confinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolaeCathleen D Valentine
Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Mol Biol Cell 22:2970-82. 2011.... 
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesityRuben Nogueiras
Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
J Neurosci 29:5916-25. 2009..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...- Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptorsA Galindo-Tovar
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Br J Pharmacol 153:710-20. 2008..We investigated the influence of the PDE3 inhibitor cilostamide and PDE4 inhibitor rolipram on the effects of (-)-adrenaline in three regions of murine heart... - Primary structure of the mouse beta 1-adrenergic receptor geneJ R Jasper
Department of Pediatrics, Stanford University, CA 94305
Biochim Biophys Acta 1178:307-9. 1993..7% identical to the human sequence, 98.5% identical to the rat sequence, and contains a consensus site for N-linked glycosylation at Asn-15 and a cAMP-dependent protein kinase phosphorylation site at Ser-301... - The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytesYang Xiang
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institution, B157 Beckman Center, Stanford Medical Center, Palo Alto, CA 94043, USA
J Biol Chem 277:33783-90. 2002..These studies suggest that association of the beta(1)AR with PSD-95 or a related protein dictates signaling specificity by retaining the receptor at the cell surface and preventing interaction with G(i)... - Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosisH Kiriazis
Department of Experimental Cardiology, Baker Heart Research Institute, Melbourne, Victoria, Australia
Br J Pharmacol 153:684-92. 2008..We investigated the effect of beta-adrenoceptors on cardiac hypertrophic growth using beta(1)- and beta(2)-adrenoreceptor knockout and wild-type (WT) mice... - Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fastingMaria Jimenez
Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
FEBS Lett 530:37-40. 2002..Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting... - Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptorsD K Rohrer
Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, California 94304, USA
J Biol Chem 274:16701-8. 1999.... - Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout miceE Devic
Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA
Mol Pharmacol 60:577-83. 2001The sympathetic nervous system modulates cardiac contractility and rate by activating beta-adrenergic receptors (beta AR) expressed on cardiac myocytes and specialized cells in the sinoatrial node and the conduction system... - Essential role of beta-adrenergic receptor kinase 1 in cardiac development and functionM Jaber
Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 93:12974-9. 1996.... - Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effectsD K Rohrer
Department of Pediatrics, Stanford University, CA 94305, USA
Proc Natl Acad Sci U S A 93:7375-80. 1996..These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes... - An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activationShinji Miura
Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Endocrinology 148:3441-8. 2007..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise... - Vagal tone dominates autonomic control of mouse heart rate at thermoneutralityS J Swoap
Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
Am J Physiol Heart Circ Physiol 294:H1581-8. 2008..These experiments conclusively demonstrate that in the absence of cold stress, regulation of vagal tone and modulation of intrinsic rate are important determinants of HR control in the mouse... - Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathyGiovanni Fajardo
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
J Mol Cell Cardiol 40:375-83. 2006..beta2-AR subtypes in knockout mice are recapitulated in myocytes isolated from these mice. beta2-ARs appear to play a cardioprotective role, whereas beta1-ARs a cardiotoxic role... - Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injuryShahab A Akhter
Department of Surgery, University of Cincinnati College of Medicine, Ohio, USA
Am J Physiol Heart Circ Physiol 290:H1427-32. 2006..Thus genetic variation of the human beta(1)-AR may play a role in cardiac functional recovery after ischemic injury... - Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension testJames J Crowley
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 31:2433-42. 2006..those for vesicular monoamine transporter 2 (VMAT2, slc18a2), alpha 2A adrenergic receptor (adra2a), and beta 1 adrenergic receptor (adrb1)... - Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4Wito Richter
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
EMBO J 27:384-93. 2008.... - Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytesBenoit Boivin
Centre de Recherche, Institut de Cardiologie de Montreal, Canada
Cardiovasc Res 71:69-78. 2006..We sought to determine if different beta-adrenergic receptor (betaAR) subtypes, and their associated signalling machinery, are functionally localized to nuclear membranes... - Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infectionN N Rocha
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Parasitology 133:729-37. 2006.... - Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytesYongyu Wang
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61822, USA
J Biol Chem 283:1799-807. 2008..This study not only helps us understand the endogenous agonist-dependent beta(2)AR signaling in animal heart but also offers an example of how G protein-coupled receptor signaling may be finely regulated by GRK in physiological settings... - Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptorsSoo Mi Kim
National Institute of Digestive and Diabetes and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Hypertension 50:103-9. 2007.... - Sema3a maintains normal heart rhythm through sympathetic innervation patterningMasaki Ieda
Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Nat Med 13:604-12. 2007..We conclude that appropriate cardiac Sema3a expression is needed for sympathetic innervation patterning and is critical for heart rate control... - Persistence of circadian variation in arterial blood pressure in beta1/beta2-adrenergic receptor-deficient miceSoo Mi Kim
National Institute of Digestive and Diabetes and Kidney Diseases, NIH, Bethesda, MD 20892, USA
Am J Physiol Regul Integr Comp Physiol 294:R1427-34. 2008..Our results also confirm that locomotor activity contributes strongly to circadian variation in blood pressure in mice... - HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specificationCarley A E Shaut
Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS Genet 4:e1000073. 2008.... - Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activationBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 28:6642-51. 2008.... - Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptorsBjörn Neubauer
Physiologisches Institut, Universitat Regensburg, D 93040 Regensburg, Germany
Am J Physiol Renal Physiol 301:F71-7. 2011..Furthermore, β-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development... - Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivoThomas Pulinilkunnil
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 286:8798-809. 2011..Furthermore, AMPK α Ser(485/491) phosphorylation may be a novel mechanism to inhibit AMPK activity in vivo and alter its biological effects... - Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantationQi Chen
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
J Biol Chem 286:4349-56. 2011..Abnormal β(2)-AR activation at early pregnancy provided a molecular clue in explaining how maternal stress at early stages could adversely affect the pregnancy outcome... - Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout miceStephanie L Catus
Department of Pharmacology, Monash University, Clayton, Victoria, Australia
Br J Pharmacol 162:1700-15. 2011..The aims of the present study are to identify which β-adrenoceptor subtypes are present in mouse astrocytes, the signal transduction mechanisms involved and whether β-adrenoceptor stimulation regulates glucose uptake... - FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytesShubai Liu
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Biochem Biophys Res Commun 404:581-6. 2011..Together, this new PKA activity biosensor provides a useful tool to directly visualize the dynamic regulation of PKA activity on the SR in cardiomyocytes under various physiological and clinical conditions... - {beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathwaysWei Wang
Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China
Am J Physiol Heart Circ Physiol 299:H322-31. 2010..Our results suggest that catecholamines induce myocyte necrosis primarily through beta(1)-AR-mediated increases in I(Ca-L), but other mechanisms are also involved in rodents... - beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytesSanthosh K Mani
Division of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty Street, Box 250773, Charleston, SC 29425, USA
J Mol Cell Cardiol 48:342-51. 2010..In conclusion, this work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart... - Differential contribution of beta-adrenergic receptors expressed on radiosensitive versus radioresistant cells to protection against inflammation and mortality in murine endotoxemiaJill Walker-Brown
Departments of Medicine and Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
Shock 32:541-7. 2009..Finally, we determined that beta3-AR subtype does not play a significant role in regulating LPS-mediated mortality and inflammation by evaluating mice lacking the beta1- and beta2-AR subtypes only... - Calmodulin kinase II is required for fight or flight sinoatrial node physiologyYuejin Wu
Departments of Internal Medicine and Molecular Physiology and Biophysics, University of Iowa, 2256 CBRB, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 106:5972-7. 2009.... - Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunctionGeertje Lewin
Institute of Pharmacology and Toxicology, University of Munster, Munster, Germany
Circulation 119:79-88. 2009.... - cAMP-mediated beta-adrenergic signaling negatively regulates Gq-coupled receptor-mediated fetal gene response in cardiomyocytesMario Patrizio
Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
J Mol Cell Cardiol 45:761-9. 2008.... - Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomyM L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Endocrinology 150:144-52. 2009..Our findings also suggest direct positive effects of weight and/or leptin on bone turnover and cortical bone structure, independent of adrenergic signaling... - Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signalingKeith Schutsky
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
J Neurosci 31:14172-81. 2011..These results demonstrate that the β(2) receptor can be a critical effector of acute stress, and that β(1) and β(2) receptors can have quite distinct roles in CNS signaling and cognition... - Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variabilityPhillip M Ecker
Dept of Pediatrics, Stanford University, Stanford, California, USA
Am J Physiol Heart Circ Physiol 290:H192-9. 2006..These results demonstrate the differential role of beta-AR subtypes in regulating autonomic signaling... - Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypesDaniel Bernstein
Dept of Pediatrics, 750 Welch Rd, Suite 305, Palo Alto, CA 94304, USA
Am J Physiol Heart Circ Physiol 289:H2441-9. 2005.... - betaAR signaling required for diet-induced thermogenesis and obesity resistanceEric S Bachman
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
Science 297:843-5. 2002..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity... - Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathyAndrea D Eckhart
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Mol Cell Cardiol 34:669-77. 2002.... - A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouseCraig J Daly
Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland
Physiol Genomics 9:85-91. 2002.... - A putative beta2-adrenoceptor from the rainbow trout (Oncorhynuchus mykiss). Molecular characterization and pharmacologyJ G Nickerson
Department of Biology, University of Ottawa, Ontario, Canada
Eur J Biochem 268:6465-72. 2001.... - Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptorsA Chruscinski
Howard Hughes Medical Institute, Stanford University, Stanford, California, USA
Mol Pharmacol 60:955-62. 2001.... - Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted miceW J Koch
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Trends Cardiovasc Med 9:77-81. 1999..Signaling through beta ARs can be dampened by the actions of the beta AR kinase, a kinase whose expression and activity are elevated in chronic human heart failure... - Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1T Nabika
Department of Laboratory Medicine, Shimane Medical University, Izumo, 693, Japan
Mamm Genome 8:215-7. 1997 - Alterations in dynamic heart rate control in the beta 1-adrenergic receptor knockout mouseD K Rohrer
Department of Pediatrics, Stanford University, California 94305, USA
Am J Physiol 274:H1184-93. 1998..Thus, in mice, the beta 1-AR is not essential for either maintenance of resting heart rate or for maximally stressed cardiovascular performance... - Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase IIWei Zhong Zhu
Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
J Clin Invest 111:617-25. 2003..These findings indicate that CaMKII constitutes a novel PKA-independent linkage of beta(1)AR stimulation to cardiomyocyte apoptosis that has been implicated in the overall process of chronic heart failure... - Acute cold/restraint stress inhibits host resistance to Listeria monocytogenes via beta1-adrenergic receptorsLing Cao
Wadsworth Center, New York State Department of Health, Empire State Plaza, 12201 0509, Albany, NY, USA
Brain Behav Immun 17:121-33. 2003.... - Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytesK E Hadri
INSERM Unité 282, Hopital Henri Mondor, 94010 Creteil, France
J Biol Chem 272:24514-21. 1997..These findings demonstrate a differential modulation by TNF-alpha of the three beta-adrenoreceptor subtypes in adipocytes, which may contribute to metabolic disorders induced by the cytokine in the adipocyte... - Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractilityWei Zhong Zhu
Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Circ Res 97:244-51. 2005.... - Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout miceGeneviève Tavernier
Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard IFR31, CHU Rangueil, Batiment L3, BP 84225, 31432 Toulouse Cedex 4, France
Mol Pharmacol 68:793-9. 2005..We conclude that the residual lipolytic effect observed in beta-less mice can be attributed to an unknown Gs-protein-coupled receptor with low affinity for catecholamines... - Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryosStefan Cikos
Institute of Animal Physiology, Slovak Academy of Sciences, Soltesovej 4, Kosice, Slovakia
Mol Reprod Dev 71:145-53. 2005..Thus, our results indicate that beta adrenergic receptors are expressed in mouse oocytes and preimplantation embryos and that ligands for the receptors can affect the mouse embryo even in the very early stages of development... - A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locusJ M Rochelle
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Genomics 14:26-31. 1992.... - Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptorLorenz Lehr
Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
FEBS Lett 576:179-82. 2004..Our data are the first report of a regulation by the beta3-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis... - Chromosomal organization of adrenergic receptor genesT L Yang-Feng
Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
Proc Natl Acad Sci U S A 87:1516-20. 1990..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules... - Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locusS A Keller
Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618
Genomics 23:309-20. 1994..This deletion, Del(19)TgN8052Mm, will be useful for genetic and functional studies of this region of mouse Chromosome 19... - PKC-alpha regulates cardiac contractility and propensity toward heart failureJulian C Braz
Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Nat Med 10:248-54. 2004..Thus, PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca(2+) and signal transduction events, which can profoundly affect propensity toward heart failure... - Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggersMark D Levin
Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 119:3420-36. 2009..These data suggest that dysfunction of melanocyte-like cells in the atrium and pulmonary veins may contribute to atrial arrhythmias... - Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarctionByungSu Yoo
Departments of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Heart Circ Physiol 297:H1377-86. 2009..Moreover, it appears that beta(1)AR signaling is detrimental to cardiac function following MI, possibly through activation of CaMKII... - Corrected centromere orientation for mouse chromosome 19 MIT markersE M Eicher
Jackson Laboratory, Bar Harbor, Maine 04609
Mamm Genome 4:223-5. 1993 - Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesisMartin Angers
Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Biochem J 416:347-55. 2008..The observed induction of Mfsd2a expression in cultured BAT cells by dibutyryl-cAMP is in agreement with this conclusion. The present study suggests that Mfsd2a plays a role in adaptive thermogenesis... - Beta1-adrenergic receptors on immune cells impair innate defenses against ListeriaRebecca T Emeny
Laboratory of Clinical and Experimental Endocrinology and Immunology, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
J Immunol 178:4876-84. 2007..In conclusion, beta1AR signaling has immunomodulatory effects on early cell-mediated immune responses; a lack of beta1AR signaling improves antilisterial defenses and cell-mediated immunity, in general... - A distinct role for norepinephrine in memory retrievalCharles F Murchison
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell 117:131-43. 2004..These findings may be relevant to symptoms in several neuropsychiatric disorders as well as the treatment of cardiac failure with beta blockers... - Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradoxDennis W McGraw
University of Cincinnati College of Medicine, 231 Albert Sabin Way, Room G062, Cincinnati, Ohio 45267, USA
J Clin Invest 112:619-26. 2003..These results establish a mechanism of the beta-agonist paradox and identify a potential asthma modifier gene (phospholipase C-beta1), which may also be a therapeutic target in asthma when chronic beta-agonists are required... - Ontogeny of humoral heart rate regulation in the embryonic mouseG A Porter
Division of Cardiology, Yale University School of Medicine, 464 Congress Ave, New Haven, CT 06520, USA
Am J Physiol Regul Integr Comp Physiol 281:R401-7. 2001..0. These results identify the adenosinergic system as the earliest and most potent regulator of embryonic cardiac function and show that prenatal responsiveness to catecholamines and acetylcholine develops at later embryonic stages... - Genetic maps of polymorphic DNA loci on rat chromosome 1Y P Ding
Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA
Genomics 36:320-7. 1996..for five genes, gamma-aminobutyric acid receptor beta3 (Gabrb3), syntaxin 2 (Stx2), adrenergic receptor beta1 (Adrb1), carcinoembryonic antigen gene family member 1 (Cgm1), and lipogenic protein S14 (Lpgp), and 20 anonymous loci .. - Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouseK Asai
Weis Center for Research, Penn State College of Medicine, Danville, Pennsylvania 17822, USA
J Clin Invest 104:551-8. 1999..This study indicates that chronic sympathetic stimulation over an extended period is deleterious and results in cardiomyopathy. Conversely, beta-AR blockade is salutary in this situation and can prevent the development of cardiomyopathy... - Molecular map of chromosome 19 including three genes affecting bleeding time: ep, ru, and bmE P O'Brien
Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Buffalo, New York 14263
Mamm Genome 5:356-60. 1994..Several markers were found to be closely linked to the three genes and should be useful as entry points in their eventual molecular identification... - Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitorW J Koch
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Science 268:1350-3. 1995..Because increased amounts of beta ARK1 and diminished cardiac beta-adrenergic responsiveness characterize heart failure, these animals may provide experimental models to study the role of beta ARK in heart disease... - Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolutionR J Oakey
Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
Genomics 10:338-44. 1991..We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor... - Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulationChihiro Hosoda
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
Mol Pharmacol 67:912-22. 2005..The study shows differential contributions of alpha1B- and alpha1D-ARs in BP regulation... - Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic miceS Engelhardt
Institut fur Pharmakologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
Proc Natl Acad Sci U S A 96:7059-64. 1999..We conclude that overexpression of beta1-adrenergic receptors in the heart may lead to a short-lived improvement of cardiac function, but that increased beta1-adrenergic receptor signalling is ultimately detrimental...
Research Grants
- Hyperglycemia, Aldose Reducatse & Murine AtherosclerosisIra Goldberg; Fiscal Year: 2005..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
- EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITYIRA JAY GOLDBERG; Fiscal Year: 2010..In addition, by understanding how fat regulates genes it is likely that better drugs can be developed for treatment of hypertriglyceridemia and insulin resistance. ..
- CORE--Skeletal Phenotyping CoreMary Bouxsein; Fiscal Year: 2007..abstract_text> ..
- ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYDaniel Bernstein; Fiscal Year: 2007..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
- Creating Glucose Responsive Cardiovascular ComplicationsIra Goldberg; Fiscal Year: 2007..Both processes will be studied in vivo and mechanistic information obtained by studying gene and protein expression. ..
- Biomechanics of Vertebral Fracture: The Framingham QCT StudyMary Bouxsein; Fiscal Year: 2007....
- EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITYIra Goldberg; Fiscal Year: 2007..abstract_text> ..
- Biomechanics of Vertebral Fracture: The Framingham QCT StudyMary L Bouxsein; Fiscal Year: 2010....
- Mechanisms of fatty acid uptake by cardiac muscleIRA JAY GOLDBERG; Fiscal Year: 2010..The experiments in this application seek to understand how fats, including dietary fat, enter the heart and to determine which of these fats are responsible for heart failure. ..
- ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYDaniel Bernstein; Fiscal Year: 2010..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
- ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYDaniel Bernstein; Fiscal Year: 2009..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
- REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTINMary Bouxsein; Fiscal Year: 2007..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
- Mechanisms of fatty acid uptake by cardiac muscleIra Goldberg; Fiscal Year: 2007..Our overall objective is to understand how the heart derived energy from fat, how it compensates for a defect in fat uptake, and how excess fat leads to cardiac dysfunction and premature death. ..
- ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINSIra Goldberg; Fiscal Year: 2003..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
- When Belief Becomes False Memory: A Processing AccountDaniel Bernstein; Fiscal Year: 2003..The proposed work will help clarify the relationship between belief and memory, thereby delineating some of the mechanisms responsible for false memory. ..
- High Resolution Ultrasound Biomicroscopy SystemDaniel Bernstein; Fiscal Year: 2005....
- Microcomputed Tomography Device (Scanco UCT40)Mary Bouxsein; Fiscal Year: 2004..abstract_text> ..
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