Gene Symbol: Adcy10
Description: adenylate cyclase 10
Alias: 4930431D04Rik, 4931412F17, Sacy, sAC, adenylate cyclase type 10, germ cell soluble adenylyl cyclase, testicular soluble adenylyl cyclase
Species: mouse
Products:     Adcy10

Top Publications

  1. Sinclair M, Wang X, Mattia M, Conti M, Buck J, Wolgemuth D, et al. Specific expression of soluble adenylyl cyclase in male germ cells. Mol Reprod Dev. 2000;56:6-11 pubmed
    ..Using the very sensitive reverse transcription-polymerase chain reaction (RT-PCR), soluble adenylyl cyclase (sAC) expression is detectable in almost all tissues examined; however, Northern analysis and in situ hybridization ..
  2. Moore S, Lai Wing Sun K, Xie F, Barker P, Conti M, Kennedy T. Soluble adenylyl cyclase is not required for axon guidance to netrin-1. J Neurosci. 2008;28:3920-4 pubmed publisher
    ..suggested that axon guidance in response to netrin-1 requires cAMP production mediated by soluble adenyl cyclase (sAC). We have used genetic, molecular and biochemical strategies to assess this issue...
  3. Hess K, Jones B, Marquez B, Chen Y, Ord T, Kamenetsky M, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005;9:249-59 pubmed
    ..Male mice lacking the bicarbonate- and calcium-responsive soluble adenylyl cyclase (sAC), the predominant source of cAMP in male germ cells, are infertile, as the sperm are immotile...
  4. Jaiswal B, Conti M. Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. J Biol Chem. 2001;276:31698-708 pubmed
    ..on two forms of adenylyl cyclase, the conventional membrane-bound ACIII and a soluble form of adenylyl cyclase (sAC)...
  5. Xie F, Garcia M, Carlson A, Schuh S, Babcock D, Jaiswal B, et al. Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Dev Biol. 2006;296:353-62 pubmed
    We previously demonstrated that male mice deficient in the soluble adenylyl cyclase (sAC) are sterile and produce spermatozoa with deficits in progressive motility and are unable to fertilize zona-intact eggs...
  6. Esposito G, Jaiswal B, Xie F, Krajnc Franken M, Robben T, Strik A, et al. Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A. 2004;101:2993-8 pubmed
    ..The intracellular rise of cAMP produced by the bicarbonate-dependent soluble adenylyl cyclase (sAC) has been suggested to play a central role in initiating the cascade of the events that culminates in spermatozoa ..
  7. Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, et al. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med. 2015;212:1021-41 pubmed publisher
    ..juxtamembrane cytoplasmic tail of CD99, the A-kinase anchoring protein ezrin, and soluble adenylyl cyclase (sAC)...
  8. Schuh S, Carlson A, McKnight G, Conti M, Hille B, Babcock D. Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists. Biol Reprod. 2006;74:492-500 pubmed
    ..contrast, the acceleration by these agents is absent in sperm that lack the predominant atypical adenylyl cyclase, SACY. Responses to these agonists are also absent in sperm from mice lacking the sperm-specific Calpha2 catalytic ..
  9. Rahman N, Ramos Espiritu L, Milner T, Buck J, Levin L. Soluble adenylyl cyclase is essential for proper lysosomal acidification. J Gen Physiol. 2016;148:325-39 pubmed publisher
    ..Soluble adenylyl cyclase (sAC) is a widely expressed source of cAMP that serves as a physiological pH sensor in cells...

More Information


  1. Wertheimer E, Krapf D, de la Vega Beltrán J, Sanchez Cardenas C, Navarrete F, Haddad D, et al. Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. J Biol Chem. 2013;288:35307-20 pubmed publisher
    ..Although the HCO3(-)-dependent soluble adenylyl cyclase Adcy10 plays a role in motility, less is known about the source of cAMP in the sperm head...
  2. Wang D, Hu J, Bobulescu I, Quill T, McLeroy P, Moe O, et al. A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proc Natl Acad Sci U S A. 2007;104:9325-30 pubmed
    ..Our analyses of the bicarbonate-dependent soluble adenylyl cyclase (sAC) signaling pathway in sNHE-null sperm cells reveal that sNHE is required for the expression of full-length sAC, and ..
  3. Zippin J, Chen Y, Straub S, Hess K, Diaz A, Lee D, et al. CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J Biol Chem. 2013;288:33283-91 pubmed publisher
    ..cyclases or via the widely expressed and structurally and biochemically distinct enzyme soluble adenylyl cyclase (sAC)...
  4. Corredor R, Trakhtenberg E, Pita Thomas W, Jin X, Hu Y, Goldberg J. Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. J Neurosci. 2012;32:7734-44 pubmed publisher
    ..We investigated the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion cells (RGCs)...
  5. Schmitz B, Nedele J, Guske K, Maase M, Lenders M, Schelleckes M, et al. Soluble adenylyl cyclase in vascular endothelium: gene expression control of epithelial sodium channel-?, Na+/K+-ATPase-?/?, and mineralocorticoid receptor. Hypertension. 2014;63:753-61 pubmed publisher
    The Ca(2+)- and bicarbonate-activated soluble adenylyl cyclase (sAC) has been identified recently as an important mediator of aldosterone signaling in the kidney...
  6. Ridnour L, Windhausen A, Isenberg J, Yeung N, Thomas D, Vitek M, et al. Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2007;104:16898-903 pubmed
  7. Marquez B, Suarez S. Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation. Reprod Fertil Dev. 2008;20:247-52 pubmed
    Soluble adenylyl cyclase (SACY) is an essential component of cAMP-signalling cascades that activate sperm motility and capacitate sperm. SACY activity is stimulated by HCO(3)(-) and Ca(2+)...
  8. Choi H, Gordon G, Zhou N, Tai C, Rungta R, Martinez J, et al. Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron. 2012;75:1094-104 pubmed publisher
    ..Here we show that a recently cloned bicarbonate (HCO??) sensor, soluble adenylyl cyclase (sAC), is highly expressed in astrocytes and becomes activated in response to HCO?? entry via the electrogenic NaHCO? ..
  9. Chen X, Baumlin N, Buck J, Levin L, Fregien N, Salathe M. A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice. Am J Respir Cell Mol Biol. 2014;51:750-60 pubmed publisher
    Ciliary beating is important for effective mucociliary clearance. Soluble adenylyl cyclase (sAC) regulates ciliary beating, and a roughly 50-kD sAC variant is expressed in axonemes...
  10. Chen J, Martinez J, Milner T, Buck J, Levin L. Neuronal expression of soluble adenylyl cyclase in the mammalian brain. Brain Res. 2013;1518:1-8 pubmed publisher
    ..Soluble adenylyl cyclase (sAC) is a novel source of cAMP subject to unique localization and regulation...
  11. Papapetropoulos A, Simoes D, Xanthou G, Roussos C, Gratziou C. Soluble guanylyl cyclase expression is reduced in allergic asthma. Am J Physiol Lung Cell Mol Physiol. 2006;290:L179-84 pubmed
    ..Indeed, in mice receiving ODQ the methacholine dose response was shifted to the left. We conclude that sGC expression is reduced in experimental asthma contributing to the observed airway hyperreactivity. ..
  12. Miranda P, Allaire A, Sosnik J, Visconti P. Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol Reprod. 2009;80:897-904 pubmed publisher
    ..Taking into consideration the requirement of the acrosome reaction for sperm to become fusogenic, these results suggest that membrane raft dynamics may have a role in sperm-egg membrane interaction. ..
  13. Unterwald E, Ivkovic S, Cuntapay M, Stroppolo A, Guinea B, Ehrlich M. Prenatal exposure to cocaine decreases adenylyl cyclase activity in embryonic mouse striatum. Brain Res Dev Brain Res. 2003;147:67-75 pubmed
    ..Alterations in the cAMP system may underlie some of the deficits seen in humans exposed in utero to cocaine. ..
  14. Marjanovic J, Li Z, Stojanovic A, Du X. Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation. J Biol Chem. 2005;280:37430-8 pubmed
    ..Our data also suggest that NO plays a biphasic role in platelet activation, a stimulatory role at low NO concentrations and an inhibitory role at high NO concentrations. ..
  15. Lee Y, Tresguerres M, Hess K, Marmorstein L, Levin L, Buck J, et al. Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. J Biol Chem. 2011;286:41353-8 pubmed publisher
    ..Here, we show that bicarbonate-sensitive soluble adenylyl cyclase (sAC) is highly expressed in the ciliary body in NPE cells, but appears to be absent from drainage tissues...
  16. Carlson A, Hille B, Babcock D. External Ca2+ acts upstream of adenylyl cyclase SACY in the bicarbonate signaled activation of sperm motility. Dev Biol. 2007;312:183-92 pubmed
    ..capacitation, by increasing flagellar beat frequency through a pathway that requires the atypical adenylyl cyclase SACY and the sperm-specific C alpha2 catalytic subunit of PKA...
  17. Farrell J, Ramos L, Tresguerres M, Kamenetsky M, Levin L, Buck J. Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS ONE. 2008;3:e3251 pubmed publisher
    Mammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy) represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases...
  18. Shaw P, Fang J, Sang A, Wang Y, Kapiloff M, Goldberg J. Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci. 2016;57:5083-5092 pubmed publisher
    We have previously demonstrated that soluble adenylyl cyclase (sAC) is necessary for retinal ganglion cell (RGC) survival and axon growth...