Adipoq

Summary

Gene Symbol: Adipoq
Description: adiponectin, C1Q and collagen domain containing
Alias: 30kDa, APN, Acdc, Acrp30, GBP28, adipo, apM1, adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement related protein, adipocyte complement-related 30 kDa protein, adipocyte, C1Q and collagen domain containing, adipocyte, C1q and collagen domain-containing protein, adipocyte-specific protein AdipoQ
Species: mouse
Products:     Adipoq

Top Publications

  1. Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, et al. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1? signaling contributing to increased vulnerability in diabetic heart. Basic Res Cardiol. 2013;108:329 pubmed publisher
    ..Whether adiponectin (APN), a potent cardioprotective molecule, regulates cardiac mitochondrial function has also not been ..
  2. Maruyama S, Shibata R, Ohashi K, Ohashi T, Daida H, Walsh K, et al. Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism. J Biol Chem. 2011;286:32790-800 pubmed publisher
    ..b>Adiponectin is an adipose-derived, cardioprotective factor that is down-regulated in obesity...
  3. Delaigle A, Jonas J, Bauche I, Cornu O, Brichard S. Induction of adiponectin in skeletal muscle by inflammatory cytokines: in vivo and in vitro studies. Endocrinology. 2004;145:5589-97 pubmed
    b>Adiponectin (ApN) is an adipocytokine that plays a fundamental role in energy homeostasis and counteracting inflammation...
  4. Subedi A, Kim M, Nepal S, Lee E, Kim J, Sohn D, et al. Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-?B pathway. FEBS Lett. 2013;587:1556-61 pubmed publisher
    ..Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR-21 and PDCD4 in RAW 264.7 macrophages...
  5. Wang Y, Xu A, Knight C, Xu L, Cooper G. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002;277:19521-9 pubmed
    It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive...
  6. Peterson J, Wei Z, Seldin M, Byerly M, Aja S, Wong G. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 2013;305:R522-33 pubmed publisher
    ..a secreted multimeric protein of the C1q family and the closest paralog of the insulin-sensitizing adipokine, adiponectin. The metabolic function of this adipose tissue-derived plasma protein remains largely unknown...
  7. Okamoto Y, Folco E, Minami M, Wara A, Feinberg M, Sukhova G, et al. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res. 2008;102:218-25 pubmed
    Obese individuals often have low plasma adiponectin and concomitant chronic inflammation with a predisposition to metabolic and cardiovascular diseases...
  8. Xu A, Wang Y, Keshaw H, Xu L, Lam K, Cooper G. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003;112:91-100 pubmed
    b>Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes...
  9. Wong G, Krawczyk S, Kitidis Mitrokostas C, Revett T, Gimeno R, Lodish H. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J. 2008;416:161-77 pubmed publisher
    The insulin-sensitizing hormone, adiponectin, belongs to the expanding C1q/TNF (tumour necrosis factor) family of proteins...
  10. Nishimura M, Izumiya Y, Higuchi A, Shibata R, Qiu J, Kudo C, et al. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation. 2008;117:216-23 pubmed
    b>Adiponectin is a fat-derived plasma protein that has beneficial actions on cardiovascular disorders...

Detail Information

Publications94

  1. Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, et al. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1? signaling contributing to increased vulnerability in diabetic heart. Basic Res Cardiol. 2013;108:329 pubmed publisher
    ..Whether adiponectin (APN), a potent cardioprotective molecule, regulates cardiac mitochondrial function has also not been ..
  2. Maruyama S, Shibata R, Ohashi K, Ohashi T, Daida H, Walsh K, et al. Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism. J Biol Chem. 2011;286:32790-800 pubmed publisher
    ..b>Adiponectin is an adipose-derived, cardioprotective factor that is down-regulated in obesity...
  3. Delaigle A, Jonas J, Bauche I, Cornu O, Brichard S. Induction of adiponectin in skeletal muscle by inflammatory cytokines: in vivo and in vitro studies. Endocrinology. 2004;145:5589-97 pubmed
    b>Adiponectin (ApN) is an adipocytokine that plays a fundamental role in energy homeostasis and counteracting inflammation...
  4. Subedi A, Kim M, Nepal S, Lee E, Kim J, Sohn D, et al. Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-?B pathway. FEBS Lett. 2013;587:1556-61 pubmed publisher
    ..Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR-21 and PDCD4 in RAW 264.7 macrophages...
  5. Wang Y, Xu A, Knight C, Xu L, Cooper G. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002;277:19521-9 pubmed
    It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive...
  6. Peterson J, Wei Z, Seldin M, Byerly M, Aja S, Wong G. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 2013;305:R522-33 pubmed publisher
    ..a secreted multimeric protein of the C1q family and the closest paralog of the insulin-sensitizing adipokine, adiponectin. The metabolic function of this adipose tissue-derived plasma protein remains largely unknown...
  7. Okamoto Y, Folco E, Minami M, Wara A, Feinberg M, Sukhova G, et al. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res. 2008;102:218-25 pubmed
    Obese individuals often have low plasma adiponectin and concomitant chronic inflammation with a predisposition to metabolic and cardiovascular diseases...
  8. Xu A, Wang Y, Keshaw H, Xu L, Lam K, Cooper G. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003;112:91-100 pubmed
    b>Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes...
  9. Wong G, Krawczyk S, Kitidis Mitrokostas C, Revett T, Gimeno R, Lodish H. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J. 2008;416:161-77 pubmed publisher
    The insulin-sensitizing hormone, adiponectin, belongs to the expanding C1q/TNF (tumour necrosis factor) family of proteins...
  10. Nishimura M, Izumiya Y, Higuchi A, Shibata R, Qiu J, Kudo C, et al. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation. 2008;117:216-23 pubmed
    b>Adiponectin is a fat-derived plasma protein that has beneficial actions on cardiovascular disorders...
  11. Miller M, Pham A, Cho J, Rosenthal P, Broide D. Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema. Am J Physiol Lung Cell Mol Physiol. 2010;299:L834-42 pubmed publisher
    b>Adiponectin is a cytokine with both proinflammatory and anti-inflammatory properties that is expressed in epithelial cells in the airway in chronic obstructive pulmonary disease-emphysema (COPD-E)...
  12. Hebbard L, Garlatti M, Young L, Cardiff R, Oshima R, Ranscht B. T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res. 2008;68:1407-16 pubmed publisher
    ..is a suggested binding partner for high molecular weight forms of the circulating, fat-secreted hormone adiponectin. We discern adiponectin in association with the T-cadherin-positive vasculature in the normal and malignant ..
  13. Wijesekara N, Krishnamurthy M, Bhattacharjee A, Suhail A, Sweeney G, Wheeler M. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. J Biol Chem. 2010;285:33623-31 pubmed publisher
    The functional impact of adiponectin on pancreatic beta cells is so far poorly understood...
  14. Shimano M, Ouchi N, Shibata R, Ohashi K, Pimentel D, Murohara T, et al. Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response. J Mol Cell Cardiol. 2010;49:210-20 pubmed publisher
    Although increasing evidence indicates that an adipokine adiponectin exerts protective actions on heart, its effects on coronary angiogenesis following pressure overload have not been examined previously...
  15. Oster R, Tishinsky J, Yuan Z, Robinson L. Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPAR? mRNA, in 3T3-L1 adipocytes. Appl Physiol Nutr Metab. 2010;35:783-9 pubmed publisher
    b>Adiponectin, a protein secreted from adipose tissue, has been shown to have anti-diabetic and anti-inflammatory effects, but its regulation is not completely understood...
  16. Iwabu M, Yamauchi T, Okada Iwabu M, Sato K, Nakagawa T, Funata M, et al. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature. 2010;464:1313-9 pubmed publisher
    b>Adiponectin is an anti-diabetic adipokine. Its receptors possess a seven-transmembrane topology with the amino terminus located intracellularly, which is the opposite of G-protein-coupled receptors...
  17. Tsao T, Tomas E, Murrey H, Hug C, Lee D, Ruderman N, et al. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem. 2003;278:50810-7 pubmed
    Acrp30/adiponectin is an adipocyte-derived serum protein with important roles in regulation of lipid and glucose metabolism, but which of its isoforms are biologically active remains controversial...
  18. Oku H, Matsuura F, Koseki M, Sandoval J, Yuasa Kawase M, Tsubakio Yamamoto K, et al. Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver. FEBS Lett. 2007;581:5029-33 pubmed
    ..In humans, plasma HDL-cholesterol levels are positively correlated with plasma adiponectin (APN) concentrations...
  19. Amin R, Mathews S, Camp H, Ding L, Leff T. Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance. Am J Physiol Endocrinol Metab. 2010;298:E28-37 pubmed publisher
    ..and genetic activation of muscle PPARgamma in muscle tissue of transgenic mice, induced the production of adiponectin directly from muscle cells...
  20. Konter J, Parker J, Baez E, Li S, Ranscht B, Denzel M, et al. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol. 2012;188:854-63 pubmed publisher
    b>Adiponectin (APN) is an adipose tissue-derived factor with anti-inflammatory and vascular protective properties whose levels paradoxically decrease with increasing body fat...
  21. Kamada Y, Matsumoto H, Tamura S, Fukushima J, Kiso S, Fukui K, et al. Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. J Hepatol. 2007;47:556-64 pubmed
    Adipose tissue produces a number of adipocytokines, including adiponectin, leptin, and tumor necrosis factor-alpha...
  22. Wang Y, Lam K, Chan L, Chan K, Lam J, Lam M, et al. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem. 2006;281:16391-400 pubmed
    b>Adiponectin is a multifunctional adipokine that circulates as several oligomeric complexes in the blood stream. However, the molecular basis that regulates the production of the adiponectin oligomers remains largely elusive...
  23. Essick E, Ouchi N, Wilson R, Ohashi K, Ghobrial J, Shibata R, et al. Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling. Am J Physiol Heart Circ Physiol. 2011;301:H984-93 pubmed publisher
    ..b>Adiponectin (APN), an adipokine, modulates cardiac hypertrophy, but it is unknown if APN inhibits ROS-induced cardiomyocyte ..
  24. Landskroner Eiger S, Qian B, Muise E, Nawrocki A, Berger J, Fine E, et al. Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin Cancer Res. 2009;15:3265-76 pubmed publisher
    ..Metabolically, one of the more important fat-derived factors ("adipokines") is adiponectin (APN). Serum concentrations of APN negatively correlate with body mass index and insulin resistance...
  25. Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A. 2004;101:2476-81 pubmed
    ..The adipose tissue produces several growth factors/hormones including leptin, tumor necrosis factor alpha, and adiponectin. It has been found that adiponectin levels are reduced in obesity...
  26. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002;8:731-7 pubmed
    Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone, by disrupting the gene that encodes it in mice...
  27. Higuchi A, Ohashi K, Kihara S, Walsh K, Ouchi N. Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression. Circ Res. 2009;104:1058-65 pubmed publisher
    The fat-derived hormone adiponectin has been shown to have a protective role in macrovascular disorders. However, nothing is known about the function of adiponectin in retinal microvessel disease...
  28. Gove M, Pini M, Fayad R, Cabay R, Fantuzzi G. Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in the transfer model of colitis. Cytokine. 2009;47:119-25 pubmed publisher
    We investigated the effect of adiponectin (APN) deficiency in the CD4(+)CD45RB(high) transfer model of colitis...
  29. Hug C, Wang J, Ahmad N, Bogan J, Tsao T, Lodish H. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A. 2004;101:10308-13 pubmed
    Acrp30/adiponectin is reduced in the serum of obese and diabetic individuals, and the genetic locus of adiponectin is linked to the metabolic syndrome...
  30. Williams A, Kasahara D, Verbout N, Fedulov A, Zhu M, Si H, et al. Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice. PLoS ONE. 2012;7:e41088 pubmed publisher
    b>Adiponectin is an adipose derived hormone that declines in obesity. We have previously shown that exogenous administration of adiponectin reduces allergic airways responses in mice...
  31. Williams G, Wang Y, Callon K, Watson M, Lin J, Lam J, et al. In vitro and in vivo effects of adiponectin on bone. Endocrinology. 2009;150:3603-10 pubmed publisher
    ..Adipocyte-derived hormones may contribute to this relationship, and adiponectin is a principal circulating adipokine. However, its effects on bone remain unclear...
  32. Fujita K, Maeda N, Sonoda M, Ohashi K, Hibuse T, Nishizawa H, et al. Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha. Arterioscler Thromb Vasc Biol. 2008;28:863-70 pubmed publisher
    b>Adiponectin is recognized as an antidiabetic, antiatherosclerotic, and anti-inflammatory protein derived from adipocytes. However, the role of adiponectin in cardiac fibrosis remains uncertain...
  33. Halberg N, Schraw T, Wang Z, Kim J, Yi J, Hamilton M, et al. Systemic fate of the adipocyte-derived factor adiponectin. Diabetes. 2009;58:1961-70 pubmed publisher
    The adipocyte-derived secretory protein adiponectin has been widely studied and shown to have potent insulin-sensitizing, antiapoptotic, and anti-inflammatory properties...
  34. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension. 2003;42:231-4 pubmed
    Endothelial dysfunction is a crucial feature in the evolution of atherosclerosis. Adiponectin is an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties...
  35. Tu Q, Zhang J, Dong L, Saunders E, Luo E, Tang J, et al. Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. J Biol Chem. 2011;286:12542-53 pubmed publisher
    b>Adiponectin is an adipokine playing an important role in regulating energy homeostasis and insulin sensitivity. However, the effect of adiponectin on bone metabolism shows contradictory results according to different research studies...
  36. Zhou L, Liu F. Autophagy: roles in obesity-induced ER stress and adiponectin downregulation in adipocytes. Autophagy. 2010;6:1196-7 pubmed publisher
    ..Obesity induces ER stress in mouse adipose tissue, which correlates with reduced adiponectin levels...
  37. Lam J, Chow K, Xu A, Lam K, Liu J, Wong N, et al. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS ONE. 2009;4:e4968 pubmed publisher
    b>Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications. A negative association of adiponectin levels with breast cancer development has been demonstrated...
  38. Berner H, Lyngstadaas S, Spahr A, Monjo M, Thommesen L, Drevon C, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone. 2004;35:842-9 pubmed
    b>Adiponectin has until now been considered to be synthesized and secreted exclusively by the adipose tissue, and is reported to influence energy homeostasis and insulin sensitivity...
  39. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-9 pubmed
    b>Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine...
  40. Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab. 2007;293:E1118-28 pubmed
    Chronic inflammation and reduced adiponectin are widely observed in the white adipose tissue in obesity. However, the cause of the changes remains to be identified...
  41. Ge Q, Ryken L, Noel L, Maury E, Brichard S. Adipokines identified as new downstream targets for adiponectin: lessons from adiponectin-overexpressing or -deficient mice. Am J Physiol Endocrinol Metab. 2011;301:E326-35 pubmed publisher
    Adipokines play a central role in the pathogenesis of the metabolic syndrome. Among them, adiponectin (ApN), a master regulator of immune and fuel homeostasis, is decreased...
  42. Lovren F, Pan Y, Quan A, Szmitko P, Singh K, Shukla P, et al. Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages. Am J Physiol Heart Circ Physiol. 2010;299:H656-63 pubmed publisher
    ..We hypothesized that adiponectin may prime human monocytes toward the M2 phenotype...
  43. Kasahara D, Kim H, Williams A, Verbout N, Tran J, Si H, et al. Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A. J Immunol. 2012;188:4558-67 pubmed publisher
    Pulmonary responses to ozone, a common air pollutant, are augmented in obese individuals. Adiponectin, an adipose-derived hormone that declines in obesity, has regulatory effects on the immune system...
  44. Yamaguchi N, Kukita T, Li Y, Kamio N, Fukumoto S, Nonaka K, et al. Adiponectin inhibits induction of TNF-alpha/RANKL-stimulated NFATc1 via the AMPK signaling. FEBS Lett. 2008;582:451-6 pubmed publisher
    We investigated here whether adiponectin can exhibit an inhibitory effect on tumor necrosis factor-alpha (TNF-alpha)- and receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis by using RAW264 cell D clone ..
  45. Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, et al. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab. 2007;6:55-68 pubmed
    b>Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues...
  46. Shafiei M, Shetty S, Scherer P, Rockey D. Adiponectin regulation of stellate cell activation via PPAR?-dependent and -independent mechanisms. Am J Pathol. 2011;178:2690-9 pubmed publisher
    In this study, we elucidated the mechanism by which adiponectin modulates hepatic stellate cell activation and fibrogenesis...
  47. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004;279:1304-9 pubmed
    b>Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro and in vivo...
  48. Qiao L, Kinney B, Yoo H, Lee B, Schaack J, Shao J. Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1. Diabetes. 2012;61:1463-70 pubmed publisher
    b>Adiponectin enhances mitochondrial biogenesis and oxidative metabolism in skeletal muscle. This study aimed to investigate the underlying mechanisms through which adiponectin induces mitochondrial biogenesis in skeletal muscle...
  49. Shetty S, Ramos Román M, Cho Y, Brown J, Plutzky J, Muise E, et al. Enhanced fatty acid flux triggered by adiponectin overexpression. Endocrinology. 2012;153:113-22 pubmed publisher
    b>Adiponectin overexpression in mice increases insulin sensitivity independent of adiposity...
  50. Nishihara T, Baba M, Matsuda M, Inoue M, Nishizawa Y, Fukuhara A, et al. Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. World J Gastroenterol. 2008;14:6473-80 pubmed
    ..and colorectal carcinogenesis in in vivo experimental model, and to determine the contribution of adiponectin deficiency to colorectal cancer development and proliferation...
  51. Denzel M, Hebbard L, Shostak G, Shapiro L, Cardiff R, Ranscht B. Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. Clin Cancer Res. 2009;15:3256-64 pubmed publisher
    High levels of the fat-secreted cytokine adiponectin (APN) are present in the circulation of healthy people, whereas low levels correlate with an increased incidence of breast cancer in women...
  52. Ma K, Cabrero A, Saha P, Kojima H, Li L, Chang B, et al. Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002;277:34658-61 pubmed
    Previous reports showed that recombinant fragments of adiponectin (adipo) displayed pharmacological effects when injected into rodents, but the relevance of these observations to the physiological function of adipo is unclear...
  53. Yokota T, Meka C, Medina K, Igarashi H, Comp P, Takahashi M, et al. Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest. 2002;109:1303-10 pubmed
    b>Adiponectin, an adipocyte-derived hormone, was recently shown to have potential therapeutic applications in diabetes and obesity because of its influence on glucose and lipid metabolism...
  54. Shu R, Zhang F, Wang F, Feng D, Li X, Ren W, et al. Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice. Lab Invest. 2009;89:1043-52 pubmed publisher
    ..b>Adiponectin is an adipocytokine secreted by mature adipocytes, and its receptors are widely distributed in many tissues, ..
  55. Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel D, et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med. 2004;10:1384-9 pubmed
    ..The adipocytokine adiponectin is decreased in patients with obesity-linked diseases...
  56. Frizzell N, Rajesh M, Jepson M, Nagai R, Carson J, Thorpe S, et al. Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin. J Biol Chem. 2009;284:25772-81 pubmed publisher
    ..is also increased in epididymal, mesenteric, and subcutaneous adipose tissue of diabetic (db/db) mice and that adiponectin is a major target for succination in both adipocytes and adipose tissue...
  57. O Shea K, Chess D, Khairallah R, Rastogi S, Hecker P, Sabbah H, et al. Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload. Am J Physiol Heart Circ Physiol. 2010;298:H1639-45 pubmed publisher
    Recent data suggest adiponectin, an adipocyte-derived hormone, affects development of heart failure in response to hypertension...
  58. Pini M, Sennello J, Chan L, Fantuzzi G. Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in mice. Endocrinology. 2006;147:5019-22 pubmed
    b>Adiponectin (APN) is an adipocyte-derived protein that regulates insulin sensitivity and displays antiinflammatory activities in a variety of experimental models...
  59. Sennello J, Fayad R, Morris A, Eckel R, Asilmaz E, Montez J, et al. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology. 2005;146:2157-64 pubmed
    ..Serum leptin and adiponectin were low in LD mice, whereas ob/ob mice had undetectable leptin, but high adiponectin...
  60. Nawrocki A, Hofmann S, Teupser D, Basford J, Durand J, Jelicks L, et al. Lack of association between adiponectin levels and atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2010;30:1159-65 pubmed publisher
    b>Adiponectin is an adipocyte-derived, secreted protein that is implicated in protection against a cluster of related metabolic disorders...
  61. Liu S, Yin T, Wei X, Yi W, Qu Y, Liu Y, et al. Downregulation of adiponectin induced by tumor necrosis factor ? is involved in the aggravation of posttraumatic myocardial ischemia/reperfusion injury. Crit Care Med. 2011;39:1935-43 pubmed publisher
    ..trauma with a special focus on the role of tumor necrosis factor ? and its potential downstream effector adiponectin, a novel adipokine with anti-inflammatory and cardioprotective properties. Laboratory study...
  62. Pajvani U, Du X, Combs T, Berg A, Rajala M, Schulthess T, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003;278:9073-85 pubmed
    Acrp30/adiponectin is an adipocyte-specific secretory protein that has recently been implicated as a mediator of systemic insulin sensitivity with liver and muscle as target organs...
  63. Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem. 2003;278:2461-8 pubmed
    The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity...
  64. Tomas E, Tsao T, Saha A, Murrey H, Zhang Cc C, Itani S, et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A. 2002;99:16309-13 pubmed
    gACRP30, the globular subunit of adipocyte complement-related protein of 30 kDa (ACRP30), improves insulin sensitivity and increases fatty acid oxidation. The mechanism by which gACRP30 exerts these effects is unknown...
  65. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941-6 pubmed
    b>Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where the gene encoding adiponectin is located...
  66. Combs T, Berg A, Rajala M, Klebanov S, Iyengar P, Jimenez Chillaron J, et al. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes. 2003;52:268-76 pubmed
    b>Adiponectin or adipocyte complement-related protein of 30 kDa (Acrp30) is a circulating protein produced exclusively in adipocytes...
  67. Ding M, Carrao A, Wagner R, Xie Y, Jin Y, Rzucidlo E, et al. Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype. J Mol Cell Cardiol. 2012;52:474-84 pubmed publisher
    b>Adiponectin is a cardioprotective adipokine derived predominantly from visceral fat. We recently demonstrated that exogenous adiponectin induces vascular smooth muscle cell (VSMC) differentiation via repression of mTORC1 and FoxO4...
  68. Shibata R, Sato K, Pimentel D, Takemura Y, Kihara S, Ohashi K, et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med. 2005;11:1096-103 pubmed
    Obesity-related disorders are associated with the development of ischemic heart disease. Adiponectin is a circulating adipose-derived cytokine that is downregulated in obese individuals and after myocardial infarction...
  69. Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002;277:25863-6 pubmed
    The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, and it has been reported to exhibit putative antiatherogenic properties in vitro...
  70. Wilk S, Scheibenbogen C, Bauer S, Jenke A, Rother M, Guerreiro M, et al. Adiponectin is a negative regulator of antigen-activated T cells. Eur J Immunol. 2011;41:2323-32 pubmed publisher
    b>Adiponectin (APN), a cytokine constitutively produced in fat tissue, has been shown to exert anti-inflammatory effects in various disease models...
  71. Civitarese A, Ukropcova B, Carling S, Hulver M, DeFronzo R, Mandarino L, et al. Role of adiponectin in human skeletal muscle bioenergetics. Cell Metab. 2006;4:75-87 pubmed
    ..Here, we report that adiponectin signaling regulates mitochondrial bioenergetics in skeletal muscle...
  72. Bueno A, Oyama L, de Oliveira C, Pisani L, Ribeiro E, Silveira V, et al. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. Pflugers Arch. 2008;455:701-9 pubmed
    ..A major protein secreted by adipose tissue is adiponectin, which has antiatherogenic and antidiabetic properties...
  73. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber M, Summer R, et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest. 2007;117:375-86 pubmed
    Obesity and type 2 diabetes are associated with chronic inflammation. Adiponectin is an adipocyte-derived hormone with antidiabetic and antiinflammatory actions...
  74. Ealey K, Kaludjerovic J, Archer M, Ward W. Adiponectin is a negative regulator of bone mineral and bone strength in growing mice. Exp Biol Med (Maywood). 2008;233:1546-53 pubmed publisher
    ..Serum levels of the adipokine adiponectin are inversely correlated with obesity, but results from studies on its relationship to bone mass are ..
  75. Asterholm I, Scherer P. Enhanced metabolic flexibility associated with elevated adiponectin levels. Am J Pathol. 2010;176:1364-76 pubmed publisher
    ..Here, we focus on the effects of the adipocyte-derived secretory molecule adiponectin on adipose tissue in mouse models with genetically altered adiponectin levels...
  76. Suzuki S, Wilson Kubalek E, Wert D, Tsao T, Lee D. The oligomeric structure of high molecular weight adiponectin. FEBS Lett. 2007;581:809-14 pubmed
    There is great interest in the structure of adiponectin as its oligomeric state may specify its biological activities. It occurs as a trimer, a hexamer and a high molecular weight complex...
  77. Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, et al. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension. 2006;47:1108-16 pubmed
    Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels are decreased in obesity and that adiponectin has many defensive properties against obesity-related diseases, such as type 2 ..
  78. Combs T, Pajvani U, Berg A, Lin Y, Jelicks L, Laplante M, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology. 2004;145:367-83 pubmed
    b>Adiponectin is a plasma protein expressed exclusively in adipose tissue...
  79. Higuchi A, Ohashi K, Shibata R, Sono Romanelli S, Walsh K, Ouchi N. Thiazolidinediones reduce pathological neovascularization in ischemic retina via an adiponectin-dependent mechanism. Arterioscler Thromb Vasc Biol. 2010;30:46-53 pubmed publisher
    ..compared with vehicle treatment, which was accompanied by increased plasma levels of the fat-derived hormone adiponectin (APN)...
  80. Shibata R, Ouchi N, Kihara S, Sato K, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem. 2004;279:28670-4 pubmed
    ..b>Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties, and its plasma ..
  81. Sam F, Duhaney T, Sato K, Wilson R, Ohashi K, Sono Romanelli S, et al. Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. Endocrinology. 2010;151:322-31 pubmed publisher
    ..In turn, hypertension is the major cause of diastolic heart failure (HF). Adiponectin, an adipose-derived plasma protein, exerts antiinflammatory and anti-hypertrophic effects and is implicated in ..
  82. Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, et al. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem. 2006;99:196-208 pubmed
    ..bone and lipid metabolism has been suggested, this study investigated the regulation of bone metabolism by adiponectin, a representative adipokine, by analyzing deficient and overexpressing transgenic mice...
  83. Qiang L, Wang H, Farmer S. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol. 2007;27:4698-707 pubmed
    b>Adiponectin is secreted from adipose tissue in response to metabolic effectors in order to sensitize the liver and muscle to insulin...
  84. Fu Y, Luo N, Klein R, Garvey W. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res. 2005;46:1369-79 pubmed
    b>Adiponectin is secreted from adipocytes, and low circulating levels have been epidemiologically associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease...