Gene Symbol: Adcy9
Description: adenylate cyclase 9
Alias: AC9, ACtp10, AW125421, D16Wsu65e, mKIAA0520, adenylate cyclase type 9, ATP pyrophosphate-lyase 9, adenylate cyclase type IX, adenylyl cyclase 9, adenylyl cyclase type 10
Species: mouse
Products:     Adcy9

Top Publications

  1. Premont R. Identification of adenylyl cyclases by amplification using degenerate primers. Methods Enzymol. 1994;238:116-27 pubmed
  2. Suzuki Y, Shen T, Poyard M, Best Belpomme M, Hanoune J, Defer N. Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle. Am J Physiol. 1998;274:C1674-85 pubmed
    ..Four isoforms of AC (AC2, AC6, AC7, and AC9) were detected by Northern blot analysis in gastrocnemius muscle, AC9 being the most abundant...
  3. Hacker B, Tomlinson J, Wayman G, Sultana R, Chan G, Villacres E, et al. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). Genomics. 1998;50:97-104 pubmed
    ..Here we report the cloning, chromosomal mapping, and regulatory properties of human AC9 (HGMW-approved symbol ADCY9)...
  4. Li Y, Baldwin T, Wang Y, Subramaniam J, Carbajal A, Brand C, et al. Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction. Sci Rep. 2017;7:5522 pubmed publisher
    Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in heart. But apart from potential IKs regulation, physiological roles for AC9 are unknown...
  5. Premont R, Matsuoka I, Mattei M, Pouille Y, Defer N, Hanoune J. Identification and characterization of a widely expressed form of adenylyl cyclase. J Biol Chem. 1996;271:13900-7 pubmed
    ..The AC9 gene has been localized to human chromosome band 16p13.3-13.2. The 8...
  6. Michalski N, Michel V, Bahloul A, Lefevre G, Barral J, Yagi H, et al. Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007;27:6478-88 pubmed
    ..The premature disappearance of these cadherin isoforms in the Vlgr1-/- mutant argues in favor of a signaling function of the ankle links in hair bundle differentiation. ..
  7. Kaya F, Belin S, Diamantidis G, Fontes M. Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?. FEBS Lett. 2008;582:3614-8 pubmed publisher
    ..In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues. ..
  8. Antoni F, Barnard R, Shipston M, Smith S, Simpson J, Paterson J. Calcineurin feedback inhibition of agonist-evoked cAMP formation. J Biol Chem. 1995;270:28055-61 pubmed
    ..Furthermore, the effect of calcineurin on cAMP synthesis appears to be associated with the expression of a novel adenylyl cyclase isotype, which is highly abundant in AtT20 cells. ..
  9. Nakashima H, Grahovac M, Mazzarella R, Fujiwara H, Kitchen J, Threat T, et al. Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. Genomics. 1999;60:152-60 pubmed
    ..Interestingly, both regions are syntenic with human chromosome 16p13.1-p13.3, suggesting that a chromosomal breakage between Nubp2 and Nubp1 probably occurred during the evolution of mouse chromosomes. ..

More Information


  1. Visel A, Alvarez Bolado G, Thaller C, Eichele G. Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain. J Comp Neurol. 2006;496:684-97 pubmed
    ..This is suggestive of functional specialization. ..
  2. Nicol X, Bennis M, Ishikawa Y, Chan G, Repérant J, Storm D, et al. Role of the calcium modulated cyclases in the development of the retinal projections. Eur J Neurosci. 2006;24:3401-14 pubmed
    ..different AC subtypes were found in the developing retinal ganglion cell layer (RGC; AC1, AC2, AC3, AC5, AC8, and AC9), and three AC subtypes were expressed in the central brain targets, the dorsal lateral geniculate nucleus (AC1 and ..
  3. Baker H, Cummings D, Munger S, Margolis J, Franzen L, Reed R, et al. Targeted deletion of a cyclic nucleotide-gated channel subunit (OCNC1): biochemical and morphological consequences in adult mice. J Neurosci. 1999;19:9313-21 pubmed
    ..The robust expression of TH in some periglomerular cells in the OCNC1-null mice suggests that receptor cells innervating these glomeruli may use an alternate signal transduction pathway. ..
  4. Li Y, Chen L, Kass R, Dessauer C. The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart. J Biol Chem. 2012;287:29815-24 pubmed publisher
    ..previously identified a subset of adenylyl cyclase (AC) isoforms that interact with Yotiao, including AC1-3 and AC9, but surprisingly, this group did not include the major cardiac isoforms AC5 and AC6...
  5. Paterson J, Smith S, Harmar A, Antoni F. Control of a novel adenylyl cyclase by calcineurin. Biochem Biophys Res Commun. 1995;214:1000-8 pubmed
    ..The enzyme messenger RNA is particularly enriched in the cerebral cortex, striatum and hippocampus, where it is localized to neuronal perikarya, indicative of an important role in neuronal function. ..
  6. Huang B, Zhao J, Lei Z, Shen S, Li D, Shen G, et al. miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA. EMBO Rep. 2009;10:180-5 pubmed publisher
    ..miR-142-3p limits the level of cAMP in CD4(+)CD25(-) T cells by inhibiting AC9 production, whereas forkhead box P3 (FOXP3) downregulates miR-142-3p to keep the AC9/cAMP pathway active in CD4(+)..