Gene Symbol: Adcy7
Description: adenylate cyclase 7
Alias: AA407758, adenylate cyclase type 7, ATP pyrophosphate-lyase 7, adenylate cyclase type VII, adenylyl cyclase 7, adenylyl cyclase type VII
Species: mouse
Products:     Adcy7

Top Publications

  1. Visel A, Alvarez Bolado G, Thaller C, Eichele G. Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain. J Comp Neurol. 2006;496:684-97 pubmed
    ..This is suggestive of functional specialization. ..
  2. McClelland K, Bell K, Larney C, Harley V, Sinclair A, Oshlack A, et al. Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015;92:145 pubmed publisher
    ..In addition, it provides a basis for targeted studies designed to identify causes of idiopathic XY DSD. ..
  3. Hines L, Hoffman P, Bhave S, Saba L, Kaiser A, Snell L, et al. A sex-specific role of type VII adenylyl cyclase in depression. J Neurosci. 2006;26:12609-19 pubmed
    ..Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness. ..
  4. Nicol X, Bennis M, Ishikawa Y, Chan G, Repérant J, Storm D, et al. Role of the calcium modulated cyclases in the development of the retinal projections. Eur J Neurosci. 2006;24:3401-14 pubmed
    ..The specificity of AC1's action is linked to its cellular localization in the RGCs and to its distinctive functional profile, compared with the other cyclases expressed in the same cells. ..
  5. Watson P, Krupinski J, Kempinski A, Frankenfield C. Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J Biol Chem. 1994;269:28893-8 pubmed
    ..Thus the ability of phorbol ester to increase basal and isoproterenol-stimulated type VII activity appears to be a direct effect on this adenylyl cyclase isoform and not the result of modification of the inhibitory G protein, Gi. ..
  6. Doyle J, Ren X, Lennon G, Stubbs L. Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice. Mamm Genome. 1997;8:113-20 pubmed
  7. Jiang L, Sternweis P, Wang J. Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. Mol Immunol. 2013;54:14-22 pubmed publisher
    ..This response is dependent on adenylyl cyclase type VII (AC7) and heterotrimeric G proteins, primarily G(12/13)...
  8. Doyle J, Hellevuo K, Stubbs L. The gene encoding adenylyl cyclase VII is located in central mouse chromosome 8. Mamm Genome. 1996;7:320-1 pubmed
  9. Suzuki Y, Shen T, Poyard M, Best Belpomme M, Hanoune J, Defer N. Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle. Am J Physiol. 1998;274:C1674-85 pubmed
    ..These results indicate that changes in AC activity and AC mRNAs play an important role in the various physiopathological states of skeletal muscle, especially during muscle atrophy. ..

More Information


  1. Michalski N, Michel V, Bahloul A, Lefevre G, Barral J, Yagi H, et al. Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007;27:6478-88 pubmed
    ..The premature disappearance of these cadherin isoforms in the Vlgr1-/- mutant argues in favor of a signaling function of the ankle links in hair bundle differentiation. ..
  2. Kaya F, Belin S, Diamantidis G, Fontes M. Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?. FEBS Lett. 2008;582:3614-8 pubmed publisher
    ..In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues. ..
  3. Jiang L, Collins J, Davis R, Fraser I, Sternweis P. Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII. J Biol Chem. 2008;283:23429-39 pubmed publisher
    ..Our results demonstrate that AC7 is a specific downstream effector of the G(12/13) pathway. ..
  4. Duan B, Davis R, Sadat E, Collins J, Sternweis P, Yuan D, et al. Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. J Immunol. 2010;185:335-44 pubmed publisher
    ..These results are the first to ascribe specific functions to an AC isoform in the immune system and emphasize the importance of cAMP synthesis by this isoform in shaping the immune responses. ..