Gene Symbol: ADA3
Description: transcriptional adaptor 3
Alias: 1110004B19Rik, ADA3, AI987856, Tada3l, transcriptional adapter 3, ADA3 homolog, ADA3-like protein, mADA3
Buryskova M, Pospisek M, Grothey A, Simmet T, Burysek L. Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes. J Biol Chem. 2004;279:4017-26 pubmed
..its N-terminal peptide (IL-1NTP) with histone acetyltransferases p300, PCAF, Gcn5 and with the adaptor component Ada3, and that it integrates into the PCAF.p300 complex in a non-destructive manner...
Orpinell M, Fournier M, Riss A, Nagy Z, Krebs A, Frontini M, et al
. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J. 2010;29:2381-94 pubmed publisher
..RNAi for the ATAC subunits Ada2a/Ada3 results in delayed M/G1 transition and pronounced cell division defects such as centrosome multiplication, ..
Guelman S, Kozuka K, Mao Y, Pham V, Solloway M, Wang J, et al
. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol. 2009;29:1176-88 pubmed publisher
Mohibi S, Gurumurthy C, Nag A, Wang J, Mirza S, Mian Y, et al
. Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression. J Biol Chem. 2012;287:29442-56 pubmed publisher
b>Ada3 protein is an essential component of histone acetyl transferase containing coactivator complexes conserved from yeast to human...
Mirza S, Katafiasz B, Kumar R, Wang J, Mohibi S, Jain S, et al
. Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability. Cell Cycle. 2012;11:4266-74 pubmed publisher
..Recently, we have shown the role of Ada3, a component of various histone acetyltransferase complexes, in cell cycle regulation, and loss of Ada3 results in ..
Mohibi S, Srivastava S, Wang France J, Mirza S, Zhao X, Band H, et al
. Alteration/Deficiency in Activation 3 (ADA3) Protein, a Cell Cycle Regulator, Associates with the Centromere through CENP-B and Regulates Chromosome Segregation. J Biol Chem. 2015;290:28299-310 pubmed publisher
b>ADA3 (alteration/deficiency in activation 3) is a conserved component of several transcriptional co-activator and histone acetyltransferase (HAT) complexes...
Mohibi S, Srivastava S, Bele A, Mirza S, Band H, Band V. Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation. Mol Cell Biol. 2016;36:2487-502 pubmed publisher
Alteration/deficiency in activation 3 (ADA3) is an essential component of specific histone acetyltransferase (HAT) complexes...
Benecke A, Gaudon C, Garnier J, vom Baur E, Chambon P, Losson R. ADA3-containing complexes associate with estrogen receptor alpha. Nucleic Acids Res. 2002;30:2508-14 pubmed
..Mouse mADA3 is 23% identical and 47% similar to yeast yADA3, and mADA3 in contrast to yADA3 does not interact with NRs ..
Meng G, Zhao Y, Nag A, Zeng M, Dimri G, Gao Q, et al
. Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. J Biol Chem. 2004;279:54230-40 pubmed
..We show that ADA3 directly interacts with ER alpha and ER beta...