Gene Symbol: Adcy4
Description: adenylate cyclase 4
Alias: mKIAA4004, adenylate cyclase type 4, ATP pyrophosphate-lyase 4, adenylate cyclase type IV, adenylyl cyclase 4
Species: mouse
Products:     Adcy4

Top Publications

  1. Edelhoff S, Villacres E, Storm D, Disteche C. Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. Mamm Genome. 1995;6:111-3 pubmed
    ..mouse chromosomes by fluorescence in situ hybridization (FISH): Adcy1 to Chr 11A2, Adcy2 to 13C1, Adcy3 to 12A-B, Adcy4 to 14D3, Adcy5 to 16B5, and Adcy6 to 15F...
  2. Gao B, Gilman A. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A. 1991;88:10178-82 pubmed
    ..R. (1991) Proc. Natl. Acad. Sci. USA 88, 10173-10177] in its amino acid sequence, lack of response to calmodulin, and synergistic activation by a combination of the Gs alpha subunit and the G-protein beta gamma subunit complex. ..
  3. Baker L, Nielsen M, Impey S, Hacker B, Poser S, Chan M, et al. Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus. J Neurosci. 1999;19:180-92 pubmed
  4. Meneray M, Lallier T. Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice. Adv Exp Med Biol. 2002;506:41-9 pubmed
  5. Visel A, Alvarez Bolado G, Thaller C, Eichele G. Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain. J Comp Neurol. 2006;496:684-97 pubmed
    ..This is suggestive of functional specialization. ..
  6. Nicol X, Bennis M, Ishikawa Y, Chan G, Repérant J, Storm D, et al. Role of the calcium modulated cyclases in the development of the retinal projections. Eur J Neurosci. 2006;24:3401-14 pubmed
    ..The specificity of AC1's action is linked to its cellular localization in the RGCs and to its distinctive functional profile, compared with the other cyclases expressed in the same cells. ..
  7. Michalski N, Michel V, Bahloul A, Lefevre G, Barral J, Yagi H, et al. Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007;27:6478-88 pubmed
    ..The premature disappearance of these cadherin isoforms in the Vlgr1-/- mutant argues in favor of a signaling function of the ankle links in hair bundle differentiation. ..
  8. Suzuki Y, Shen T, Poyard M, Best Belpomme M, Hanoune J, Defer N. Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle. Am J Physiol. 1998;274:C1674-85 pubmed
    ..These results indicate that changes in AC activity and AC mRNAs play an important role in the various physiopathological states of skeletal muscle, especially during muscle atrophy. ..
  9. Al Hakim A, Rui X, Tsao J, Albert P, Schimmer B. Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4. Mol Cell Endocrinol. 2004;214:155-65 pubmed
    ..Taken together, these observations indicate that AC-4 deficiency is a hallmark of the forskolin-resistant phenotype of these mutants and suggest that AC-4 is an important target of forskolin action in the Y1 adrenal cell line. ..

More Information


  1. Rui X, Tsao J, Scheys J, Hammer G, Schimmer B. Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells. Endocrinology. 2008;149:3668-78 pubmed publisher
    The type 4 adenylyl cyclase, Adcy4, is the least abundant of five different adenylyl cyclase isoforms expressed in the Y1 mouse adrenocortical cell line and is deficient in a Y1 mutant with impaired steroidogenic factor 1 (SF1) activity...
  2. Kittikulsuth W, Stuart D, Kohan D. Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling. Physiol Rep. 2014;2:e00277 pubmed publisher
    ..Therefore, we generated mice with loxP-flanked critical exons in the Adcy4 gene and bred with mice expressing the aquaporin-2/Cre recombinase transgene to yield CD principal cell-specific ..