Gene Symbol: Adra1d
Description: adrenergic receptor, alpha 1d
Alias: Adra-1, Adra1, Adra1a, Gpcr8, Spr8, [a]1d, alpha1D-AR, alpha-1D adrenergic receptor, alpha-1A adrenergic receptor, alpha-1D adrenoceptor, alpha-1D adrenoreceptor
Species: mouse
Products:     Adra1d

Top Publications

  1. Abe Dohmae S, Takagi Y, Harada N. Autonomous expression of aromatase during development of mouse brain is modulated by neurotransmitters. J Steroid Biochem Mol Biol. 1997;61:299-306 pubmed
  2. Erami C, Zhang H, Tanoue A, Tsujimoto G, Thomas S, Faber J. Adrenergic catecholamine trophic activity contributes to flow-mediated arterial remodeling. Am J Physiol Heart Circ Physiol. 2005;289:H744-53 pubmed
    ..These findings suggest that catecholamine-induced trophic activity contributes to both flow-mediated negative remodeling and adaptive positive arterial remodeling. ..
  3. Methven L, Simpson P, McGrath J. Alpha1A/B-knockout mice explain the native alpha1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other alpha1-subtypes. Br J Pharmacol. 2009;158:1663-75 pubmed publisher
    ..Equivalent levels of receptors did not correspond to equivalent responses. In conclusion, alpha(1)-subtypes do not interact but provide independent alternative signals for vascular regulation. ..
  4. Schneider B, Pietri M, Mouillet Richard S, Ermonval M, Mutel V, Launay J, et al. Control of bioamine metabolism by 5-HT2B and alpha 1D autoreceptors through reactive oxygen species and tumor necrosis factor-alpha signaling in neuronal cells. Ann N Y Acad Sci. 2006;1091:123-41 pubmed
    ..Eventually, we might explain the origin of oxidative stress and high level of TNF-alpha in neurodegenerative diseases as a consequence of deviation of normal signaling pathways coupled to neurotransmitters. ..
  5. McKenzie A, Li X, Largaespada D, Sato A, Kaneda A, Zurawski S, et al. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol. 1993;150:5436-44 pubmed
    ..Both genes map to chromosomal locations adjacent to genes encoding other cytokines, including IL-3, GM-CSF, IL-5, and IL-4, suggesting that IL-13 is another member of this cytokine gene family that may have arisen by gene duplication. ..
  6. Carlson G, Ebeling C, Torchia M, Westaway D, Prusiner S. Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse. Genetics. 1993;133:979-88 pubmed
    ..Thus, Prn-pb transgenes and Prn-i may modulate scrapie pathogenesis by different mechanisms. ..
  7. Turnbull L, McCloskey D, O Connell T, Simpson P, Baker A. Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. Am J Physiol Heart Circ Physiol. 2003;284:H1104-9 pubmed
    ..Furthermore, alpha(1)-AR inotropic responses depend critically on the experimental conditions. ..
  8. Han S, Herbison A. Norepinephrine suppresses gonadotropin-releasing hormone neuron excitability in the adult mouse. Endocrinology. 2008;149:1129-35 pubmed
    ..These data force a reanalysis of existing models explaining the effects of NE on gonadotropin secretion. ..
  9. Hosoda C, Koshimizu T, Tanoue A, Nasa Y, Oikawa R, Tomabechi T, et al. Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation. Mol Pharmacol. 2005;67:912-22 pubmed
    ..The study shows differential contributions of alpha1B- and alpha1D-ARs in BP regulation. ..

More Information


  1. Yang Feng T, Xue F, Zhong W, Cotecchia S, Frielle T, Caron M, et al. Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990;87:1516-20 pubmed
    ..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules. ..
  2. Alonso Llamazares A, Zamanillo D, Casanova E, Ovalle S, Calvo P, Chinchetru M. Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse. J Neurochem. 1995;65:2387-92 pubmed
    ..The alpha 1a subtype is also expressed in many tissues, whereas the alpha 1b subtype has a more restricted expression, with high levels in striatum, brainstem, and diencephalus. ..
  3. Milligan G, Svoboda P, Brown C. Why are there so many adrenoceptor subtypes?. Biochem Pharmacol. 1994;48:1059-71 pubmed
  4. Kandasamy K, Choudhury S, Singh V, Addison M, Darzi S, Kasa J, et al. Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of α1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta. J Cardiovasc Pharmacol Ther. 2016;21:100-13 pubmed publisher
  5. Rockman H, Koch W, Lefkowitz R. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol. 1997;272:H1553-9 pubmed
    ..The purpose of this review is to summarize current knowledge about the regulation of cardiovascular homeostasis involving signaling pathways through stimulation of adrenergic receptors...
  6. Buckwalter M, Katz R, Camper S. Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross. Genomics. 1991;10:515-26 pubmed
    ..The localization of the alpha 1 adrenergic receptor, Adra-1, extends a known region of synteny conservation between mouse chromosome 11 and human chromosome 5, and suggests that a human counterpart to df would map to human chromosome 5. ..
  7. Villalobos Molina R, Vázquez Cuevas F, Lopez Guerrero J, Figueroa García M, Gallardo Ortiz I, Ibarra M, et al. Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II. Auton Autacoid Pharmacol. 2008;28:61-7 pubmed publisher
  8. Gericke A, Kordasz M, Steege A, Sanbe A, Goloborodko E, Vetter J, et al. Functional role of ?1-adrenoceptor subtypes in murine ophthalmic arteries. Invest Ophthalmol Vis Sci. 2011;52:4795-9 pubmed publisher
    ..These findings provide evidence that the ?(1A)-AR subtype mediates adrenergic vasoconstriction in murine ophthalmic arteries. ..
  9. Pietri M, Schneider B, Mouillet Richard S, Ermonval M, Mutel V, Launay J, et al. Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells. FASEB J. 2005;19:1078-87 pubmed
  10. Mishima K, Tanoue A, Tsuda M, Hasebe N, Fukue Y, Egashira N, et al. Characteristics of behavioral abnormalities in alpha1d-adrenoceptors deficient mice. Behav Brain Res. 2004;152:365-73 pubmed
  11. Ross S, Rorabaugh B, Chalothorn D, Yun J, Gonzalez Cabrera P, McCune D, et al. The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model. Cardiovasc Res. 2003;60:598-607 pubmed
    ..These results suggest that the alpha(1B)-AR does not have a major role in the positive inotropic response in the mouse myocardium but may negatively modulate the response of the alpha(1A)-AR. ..
  12. Arai K, Tanoue A, Goda N, Takeda M, Takahashi K, Tsujimoto G. Characterization of the mouse alpha1D-adrenergic receptor gene. Jpn J Pharmacol. 1999;81:271-8 pubmed
    ..Isolation of this gene will allow further investigation, via gene knock-outs and deletion mutants, of the mechanisms of transcriptional regulation and a greater understanding of the physiological role of alpha1D-AR. ..
  13. Chu C, Kunitake T, Kato K, Watanabe S, Qiu D, Tanoue A, et al. The alpha 1D-adrenergic receptor modulates cardiovascular and drinking responses to central salt loading in mice. Neurosci Lett. 2004;356:33-6 pubmed
    ..These results suggest that alpha(1D)-AR is, at least in part, involved in central salt-induced but not ANG II-induced hypertension and water intake. ..
  14. Tanoue A, Nasa Y, Koshimizu T, Shinoura H, Oshikawa S, Kawai T, et al. The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. J Clin Invest. 2002;109:765-75 pubmed
    ..We conclude that the alpha(1D)-AR participates directly in sympathetic regulation of systemic blood pressure by vasoconstriction. ..
  15. Bexis S, Cleary L, McGrath J, Tanoue A, Tsujimoto G, Docherty J. Alpha(1D)-adrenoceptors mediate nerve and agonist-evoked contractions in mouse vas deferens: evidence obtained from knockout technology. Auton Autacoid Pharmacol. 2008;28:81-5 pubmed publisher
    ..5 It is concluded that alpha(1D)-adrenoceptors mediate a component of nerve- and agonist-evoked contractions of the vas deferens of WT mice. ..
  16. Lyssand J, DeFino M, Tang X, Hertz A, Feller D, Wacker J, et al. Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J Biol Chem. 2008;283:18792-800 pubmed publisher
    ..Our findings demonstrate that syntrophin and utrophin associate with alpha(1D)-ARs to create a functional signalosome, which is essential for alpha(1D)-AR regulation of vascular tone and blood pressure. ..
  17. Oikawa R, Hosoda C, Nasa Y, Daicho T, Tanoue A, Tsujimoto G, et al. Decreased susceptibility to salt-induced hypertension in subtotally nephrectomized mice lacking the vasopressin V1a receptor. Cardiovasc Res. 2010;87:187-94 pubmed publisher
  18. Alday A, Urrutia J, Gallego M, Casis O. ?1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels. Channels (Austin). 2010;4:168-78 pubmed
    ..Therefore, both groups of preassembled proteins are maintained in close proximity by caveolin-3. A different I(to) channel population localizes in non-caveolar membrane rafts and is not sensitive to ?1-adrenergic regulation. ..
  19. Cohn H, Harris D, Pesant S, Pfeiffer M, Zhou R, Koch W, et al. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. Am J Physiol Heart Circ Physiol. 2008;295:H1695-704 pubmed publisher
    ..This is the first study to suggest that VSM alpha(1D)ARs are a GRK2 substrate in vivo. ..
  20. Kobayashi S, Tomiyama Y, Hoyano Y, Yamazaki Y, Kusama H, Itoh Y, et al. Gene expressions and mechanical functions of ?1-adrenoceptor subtypes in mouse ureter. World J Urol. 2009;27:775-80 pubmed publisher
  21. Chen Z, Hague C, Hall R, Minneman K. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. J Biol Chem. 2006;281:12414-20 pubmed
    ..This direct interaction may provide new information about the regulation of alpha1D-AR signaling and the role of syntrophins in modulating G protein-coupled receptor function. ..
  22. Pulinilkunnil T, He H, Kong D, Asakura K, Peroni O, Lee A, et al. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011;286:8798-809 pubmed publisher
    ..Furthermore, AMPK ? Ser(485/491) phosphorylation may be a novel mechanism to inhibit AMPK activity in vivo and alter its biological effects. ..
  23. Oakey R, Caron M, Lefkowitz R, Seldin M. Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics. 1991;10:338-44 pubmed
    ..We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor. ..
  24. Sadalge A, Coughlin L, Fu H, Wang B, Valladares O, Valentino R, et al. alpha 1d Adrenoceptor signaling is required for stimulus induced locomotor activity. Mol Psychiatry. 2003;8:664-72 pubmed
    ..While the sensitivity of noradrenergic neurons to environmental stimuli has been well documented, our data demonstrate that at least some of these post-synaptic responses are mediated by alpha 1d adrenergic receptors. ..
  25. Hosoda C, Hiroyama M, Sanbe A, Birumachi J, Kitamura T, Cotecchia S, et al. Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery. Am J Physiol Heart Circ Physiol. 2007;293:H514-9 pubmed
    ..These results suggest that lack of both alpha(1A)- and alpha(1B)-ARs could be necessary to inhibit neointimal formation in the mouse femoral artery. ..
  26. Sporkova A, PEREZ RIVERA A, Galligan J. Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries. Eur J Pharmacol. 2010;643:239-46 pubmed publisher
    ..This interaction enhances venous adrenergic reactivity. Mesenteric vein-specific alpha(2)-adrenoceptor linked Ca(2+) and perhaps other signaling pathways account for enhanced venous adrenergic reactivity. ..
  27. Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, et al. Alpha1-adrenoceptors are required for normal male sexual function. Br J Pharmacol. 2007;152:332-40 pubmed
    ..These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility. ..
  28. Daly C, Ross R, Whyte J, Henstridge C, Irving A, McGrath J. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol. 2010;159:787-96 pubmed publisher
  29. Buckwalter M, Testa C, Noebels J, Camper S. Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response. Genomics. 1993;17:279-86 pubmed
    ..Synteny homology and phenotypic similarities suggest that spasmodic mice may be a genetic model for the inherited human startle disease, hyperekplexia (STHE). ..
  30. Faber J, Szymeczek C, Cotecchia S, Thomas S, Tanoue A, Tsujimoto G, et al. Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2007;292:H2316-23 pubmed
    ..These data suggest that catecholamine stimulation of alpha(1B)- and alpha(1D)-ARs contributes significantly to vascular remodeling in hypoxic PH. ..
  31. Suzuki F, Miyamoto S, Takita M, Oshita M, Watanabe Y, Kakizuka A, et al. Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor. Biochim Biophys Acta. 1997;1323:6-11 pubmed
    ..Competitive RT/PCR assays revealed wide tissue distribution of the alpha 1d-adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex. ..
  32. Wang G, Yeh C, Jensen B, Mann M, Simpson P, Baker A. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol. 2010;298:H913-20 pubmed publisher
    ..Since alpha(1)-AR agonist catecholamines are elevated in heart failure, increased alpha(1)-AR inotropic responses in the RV myocardium may be adaptive in heart failure by helping the failing RV respond to increased pulmonary pressures. ..
  33. Kordasz M, Manicam C, Steege A, Goloborodko E, Amato C, Laspas P, et al. Role of α₁-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice. Invest Ophthalmol Vis Sci. 2014;55:8295-301 pubmed publisher
    ..The lack of a single α₁-AR subtype does not appear to cause atrophy in the mouse iris. ..
  34. Nagle D, McGrail S, Vitale J, Woolf E, Dussault B, DiRocco L, et al. The mahogany protein is a receptor involved in suppression of obesity. Nature. 1999;398:148-52 pubmed
  35. Chalothorn D, McCune D, Edelmann S, Tobita K, Keller B, Lasley R, et al. Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes. J Pharmacol Exp Ther. 2003;305:1045-53 pubmed
    ..The alpha 1B-AR appears to be involved in the regulation of cardiac growth and contractile function, whereas the alpha 1D-AR is coupled to smooth muscle contraction and the regulation of systemic arterial blood pressure. ..
  36. Harasawa I, Honda K, Tanoue A, Shinoura H, Ishida Y, Okamura H, et al. Responses to noxious stimuli in mice lacking alpha(1d)-adrenergic receptors. Neuroreport. 2003;14:1857-60 pubmed
    ..These results suggest that alpha1d-AR in the spinal cord contributes to thermal pronociception; and that the jump behavior seen when escaping from heat is inhibited via the supraspinal alpha1d-AR. ..
  37. Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, et al. Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice. PLoS ONE. 2015;10:e0133664 pubmed publisher
    ..We also revealed the important role of β1- and α1-AR-mediated signaling in the development of AF through in-vivo and in-vitro experiments. ..
  38. Tanoue A, Koba M, Miyawaki S, Koshimizu T, Hosoda C, Oshikawa S, et al. Role of the alpha1D-adrenergic receptor in the development of salt-induced hypertension. Hypertension. 2002;40:101-6 pubmed
  39. Shi T, Papay R, Perez D. The role of ?1-adrenergic receptors in regulating metabolism: increased glucose tolerance, leptin secretion and lipid oxidation. J Recept Signal Transduct Res. 2017;37:124-132 pubmed publisher
  40. Koshimizu T, Tanoue A, Tsujimoto G. Clinical implications from studies of alpha1 adrenergic receptor knockout mice. Biochem Pharmacol. 2007;73:1107-12 pubmed
    ..By combining gene targeting techniques with pharmacological tools, the specific roles of alpha1-AR subtypes could be delineated. ..
  41. Cikos S, Rehák P, Czikková S, Veselá J, Koppel J. Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes. Reproduction. 2007;133:1139-47 pubmed