Gene Symbol: Adgrg2
Description: adhesion G protein-coupled receptor G2
Alias: AW212196, B830041D06Rik, Gpr64, Me6, adhesion G-protein coupled receptor G2, G protein coupled receptor He6, G-protein coupled receptor 64, LNB-TM7 heptahelical receptor Me6, epididymis-specific protein 6
Obermann H, Samalecos A, Osterhoff C, Schröder B, Heller R, Kirchhoff C. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev. 2003;64:13-26 pubmed
Human Epididymis-specific protein 6 [HE6 (GPR64)] is a highly conserved, tissue-specific seven-transmembrane receptor of the human epididymis...
Davies B, Baumann C, Kirchhoff C, Ivell R, Nubbemeyer R, Habenicht U, et al
. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol. 2004;24:8642-8 pubmed
Human epididymal protein 6 (HE6; also known as GPR64) is an orphan member of the LNB-7TM (B(2)) subfamily of G-protein-coupled receptors...
Dykes I, Tempest L, Lee S, Turner E. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011;31:9789-99 pubmed publisher
Eng S, Dykes I, Lanier J, Fedtsova N, Turner E. POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. Neural Dev. 2007;2:3 pubmed
Kirchhoff C, Osterhoff C, Samalecos A. HE6/GPR64 adhesion receptor co-localizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Reproduction. 2008;136:235-45 pubmed publisher
A role for HE6/GPR64 in male excurrent ducts in the regulation of water balance was suggested from targeted gene mutation in the mouse. Results of the present immunolocalization study strengthen this hypothesis...
Teplyuk N, Galindo M, Teplyuk V, Pratap J, Young D, Lapointe D, et al
. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97 pubmed publisher
..g. Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13)...
Demberg L, Rothemund S, SchÃ¶neberg T, Liebscher I. Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2. Biochem Biophys Res Commun. 2015;464:743-7 pubmed publisher
The epididymis-specific adhesion G protein-coupled receptor (aGPCR) GPR64/ADGRG2 has been shown to be a key-player in the male reproductive system...
Davies B, Behnen M, Cappallo Obermann H, Spiess A, Theuring F, Kirchhoff C. Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption. Mol Reprod Dev. 2007;74:539-53 pubmed
Targeted disruption of the epididymis-specific HE6/Gpr64 receptor gene in mice led to male infertility...
Richter G, Fasan A, Hauer K, Grunewald T, Berns C, Rössler S, et al
. G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1. J Pathol. 2013;230:70-81 pubmed publisher
Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G-protein coupled receptor 64 (GPR64), an orphan receptor with normal expression restricted to human epididymis is specifically over-expressed in ES among sarcoma, ..