Genomes and Genes
Gene Symbol: Adcy7
Description: adenylate cyclase 7
Alias: AA407758, adenylate cyclase type 7, ATP pyrophosphate-lyase 7, adenylate cyclase type VII, adenylyl cyclase 7, adenylyl cyclase type VII
- Michalski N, Michel V, Bahloul A, Lefevre G, Barral J, Yagi H, et al. Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007;27:6478-88 pubmed..The premature disappearance of these cadherin isoforms in the Vlgr1-/- mutant argues in favor of a signaling function of the ankle links in hair bundle differentiation. ..
- Kaya F, Belin S, Diamantidis G, Fontes M. Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?. FEBS Lett. 2008;582:3614-8 pubmed publisher..In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues. ..
- Jiang L, Collins J, Davis R, Fraser I, Sternweis P. Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII. J Biol Chem. 2008;283:23429-39 pubmed publisher..Our results demonstrate that AC7 is a specific downstream effector of the G(12/13) pathway. ..
- Duan B, Davis R, Sadat E, Collins J, Sternweis P, Yuan D, et al. Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. J Immunol. 2010;185:335-44 pubmed publisher..These results are the first to ascribe specific functions to an AC isoform in the immune system and emphasize the importance of cAMP synthesis by this isoform in shaping the immune responses. ..