Adamts20

Summary

Gene Symbol: Adamts20
Description: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Alias: Adamst20, bt, A disintegrin and metalloproteinase with thrombospondin motifs 20, ADAM-TS 20, ADAM-TS20, OTTMUSP00000031011, OTTMUSP00000031088, belted
Species: mouse

Publications

  1. The genetics of blind--a lethal factor in mice
    L S Teicher
    J Hered 69:86-90
  2. Progressive ankylosis, a new skeletal mutation in the mouse
    H O Sweet
    J Hered 72:87-93
  3. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer
    E Di Pasquale
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurophysiol 77:621-31
  4. Assignment of the murine protein kinase gene DLK to chromosome 15 in the vicinity of the bt/Koa locus by genetic linkage analysis
    T Watanabe
    Department of Molecular Information, Tokyo University, Japan
    Genomics 40:375-6
  5. Strain-specific white-spotting patterns in laboratory mice
    M L Lamoreux
    Department of Veterinary Pathobiology, Texas A and M University, College Station 77843, USA
    Pigment Cell Res 12:383-90
  6. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
    Robert P T Somerville
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:9503-13
  7. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain
    Maria Llamazares
    Departamento de Bioquíimica y Biologíia Molecular, Facultad de Medicina, Instituto Universitario de Oncologíia, Universidad de Oviedo, 33006 Oviedo, Spain
    J Biol Chem 278:13382-9
  8. A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation
    Cherie Rao
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02476, USA
    Development 130:4665-72
  9. AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS
    T C Mayer
    Dev Biol 22:269-86
  10. Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 123:294-7

Scientific Experts

  • J P Sundberg
  • M L Lamoreux
  • Suneel S Apte
  • Debra L Silver
  • William J Pavan
  • Cherie Rao
  • Robert P T Somerville
  • Katherine A Jungers
  • Maria Llamazares
  • Ling Hou
  • Mary E Young
  • Robert Somerville
  • T Watanabe
  • E Di Pasquale
  • John D McPherson
  • Stephen Evanko
  • Monique Ross
  • Jean Michel Longpre
  • David R Beier
  • Thomas N Wight
  • Dorothee Foernzler
  • J Michael Engle
  • Shanming Liu
  • Stacie K Loftus
  • Santiago Cal
  • Jean-Michel Longpre
  • Richard Leduc
  • J L Noebels
  • M Obinata
  • M Yanagisawa
  • Y Matsui
  • K D Keegan
  • N Matsubara
  • M Sekiguchi
  • M T Davisson
  • H O Sweet
  • E M Eicher
  • P M Hogarth
  • K Shimai
  • H Guo
  • D R Beier
  • C E Horton
  • P W Lane
  • C Stieler
  • T C Mayer
  • L S Teicher
  • D P Dickinson
  • M E Wallace
  • T S Hauschka
  • R S Nowakowski
  • B A Holdridge
  • P Leder
  • B B Jacobs
  • K W Gross
  • H M Liu
  • S A Mallyon
  • V R Sutton
  • C Spencer
  • I F McKenzie
  • W F Hollander
  • E C Akeson
  • A Leder
  • K M Curnow
  • A B Retik
  • B K Lee
  • K Abel
  • X Qiao
  • N L Hawes
  • E L Maltby
  • J E Womack
  • B A Taylor
  • R Wallace
  • E W Caspari
  • G T Bernstein
  • R T Bronson
  • J Near
  • T H Roderick
  • C C Morton
  • M C Green
  • J Mandell
  • J B Jacobs

Detail Information

Publications23

  1. The genetics of blind--a lethal factor in mice
    L S Teicher
    J Hered 69:86-90
    ..The gene is located on chromosome 15, between uw and bt. The distance uw--Bld is 28.2 +/- 5.1 cM: Bld--bt is 14.9 +/- 2.7 cM: and Bld--Ca is 24.6 +/- 2.6 cM...
  2. Progressive ankylosis, a new skeletal mutation in the mouse
    H O Sweet
    J Hered 72:87-93
    ..The new mutation is closely linked, with about 4 percent recombination, to underwhite on chr 15...
  3. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer
    E Di Pasquale
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurophysiol 77:621-31
    ..This defect could lower the threshold for aberrant thalamocortical spike wave oscillations in vivo, and may contribute to the mechanism of one form of inherited absence epilepsy...
  4. Assignment of the murine protein kinase gene DLK to chromosome 15 in the vicinity of the bt/Koa locus by genetic linkage analysis
    T Watanabe
    Department of Molecular Information, Tokyo University, Japan
    Genomics 40:375-6
  5. Strain-specific white-spotting patterns in laboratory mice
    M L Lamoreux
    Department of Veterinary Pathobiology, Texas A and M University, College Station 77843, USA
    Pigment Cell Res 12:383-90
    ..spotting were examined on mice mutant at the piebald (s), patch (Ph), dominant spotting (W(J2)) rumpwhite (Rw) or belted (bt) loci...
  6. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
    Robert P T Somerville
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:9503-13
    ..b>ADAMTS20 is very sparingly expressed, although it is detectable in epithelial cells of the breast and lung...
  7. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain
    Maria Llamazares
    Departamento de Bioquíimica y Biologíia Molecular, Facultad de Medicina, Instituto Universitario de Oncologíia, Universidad de Oviedo, 33006 Oviedo, Spain
    J Biol Chem 278:13382-9
    ..These data suggest that this novel enzyme may play a role in the tissue remodeling process occurring in both normal and pathological conditions...
  8. A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation
    Cherie Rao
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02476, USA
    Development 130:4665-72
    ..We report here that bt mice carry mutations in Adamts20, a novel member of the ADAMTS family of secreted metalloproteases...
  9. AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS
    T C Mayer
    Dev Biol 22:269-86
  10. Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 123:294-7
    ..These results indicate the necessity of integrating both gene association and genome-wide linkage studies in both mice and humans to understand the complex nature of these and other polygenic diseases...
  11. Association of megacolon with a new dominant spotting gene (Dom) in the mouse
    P W Lane
    J Hered 75:435-9
    ..6 +/- 1.6 units proximal to Ca. Hairy ears, Eh, a semidominant gene also on chr 15 is shown to have a suppressing effect on crossing over in this section of chr 15...
  12. Recessive yellow and its interaction with belted in the mouse
    T S Hauschka
    J Hered 59:339-41
  13. Location of the velvet coat mutant in linkage group VI of the mouse
    C Stieler
    J Hered 63:212-4
  14. Chromosomal location of soluble glutamic-pyruvic transaminase-1 (Gpt-1) in the mouse
    E M Eicher
    Biochem Genet 15:1-8
    ..Three-point linkage analysis established th location of Gpt-1 on chromosome 15 between uw and bt. In addition, a new staining procedure is described that allows the visualization of GPT activity on gels by the ..
  15. Cytoarchitectonic abnormalities in hippocampal formation and cerebellum of dreher mutant mouse
    M Sekiguchi
    Department of Anatomy, Tokai University School of Medicine, Kanagawa, Japan
    Brain Res Dev Brain Res 67:105-12
    ..In addition, the fact that the phenotypic abnormalities in homozygous dreher mice produces different abnormal morphologies in different specimens may be useful for analyzing the development of the hippocampal formation and cerebellum...
  16. The hairy ears (Eh) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15
    M T Davisson
    Jackson Laboratory, Bar Harbor, ME 04609
    Genet Res 56:167-78
    ..The effect of the inversion extends over a minimum of 30 cM, taking into account the genetic data and the cytologically determined chromosomal involvement extending to the region of the telomere...
  17. Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures
    J L Noebels
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030
    Epilepsy Res 7:129-35
    ....
  18. Genetic and tissue-specific variation in the expression of a closely linked murine multigene family on chromosome 15 that encodes salivary and lacrimal proteins
    D P Dickinson
    Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, Buffalo, New York 14263
    Biochem Genet 27:613-37
    ..Most, and probably all, of these homologues are clustered at a new locus near belted (bt) on chromosome 15, which we designate Spt (salivary protein)...
  19. Perinatal lethality (ple): a mutation caused by integration of a transgene into distal mouse chromosome 15
    D R Beier
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115
    Genomics 4:498-504
    ..It appears likely that a recessive insertional mutation has occurred as a result of transgene integration into a locus required for postnatal viability. We call this mutation transgenic perinatal lethality (Tg.ple)...
  20. Mapping of the mouse Ly-6, Xp-14, and Gdc-1 loci to chromosome 15
    P M Hogarth
    Immunogenetics 25:21-7
    ....
  21. Congenital progressive hydronephrosis in mice: a new recessive mutation
    C E Horton
    Department of Surgery, Children s Hospital, Boston, Massachusetts
    J Urol 140:1310-5
    ..The cph mouse strain provides a reproducible model for analysis of the onset and development of obstructive uropathic conditions in the neonatal period...
  22. Unusual recombination values and the mapping of the lethal miniature in the house mouse
    M E Wallace
    Genet Res 20:257-62
  23. The secreted metalloprotease ADAMTS20 is required for melanoblast survival
    Debra L Silver
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Genet 4:e1000003
    b>ADAMTS20 (Adisintegrin-like and metalloprotease domain with thrombospondin type-1 motifs) is a member of a family of secreted metalloproteases that can process a variety of extracellular matrix (ECM) components and secreted molecules...