Adh4

Summary

Gene Symbol: Adh4
Description: alcohol dehydrogenase 4 (class II), pi polypeptide
Alias: Adh2, alcohol dehydrogenase 4, alcohol dehydrogenase II, alcohol dehydrogenase class II, class II type ADH
Species: mouse

Top Publications

  1. ncbi Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3
    R S Holmes
    Biochem Genet 17:461-72. 1979
  2. ncbi Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice
    Andrea Carmine Belin
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Behav Brain Res 217:439-45. 2011
  3. ncbi Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism
    M Hellgren
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
    Cell Mol Life Sci 64:498-505. 2007
  4. ncbi High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS J 274:1212-23. 2007
  5. ncbi Merging protein, gene and genomic data: the evolution of the MDR-ADH family
    R Gonzalez-Duarte
    Departament de Genetica, Universitat de Barcelona, Avda Diagonal 645, Barcelona 08028, Spain
    Heredity (Edinb) 95:184-97. 2005
  6. ncbi Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4
    Xixuan H Collins
    Department of Biochemistry, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:33157-64. 2005
  7. ncbi Enzymatic mechanism of low-activity mouse alcohol dehydrogenase 2
    Patrik Strömberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Biochemistry 43:1323-8. 2004
  8. ncbi Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain
    Dagmar Galter
    Department of Neuroscience, Clinical Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden
    Eur J Biochem 270:1316-26. 2003
  9. ncbi Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 269:2607-12. 2002
  10. ncbi Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:13804-11. 2002

Scientific Experts

  • R Gonzalez-Duarte
  • Gregg Duester
  • Dagmar Galter
  • Andrea Carmine Belin
  • Marie Westerlund
  • Andrei Molotkov
  • S M Ulven
  • Ali G Fenstermaker
  • S Svensson
  • J O Hoog
  • M Hellgren
  • Xixuan H Collins
  • Lars Olson
  • Michael R Felder
  • Kristine B Berst
  • Bryce V Plapp
  • Patrik Strömberg
  • P Stromberg
  • Gabor Szalai
  • Sven Ove Ogren
  • Karin Pernold
  • Eva Lindqvist
  • R Blomhoff
  • T E Gundersen
  • A K Sakhi
  • Anna Anvret
  • Yimin Zou
  • Andre Goffinet
  • Youri Adolfs
  • Asheeta A Prasad
  • Ahmad Bechara
  • Fadel Tissir
  • R Jeroen Pasterkamp
  • O Gallego
  • S Martras
  • B Persson
  • X Pares
  • J Farres
  • Neal L Weintraub
  • Arthur A Spector
  • Steven A Moore
  • Xiang Fang
  • T Verugopal Raju
  • John R Falck
  • Shawn D Harmon
  • Terry L Kaduce
  • Jan Olov Höög
  • Stefan Svensson
  • Silvia Buervenich
  • Andrea Carmine
  • Mario H Foglio
  • ShaoPing Lin
  • Bruce A Roe
  • Robert Friedman
  • Honggui Jia
  • Xiaohong Fan
  • Arnold E Cuenca
  • Louise Deltour
  • J C Glover
  • V O Landaas
  • G Schneider
  • M S Weedon
  • T Sandalova
  • S H Fromm
  • B A Geronimo
  • J O Moskaug
  • R S Holmes

Detail Information

Publications16

  1. ncbi Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3
    R S Holmes
    Biochem Genet 17:461-72. 1979
    ....
  2. ncbi Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice
    Andrea Carmine Belin
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Behav Brain Res 217:439-45. 2011
    Class IV alcohol dehydrogenase (ADH4) efficiently reduces aldehydes produced during lipid peroxidation, and may thus serve to protect from toxic effects of aldehydes e.g. on neurons...
  3. ncbi Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism
    M Hellgren
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
    Cell Mol Life Sci 64:498-505. 2007
    ..retinaldehyde has been investigated with focus on the activities of human, mouse and rat alcohol dehydrogenase 2 (ADH2), an intriguing enzyme with apparently different functions in human and rodents...
  4. ncbi High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS J 274:1212-23. 2007
    ..involvement of alcohol and aldehyde dehydrogenases (ADH; ALDH) by identifying genetic variants in ADH1C and ADH4 that associate with PD...
  5. ncbi Merging protein, gene and genomic data: the evolution of the MDR-ADH family
    R Gonzalez-Duarte
    Departament de Genetica, Universitat de Barcelona, Avda Diagonal 645, Barcelona 08028, Spain
    Heredity (Edinb) 95:184-97. 2005
    ..The data now available provide a comprehensive scenario, from which a reliable picture of the evolutionary history of this family can be made...
  6. ncbi Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4
    Xixuan H Collins
    Department of Biochemistry, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:33157-64. 2005
    ..Purified mouse and human ADH4, human ADH3, and horse liver ADH1 efficiently oxidized 20-HETE, and ADH4 and ADH3 were detected in MSMC and MEC by ..
  7. ncbi Enzymatic mechanism of low-activity mouse alcohol dehydrogenase 2
    Patrik Strömberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Biochemistry 43:1323-8. 2004
    b>ADH2 is a member of one of the six classes of mammalian alcohol dehydrogenases, which catalyze the reversible oxidation of alcohols using NAD(+) as a cofactor...
  8. ncbi Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain
    Dagmar Galter
    Department of Neuroscience, Clinical Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden
    Eur J Biochem 270:1316-26. 2003
    ..Our results thus support the notion that the only ADH expressed in adult mouse, rat and human brain is class III ADH...
  9. ncbi Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 269:2607-12. 2002
    ..Here, Adh1, Adh3, and Adh4 null mutant mice have been examined following acute and chronic vitamin A excess...
  10. ncbi Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:13804-11. 2002
    The ability of class I alcohol dehydrogenase (ADH1) and class IV alcohol dehydrogenase (ADH4) to metabolize retinol to retinoic acid is supported by genetic studies in mice carrying Adh1 or Adh4 gene disruptions...
  11. ncbi Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes
    Gabor Szalai
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Eur J Biochem 269:224-32. 2002
    ..The mouse genes are all in the same transcriptional orientation in the order Adh4-Adh1-Adh5a-Adh5b-Adh5ps-Adh2-Adh3...
  12. ncbi Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally
    S M Ulven
    Institute for Nutrition Research, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway
    Dev Dyn 222:341-53. 2001
    ..It sets definite limits on how much 9-cis-RA potentially is present and demonstrates that at-RA predominates over 9-cis-RA by at least 30- to 180-fold in different spinal cord regions...
  13. ncbi Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency
    S Svensson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    J Mol Biol 302:441-53. 2000
    The structure of mouse class II alcohol dehydrogenase (ADH2) has been determined in a binary complex with the coenzyme NADH and in a ternary complex with both NADH and the inhibitor N-cyclohexylformamide to 2.2 A and 2...
  14. ncbi Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid
    S M Ulven
    Institute for Nutrition Research, University of Oslo, Blindern, Oslo, 0316, Norway
    Dev Biol 220:379-91. 2000
    ..binding proteins, and two enzymes able to convert retinol to retinal (retinol dehydrogenase 5 (RDH5) and alcohol dehydrogenase 4 (ADH4))...
  15. ncbi A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse enzyme
    S Svensson
    Department of Medical Biochemistry, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Biol Chem 274:29712-9. 1999
    ..All these data indicate that the mammalian class II alcohol dehydrogenase line is divided into two structurally and functionally distinct subgroups...
  16. ncbi Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem
    Ali G Fenstermaker
    University of California, San Diego, La Jolla, CA 92093, USA
    J Neurosci 30:16053-64. 2010
    ..Overall, our data suggest that Wnt/planar cell polarity signaling may be a global anterior-posterior guidance mechanism that controls axonal and cellular organization beyond the spinal cord...