Adra1b

Summary

Gene Symbol: Adra1b
Description: adrenergic receptor, alpha 1b
Alias: [a]1b, alpha-1B adrenergic receptor, alpha-1B adrenoceptor, alpha-1B adrenoreceptor, alpha1B-adrenergic receptor
Species: mouse
Products:     Adra1b

Top Publications

  1. Koshimizu T, Tanoue A, Tsujimoto G. Clinical implications from studies of alpha1 adrenergic receptor knockout mice. Biochem Pharmacol. 2007;73:1107-12 pubmed
    ..By combining gene targeting techniques with pharmacological tools, the specific roles of alpha1-AR subtypes could be delineated. ..
  2. Cikos S, Rehák P, Czikková S, Veselá J, Koppel J. Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes. Reproduction. 2007;133:1139-47 pubmed
  3. Kordasz M, Manicam C, Steege A, Goloborodko E, Amato C, Laspas P, et al. Role of α₁-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice. Invest Ophthalmol Vis Sci. 2014;55:8295-301 pubmed publisher
    ..The lack of a single α₁-AR subtype does not appear to cause atrophy in the mouse iris. ..
  4. Cross J, Flannery M, Blanar M, Steingrimsson E, Jenkins N, Copeland N, et al. Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995;121:2513-23 pubmed
    ..These data demonstrate a role for HLH factors in regulating trophoblast development and indicate a positive role for Hxt in promoting the formation of trophoblast giant cells. ..
  5. Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, et al. Alpha1-adrenoceptors are required for normal male sexual function. Br J Pharmacol. 2007;152:332-40 pubmed
    ..These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility. ..
  6. Gutiérrez Fernández M, Higareda Mendoza A, Gómez Correa C, Pardo Galván M. The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity. BMC Biochem. 2015;16:25 pubmed publisher
    ..The eIf3f/alpha 1B-ADR complex is found in mammals and is not tissue specific. ..
  7. Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, et al. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol Cell Biol. 2008;28:3424-36 pubmed publisher
    ..These findings indicate that MURC modulates RhoA signaling and that MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias. ..
  8. Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, et al. Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates. J Neurosci. 2002;22:2873-84 pubmed
  9. Knauber J, Muller W. Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the alpha(1b)-adrenoceptor. Eur Neuropsychopharmacol. 2000;10:423-7 pubmed
    ..Furthermore, this model of knockout mice may be useful in elucidating the role of alpha(1B)-AR in dementias involving deficits of the noradrenergic system. ..

More Information

Publications69

  1. Abe Dohmae S, Takagi Y, Harada N. Autonomous expression of aromatase during development of mouse brain is modulated by neurotransmitters. J Steroid Biochem Mol Biol. 1997;61:299-306 pubmed
  2. Hosoda C, Hiroyama M, Sanbe A, Birumachi J, Kitamura T, Cotecchia S, et al. Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery. Am J Physiol Heart Circ Physiol. 2007;293:H514-9 pubmed
    ..These results suggest that lack of both alpha(1A)- and alpha(1B)-ARs could be necessary to inhibit neointimal formation in the mouse femoral artery. ..
  3. Roller M, Lossie A, Koken M, Smit E, Hagemeijer A, Camper S. Localization of sequences related to the human RAD6 DNA repair gene on mouse chromosomes 11 and 13. Mamm Genome. 1995;6:305-6 pubmed
  4. Pulinilkunnil T, He H, Kong D, Asakura K, Peroni O, Lee A, et al. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011;286:8798-809 pubmed publisher
    ..Furthermore, AMPK ? Ser(485/491) phosphorylation may be a novel mechanism to inhibit AMPK activity in vivo and alter its biological effects. ..
  5. Wright C, Chen Q, Baye N, Huang Y, Healy C, Kasinathan S, et al. Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ Res. 2008;103:992-1000 pubmed publisher
    ..In summary, our results show that nuclear alpha1-ARs transduce signals to caveolae at the plasma membrane in cardiac myocytes. ..
  6. García Sáinz J, Casas González P, Romero Avila M, Gonzalez Espinosa C. Characterization of the hepatic alpha 1B-adrenoceptors of rats, mice and hamsters. Life Sci. 1994;54:1995-2003 pubmed
    ..Total RNA obtained from the liver of these species hybridized with the alpha 1B-adrenergic cDNA probe. The data suggest that these receptors correspond to the alpha 1B subtype. ..
  7. Zuscik M, Sands S, Ross S, Waugh D, Gaivin R, Morilak D, et al. Overexpression of the alpha1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophy. Nat Med. 2000;6:1388-94 pubmed
    ..Our results indicate that overstimulation of alpha1BAR leads to apoptotic neurodegeneration with a corresponding multiple system atrophy indicative of Shy-Drager syndrome, a disease whose etiology is unknown. ..
  8. Telegdy G, Schally A. Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Behav Brain Res. 2012;233:232-6 pubmed publisher
  9. McCloskey D, Turnbull L, Swigart P, O Connell T, Simpson P, Baker A. Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice. J Mol Cell Cardiol. 2003;35:1207-16 pubmed
  10. Shworak N, Liu J, Petros L, Zhang L, Kobayashi M, Copeland N, et al. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem. 1999;274:5170-84 pubmed
    ..Moreover, the extensive number of 3OST genes with diverse expression patterns of multiple transcripts suggests that the novel 3-OST enzymes, like 3-OST-1, regulate important biologic properties of heparan sulfate proteoglycans. ..
  11. Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins Chow D, et al. Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5. Cytogenet Cell Genet. 1995;68:19-24 pubmed
    ..The location of the human homologue has been determined using both somatic cell hybrid genetic analysis and fluorescence in situ hybridization. These analyses have mapped the human locus U2AFBPL to human chromosome 5q23-->q31. ..
  12. Auclair A, Cotecchia S, Glowinski J, Tassin J. D-amphetamine fails to increase extracellular dopamine levels in mice lacking alpha 1b-adrenergic receptors: relationship between functional and nonfunctional dopamine release. J Neurosci. 2002;22:9150-4 pubmed
    ..These results suggest that alpha1b-adrenergic receptors may be important therapeutic pharmacological targets not only in addiction but also in psychosis because most neuroleptics possess anti-alpha1-adrenergic properties. ..
  13. Battaglia G, Fornai F, Busceti C, Lembo G, Nicoletti F, De Blasi A. Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003;86:413-21 pubmed
    ..Pharmacological blockade of alpha-adrenergic receptors with prazosin also protected wild-type mice against MA toxicity. These results suggests that alpha1b-ARs may play a role in the toxicity of MA on nigro-striatal DA neurons. ..
  14. Cavalli A, Lattion A, Hummler E, Nenniger M, Pedrazzini T, Aubert J, et al. Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor. Proc Natl Acad Sci U S A. 1997;94:11589-94 pubmed
  15. Huang Y, Wright C, Merkwan C, Baye N, Liang Q, Simpson P, et al. An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 2007;115:763-72 pubmed
    ..Absence of the alpha1A-ERK pathway can explain the failure to activate ERK after aortic constriction in alpha1ABKO mice and can contribute to the development of apoptosis, dilated cardiomyopathy, and death. ..
  16. Ross S, Rorabaugh B, Chalothorn D, Yun J, Gonzalez Cabrera P, McCune D, et al. The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model. Cardiovasc Res. 2003;60:598-607 pubmed
    ..These results suggest that the alpha(1B)-AR does not have a major role in the positive inotropic response in the mouse myocardium but may negatively modulate the response of the alpha(1A)-AR. ..
  17. Buckwalter M, Lossie A, Scarlett L, Camper S. Localization of the human chromosome 5q genes Gabra-1, Gabrg-2, Il-4, Il-5, and Irf-1 on mouse chromosome 11. Mamm Genome. 1992;3:604-7 pubmed
  18. Doze V, Handel E, Jensen K, Darsie B, Luger E, Haselton J, et al. alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. Brain Res. 2009;1285:148-57 pubmed publisher
    ..These data suggest that alpha(1A)-ARs may be a useful therapeutic target for the treatment of depression. ..
  19. Tanaka K, Hirai T, Kodama D, Kondo H, Hamamura K, Togari A. α1B -Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts. Br J Pharmacol. 2016;173:1058-69 pubmed publisher
  20. Lomasney J, Cotecchia S, Lorenz W, Leung W, Schwinn D, Yang Feng T, et al. Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. J Biol Chem. 1991;266:6365-9 pubmed
    ..This study provides definitive evidence for the existence of three alpha 1-adrenergic receptor subtypes. ..
  21. Gericke A, Kordasz M, Steege A, Sanbe A, Goloborodko E, Vetter J, et al. Functional role of ?1-adrenoceptor subtypes in murine ophthalmic arteries. Invest Ophthalmol Vis Sci. 2011;52:4795-9 pubmed publisher
    ..These findings provide evidence that the ?(1A)-AR subtype mediates adrenergic vasoconstriction in murine ophthalmic arteries. ..
  22. Watkins Chow D, Buckwalter M, Newhouse M, Lossie A, Brinkmeier M, Camper S. Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5. Genomics. 1997;40:114-22 pubmed
    ..Comparison of the mouse and human maps with data for other species provides an emerging picture of mammalian chromosome evolution. ..
  23. Burcelin R, Uldry M, Foretz M, Perrin C, Dacosta A, Nenniger Tosato M, et al. Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype. J Biol Chem. 2004;279:1108-15 pubmed
  24. Papay R, Zuscik M, Ross S, Yun J, McCune D, Gonzalez Cabrera P, et al. Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation. J Neurochem. 2002;83:623-34 pubmed
    ..We conclude that overexpression of the alpha(1B)-AR can cause a synucleinopathy similar to other parkinsonian syndromes. ..
  25. Yang Feng T, Xue F, Zhong W, Cotecchia S, Frielle T, Caron M, et al. Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990;87:1516-20 pubmed
    ..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules. ..
  26. Rossi D, Hardiman G, Copeland N, Gilbert D, Jenkins N, Zlotnik A, et al. Cloning and characterization of a new type of mouse chemokine. Genomics. 1998;47:163-70 pubmed
    ..The novel location of this gene from other chemokine gene clusters adds to the notion that CX3C is a fundamentally new class of chemokine. ..
  27. Nalepa I, Vetulani J, Borghi V, Kowalska M, Przewłocka B, Pavone F. Formalin hindpaw injection induces changes in the [3H]prazosin binding to alpha1-adrenoceptors in specific regions of the mouse brain and spinal cord. J Neural Transm (Vienna). 2005;112:1309-19 pubmed
    ..These results provide the first description of changes at the level of central alpha1-adrenoceptors' binding during the formalin-induced pain in mice. Their distribution suggests that they may have a functional meaning. ..
  28. Osaki E, Nishina Y, Inazawa J, Copeland N, Gilbert D, Jenkins N, et al. Identification of a novel Sry-related gene and its germ cell-specific expression. Nucleic Acids Res. 1999;27:2503-10 pubmed
    ..Mapping analyses revealed that the Sox30 gene is located on human chromosome 5 (5q33) and on mouse chromosome 11. ..
  29. Böhmer T, Manicam C, Steege A, Michel M, Pfeiffer N, Gericke A. The ??B -adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium. Br J Pharmacol. 2014;171:3858-67 pubmed publisher
    ..Hence, the ??B-adrenoceptor may represent a target to selectively modulate retinal blood flow in ocular diseases associated with endothelial dysfunction. ..
  30. Telegdy G, Schally A. Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning. Behav Brain Res. 2012;233:326-30 pubmed publisher
    ..The results demonstrate that the muscarinic acetylcholine receptor, the 5-HT1/5-HT2 serotonergic receptor and opioid receptors are involved as mediators in the action of MZ-4-71 on the consolidation of passive avoidance learning. ..
  31. Turnbull L, McCloskey D, O Connell T, Simpson P, Baker A. Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. Am J Physiol Heart Circ Physiol. 2003;284:H1104-9 pubmed
    ..Furthermore, alpha(1)-AR inotropic responses depend critically on the experimental conditions. ..
  32. O Connell T, Swigart P, Rodrigo M, Ishizaka S, Joho S, Turnbull L, et al. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest. 2006;116:1005-15 pubmed
    ..overload in mice with double KO of the 2 main alpha1-AR subtypes in the heart, alpha 1A (Adra1a) and alpha 1B (Adra1b)...
  33. O Connell T, Ishizaka S, Nakamura A, Swigart P, Rodrigo M, Simpson G, et al. The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest. 2003;111:1783-91 pubmed
    ..Thus, alpha(1)-ARs in male mice are required for the physiological hypertrophy of normal postnatal cardiac development and for an adaptive response to cardiac stress. ..
  34. Chotalia M, Smallwood S, Ruf N, Dawson C, Lucifero D, Frontera M, et al. Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev. 2009;23:105-17 pubmed publisher
  35. Alonso Llamazares A, López Alonso J, del Barrio M, Casanova E, Calvo P, Chinchetru M. Cloning of chicken and mouse alpha 1b adrenergic receptor. Biochim Biophys Acta. 1998;1396:263-6 pubmed
    A partial cDNA encoding most of the third intracellular loop of the chicken alpha 1b adrenergic receptor subtype, obtained by reverse transcription-polymerase chain reaction (RT-PCR) techniques using degenerate primers derived from ..
  36. Townsend S, Jung A, Hoe Y, Lefkowitz R, Khan S, Lemmon C, et al. Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. Hypertension. 2004;44:776-82 pubmed
    ..The critical role for alpha(1B)AR in neuroeffector regulation of vascular tone and myocardial contractility has profound clinical implications for designing therapies for orthostatic intolerance. ..
  37. Huang Y, Wright C, Kobayashi S, Healy C, Elgethun M, Cypher A, et al. GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling. Am J Physiol Heart Circ Physiol. 2008;295:H699-707 pubmed publisher
    ..This also identifies an important mechanistic difference in alpha1-signaling between adult and neonatal cardiac myocytes. ..
  38. Buckwalter M, Testa C, Noebels J, Camper S. Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response. Genomics. 1993;17:279-86 pubmed
    ..Synteny homology and phenotypic similarities suggest that spasmodic mice may be a genetic model for the inherited human startle disease, hyperekplexia (STHE). ..
  39. Faber J, Szymeczek C, Cotecchia S, Thomas S, Tanoue A, Tsujimoto G, et al. Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2007;292:H2316-23 pubmed
    ..These data suggest that catecholamine stimulation of alpha(1B)- and alpha(1D)-ARs contributes significantly to vascular remodeling in hypoxic PH. ..
  40. Oakey R, Caron M, Lefkowitz R, Seldin M. Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics. 1991;10:338-44 pubmed
    ..We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor. ..
  41. Pizzanelli C, Lazzeri G, Fulceri F, Giorgi F, Pasquali L, Cifelli G, et al. Lack of alpha 1b-adrenergic receptor protects against epileptic seizures. Epilepsia. 2009;50 Suppl 1:59-64 pubmed publisher
    ..These data, although confirming a pivotal role of alpha 1b-AR in modulating seizure threshold and neuronal death, offer a novel target, which may be used to develop novel anticonvulsants and neuroprotective agents. ..
  42. Spreng M, Cotecchia S, Schenk F. A behavioral study of alpha-1b adrenergic receptor knockout mice: increased reaction to novelty and selectively reduced learning capacities. Neurobiol Learn Mem. 2001;75:214-29 pubmed
    ..The lack of alpha-1b adrenergic receptors in spatial orientation does not seem important in cue-rich tasks but may interfere with orientation in situations providing distant cues only. ..
  43. Hirota J, Ando H, Hamada K, Mikoshiba K. Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. Biochem J. 2003;372:435-41 pubmed
    ..This could be due to co-expression of CARP with IP(3)R in Purkinje cells and its inhibitory effects on IP(3) binding. ..
  44. Kobayashi S, Tomiyama Y, Hoyano Y, Yamazaki Y, Kusama H, Itoh Y, et al. Gene expressions and mechanical functions of ?1-adrenoceptor subtypes in mouse ureter. World J Urol. 2009;27:775-80 pubmed publisher
  45. Hirai T, Tanaka K, Togari A. α1B-Adrenergic receptor signaling controls circadian expression of Tnfrsf11b by regulating clock genes in osteoblasts. Biol Open. 2015;4:1400-9 pubmed publisher
  46. Shi T, Gaivin R, McCune D, Gupta M, Perez D. Dominance of the alpha1B-adrenergic receptor and its subcellular localization in human and TRAMP prostate cancer cell lines. J Recept Signal Transduct Res. 2007;27:27-45 pubmed
  47. Milano C, Allen L, Rockman H, Dolber P, McMinn T, Chien K, et al. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science. 1994;264:582-6 pubmed
    ..Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state. ..
  48. Rivard K, Trépanier Boulay V, Rindt H, Fiset C. Electrical remodeling in a transgenic mouse model of alpha1B-adrenergic receptor overexpression. Am J Physiol Heart Circ Physiol. 2009;296:H704-18 pubmed publisher
    ..Taken together, these data provide strong evidence for a pathological role of chronic alpha(1B)-AR activity in the development of repolarization defects and ventricular arrhythmias. ..
  49. Chen H, Thalmann I, Adams J, Avraham K, Copeland N, Jenkins N, et al. cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs. Genomics. 1995;27:389-98 pubmed publisher
    ..The Ocp2 gene was mapped to mouse chromosome 4 as well as 11. Our results suggest that OCP-II may be involved in transcription regulation for the development or maintenance of specialized functions of the inner ear...
  50. Szondy Z, Mastroberardino P, Varadi J, Farrace M, Nagy N, Bak I, et al. Tissue transglutaminase (TG2) protects cardiomyocytes against ischemia/reperfusion injury by regulating ATP synthesis. Cell Death Differ. 2006;13:1827-9 pubmed
  51. Vecchione C, Fratta L, Rizzoni D, Notte A, Poulet R, Porteri E, et al. Cardiovascular influences of alpha1b-adrenergic receptor defect in mice. Circulation. 2002;105:1700-7 pubmed
  52. Buckwalter M, Katz R, Camper S. Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross. Genomics. 1991;10:515-26 pubmed
    ..The localization of the alpha 1 adrenergic receptor, Adra-1, extends a known region of synteny conservation between mouse chromosome 11 and human chromosome 5, and suggests that a human counterpart to df would map to human chromosome 5. ..
  53. Spicer A, Roller M, Camper S, McPherson J, Wasmuth J, Hakim S, et al. The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. Genomics. 1995;30:115-7 pubmed
    ..The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias. ..
  54. McKenzie A, Li X, Largaespada D, Sato A, Kaneda A, Zurawski S, et al. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol. 1993;150:5436-44 pubmed
    ..Both genes map to chromosomal locations adjacent to genes encoding other cytokines, including IL-3, GM-CSF, IL-5, and IL-4, suggesting that IL-13 is another member of this cytokine gene family that may have arisen by gene duplication. ..
  55. Rockman H, Koch W, Lefkowitz R. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am J Physiol. 1997;272:H1553-9 pubmed
    ..The purpose of this review is to summarize current knowledge about the regulation of cardiovascular homeostasis involving signaling pathways through stimulation of adrenergic receptors...
  56. Alonso Llamazares A, Zamanillo D, Casanova E, Ovalle S, Calvo P, Chinchetru M. Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse. J Neurochem. 1995;65:2387-92 pubmed
    ..The alpha 1a subtype is also expressed in many tissues, whereas the alpha 1b subtype has a more restricted expression, with high levels in striatum, brainstem, and diencephalus. ..
  57. Hosoda C, Koshimizu T, Tanoue A, Nasa Y, Oikawa R, Tomabechi T, et al. Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation. Mol Pharmacol. 2005;67:912-22 pubmed
    ..The study shows differential contributions of alpha1B- and alpha1D-ARs in BP regulation. ..
  58. Zhang H, Cotecchia S, Thomas S, Tanoue A, Tsujimoto G, Faber J. Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling. Am J Physiol Heart Circ Physiol. 2004;287:H2106-14 pubmed
    ..These studies suggest that the trophic effects of catecholamines are mediated primarily by alpha1B-ARs in mouse carotid and contribute to hypertrophic growth after vascular injury. ..
  59. Zuscik M, Chalothorn D, Hellard D, Deighan C, McGee A, Daly C, et al. Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor. J Biol Chem. 2001;276:13738-43 pubmed
    ..These results also suggest that this receptor subtype is not involved in the classic vasoconstrictory action of alpha(1)ARs that is important in systemic regulation of blood pressure. ..
  60. Mhaouty Kodja S, Lozach A, Habert R, Tanneux M, Guigon C, Brailly Tabard S, et al. Fertility and spermatogenesis are altered in {alpha}1b-adrenergic receptor knockout male mice. J Endocrinol. 2007;195:281-92 pubmed
    ..It is thus hypothesized that the absence of alpha1b-AR alters either directly germ cells or indirectly Sertoli cell/Leydig cell communications in infertile alpha1b-AR-KO mice. ..