Gene Symbol: Acvr1
Description: activin A receptor, type 1
Alias: ALK2, ActR-I, ActRIA, Acvr, Acvrlk2, Alk-2, Alk8, D330013D15Rik, SKR1, Tsk7L, activin receptor type-1, TGF-B superfamily receptor type I, TSK-7L, TSR-I, activin receptor type I, serine/threonine-protein kinase receptor R1
Species: mouse
Products:     Acvr1

Top Publications

  1. Chakkalakal S, Zhang D, Culbert A, Convente M, Caron R, Wright A, et al. An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva. J Bone Miner Res. 2012;27:1746-56 pubmed publisher
    ..617G?>?A; R206H) in the gene encoding ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor...
  2. Dudas M, Sridurongrit S, Nagy A, Okazaki K, Kaartinen V. Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech Dev. 2004;121:173-82 pubmed
    ..BMPs signal through a receptor complex composed of type I and type II receptors. Type I receptors (Alk2, Alk3 and Alk6) are the primary determinants of signaling specificity and therefore understanding their function is ..
  3. Fukuda T, Kohda M, Kanomata K, Nojima J, Nakamura A, Kamizono J, et al. Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem. 2009;284:7149-56 pubmed publisher
    ..a mutation involving a single amino acid substitution in a bone morphogenetic protein (BMP) type I receptor, ALK2, was identified in patients with FOP...
  4. Rajagopal R, Dattilo L, Kaartinen V, Deng C, Umans L, Zwijsen A, et al. Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival. Invest Ophthalmol Vis Sci. 2008;49:4953-60 pubmed publisher
    ..The purpose of this study was to analyze the function(s) of the type 1 BMP receptor, Acvr1, in lens development...
  5. Song G, Kim H, Woo K, Baek J, Kim G, Choi J, et al. Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva. J Biol Chem. 2010;285:22542-53 pubmed publisher
    ..617G>A; p.R206H, in the activin A receptor type 1 (ACVR1) gene, one of the bone morphogenetic protein type I receptors (BMPR-Is)...
  6. Mishina Y, Crombie R, Bradley A, Behringer R. Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol. 1999;213:314-26 pubmed
    ..Alk2, also known as ActRIA, Tsk7L, and SKR1, encodes a type I TGF-beta family receptor for activins and BMP-7...
  7. Kaartinen V, Nagy A. Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo. Genesis. 2001;31:126-9 pubmed
    ..This method is rapid and easy and does not require any special equipment. Moreover, because superovulated mice can be used as donors, this method does not necessitate a large number of mice. ..
  8. Kaartinen V, Dudas M, Nagy A, Sridurongrit S, Lu M, Epstein J. Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development. 2004;131:3481-90 pubmed
    ..We have used a Cre/loxP system for neural crest-specific deletion of the type I receptor, ALK2, in mouse embryos...
  9. Gu Z, Reynolds E, Song J, Lei H, Feijen A, Yu L, et al. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development. 1999;126:2551-61 pubmed
    b>ActRIA (or ALK2), one of the type I receptors of the transforming growth factor-beta (TGF-beta) superfamily, can bind both activin and bone morphogenetic proteins (BMPs) in conjunction with the activin and BMP type II receptors, ..

More Information


  1. Roelen B, Goumans M, Van Rooijen M, Mummery C. Differential expression of BMP receptors in early mouse development. Int J Dev Biol. 1997;41:541-9 pubmed
    ..In postimplantation embryos BMPR-II transcripts were first detected from 6.0 days post coitum. In situ hybridization analysis revealed that BMPR-II mRNA is ubiquitously expressed in the entire embryo at least until midgestation. ..
  2. Jiang F, Harrison L. Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells. Exp Cell Res. 2005;308:114-22 pubmed
    ..These results demonstrate a convergence of BMP and Ln-1 signaling through P13K and MAP kinase pathways to induce proliferation and colony formation in E15.5 fetal mouse pancreatic cells. ..
  3. Clementi C, Tripurani S, Large M, Edson M, Creighton C, Hawkins S, et al. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013;9:e1003863 pubmed publisher
    ..In this study, we investigated the roles of the BMP type 1 receptor, activin-like kinase 2 (ALK2), during mouse pregnancy by producing mice carrying a conditional ablation of Alk2 in the uterus (Alk2 cKO mice)...
  4. Kamiya Y, Miyazono K, Miyazawa K. Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction. J Biol Chem. 2010;285:30804-13 pubmed publisher
    ..Smad7 thus has an additional mode of interaction with TGF-? family type I receptors not possessed by Smad6, which may play roles in mediating the inhibitory effects unique to Smad7. ..
  5. Rajagopal R, Huang J, Dattilo L, Kaartinen V, Mishina Y, Deng C, et al. The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol. 2009;335:305-16 pubmed publisher the ectoderm that will form the lens, we deleted the genes encoding the type I BMP receptors, Bmpr1a and Acvr1, and the canonical transducers of BMP signaling, Smad4, Smad1 and Smad5...
  6. Zhou F, Xie F, Jin K, Zhang Z, Clerici M, Gao R, et al. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO J. 2017;36:1623-1639 pubmed publisher
    ..Moreover, zebrafish depleted of USP4 exhibited defective cell migration and slower coordinated cell movement known as epiboly, both of which could be rescued by SMAD4. Therefore, USP4 is a critical determinant of SMAD4 activity. ..
  7. Schmitt J, Mielke R, Schrewe H. Genomic organization of a mouse type I activin receptor. Biochem Biophys Res Commun. 1995;213:211-7 pubmed
    ..Using the mouse tsk7L cDNA, 4 overlapping lambda clones containing the activin receptor IA (ActRIA) gene were isolated from a mouse 129 Sv genomic library...
  8. de Sousa Lopes S, Roelen B, Monteiro R, Emmens R, Lin H, Li E, et al. BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 2004;18:1838-49 pubmed
    ..Here, we demonstrate that BMP4 produced in the extraembryonic ectoderm signals through ALK2, a type I BMP receptor, in the visceral endoderm (VE) to induce formation of PGCs from the epiblast...
  9. Luo J, Tang M, Huang J, He B, Gao J, Chen L, et al. TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. J Biol Chem. 2010;285:29588-98 pubmed publisher
    ..However, using dominant-negative mutants for the seven type I receptors, we demonstrate that only ALK1 and ALK2 mutants effectively inhibit BMP9-induced osteogenic differentiation in vitro and ectopic ossification in MSC ..
  10. Hill C, Yuasa M, Schoenecker J, Goudy S. Jagged1 is essential for osteoblast development during maxillary ossification. Bone. 2014;62:10-21 pubmed publisher
    ..JAG1-Fc rescued in vitro mineralization and osteoblast gene expression changes. These data suggest that JAG1 signaling in CNC-derived MEMM cells is required for osteoblast development and differentiation during maxillary ossification. ..
  11. Rigueur D, Brugger S, Anbarchian T, Kim J, Lee Y, Lyons K. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res. 2015;30:733-41 pubmed publisher
    ..BMPs transduce their signals through three type I receptors: BMPR1A, BMPR1B, and ACVR1/ALK2...
  12. Choe Y, Kozlova A, Graf D, Pleasure S. Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci. 2013;33:6766-75 pubmed publisher
    ..Conditional deletion of Activin receptor type I (Acvr1) or Smad4 (a downstream target nuclear effector of Bmp signaling) in DG neural stem cells resulted ..
  13. Wang J, Nagy A, Larsson J, Dudas M, Sucov H, Kaartinen V. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol. 2006;6:51 pubmed
    ..Our results demonstrate that ALK5-mediated signaling in neural crest cells plays an essential cell-autonomous role in the pharyngeal and cardiac outflow tract development. ..
  14. Yoshikawa S, Aota S, Shirayoshi Y, Okazaki K. The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryo. Mech Dev. 2000;91:439-44 pubmed
    ..Interestingly, in the lens placodes and in early Rathke's pouch, ActR-I protein is transiently localized at the apical surface of the epithelial cells, indicating the presence of an apical-basal asymmetry in these cells. ..
  15. Mayeur C, Lohmeyer L, Leyton P, Kao S, Pappas A, Kolodziej S, et al. The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Blood. 2014;123:2261-8 pubmed publisher
    ..Using mice with hepatocyte-specific deficiency of Alk2 or Alk3, we sought to identify the BMP type I receptor that participates in IL-6-mediated induction of hepcidin ..
  16. Gold E, Zellhuber McMillan S, Risbridger G, Marino F. Regional localization of activin-βA, activin-βC, follistatin, proliferation, and apoptosis in adult and developing mouse prostate ducts. Gene Expr Patterns. 2017;23-24:70-79 pubmed publisher
    ..In conclusion, the present study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development. ..
  17. Nakamura M, Matzuk M, Gerstmayer B, Bosio A, Lauster R, Miyachi Y, et al. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J. 2003;17:497-9 pubmed
    ..These observations suggest that follistatin and activin interaction plays an important role in both HF development and cycling, possibly in part by regulating expression of BMP-2 and its antagonist. ..
  18. Mura M, Cappato S, Giacopelli F, Ravazzolo R, Bocciardi R. The role of the 3'UTR region in the regulation of the ACVR1/Alk-2 gene expression. PLoS ONE. 2012;7:e50958 pubmed publisher
    The ACVR1/Alk-2 gene, encoding a BMP type I receptor, is mutated in Fibrodysplasia Ossificans Progressiva, a severe form of heterotopic ossification...
  19. Piek E, Van Dinther M, Parks W, Sallee J, Bottinger E, Roberts A, et al. RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Biochem J. 2004;383:187-99 pubmed
  20. Dudas M, Nagy A, Laping N, Moustakas A, Kaartinen V. Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004;266:96-108 pubmed
    ..Based on these observations, we conclude that the Smad2-dependent Alk-5 signaling pathway is dominant in palatal fusion driven by Tgf-beta3. ..
  21. Dey D, Bagarova J, Hatsell S, Armstrong K, Huang L, Ermann J, et al. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016;8:366ra163 pubmed
    ..HO) syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I receptor ACVR1, manifests with progressive ossification of skeletal muscles, tendons, ligaments, and joints...
  22. Caronia G, Wilcoxon J, Feldman P, Grove E. Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior. J Neurosci. 2010;30:6291-301 pubmed publisher
  23. Komatsu Y, Kaartinen V, Mishina Y. Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry. Development. 2011;138:3915-20 pubmed publisher
    ..Here, we show that the epiblast-specific deletion of the gene encoding the BMP type 1 receptor (Acvr1) compromised development of nodal cilia, which results in defects in leftward fluid flow and, thus, abnormalities ..
  24. Peng C, Mukai S. Activins and their receptors in female reproduction. Biochem Cell Biol. 2000;78:261-79 pubmed
    ..Special effort is made to compare activins and their receptors in different vertebrates. ..
  25. Suzuki Y, Ohga N, Morishita Y, Hida K, Miyazono K, Watabe T. BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci. 2010;123:1684-92 pubmed publisher
    ..These findings suggest that BMP-9 signaling activates the endothelium tested in the present study via ALK-1. ..
  26. Coda D, Gaarenstroom T, East P, Patel H, Miller D, Lobley A, et al. Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling. elife. 2017;6: pubmed publisher
    ..Thus SMAD2 binding does not linearly equate with transcriptional kinetics, and our data suggest that SMAD2 recruits multiple co-factors during sustained signaling to shape the downstream transcriptional program. ..
  27. Ameerun R, de Winter J, van den Eijnden van Raaij A, den Hertog J, de Laat S, Tertoolen L. Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells. Cell Growth Differ. 1996;7:1679-88 pubmed
    ..These results strengthen the notion that activin and bFGF are important regulators of neurogenesis in the mammalian embryo. ..
  28. Song T, Wang W, Xu J, Zhao D, Dong Q, Li L, et al. Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2. Int J Biochem Cell Biol. 2013;45:1639-46 pubmed publisher blocking BMP9-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2 in MSCs...
  29. Pan H, Zhang H, Abraham P, Komatsu Y, Lyons K, Kaartinen V, et al. BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development. Dev Biol. 2017;429:260-270 pubmed publisher
    ..In this study, we superimposed heterozygous null mutations of the other two BMP type I receptors, Bmpr1b and Acvr1 (ca1A;1bH and ca1A;AcH respectively hereafter) to further dissect involvement of BMP-Smad signaling...
  30. Vesper A, Raetzman L, Camper S. Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Endocrinology. 2006;147:1654-63 pubmed
    ..We hypothesize that variation in PROP1 expression could affect the growth spurt and the onset of puberty in humans...
  31. Schulz T, Huang P, Huang T, Xue R, McDougall L, Townsend K, et al. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature. 2013;495:379-83 pubmed publisher
    ..This sophisticated regulatory mechanism of body temperature may participate in the control of energy balance and metabolic disease. ..
  32. Komatsu Y, Scott G, Nagy A, Kaartinen V, Mishina Y. BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Dev Dyn. 2007;236:512-7 pubmed
    ..Previously, it was shown that BMP type I receptor ALK2 (also known as ACVRI, ActRI, or ActRIA) was important for normal mouse gastrulation by deleting exon 4 or exon 5 of Alk2...
  33. Mollah M, Ishikawa A. Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight. Mamm Genome. 2011;22:282-9 pubmed publisher
    ..These findings illustrate the complex genetic nature of body weight regulation and support the importance of subcongenic mouse analysis to dissect closely linked loci. ..
  34. Kishigami S, Yoshikawa S, Castranio T, Okazaki K, Furuta Y, Mishina Y. BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev Biol. 2004;276:185-93 pubmed
    ..Mouse embryonic stem (ES) cells with a homozygous deletion at Acvr1 were used to generate chimeric embryos...
  35. Martinez G, Mishina Y, Bertram J. BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies. Int J Dev Biol. 2002;46:525-33 pubmed
    ..Noggin did not alter metanephric development in vitro, but did block the effect of BMP4. The experiments described in this study have shown that BMP4 has distinct roles from BMP2 in metanephric development...
  36. Yano M, Kawao N, Tamura Y, Okada K, Kaji H. A novel factor, Tmem176b, induced by activin-like kinase 2 signal promotes the differentiation of myoblasts into osteoblasts. Exp Clin Endocrinol Diabetes. 2014;122:7-14 pubmed publisher
    ..The constitutively activating mutation (R206H) of the BMP type I receptor, activin-like-kinase 2 (ALK2), causes fibrodysplasia ossificans progressiva (FOP), which is characterized by extensive ossifications within ..
  37. Nakamura T, Sugino K, Kurosawa N, Sawai M, Takio K, Eto Y, et al. Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity. J Biol Chem. 1992;267:18924-8 pubmed
    ..These results suggest that signal transduction of activin employs a novel pathway via a new class of cellular receptor in EC P19 cells. ..
  38. Osuru H, Monroe J, Chebolu A, Akamune J, Pramoonjago P, Ranpura S, et al. The acrosomal protein SP-10 (Acrv1) is an ideal marker for staging of the cycle of seminiferous epithelium in the mouse. Mol Reprod Dev. 2014;81:896-907 pubmed publisher
    ..The anti-SP-10 antibody works well in different fixatives, on paraffin-embedded as well as cryosections, and has been shown to be useful for characterizing spermatogenic defects in mutant mice. ..
  39. Agrotis A, Samuel M, Prapas G, Bobik A. Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteins. Biochem Biophys Res Commun. 1996;219:613-8 pubmed
    ..Our finding that multiple ALKs are expressed by VSMCs would account for the multiplicity of effects TGF-beta peptides exert on these cells. ..
  40. Schwartze J, Becker S, Sakkas E, Wujak Ł, Niess G, Usemann J, et al. Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-? signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts. J Biol Chem. 2014;289:3262-75 pubmed publisher
  41. Culbert A, Chakkalakal S, Theosmy E, Brennan T, Kaplan F, Shore E. Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells. 2014;32:1289-300 pubmed publisher
    ..Gain-of-function mutations in ALK2, a type I BMP receptor, cause the debilitating disorder fibrodysplasia ossificans progressiva (FOP) and result in ..
  42. Agarwal S, Loder S, Brownley C, Eboda O, Peterson J, Hayano S, et al. BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints. Dev Biol. 2015;400:202-9 pubmed publisher
    BMP signaling mediated by ACVR1 plays a critical role for development of multiple structures including the cardiovascular and skeletal systems...
  43. Bagarova J, Vonner A, Armstrong K, Börgermann J, Lai C, Deng D, et al. Constitutively active ALK2 receptor mutants require type II receptor cooperation. Mol Cell Biol. 2013;33:2413-24 pubmed publisher
    ..syndrome resulting from highly conserved activating mutations of the glycine-serine-rich (GS) regulatory domain of ACVR1, encoding bone morphogenetic protein (BMP) type I receptor ALK2, which lead to inappropriate signaling and ..
  44. Chen S, Han B, Zhu Y, Mahabole M, Huang J, Beebe D, et al. HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells. Stem Cells. 2015;33:3341-55 pubmed publisher
    ..translocation of pSmad1/5/8 was prohibited in hLEPCs when reunioned with mLNCs of conditionally deleted Bmpr1a;Acvr1(DCKO) mice...
  45. Podkowa M, Christova T, Zhao X, Jian Y, Attisano L. p21-Activated kinase (PAK) is required for Bone Morphogenetic Protein (BMP)-induced dendritogenesis in cortical neurons. Mol Cell Neurosci. 2013;57:83-92 pubmed publisher
    ..a key regulator of diverse neuronal processes and an upstream activator of LIMK, binds to the BMP type I receptor, ALK2. Although, PAK1 is dispensable for activation of the Smad transcriptional mediators, abrogation of PAK1 expression ..
  46. Kaplan F, Chakkalakal S, Shore E. Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis. Dis Model Mech. 2012;5:756-62 pubmed publisher
    ..617G>A; R206H) in the gene encoding ACVR1 (also known as ALK2), a bone morphogenetic protein (BMP) type I receptor...
  47. Hatsell S, Idone V, Wolken D, Huang L, Kim H, Wang L, et al. ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Sci Transl Med. 2015;7:303ra137 pubmed publisher
    ..FOP results from mutations in the intracellular domain of the type I BMP (bone morphogenetic protein) receptor ACVR1; the most common mutation alters arginine 206 to histidine (ACVR1(R206H)) and has been thought to drive ..
  48. Mathews L, Vale W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 1991;65:973-82 pubmed
    ..elegans daf-1 gene product, a putative transmembrane serine/threonine-specific protein kinase for which the ligand is not known. ..
  49. Visser J, Olaso R, Verhoef Post M, Kramer P, Themmen A, Ingraham H. The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol Endocrinol. 2001;15:936-45 pubmed
    ..Among the multiple type I candidates tested, only ALK2 resulted in significant enhancement of the MIS signaling response...
  50. Lees Shepard J, Yamamoto M, Biswas A, Stoessel S, Nicholas S, Cogswell C, et al. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva. Nat Commun. 2018;9:471 pubmed publisher
    ..fibro/adipogenic progenitors (FAPs) are a major cell-of-origin of HO in an accurate genetic mouse model of FOP (Acvr1 tnR206H )...
  51. Verschueren K, Dewulf N, Goumans M, Lonnoy O, Feijen A, Grimsby S, et al. Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech Dev. 1995;52:109-23 pubmed
  52. Shi C, Iura A, Terajima M, Liu F, Lyons K, Pan H, et al. Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors. Sci Rep. 2016;6:24256 pubmed publisher
    We previously found that disruption of two type I BMP receptors, Bmpr1a and Acvr1, respectively, in an osteoblast-specific manner, increased bone mass in mice...
  53. Peterson J, Eboda O, Agarwal S, Ranganathan K, Buchman S, Lee M, et al. Targeting of ALK2, a Receptor for Bone Morphogenetic Proteins, Using the Cre/lox System to Enhance Osseous Regeneration by Adipose-Derived Stem Cells. Stem Cells Transl Med. 2014;3:1375-80 pubmed publisher
    ..We believe the osteogenic phenotype caused by mutations in ALK2 can be harnessed in adipose-derived stem cells (ASCs) to improve bone tissue engineering...
  54. Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, et al. A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H. Biochem Biophys Res Commun. 2011;407:213-8 pubmed publisher
    ..Constitutively activated mutants of a bone morphogenetic protein (BMP) receptor, ALK2, have been identified in patients with FOP...
  55. Rosendahl A, Pardali E, Speletas M, Ten Dijke P, Heldin C, Sideras P. Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Cell Mol Biol. 2002;27:160-9 pubmed
  56. Leyton P, Beppu H, Pappas A, Martyn T, Derwall M, Baron D, et al. Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function. PLoS ONE. 2013;8:e76947 pubmed publisher
    ..conditional knockout mice to selectively deplete BMP receptors, we observed that the tail domain of Bmpr2 inhibits Alk2?mediated BMP7 signaling...
  57. Liang G, Zhang X, Wang J, Sun Y, Sun X, Cheng S, et al. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse. Stem Cells Dev. 2015;24:2455-65 pubmed publisher
    ..In this study, we reported that activin receptors (including ActRIA, ActRIB, ActRIIA, and ActRIIB) are expressed throughout the development of the mouse ovaries from 12...
  58. Kemoun P, Laurencin Dalicieux S, Rue J, Vaysse F, Romeas A, Arzate H, et al. Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontium. Tissue Cell. 2007;39:257-66 pubmed
    ..These results suggest that STRO-1 positive DF cells may be target of BMPs secreted by HERS. BMP-3 might be involved in the arrest of this process by inhibiting the signaling provided by cementogenic and osteogenic BMPs...
  59. Leikauf G, Concel V, Liu P, Bein K, Berndt A, Ganguly K, et al. Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1. Am J Respir Crit Care Med. 2011;183:1499-509 pubmed publisher
    ..5-fold. Associations were identified on chromosomes 1, 2, 4, 11, and 12. Seven genes (Acvr1, Cacnb4, Ccdc148, Galnt13, Rfwd2, Rpap2, and Tgfbr3) had single nucleotide polymorphism (SNP) associations within ..
  60. Kamiya N, KAARTINEN V, Mishina Y. Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1. Biochem Biophys Res Commun. 2011;414:326-30 pubmed publisher
    ..The BMP receptor ACVR1, which is a key receptor of BMP7, is expressed in bone...
  61. Noda K, Mishina Y, Komatsu Y. Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2016;415:306-313 pubmed publisher
    ..In this study, we show that enhanced BMP signaling through constitutively active ACVR1 in palatal epithelium causes submucous cleft palate in mice...
  62. Simmons D, Cross J. Determinants of trophoblast lineage and cell subtype specification in the mouse placenta. Dev Biol. 2005;284:12-24 pubmed
    ..Here, we review recent insights into the molecular pathways regulating trophoblast lineage segregation, stem cell maintenance, and subtype differentiation. ..
  63. Izon D, Punt J, Xu L, Karnell F, Allman D, Myung P, et al. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity. 2001;14:253-64 pubmed
  64. Fernandez Valdivia R, Zhang Y, Pai S, Metzker M, Schumacher A. l7Rn6 encodes a novel protein required for clara cell function in mouse lung development. Genetics. 2006;172:389-99 pubmed
    ..Thus, l7Rn6 represents a novel protein required for organization and/or function of the secretory apparatus in Clara cells in mouse lung. ..
  65. Ebner R, Chen R, Shum L, Lawler S, Zioncheck T, Lee A, et al. Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science. 1993;260:1344-8 pubmed
    ..A murine serine-threonine kinase receptor, Tsk 7L, was cloned that shared a conserved extracellular domain with the type II TGF-beta receptor...
  66. Orvis G, Jamin S, Kwan K, Mishina Y, Kaartinen V, Huang S, et al. Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse. Biol Reprod. 2008;78:994-1001 pubmed publisher
    ..tissue-specific gene inactivation with an Amhr2-Cre allele, we have determined that two TGF-beta type I receptors (Acvr1 and Bmpr1a) and all three BMP receptor-Smads (Smad1, Smad5, and Smad8) function redundantly in transducing the ..
  67. Choudhary B, Zhou J, Li P, Thomas S, Kaartinen V, Sucov H. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis. 2009;47:115-21 pubmed publisher
    ..In mutant tissue, lysyl oxidase expression was substantially reduced, which may contribute to the observed pathology. ..
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    ..Two BMP type I receptors, Alk2 (Acvr1) and Alk3 (Bmpr1a), are expressed in murine hepatocytes...
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    ..Here, we used the Cre/loxP system for endothelial-specific deletion of the type I receptor Alk2 in mouse embryos...