Genomes and Genes
Gene Symbol: Adra1d
Description: adrenergic receptor, alpha 1d
Alias: Adra-1, Adra1, Adra1a, Gpcr8, Spr8, [a]1d, alpha1D-AR, alpha-1D adrenergic receptor, alpha-1A adrenergic receptor, alpha-1D adrenoceptor, alpha-1D adrenoreceptor
- Yang Feng T, Xue F, Zhong W, Cotecchia S, Frielle T, Caron M, et al. Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990;87:1516-20 pubmed..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules. ..
- Alonso Llamazares A, Zamanillo D, Casanova E, Ovalle S, Calvo P, Chinchetru M. Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse. J Neurochem. 1995;65:2387-92 pubmed..The alpha 1a subtype is also expressed in many tissues, whereas the alpha 1b subtype has a more restricted expression, with high levels in striatum, brainstem, and diencephalus. ..
- Milligan G, Svoboda P, Brown C. Why are there so many adrenoceptor subtypes?. Biochem Pharmacol. 1994;48:1059-71 pubmed
- Kandasamy K, Choudhury S, Singh V, Addison M, Darzi S, Kasa J, et al. Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of Î±1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta. J Cardiovasc Pharmacol Ther. 2016;21:100-13 pubmed publisher
- Rockman H, Koch W, Lefkowitz R. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol. 1997;272:H1553-9 pubmed..The purpose of this review is to summarize current knowledge about the regulation of cardiovascular homeostasis involving signaling pathways through stimulation of adrenergic receptors...
- Buckwalter M, Katz R, Camper S. Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross. Genomics. 1991;10:515-26 pubmed..The localization of the alpha 1 adrenergic receptor, Adra-1, extends a known region of synteny conservation between mouse chromosome 11 and human chromosome 5, and suggests that a human counterpart to df would map to human chromosome 5. ..
- Villalobos Molina R, Vázquez Cuevas F, Lopez Guerrero J, Figueroa García M, Gallardo Ortiz I, Ibarra M, et al. Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II. Auton Autacoid Pharmacol. 2008;28:61-7 pubmed publisher
- Gericke A, Kordasz M, Steege A, Sanbe A, Goloborodko E, Vetter J, et al. Functional role of ?1-adrenoceptor subtypes in murine ophthalmic arteries. Invest Ophthalmol Vis Sci. 2011;52:4795-9 pubmed publisher..These findings provide evidence that the ?(1A)-AR subtype mediates adrenergic vasoconstriction in murine ophthalmic arteries. ..
- Pietri M, Schneider B, Mouillet Richard S, Ermonval M, Mutel V, Launay J, et al. Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells. FASEB J. 2005;19:1078-87 pubmed
- Mishima K, Tanoue A, Tsuda M, Hasebe N, Fukue Y, Egashira N, et al. Characteristics of behavioral abnormalities in alpha1d-adrenoceptors deficient mice. Behav Brain Res. 2004;152:365-73 pubmed
- Ross S, Rorabaugh B, Chalothorn D, Yun J, Gonzalez Cabrera P, McCune D, et al. The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model. Cardiovasc Res. 2003;60:598-607 pubmed..These results suggest that the alpha(1B)-AR does not have a major role in the positive inotropic response in the mouse myocardium but may negatively modulate the response of the alpha(1A)-AR. ..
- Arai K, Tanoue A, Goda N, Takeda M, Takahashi K, Tsujimoto G. Characterization of the mouse alpha1D-adrenergic receptor gene. Jpn J Pharmacol. 1999;81:271-8 pubmed..Isolation of this gene will allow further investigation, via gene knock-outs and deletion mutants, of the mechanisms of transcriptional regulation and a greater understanding of the physiological role of alpha1D-AR. ..
- Chu C, Kunitake T, Kato K, Watanabe S, Qiu D, Tanoue A, et al. The alpha 1D-adrenergic receptor modulates cardiovascular and drinking responses to central salt loading in mice. Neurosci Lett. 2004;356:33-6 pubmed..These results suggest that alpha(1D)-AR is, at least in part, involved in central salt-induced but not ANG II-induced hypertension and water intake. ..
- Tanoue A, Nasa Y, Koshimizu T, Shinoura H, Oshikawa S, Kawai T, et al. The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. J Clin Invest. 2002;109:765-75 pubmed..We conclude that the alpha(1D)-AR participates directly in sympathetic regulation of systemic blood pressure by vasoconstriction. ..
- Bexis S, Cleary L, McGrath J, Tanoue A, Tsujimoto G, Docherty J. Alpha(1D)-adrenoceptors mediate nerve and agonist-evoked contractions in mouse vas deferens: evidence obtained from knockout technology. Auton Autacoid Pharmacol. 2008;28:81-5 pubmed publisher..5 It is concluded that alpha(1D)-adrenoceptors mediate a component of nerve- and agonist-evoked contractions of the vas deferens of WT mice. ..
- Lyssand J, DeFino M, Tang X, Hertz A, Feller D, Wacker J, et al. Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J Biol Chem. 2008;283:18792-800 pubmed publisher..Our findings demonstrate that syntrophin and utrophin associate with alpha(1D)-ARs to create a functional signalosome, which is essential for alpha(1D)-AR regulation of vascular tone and blood pressure. ..
- Alday A, Urrutia J, Gallego M, Casis O. ?1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels. Channels (Austin). 2010;4:168-78 pubmed..Therefore, both groups of preassembled proteins are maintained in close proximity by caveolin-3. A different I(to) channel population localizes in non-caveolar membrane rafts and is not sensitive to ?1-adrenergic regulation. ..
- Cohn H, Harris D, Pesant S, Pfeiffer M, Zhou R, Koch W, et al. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. Am J Physiol Heart Circ Physiol. 2008;295:H1695-704 pubmed publisher..This is the first study to suggest that VSM alpha(1D)ARs are a GRK2 substrate in vivo. ..
- Chen Z, Hague C, Hall R, Minneman K. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. J Biol Chem. 2006;281:12414-20 pubmed..This direct interaction may provide new information about the regulation of alpha1D-AR signaling and the role of syntrophins in modulating G protein-coupled receptor function. ..
- Pulinilkunnil T, He H, Kong D, Asakura K, Peroni O, Lee A, et al. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011;286:8798-809 pubmed publisher..Furthermore, AMPK ? Ser(485/491) phosphorylation may be a novel mechanism to inhibit AMPK activity in vivo and alter its biological effects. ..
- Oakey R, Caron M, Lefkowitz R, Seldin M. Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics. 1991;10:338-44 pubmed..We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor. ..
- Sadalge A, Coughlin L, Fu H, Wang B, Valladares O, Valentino R, et al. alpha 1d Adrenoceptor signaling is required for stimulus induced locomotor activity. Mol Psychiatry. 2003;8:664-72 pubmed..While the sensitivity of noradrenergic neurons to environmental stimuli has been well documented, our data demonstrate that at least some of these post-synaptic responses are mediated by alpha 1d adrenergic receptors. ..
- Hosoda C, Hiroyama M, Sanbe A, Birumachi J, Kitamura T, Cotecchia S, et al. Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery. Am J Physiol Heart Circ Physiol. 2007;293:H514-9 pubmed..These results suggest that lack of both alpha(1A)- and alpha(1B)-ARs could be necessary to inhibit neointimal formation in the mouse femoral artery. ..
- Sporkova A, PEREZ RIVERA A, Galligan J. Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries. Eur J Pharmacol. 2010;643:239-46 pubmed publisher..This interaction enhances venous adrenergic reactivity. Mesenteric vein-specific alpha(2)-adrenoceptor linked Ca(2+) and perhaps other signaling pathways account for enhanced venous adrenergic reactivity. ..
- Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, et al. Alpha1-adrenoceptors are required for normal male sexual function. Br J Pharmacol. 2007;152:332-40 pubmed..These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility. ..
- Buckwalter M, Testa C, Noebels J, Camper S. Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response. Genomics. 1993;17:279-86 pubmed..Synteny homology and phenotypic similarities suggest that spasmodic mice may be a genetic model for the inherited human startle disease, hyperekplexia (STHE). ..
- Faber J, Szymeczek C, Cotecchia S, Thomas S, Tanoue A, Tsujimoto G, et al. Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2007;292:H2316-23 pubmed..These data suggest that catecholamine stimulation of alpha(1B)- and alpha(1D)-ARs contributes significantly to vascular remodeling in hypoxic PH. ..
- Suzuki F, Miyamoto S, Takita M, Oshita M, Watanabe Y, Kakizuka A, et al. Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor. Biochim Biophys Acta. 1997;1323:6-11 pubmed..Competitive RT/PCR assays revealed wide tissue distribution of the alpha 1d-adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex. ..
- Wang G, Yeh C, Jensen B, Mann M, Simpson P, Baker A. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol. 2010;298:H913-20 pubmed publisher..Since alpha(1)-AR agonist catecholamines are elevated in heart failure, increased alpha(1)-AR inotropic responses in the RV myocardium may be adaptive in heart failure by helping the failing RV respond to increased pulmonary pressures. ..
- Kordasz M, Manicam C, Steege A, Goloborodko E, Amato C, Laspas P, et al. Role of Î±â‚-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice. Invest Ophthalmol Vis Sci. 2014;55:8295-301 pubmed publisher..The lack of a single Î±â‚-AR subtype does not appear to cause atrophy in the mouse iris. ..
- Nagle D, McGrail S, Vitale J, Woolf E, Dussault B, DiRocco L, et al. The mahogany protein is a receptor involved in suppression of obesity. Nature. 1999;398:148-52 pubmed
- Chalothorn D, McCune D, Edelmann S, Tobita K, Keller B, Lasley R, et al. Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes. J Pharmacol Exp Ther. 2003;305:1045-53 pubmed..The alpha 1B-AR appears to be involved in the regulation of cardiac growth and contractile function, whereas the alpha 1D-AR is coupled to smooth muscle contraction and the regulation of systemic arterial blood pressure. ..
- Harasawa I, Honda K, Tanoue A, Shinoura H, Ishida Y, Okamura H, et al. Responses to noxious stimuli in mice lacking alpha(1d)-adrenergic receptors. Neuroreport. 2003;14:1857-60 pubmed..These results suggest that alpha1d-AR in the spinal cord contributes to thermal pronociception; and that the jump behavior seen when escaping from heat is inhibited via the supraspinal alpha1d-AR. ..
- Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, et al. Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through Î²1- and Î±1-Adrenergic Receptor-Mediated Signaling in Mice. PLoS ONE. 2015;10:e0133664 pubmed publisher..We also revealed the important role of Î²1- and Î±1-AR-mediated signaling in the development of AF through in-vivo and in-vitro experiments. ..
- Tanoue A, Koba M, Miyawaki S, Koshimizu T, Hosoda C, Oshikawa S, et al. Role of the alpha1D-adrenergic receptor in the development of salt-induced hypertension. Hypertension. 2002;40:101-6 pubmed
- Koshimizu T, Tanoue A, Tsujimoto G. Clinical implications from studies of alpha1 adrenergic receptor knockout mice. Biochem Pharmacol. 2007;73:1107-12 pubmed..By combining gene targeting techniques with pharmacological tools, the specific roles of alpha1-AR subtypes could be delineated. ..
- Cikos S, Rehák P, Czikková S, Veselá J, Koppel J. Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes. Reproduction. 2007;133:1139-47 pubmed