Adcyap1

Summary

Gene Symbol: Adcyap1
Description: adenylate cyclase activating polypeptide 1
Alias: PACAP, pituitary adenylate cyclase-activating polypeptide
Species: mouse
Products:     Adcyap1

Top Publications

  1. Matsuyama S, Matsumoto A, Hashimoto H, Shintani N, Baba A. Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice. Neuroreport. 2003;14:2095-8 pubmed
    The present study was conducted to clarify a role of pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP type 1 receptor (PAC1R) in learning and memory function...
  2. Lelievre V, Seksenyan A, Nobuta H, Yong W, Chhith S, Niewiadomski P, et al. Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol. 2008;313:359-70 pubmed
    ..One molecule that can influence PKA activity is pituitary adenylyl cyclase-activating peptide (PACAP), which has been shown to regulate cerebellar granule precursor proliferation in vitro, a cell population thought ..
  3. Nicot A, Lelievre V, Tam J, Waschek J, Dicicco Bloom E. Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation. J Neurosci. 2002;22:9244-54 pubmed
    ..In the embryo, pituitary adenylate cyclase-activating polypeptide (PACAP) receptor 1 (PAC1) signaling regulates neural precursor proliferation...
  4. Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, et al. Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations. PLoS ONE. 2010;5:e8596 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in multiple brain functions...
  5. Reglodi D, Kiss P, Szabadfi K, Atlasz T, Gabriel R, Horvath G, et al. PACAP is an endogenous protective factor-insights from PACAP-deficient mice. J Mol Neurosci. 2012;48:482-92 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widespread neuropeptide with a diverse array of biological functions. Not surprisingly, the lack of endogenous PACAP therefore results in a variety of abnormalities...
  6. Ohtaki H, Nakamachi T, Dohi K, Aizawa Y, Takaki A, Hodoyama K, et al. Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc Natl Acad Sci U S A. 2006;103:7488-93 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) has been reported to decrease ischemic neuronal damage and increase IL-6 secretion in rats. However, the mechanisms underlying neuroprotection are still to be fully elucidated...
  7. Mabuchi T, Shintani N, Matsumura S, Okuda Ashitaka E, Hashimoto H, Muratani T, et al. Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain. J Neurosci. 2004;24:7283-91 pubmed
    ..The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and implicated in neurotransmission, neural plasticity, and ..
  8. Hazama K, Hayata Takano A, Uetsuki K, Kasai A, Encho N, Shintani N, et al. Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice. PLoS ONE. 2014;9:e89153 pubmed publisher
    Accumulating evidence from human genetic studies implicates the pituitary adenylate cyclase-activating polypeptide (PACAP) gene as a risk factor for psychiatric disorders, including schizophrenia and stress-related diseases...
  9. Gaszner B, Kormos V, Kozicz T, Hashimoto H, Reglodi D, Helyes Z. The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger-Westphal n. Neuroscience. 2012;202:283-99 pubmed publisher
    Pituitary adenylate-cyclase activating polypeptide (PACAP) has been implicated in the (patho)physiology of stress-adaptation...

More Information

Publications85

  1. Stroth N, Eiden L. Stress hormone synthesis in mouse hypothalamus and adrenal gland triggered by restraint is dependent on pituitary adenylate cyclase-activating polypeptide signaling. Neuroscience. 2010;165:1025-30 pubmed publisher
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed in central and peripheral parts of these circuits and has recently been identified as a candidate ..
  2. Tomimoto S, Ojika T, Shintani N, Hashimoto H, Hamagami K, Ikeda K, et al. Markedly reduced white adipose tissue and increased insulin sensitivity in adcyap1-deficient mice. J Pharmacol Sci. 2008;107:41-8 pubmed
    ..of PACAP on glucose homeostasis, body weight, and adipose tissue mass was examined by comparing mice lacking the Adcyap1 gene encoding PACAP (Adcyap1(-/-)) with wild-type littermate controls...
  3. Ago Y, Yoneyama M, Ishihama T, Kataoka S, Kawada K, Tanaka T, et al. Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis. Neuroscience. 2011;172:554-61 pubmed publisher
    ..The present study investigated the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in adult hippocampal neurogenesis under standard or enriched rearing conditions...
  4. Hatanaka M, Tanida M, Shintani N, Isojima Y, Kawaguchi C, Hashimoto H, et al. Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice. Neurosci Lett. 2008;444:153-6 pubmed publisher
    ..whether PACAP participates in light-induced regulation of sympatho-adrenal activity by using PACAP-deficient (Adcyap1(-/-)) mice...
  5. Szabadfi K, Atlasz T, Kiss P, Dányádi B, Tamas A, Helyes Z, et al. Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo. Neurotox Res. 2012;21:41-8 pubmed publisher
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroprotective peptide exerting protective effects in neuronal injuries...
  6. Colwell C, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, et al. Selective deficits in the circadian light response in mice lacking PACAP. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1194-201 pubmed
    ..of retinal ganglion cells that contain both glutamate and pituitary adenylyl cyclase-activating peptide (PACAP)...
  7. Tsukiyama N, Saida Y, Kakuda M, Shintani N, Hayata A, Morita Y, et al. PACAP centrally mediates emotional stress-induced corticosterone responses in mice. Stress. 2011;14:368-75 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide widely distributed in the nervous system...
  8. Delgado M, Leceta J, Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microglia. J Leukoc Biol. 2003;73:155-64 pubmed
    ..neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP) on the production of various proinflammatory factors by endotoxin-stimulated microglia...
  9. Tan Y, Abad C, Lopez R, Dong H, Liu S, Lee A, et al. Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2009;106:2012-7 pubmed publisher
    Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a widely expressed neuropeptide originally discovered in the hypothalamus...
  10. Shintani N, Mori W, Hashimoto H, Imai M, Tanaka K, Tomimoto S, et al. Defects in reproductive functions in PACAP-deficient female mice. Regul Pept. 2002;109:45-8 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved neuropeptide and widely expressed in both brain and peripheral tissues, including several reproductive organs (e.g., testis and ovary)...
  11. Sandor K, Kormos V, Botz B, Imreh A, Bölcskei K, Gaszner B, et al. Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice. Neuropeptides. 2010;44:363-71 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and its receptors (PAC1 and VPAC) have been shown in the spinal dorsal horn, dorsal root ganglia and sensory nerve terminals...
  12. Shintani N, Hashimoto H, Tanaka K, Kawagishi N, Kawaguchi C, Hatanaka M, et al. Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-). Ann N Y Acad Sci. 2006;1070:545-9 pubmed
    ..We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP (Adcyap1-/-) displayed intense jumping behavior when placed in a novel ..
  13. Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, et al. Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. J Neurochem. 2009;110:595-602 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with pleiotropic functions...
  14. Cazillis M, Gonzalez B, Billardon C, Lombet A, Fraichard A, Samarut J, et al. VIP and PACAP induce selective neuronal differentiation of mouse embryonic stem cells. Eur J Neurosci. 2004;19:798-808 pubmed
    ..Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are neuropeptides expressed in early development which affect neuronal precursor proliferation and neuronal ..
  15. Adams B, Gray S, Isaac E, Bianco A, Vidal Puig A, Sherwood N. Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology. 2008;149:1571-80 pubmed
    Disruption of the pituitary adenylate cyclase-activating polypeptide (PACAP) gene in mice has demonstrated a role for this highly conserved neuropeptide in the regulation of metabolism and temperature control...
  16. Tanaka K, Shintani N, Hashimoto H, Kawagishi N, Ago Y, Matsuda T, et al. Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. J Neurosci. 2006;26:5091-7 pubmed
    ..Mice lacking the Adcyap1 gene encoding the neuropeptide pituitary adenylate cyclase-activating polypeptide (Adcyap1(-/-)) display ..
  17. Armstrong B, Abad C, Chhith S, Cheung Lau G, Hajji O, Nobuta H, et al. Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide. Neuroscience. 2008;151:63-73 pubmed
    ..in injured peripheral neurons is an induction in expression of pituitary adenylyl cyclase activating peptide (PACAP), a neuropeptide with putative neuroprotective and neuritogenic actions...
  18. Botz B, Imreh A, Sandor K, Elekes K, Szolcsanyi J, Reglodi D, et al. Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions. Peptides. 2013;43:105-12 pubmed publisher
    Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation ..
  19. Gray S, Cummings K, Jirik F, Sherwood N. Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism. Mol Endocrinol. 2001;15:1739-47 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a hormone belonging to the glucagon superfamily of hormones. These hormones are known to play important roles in metabolism and growth...
  20. Hashimoto H, Shintani N, Tanaka K, Mori W, Hirose M, Matsuda T, et al. Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A. 2001;98:13355-60 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain...
  21. Hamelink C, Tjurmina O, Damadzic R, Young W, Weihe E, Lee H, et al. Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci U S A. 2002;99:461-6 pubmed
    ..specific antibodies against the secretin-related neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) and the vesicular acetylcholine transporter (VAChT) revealed that PACAP is found in nerve terminals at all mouse ..
  22. Yajima Y, Akita Y, Saito T, Kawashima S. VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells. J Biochem. 1998;123:1024-30 pubmed
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) also stimulated the release of Gsalpha from membranes of GH4C1 cells...
  23. Hannibal J, Georg B, Fahrenkrug J. PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. PLoS ONE. 2017;12:e0188166 pubmed publisher
    The two sister peptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing ..
  24. Lelievre V, Hu Z, Byun J, Ioffe Y, Waschek J. Fibroblast growth factor-2 converts PACAP growth action on embryonic hindbrain precursors from stimulation to inhibition. J Neurosci Res. 2002;67:566-73 pubmed
    Pituitary adenylyl cyclase activating peptide (PACAP) has been shown either to stimulate or to inhibit neural cell proliferation depending on the origin of the cell population...
  25. Helyes Z, Kun J, Dobrosi N, Sándor K, Németh J, Perkecz A, et al. Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema. J Invest Dermatol. 2015;135:2209-2218 pubmed publisher
    Although pituitary adenylate cyclase-activating polypeptide (PACAP) was described as a key vasoregulator in human skin, little is known about its expression in mouse skin...
  26. Brubel R, Kiss P, Vincze A, Varga A, Varnagy A, Bodis J, et al. Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility. J Mol Neurosci. 2012;48:623-30 pubmed
    b>Pituitary adenylate cyclase activating polypeptide (PACAP), a neuropeptide with diverse effects, was originally isolated as a hypothalamo-hypophyseal peptide...
  27. Tanaka K, Kunishige Yamamoto A, Hashimoto H, Shintani N, Hayata A, Baba A. Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice. Biochem Biophys Res Commun. 2010;391:773-7 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice display remarkable behavioral changes including increased novelty-seeking behavior and reduced hypothermia induced by either serotonin (5-HT)(1A) receptor agonists ..
  28. Ding W, Manni M, Stohl L, Zhou X, Wagner J, Granstein R. Pituitary adenylate cyclase-activating peptide and vasoactive intestinal polypeptide bias Langerhans cell Ag presentation toward Th17 cells. Eur J Immunol. 2012;42:901-11 pubmed publisher
    ..the neuropeptides vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) inhibit LC Ag presentation for Th1-type immune responses...
  29. MacDonald D, Weerapura M, Beazely M, Martin L, Czerwinski W, Roder J, et al. Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src. J Neurosci. 2005;25:11374-84 pubmed
    ..Pituitary adenylate cyclase activating peptide (PACAP) is implicated in the regulation of synaptic plasticity because it enhances NMDAR responses by stimulating Galphas-..
  30. Yan Y, Zhou X, Pan Z, Ma J, Waschek J, Dicicco Bloom E. Pro- and anti-mitogenic actions of pituitary adenylate cyclase-activating polypeptide in developing cerebral cortex: potential mediation by developmental switch of PAC1 receptor mRNA isoforms. J Neurosci. 2013;33:3865-78 pubmed publisher
    During corticogenesis, pituitary adenylate cyclase-activating polypeptide (PACAP; ADCYAP1) may contribute to proliferation control by activating PAC1 receptors of neural precursors in the embryonic ventricular zone...
  31. Horvath G, Mark L, Brubel R, Szakaly P, Racz B, Kiss P, et al. Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro. Neurosci Lett. 2010;469:70-4 pubmed publisher
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide, showing widespread occurrence in the nervous system and also in peripheral organs...
  32. Arata S, Nakamachi T, Onimaru H, Hashimoto H, Shioda S. Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse. Eur J Neurosci. 2013;37:407-16 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide expressed widely in nervous tissues...
  33. Prévost G, Arabo A, Jian L, Quelennec E, Cartier D, Hassan S, et al. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human ?-cells and its targeted inactivation impairs glucose tolerance. Endocrinology. 2013;154:3796-806 pubmed publisher
    ..Finally, we found that SelT is up-regulated by pituitary adenylate cyclase-activating polypeptide (PACAP) in ?-pancreatic cells and that SelT could act by facilitating a feed-forward mechanism to potentiate insulin ..
  34. Lee E, Kim S, Lee S, Baek K, Seo S. Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation. J Biol Chem. 2015;290:21019-31 pubmed publisher
    Pituitary adenylate cyclase-activating peptide (PACAP) is a neurotrophic peptide involved in a wide range of nervous functions, including development, differentiation, and survival, and various aspects of learning and memory...
  35. Nakamachi T, Li M, Shioda S, Arimura A. Signaling involved in pituitary adenylate cyclase-activating polypeptide-stimulated ADNP expression. Peptides. 2006;27:1859-64 pubmed
    ..A PKA inhibitor suppressed the response at nanomolar concentration only. These findings suggest that ADNP expression is mediated through multiple receptors and signaling pathways that are regulated by different concentrations of PACAP.
  36. Okazaki K, Itoh Y, Ogi K, Ohkubo S, Onda H. Characterization of murine PACAP mRNA. Peptides. 1995;16:1295-9 pubmed
    A murine PACAP precursor cDNA was isolated by screening a brain cDNA library. The amino acid sequence of the precursor was highly similar (from 81% to 93% similarity) to its rat, human, and ovine counterparts...
  37. Toyoshima M, Takeuchi T, Goto H, Mukai K, Shintani N, Hashimoto H, et al. Roles of PACAP and PHI as inhibitory neurotransmitters in the circular muscle of mouse antrum. Pflugers Arch. 2006;451:559-68 pubmed
    ..responses of the gastric antrum were studied in wild-type and pituitary adenylate cyclase-activating polypeptide (PACAP) -knockout (KO) mice...
  38. Nakata M, Kohno D, Shintani N, Nemoto Y, Hashimoto H, Baba A, et al. PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus. Neurosci Lett. 2004;370:252-6 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) potentiates both insulin release from islets and insulin action in adipocytes. Therefore, this peptide is considered a regulator of glucose homeostasis...
  39. Kanekar S, Gandham M, Lucero M. PACAP protects against TNF?-induced cell death in olfactory epithelium and olfactory placodal cell lines. Mol Cell Neurosci. 2010;45:345-54 pubmed publisher
    In mouse olfactory epithelium (OE), pituitary adenylate cyclase-activating peptide (PACAP) protects against axotomy-induced apoptosis...
  40. Hagi K, Azuma Y, Nakajima H, Shintani N, Hashimoto H, Baba A, et al. Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus. Eur J Pharmacol. 2008;590:80-6 pubmed publisher
    ..The sustained relaxation in pituitary adenylate cyclase-activating peptide (PACAP)-knockout mouse, which was smaller than that of the wild-type mouse, was also inhibited by l-nitroarginine...
  41. von Gall C, Duffield G, Hastings M, Kopp M, Dehghani F, Korf H, et al. CREB in the mouse SCN: a molecular interface coding the phase-adjusting stimuli light, glutamate, PACAP, and melatonin for clockwork access. J Neurosci. 1998;18:10389-97 pubmed
    ..temporally gated resetting actions of two RHT transmitters, pituitary adenylate cyclase-activating polypeptide (PACAP) and glutamate...
  42. Broca C, Quoyer J, Costes S, Linck N, Varrault A, Deffayet P, et al. beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells. J Biol Chem. 2009;284:4332-42 pubmed publisher
    In pancreatic beta-cells, the pituitary adenylate cyclase-activating polypeptide (PACAP) exerts a potent insulin secretory effect via PAC(1) and VPAC receptors (Rs) through the Galpha(s)/cAMP/protein kinase A pathway...
  43. Takuma K, Maeda Y, Ago Y, Ishihama T, Takemoto K, Nakagawa A, et al. An enriched environment ameliorates memory impairments in PACAP-deficient mice. Behav Brain Res. 2014;272:269-78 pubmed publisher
    We previously found that juvenile pituitary adenylate cyclase-activating polypeptide (PACAP)-knockout (PACAP(-/-)) mice reared in an enriched environment (EE) for 4 weeks showed attenuated hyperactivity, jumping behavior, impairments in ..
  44. Ivic I, Fulop B, Juhasz T, Reglodi D, Toth G, Hashimoto H, et al. Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice. J Vasc Res. 2017;54:180-192 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide in the VIP/secretin/glucagon peptide superfamily...
  45. Hamagami K, Sakurai Y, Shintani N, Higuchi N, Ikeda K, Hashimoto H, et al. Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice. J Pharmacol Sci. 2009;110:451-8 pubmed
    ..is associated with intrapancreatic accumulation of pituitary adenylate cyclase-activating polypeptide (PACAP) accompanied with an altered inflammatory response (Michalski et al., Am J Physiol Gastrointest Liver Physiol...
  46. Dragich J, Loh D, Wang L, Vosko A, Kudo T, Nakamura T, et al. The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus. Eur J Neurosci. 2010;31:864-75 pubmed publisher
    ..deficient in either vasoactive intestinal peptide (VIP) or pituitary adenylate cyclase-activating polypeptide (PACAP) exhibit specific deficits in the behavioral response of their circadian system to light...
  47. Shudo Y, Shimojo M, Fukunaga M, Ito S. Pituitary adenylate cyclase-activating polypeptide is regulated by alternative splicing of transcriptional repressor REST/NRSF in nerve injury. Life Sci. 2015;143:174-81 pubmed publisher
    ..We previously reported that pituitary adenylate-cyclase activating polypeptide (PACAP) is required for the development of spinal sensitization and induction of NP...
  48. Delgado M. Inhibition of interferon (IFN) gamma-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-10, and inducible nitric-oxide synthase expression. J Biol Chem. 2003;278:27620-9 pubmed
    ..The neuropeptides vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase activating polypeptide (PACAP) are two potent microglia-deactivating factors that inhibit the production of ..
  49. Vaudry D, Hamelink C, Damadzic R, Eskay R, Gonzalez B, Eiden L. Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. Peptides. 2005;26:2518-24 pubmed
    ..Exogenous pituitary adenylate cyclase-activating polypeptide (PACAP) increases cerebellar granule cell survival and differentiation in culture, and enhances the number of neuroblasts ..
  50. Nemetz N, Abad C, Lawson G, Nobuta H, Chhith S, Duong L, et al. Induction of colitis and rapid development of colorectal tumors in mice deficient in the neuropeptide PACAP. Int J Cancer. 2008;122:1803-9 pubmed
    Pituitary adenylyl cyclase activating peptide (PACAP) is expressed in central, sensory, autonomic, and enteric neurons...
  51. Waschek J, Cohen J, Chi G, Proszynski T, Niewiadomski P. PACAP Promotes Matrix-Driven Adhesion of Cultured Adult Murine Neural Progenitors. ASN Neuro. 2017;9:1759091417708720 pubmed publisher
    ..We show that the neuropeptide PACAP (pituitary adenylate cyclase-activating polypeptide) affects subventricular zone-derived aNPCs by increasing their ..
  52. Dogrukol Ak D, Kumar V, Ryerse J, Farr S, Verma S, Nonaka N, et al. Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models. J Cereb Blood Flow Metab. 2009;29:411-22 pubmed publisher
    ..a therapeutic concentration of the neurotrophic peptide pituitary adenylate cyclase-activating polypeptide (PACAP) 27 to brain in animal models of Alzheimer's and stroke...
  53. Farkas J, Kovács L, Gaspar L, Nafz A, Gaszner T, Ujvári B, et al. Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background. Neuroscience. 2017;354:11-29 pubmed publisher
    ..Genetic predisposition (hit 1, mutation of pituitary adenylate cyclase-activating polypeptide, PACAP gene), early-life adversity (hit 2, 180-min maternal deprivation, MD180) and chronic variable mild stress (hit 3, ..
  54. Fujii H, Ishihama T, Ago Y, Shintani N, Kakuda M, Hashimoto H, et al. Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice. Peptides. 2007;28:1674-9 pubmed
    Mice lacking the PACAP gene (PACAP(-/-)) display psychomotor abnormalities such as novelty-induced hyperactivity and jumping behavior, and they show different responses to amphetamine, a typical psychostimulant...
  55. Arsenijevic T, Gregoire F, Chiadak J, Courtequisse E, Bolaky N, Perret J, et al. Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway. PLoS ONE. 2013;8:e72607 pubmed publisher
    Pituitary adenylate cyclase activating peptide (PACAP) belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) family...
  56. Botz B, B lcskei K, Kereskai L, Kov cs M, N meth T, Szigeti K, et al. Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model. Arthritis Rheumatol. 2014;66:2739-50 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) expressed in capsaicin-sensitive sensory neurons and immune cells has divergent functions in inflammatory and pain processes...
  57. Rene F, Monnier D, Gaiddon C, Felix J, Loeffler J. Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes. Neuroendocrinology. 1996;64:2-13 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors were characterized and their function investigated in mouse pituitary neurointermediate lobe explants...
  58. White S, May V, Braas K. Organization of the rat PACAP gene. Ann N Y Acad Sci. 2000;921:370-2 pubmed
    The rat PACAP gene has been isolated, cloned, and sequenced. The gene organization is very similar to that of the mouse and human PACAP genes...
  59. Cummings K, Pendlebury J, Sherwood N, Wilson R. Sudden neonatal death in PACAP-deficient mice is associated with reduced respiratory chemoresponse and susceptibility to apnoea. J Physiol. 2004;555:15-26 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice are more prone to sudden death during postnatal weeks 1-3 than wild-type littermates...
  60. Krashes M, Shah B, Madara J, Olson D, Strochlic D, Garfield A, et al. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014;507:238-42 pubmed publisher
    ..thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1)...
  61. Shibasaki Y, Hayata Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, et al. Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide. Neuroscience. 2015;297:95-104 pubmed publisher
    ..ATX treatment significantly alleviated hyperactivity of pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient (PACAP(-/-)) mice with C57BL/6J and 129S6/SvEvTac hybrid background...
  62. Nishimoto M, Furuta A, Aoki S, Kudo Y, Miyakawa H, Wada K. PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells. Glia. 2007;55:317-27 pubmed
    The Pituitary adenylate cyclase-activating peptide (PACAP) ligand/type 1 receptor (PAC1) system regulates neurogenesis and gliogenesis...
  63. Sakurai Y, Inoue H, Shintani N, Arimori A, Hamagami K, Hayata Takano A, et al. Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in ? cells. J Mol Neurosci. 2012;48:647-53 pubmed
    ..cell-specific overexpression of pituitary adenylate cyclase-activating polypeptide (PACAP), an insulinotropic neuropeptide, decreased the insulin levels required to compensate for hyperglycemia...
  64. Allais A, Burel D, Roy V, Arthaud S, Galas L, Isaac E, et al. Balanced effect of PACAP and FasL on granule cell death during cerebellar development: a morphological, functional and behavioural characterization. J Neurochem. 2010;113:329-40 pubmed publisher
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts a powerful protective effect on cerebellar granule cells by inhibiting the caspase 3...
  65. Li M, Balamuthusamy S, Khan A, Maderdrut J, Simon E, Batuman V. Pituitary adenylate cyclase-activating polypeptide ameliorates cisplatin-induced acute kidney injury. Peptides. 2010;31:592-602 pubmed publisher
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to protect kidneys from ischemic injury and light chain-induced damage by modulating inflammation...
  66. Fahrenkrug J. PACAP--a multifacetted neuropeptide. Chronobiol Int. 2006;23:53-61 pubmed
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) was originally isolated from ovine hypothalamus based on its ability to stimulate cAMP production in pituitary cell cultures...
  67. Laszlo E, Varga A, Kovacs K, Jancso G, Kiss P, Tamas A, et al. Ischemia/reperfusion-induced Kidney Injury in Heterozygous PACAP-deficient Mice. Transplant Proc. 2015;47:2210-5 pubmed publisher
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with very diverse distribution and functions...
  68. Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, et al. Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain. Acta Neurochir Suppl. 2010;106:43-6 pubmed publisher
    b>Pituitary adenylate cyclase activating polypeptide is a pleiotropic neuropeptide...
  69. Bröhl D, Strehle M, Wende H, Hori K, Bormuth I, Nave K, et al. A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord. Dev Biol. 2008;322:381-93 pubmed publisher
    ..We conclude that a transcriptional network operates in maturing dorsal horn neurons that coordinately determines transmitter and peptidergic fate. ..
  70. Ji H, Zhang Y, Shen X, Gao F, Huang C, Abad C, et al. Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway. Hepatology. 2013;57:1225-37 pubmed publisher
    ..function and potential therapeutic potential of neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) in a murine model of partial liver "warm" ischemia (90 minutes) followed by reperfusion...
  71. Niewiadomski P, Zhujiang A, Youssef M, Waschek J. Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA. Cell Signal. 2013;25:2222-30 pubmed publisher
    ..b>Pituitary adenylate cyclase activating polypeptide (PACAP) inhibits Shh-driven proliferation of cGCPs and acts as tumor suppressor in murine ..
  72. Tsumuraya T, Ohtaki H, Song D, Sato A, Watanabe J, Hiraizumi Y, et al. Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP). J Neuroinflammation. 2015;12:35 pubmed publisher
    ..Recently, we found that expression of the gene for mouse PACAP (Adcyap1) was greater in animals receiving hMSCs with neural injury such as ischemia...
  73. Hill J, Chan S, Kuri B, Smith C. Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells. J Biol Chem. 2011;286:42459-69 pubmed publisher
    ..2 calcium influx in mouse chromaffin cells in situ. Pituitary adenylate cyclase-activating peptide (PACAP) is an excitatory neuroactive peptide transmitter released by the splanchnic nerve under elevated sympathetic ..
  74. Mihalas A, Elsen G, Bedogni F, Daza R, Ramos Laguna K, Arnold S, et al. Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity. Cell Rep. 2016;16:92-105 pubmed publisher
    ..Our findings indicate that upper-layer genesis depends on IPs from many stages of corticogenesis and that Tbr2 regulates the tempo of laminar fate implementation for all cortical layers. ..
  75. Reglodi D, Cseh S, Somoskoi B, Fulop B, Szentléleky E, Szegeczki V, et al. Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice. Reproduction. 2018;155:129-139 pubmed publisher
    b>PACAP is a neuropeptide with diverse functions in various organs, including reproductive system...
  76. Tsuchikawa D, Nakamachi T, Tsuchida M, Wada Y, Hori M, Farkas J, et al. Neuroprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on spinal cord injury. J Mol Neurosci. 2012;48:508-17 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuroprotective peptide expressed in the central nervous system...