Adipor1

Summary

Gene Symbol: Adipor1
Description: adiponectin receptor 1
Alias: 2810031L11Rik, ACDCR1, CGI-45, Paqr1, adiponectin receptor protein 1, progestin and adipoQ receptor family member 1, progestin and adipoQ receptor family member I
Species: mouse
Products:     Adipor1

Top Publications

  1. Berner H, Lyngstadaas S, Spahr A, Monjo M, Thommesen L, Drevon C, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone. 2004;35:842-9 pubmed
    ..demonstrating transcription, translation, and secretion of adiponectin, as well as expression of its receptors, AdipoR1 and AdipoR2, in bone-forming cells...
  2. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, Maki T, et al. Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes. 2005;54:3358-70 pubmed
  3. Wade T, Mathur A, Lu D, Swartz Basile D, Pitt H, Zyromski N. Adiponectin receptor-1 expression is decreased in the pancreas of obese mice. J Surg Res. 2009;154:78-84 pubmed publisher
    ..Adiponectin acts through two receptors, AdipoR1 and AdipoR2; no data are currently available regarding adiponection receptor expression in the obese murine ..
  4. Iwabu M, Yamauchi T, Okada Iwabu M, Sato K, Nakagawa T, Funata M, et al. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature. 2010;464:1313-9 pubmed publisher
    ..Here we provide evidence that adiponectin induces extracellular Ca(2+) influx by adiponectin receptor 1 (AdipoR1), which was necessary for subsequent activation of Ca(2+)/calmodulin-dependent protein kinase kinase beta (..
  5. Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med. 2007;13:332-9 pubmed
    Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1 and AdipoR2 serve as receptors for adiponectin in vitro, and their reduction in obesity seems to be correlated with reduced adiponectin ..
  6. Mao X, Kikani C, Riojas R, Langlais P, Wang L, Ramos F, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol. 2006;8:516-23 pubmed
    ..Two seven-transmembrane domain-containing proteins, AdipoR1 and AdipoR2, have recently been identified as adiponectin receptors, yet signalling events downstream of these ..
  7. Bjursell M, Ahnmark A, Bohlooly Y M, William Olsson L, Rhedin M, Peng X, et al. Opposing effects of adiponectin receptors 1 and 2 on energy metabolism. Diabetes. 2007;56:583-93 pubmed
    ..Adiponectin binds to two different seven-transmembrane domain receptors termed AdipoR1 and AdipoR2...
  8. Bullen J, Bluher S, Kelesidis T, Mantzoros C. Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2007;292:E1079-86 pubmed
    ..We hypothesized that high-fat diet would decrease adiponectin but increase adiponectin receptor (AdipoR1 and AdipoR2) expression in diet-induced obesity (DIO)-prone C57BL/6J and DIO-resistant A/J mice...
  9. Lin T, Qiu Y, Liu Y, MOHAN R, Li Q, Lei B. Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas. Mol Vis. 2013;19:1769-78 pubmed
    ..05 regarded as statistically significant. APN, AdipoR1, and AdipoR2 were identified in the neural retina and in the RPE-choroid of humans and mice...

More Information

Publications76

  1. Luo N, Chung B, Wang X, Klein R, Tang C, Garvey W, et al. Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages. Atherosclerosis. 2013;228:124-35 pubmed publisher
    ..in vivo, we generated transgenic mice which specifically overexpress the gene coding for adiponectin receptor 1 (AdipoR1) in mouse macrophages using the human scavenger receptor A-I gene (SR-AI) enhancer/promoter...
  2. Bauer S, Weigert J, Neumeier M, Wanninger J, Schaffler A, Luchner A, et al. Low-abundant adiponectin receptors in visceral adipose tissue of humans and rats are further reduced in diabetic animals. Arch Med Res. 2010;41:75-82 pubmed publisher
    ..The antidiabetic adipokine adiponectin acts through two receptors, AdipoR1 and AdipoR2, but so far mainly mRNA expression has been measured in adipocytes and adipose tissues...
  3. Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, et al. Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab. 2011;13:401-412 pubmed publisher
    ..antidiabetic adipokine, are currently attributed to the activation of two critical molecules downstream of AdipoR1 and R2: AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor ? (PPAR?)...
  4. Winzell M, Nogueiras R, Dieguez C, Ahren B. Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun. 2004;321:154-60 pubmed
    ..Furthermore, RT-PCR revealed the expression of the adiponectin receptor AdipoR1 mRNA in mouse islets, however, with no difference in the degree of expression level between the two feeding ..
  5. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-9 pubmed
    ..Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning...
  6. Farias J, Maggi R, Tromm C, Silva L, Luciano T, Marques S, et al. Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice. Lipids Health Dis. 2012;11:134 pubmed publisher
    ..in the degree of the insulin resistance in mice fed with a high-fat diet, and assess adiponectin receptors (ADIPOR1 and ADIPOR2) and endosomal adaptor protein APPL1 in different tissues...
  7. Klein I, Sanchez Alavez M, Tabarean I, Schaefer J, Holmberg K, Klaus J, et al. AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin. Brain Res. 2011;1423:1-9 pubmed publisher
    ..We found that adiponectin type 1 and type 2 receptors (AdipoR1 and AdipoR2) are expressed in warm sensitive neurons of the hypothalamic preoptic area (POA) which play a ..
  8. Neumeier M, Hellerbrand C, Gabele E, Buettner R, Bollheimer C, Weigert J, et al. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. World J Gastroenterol. 2006;12:5490-4 pubmed
    ..in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level...
  9. Fujimoto N, Matsuo N, Sumiyoshi H, Yamaguchi K, Saikawa T, Yoshimatsu H, et al. Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos. Biochim Biophys Acta. 2005;1731:1-12 pubmed
    ..These data indicate that adiponectin has important roles in glucose and lipid metabolism during the perinatal period. ..
  10. Neumeier M, Krautbauer S, Schmidhofer S, Hader Y, Eisinger K, Eggenhofer E, et al. Adiponectin receptor 1 C-terminus interacts with PDZ-domain proteins such as syntrophins. Exp Mol Pathol. 2013;95:180-6 pubmed publisher
    Adiponectin receptor 1 (AdipoR1) is one of the two signaling receptors of adiponectin with multiple beneficial effects in metabolic diseases...
  11. Song W, Guo F, Zhong H, Liu L, Yang R, Wang Q, et al. Therapeutic window of globular adiponectin against cerebral ischemia in diabetic mice: the role of dynamic alteration of adiponectin/adiponectin receptor expression. Sci Rep. 2015;5:17310 pubmed publisher
    ..APN levels increased and peaked in T1DM-2W mice, and reduced to normal in T1DM-8W mice, while the APN receptor 1 (AdipoR1) expression change was the opposite...
  12. Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu Ito M, Enomoto T, et al. C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism. Mol Cell Biol. 2015;35:2173-85 pubmed publisher
    ..of proinflammatory genes, which was reversed by blockade of AMPK or ablation of adiponectin receptor I (AdipoR1)...
  13. Qiao L, Yoo H, Madon A, Kinney B, Hay W, Shao J. Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012;61:3199-207 pubmed publisher
    ..Together, our study indicates that adiponectin enhances fetal fat deposition and plays an important role in maternal obesity-induced high birth weight. ..
  14. Lin T, He F, Lei B. [Expressions of adiponectin and its receptors in the retina of normal and type 1 diabetic mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:1543-7 pubmed
    ..The expressions of adiponectin and AdipoR1 were up-regulated in the retina of mice with T1DM while AdipoR2 expression exhibited no significant changes...
  15. Choi J, Kobayashi H, Okuda H, Harada K, Takeda M, Fujimoto H, et al. β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice. PLoS ONE. 2018;13:e0190863 pubmed publisher
    ..protection and its down-stream signaling events, we have generated β-cell-specific rat insulin promoter (RIP)-AdipoR1 transgenic mice (AdipoR1 mice), in which the adiponectin receptor, AdipoR1, is overexpressed in β-cells in a ..
  16. Wang Y, Gao E, Lau W, Wang Y, Liu G, Li J, et al. G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart. Circulation. 2015;131:1392-404 pubmed publisher
    ..b>AdipoR1 and AdipoR2 are not phosphorylated in the normal heart...
  17. Guillod Maximin E, Roy A, Vacher C, Aubourg A, Bailleux V, Lorsignol A, et al. Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons. J Endocrinol. 2009;200:93-105 pubmed publisher
    Adiponectin is involved in the control of energy homeostasis in peripheral tissues through Adipor1 and Adipor2 receptors...
  18. Wang C, Xin X, Xiang R, Ramos F, Liu M, Lee H, et al. Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem. 2009;284:31608-15 pubmed publisher
    ..Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adiponectin signaling in muscle cells...
  19. Khan M, Singh A, Joharapurkar A, Yadav M, Shree S, Kumar H, et al. Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia. Diabetes. 2015;64:2609-23 pubmed publisher
    ..by 6-C-β-d-glucopyranosyl-(2S,3S)-(+)-5,7,3',4'-tetrahydroxydihydroflavonol (GTDF), an adiponectin receptor 1 (AdipoR1) agonist, as well as metformin in db mice that lacked AdipoR1 expression in muscle but not bone restored ..
  20. Steyn F, Boehme F, Vargas E, Wang K, Parkington H, Rao J, et al. Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca(2+) signalling in rat somatotrophs in vitro. J Neuroendocrinol. 2009;21:698-704 pubmed publisher
    ..This report characterise the expression and interaction of adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) and adiponectin, respectively, in regulating the activity of GH secreting cells...
  21. Parker Duffen J, Nakamura K, Silver M, Kikuchi R, Tigges U, Yoshida S, et al. T-cadherin is essential for adiponectin-mediated revascularization. J Biol Chem. 2013;288:24886-97 pubmed publisher
    ..These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin. ..
  22. Schmidt T, Fischer S, Tsikolia N, Navarrete Santos A, Rohrbach S, Ramin N, et al. Expression of adipokines in preimplantation rabbit and mice embryos. Histochem Cell Biol. 2008;129:817-25 pubmed publisher
    ..Both, trophoblast and embryoblast were adiponectin positive. Real time PCR for adipoR1 and adipoR2 in rabbit blastocysts of different gastrulation stages at day 6 p.c...
  23. Shibata S, Tada Y, Hau C, Mitsui A, Kamata M, Asano Y, et al. Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells. Nat Commun. 2015;6:7687 pubmed publisher
    ..Adiponectin directly acts on murine dermal γδ-T cells to suppress IL-17 synthesis via AdipoR1. We furthermore demonstrate here that the adiponectin level of skin tissue as well as subcutaneous fat is ..
  24. Du Y, Li R, Lau W, Zhao J, Lopez B, Christopher T, et al. Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling. PLoS ONE. 2016;11:e0152247 pubmed publisher
    ..01), an endothelium-dependent and nitric oxide (NO)-mediated process. Knockout of adiponectin receptor 1 (AdipoR1) or caveolin-1 (Cav-1, a cell signaling facilitating molecule), but not adiponectin receptor 2 (AdipoR2) ..
  25. Goto T, Teraminami A, Lee J, Ohyama K, Funakoshi K, Kim Y, et al. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice. J Nutr Biochem. 2012;23:768-76 pubmed publisher
    ..The messenger RNA expression levels of hepatic adiponectin receptor (AdipoR)-1 and AdipoR2 and skeletal muscular AdipoR1 were up-regulated by tiliroside treatment...
  26. Parker Duffen J, Nakamura K, Silver M, Zuriaga M, MacLauchlan S, Aprahamian T, et al. Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo. J Biol Chem. 2014;289:16200-13 pubmed publisher
    ..Two candidate adiponectin receptors, AdipoR1 and AdipoR2, are uncharacterized with regard to cardiovascular tissue homeostasis, and their in vivo metabolic ..
  27. Ramos Ramírez P, Malmhäll C, Johansson K, Lötvall J, Bossios A. Weight Gain Alters Adiponectin Receptor 1 Expression on Adipose Tissue-Resident Helios+ Regulatory T Cells. Scand J Immunol. 2016;83:244-54 pubmed publisher
    ..Adiponectin acts through binding to adiponectin receptor 1 and 2 (AdipoR1/AdipoR2). AdipoR1 is ubiquitously expressed, whereas AdipoR2 is restricted to skeletal muscle and liver...
  28. Arnold N, Mahmood A, Ramdas M, Ehlinger P, Pulakat L. Regulation of the cardioprotective adiponectin and its receptor AdipoR1 by salt. Can J Physiol Pharmacol. 2017;95:305-309 pubmed publisher
    ..Low circulating APN serves as a biomarker for cardiovascular risk. Ablation of adiponectin receptor 1 (AdipoR1) causes myocardial mitochondrial dysfunction...
  29. Shibata S, Tada Y, Asano Y, Hau C, Kato T, Saeki H, et al. Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway. J Immunol. 2012;189:3231-41 pubmed publisher
    ..This proliferative and migratory effect of adiponectin was mediated via AdipoR1/AdipoR2 and the ERK signaling pathway...
  30. Kadowaki T, Yamauchi T, Waki H, Iwabu M, Okada Iwabu M, Nakamura M. Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis. Cold Spring Harb Symp Quant Biol. 2011;76:257-65 pubmed publisher
    ..Plasma adiponectin and adiponectin receptor (AdipoR1) in muscle are down-regulated in obesity...
  31. van Stijn C, Kim J, Lusis A, Barish G, Tangirala R. Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response. FASEB J. 2015;29:636-49 pubmed publisher
    ..that exerts anti-inflammatory, antidiabetic, and antiatherogenic effects through its receptors (AdipoRs), AdipoR1 and AdipoR2, is an important therapeutic target...
  32. Arumugam R, Fleenor D, Freemark M. Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. Endocrine. 2007;32:182-91 pubmed
    ..Adiponectin receptor 1 and 2 (AdipoR1 and R2) mRNA levels in liver and skeletal muscle were normal but hepatic insulin receptor mRNA was increased...
  33. Rice D, Calandria J, Gordon W, Jun B, Zhou Y, Gelfman C, et al. Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Nat Commun. 2015;6:6228 pubmed publisher
    ..Here we report the discovery of adiponectin receptor 1 (AdipoR1) as a regulator of these cells' functions...
  34. Chou I, Chiu Y, Ding S, Liu B, Lin Y, Chen C. Adiponectin receptor 1 overexpression reduces lipid accumulation and hypertrophy in the heart of diet-induced obese mice--possible involvement of oxidative stress and autophagy. Endocr Res. 2014;39:173-9 pubmed publisher
    Studies show that adiponectin and its receptors (AdipoR1 and 2) play important roles in regulating glucose and lipid metabolism in mice...
  35. Inukai K, Nakashima Y, Watanabe M, Takata N, Sawa T, Kurihara S, et al. Regulation of adiponectin receptor gene expression in diabetic mice. Am J Physiol Endocrinol Metab. 2005;288:E876-82 pubmed
    ..The following two adiponectin receptor types were recently identified: AdipoR1 is abundantly expressed in muscle, whereas AdipoR2 is predominantly expressed in the liver...
  36. Lin Y, Chen C, Ding S. Adiponectin receptor 1 resists the decline of serum osteocalcin and GPRC6A expression in ovariectomized mice. PLoS ONE. 2017;12:e0189063 pubmed publisher
    ..Our findings imply the possibility to ameliorate menopause-induced metabolic disorder by GPRC6A and adiponectin signaling. ..
  37. Qiao L, Yoo H, Bosco C, Lee B, Feng G, Schaack J, et al. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014;57:1027-36 pubmed publisher
    ..Paradoxically, we found that the anti-thermogenic effect of adiponectin requires neither AdipoR1 nor AdipoR2, two well-known adiponectin receptors...
  38. Hass N, Haub H, Stevens R, Breer H, Schwarzenbacher K. Expression of adiponectin receptor 1 in olfactory mucosa of mice. Cell Tissue Res. 2008;334:187-97 pubmed publisher
    b>AdipoR1 and AdipoR2 are receptors for the adipocyte-derived hormone adiponectin, which is an important regulator of glucose and lipid metabolism, and which has also been implicated in the control of food intake and energy homeostasis...
  39. Bluher M, Fasshauer M, Kralisch S, Schön M, Krohn K, Paschke R. Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice. Biochem Biophys Res Commun. 2005;329:1127-32 pubmed
    ..Recently, two receptors of this adipocyte-secreted hormone, adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2), have been cloned...
  40. Liu B, Lin Y, Wang Y, Huang C, Chen C, Wu S, et al. Porcine adiponectin receptor 1 transgene resists high-fat/sucrose diet-induced weight gain, hepatosteatosis and insulin resistance in mice. Exp Anim. 2013;62:347-60 pubmed
    ..In this study, we generated mice overexpressing the porcine Adipor1 transgene (pAdipor1) to study its beneficial effects in metabolic syndromes as expressed in diet-induced obesity, ..
  41. Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, et al. Adiponectin confers protection from acute colitis and restricts a B cell immune response. J Biol Chem. 2017;292:6569-6582 pubmed publisher
    ..HCT116 colonic epithelial cells were employed to analyze the in vitro effects of adiponectin and AdipoR1 interactions in colonic injury following dextran sulfate sodium treatment...
  42. Song J, Kang S, Kim E, Kim C, Song H, Lee J. Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study. Cell Death Dis. 2015;6:e1844 pubmed publisher
    ..We showed that AdipoR1 protects cell damage and synaptic dysfunction in the mouse brain in hyperglycemia...
  43. Luo N, Wang X, Zhang W, Garvey W, Fu Y. AdR1-TG/TALLYHO mice have improved lipid accumulation and insulin sensitivity. Biochem Biophys Res Commun. 2013;433:567-72 pubmed publisher
  44. Huang H, Iida K, Sone H, Ajisaka R. The regulation of adiponectin receptors expression by acute exercise in mice. Exp Clin Endocrinol Diabetes. 2007;115:417-22 pubmed
    ..Recently, two types of adiponectin receptors (AdipoR1 and AdipoR2) were identified...
  45. Da Wa C, Zhao F, Qi Y, Chen L, Huo Y. [Role of adiponectin and its receptors in anti-atherosclerotic effects of pioglitazone on ApoE knocked out mice]. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:174-8 pubmed
    ..Expression levels of the adiponectin receptor 1(AdipoR1)and adiponectin receptor 2 (AdipoR2) in vessels were analyzed(RT-PCR)...
  46. Sideri A, Stavrakis D, Bowe C, Shih D, Fleshner P, Arsenescu V, et al. Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1. Am J Physiol Gastrointest Liver Physiol. 2015;308:G591-604 pubmed publisher
    ..Fat-conditioned media reduced adiponectin receptor 1 (AdipoR1) expression in human NCM460 colonic epithelial cells...
  47. Wu W, Sun Y, Zhao C, Zhao C, Chen X, Wang G, et al. Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPAR? signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2016;48:509-19 pubmed publisher
    ..Furthermore, AdipoR1, not AdipoR2, was first identified as a receptor of CTRP6 during the process of mitotic clonal expansion...
  48. Yau S, Li A, Hoo R, Ching Y, Christie B, Lee T, et al. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc Natl Acad Sci U S A. 2014;111:15810-5 pubmed publisher
  49. Sun X, He J, Mao C, Han R, Wang Z, Liu Y, et al. Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element. FEBS Lett. 2008;582:3401-7 pubmed publisher
    ..hormone that has anti-diabetic and anti-atherogenic effects through interaction with adiponectin receptors AdipoR1 and AdipoR2. We analyzed the transcriptional regulation of AdipoR1 by insulin...
  50. Kajimura D, Lee H, Riley K, Arteaga Solis E, Ferron M, Zhou B, et al. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 2013;17:901-15 pubmed publisher
    ..It also proposes that adiponectin regulation of bone mass occurs through a PI3-kinase-FoxO1 pathway. ..
  51. Guo F, Jiang T, Song W, Wei H, Wang F, Liu L, et al. Electroacupuncture attenuates cerebral ischemia-reperfusion injury in diabetic mice through adiponectin receptor 1-mediated phosphorylation of GSK-3?. Mol Neurobiol. 2015;51:685-95 pubmed publisher
    ..plasma and cerebral adiponectin (APN) were measured as well as the expression of cerebral adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2)...
  52. Lin Y, Chen C, Chuang T, Lin Y, Liu H, Mersmann H, et al. Adiponectin receptor 1 regulates bone formation and osteoblast differentiation by GSK-3?/?-catenin signaling in mice. Bone. 2014;64:147-54 pubmed publisher
    ..study was to use porcine adiponectin receptor 1 transgenic mice (pAdipoR1) as a model to evaluate the role of AdipoR1 on bone physiology at different ages...
  53. Gonez L, Naselli G, Banakh I, Niwa H, Harrison L. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Mol Med. 2008;14:697-704 pubmed publisher
    ..We propose that PAQR10 may act at the level of the mitochondrion to regulate pancreatic endocrine cell development/survival. ..
  54. Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M, Sugimoto T. Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biol. 2007;8:51 pubmed
    ..Adiponectin receptor type 1 (AdipoR1) mRNA was detected in the cells by RT-PCR...
  55. Li P, Sun F, Cao H, Ma Q, Pan C, Ma J, et al. Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: adiponectin regulates steroidogenesis. Biochem Biophys Res Commun. 2009;390:1208-13 pubmed publisher
    ..We found, for the first time, that adiponectin receptor (AdipoR1 and AdipoR2) mRNA and protein were expressed in mouse adrenal and adrenocortical Y-1 cells...
  56. Sattar A, Sattar R. Insulin-regulated expression of adiponectin receptors in muscle and fat cells. Cell Biol Int. 2012;36:1293-7 pubmed publisher
    Adp (adiponectin), an adipocyte-secreted hormone, exerts its effect via its specific receptors, AdipoR1 and AdipoR2 (adiponectin receptors 1 and 2), on insulin-sensitive cells in muscle, liver and adipose tissues, and plays an important ..
  57. Wang Y, Lau W, Gao E, Tao L, Yuan Y, Li R, et al. Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury. Am J Physiol Endocrinol Metab. 2010;298:E663-70 pubmed publisher
    ..05). Myocytes from adiponectin receptor 1 knockdown (AdipoR1-KD) or AdipoR1-KD/AdipoR2-KO mice had slightly increased SI/R injury, but the difference was not statistically ..
  58. Cheng L, Li B, Chen X, Su J, Wang H, Yu S, et al. CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1? activation. Biochem Biophys Res Commun. 2016;477:685-691 pubmed publisher
    ..of SIRT1 in HAECs impeded the effect of CTRP9 on mitochondrial biogenesis, while silencing the expression of AdipoR1 in HAECs reversed the expression of SIRT1 and PGC-1?...
  59. Kosel D, Heiker J, Juhl C, Wottawah C, Bluher M, Mörl K, et al. Dimerization of adiponectin receptor 1 is inhibited by adiponectin. J Cell Sci. 2010;123:1320-8 pubmed publisher
    b>AdipoR1 and AdipoR2 are newly discovered members of the huge family of seven-transmembrane receptors, but both receptors are structurally and functionally different from G-protein-coupled receptors...
  60. Zhou Y, Sun X, Jin L, Stringfield T, Lin L, Chen Y. Expression profiles of adiponectin receptors in mouse embryos. Gene Expr Patterns. 2005;5:711-5 pubmed
    ..Adiponectin exerts its function by interacting with membrane receptors, including AdipoR1 and AdipoR2. We investigated the expression pattern of these two adiponectin receptors in mouse embryos...
  61. Alzahrani B, Iseli T, Ramezani Moghadam M, Ho V, Wankell M, Sun E, et al. The role of AdipoR1 and AdipoR2 in liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2018;1864:700-708 pubmed publisher
    Activation of the adiponectin (APN) signaling axis retards liver fibrosis. However, understanding of the role of AdipoR1 and AdipoR2 in mediating this response is still rudimentary...
  62. Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, et al. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem. 2004;279:30817-22 pubmed
    ..We reported previously that AdipoR1 and -R2 serve as receptors for adiponectin and mediate increased fatty acid oxidation and glucose uptake by ..
  63. Koentges C, König A, Pfeil K, Hölscher M, Schnick T, Wende A, et al. Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol. 2015;110:37 pubmed publisher
    ..We aimed to define the roles of adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2) in adiponectin-evoked regulation of mitochondrial function in the heart...
  64. Lindgren A, Levin M, Rodrigo Blomqvist S, Wikström J, Ahnmark A, Mogensen C, et al. Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice. PLoS ONE. 2013;8:e80330 pubmed publisher
    ..has been shown to have beneficial cardiovascular effects and to signal through the adiponectin receptors, AdipoR1 and AdipoR2...
  65. Wu L, Xu B, Fan W, Zhu X, Wang G, Zhang A. Adiponectin protects Leydig cells against proinflammatory cytokines by suppressing the nuclear factor-?B signaling pathway. FEBS J. 2013;280:3920-7 pubmed publisher
    ..Thus, our data clearly indicate that adiponectin plays a protective role in Leydig cells through its anti-inflammatory actions...
  66. Cikos S, Burkuš J, Bukovská A, Fabian D, Rehák P, Koppel J. Expression of adiponectin receptors and effects of adiponectin isoforms in mouse preimplantation embryos. Hum Reprod. 2010;25:2247-55 pubmed publisher
    ..Using RT-PCR and immunohistochemistry, we found expression of adiponectin receptors AdipoR1 and AdipoR2, at the mRNA and protein level, in mouse ovulated oocytes and preimplantation embryos...
  67. Kim S, Marquard K, Stephens S, Louden E, Allsworth J, Moley K. Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus. Hum Reprod. 2011;26:82-95 pubmed publisher
    ..By real-time quantitative PCR, mRNA transcripts for Adipoq, AdipoR1, AdipoR2, Ppara, Ppard, FATP1 (SLC27A1) and acyl CoA oxidase (Acox1) were identified in mouse 2-cell and 8-cell ..