Gene Symbol: Actl6a
Description: actin-like 6A
Alias: 2810432C06Rik, AI851094, ARP4, Actl6, Baf53a, C79802, actin-like protein 6A, 53 kDa BRG1-associated factor A, BRG1-associated factor 53A, BRG1/brm-associated factor 53A, actin-like 6, actin-related protein Baf53a
Species: mouse
Products:     Actl6a

Top Publications

  1. Olave I, Wang W, Xue Y, Kuo A, Crabtree G. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002;16:2509-17 pubmed
    ..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons. ..
  2. Lessard J, Wu J, Ranish J, Wan M, Winslow M, Staahl B, et al. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 2007;55:201-15 pubmed
    ..progenitor cells express complexes in which BAF45a, a Kr├╝ppel/PHD domain protein and the actin-related protein BAF53a are quantitatively associated with the SWI2/SNF2-like ATPases, Brg and Brm...
  3. Lee K, Kang M, Kwon S, Kwon Y, Kim K, Lim J, et al. Expansion of chromosome territories with chromatin decompaction in BAF53-depleted interphase cells. Mol Biol Cell. 2007;18:4013-23 pubmed
    ..These results indicate that BAF53 contributes to the polymeric properties and/or the internal meshwork interactions of the chromatin fiber probably via a novel mechanism. ..
  4. Lee K, Shim J, Kang M, Kim J, Ahn J, Yoo S, et al. Association of BAF53 with mitotic chromosomes. Mol Cells. 2007;24:288-93 pubmed
    ..BAF53 was also found in the mitotic chromosome fraction of sucrose gradients. Association of BAF53 with mitotic chromosomes would allow its rapid activation on the chromatin upon exit from mitosis. ..
  5. Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M. Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex. Biochem Biophys Res Commun. 2002;299:328-34 pubmed
    ..The Arp4 subfamily of Arps is localized in the nucleus, and a mammalian isoform, ArpNbeta (also known as BAF53), is a ..
  6. Krasteva V, Buscarlet M, Diaz Tellez A, Bernard M, Crabtree G, Lessard J. The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function. Blood. 2012;120:4720-32 pubmed publisher
    ..Here we provide the first evidence that the actin-related protein BAF53a, a subunit of BAF complexes preferentially expressed in long-term repopulating stem cells, is essential for adult ..
  7. Staahl B, Tang J, Wu W, Sun A, Gitler A, Yoo A, et al. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013;33:10348-61 pubmed publisher
  8. Lu W, Fang L, Ouyang B, Zhang X, Zhan S, Feng X, et al. Actl6a protects embryonic stem cells from differentiating into primitive endoderm. Stem Cells. 2015;33:1782-93 pubmed publisher
    Actl6a (actin-like protein 6A, also known as Baf53a or Arp4) is a subunit shared by multiple complexes including esBAF, INO80, and Tip60-p400, whose main components (Brg1, Ino80, and p400, respectively) are crucial for the maintenance of ..
  9. Saladi S, Ross K, Karaayvaz M, Tata P, Mou H, Rajagopal J, et al. ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell. 2017;31:35-49 pubmed publisher
    ..Here, we reveal that ACTL6A, encoding an SWI/SNF subunit linked to stem cell and progenitor cell function, is frequently co-amplified and ..

More Information


  1. Zhao K, Wang W, Rando O, Xue Y, Swiderek K, Kuo A, et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998;95:625-36 pubmed
    ..This work indicates that membrane signals control the activity of the mammalian SWI/SNF or BAF complex and demonstrates a direct interface between signaling and chromatin regulation. ..
  2. Lee J, Chang S, Shim J, Lee J, Yoshida M, Kwon H. Cytoplasmic localization and nucleo-cytoplasmic shuttling of BAF53, a component of chromatin-modifying complexes. Mol Cells. 2003;16:78-83 pubmed
    ..The nucleocytoplasmic shuttling and the punctate staining of the cytoplasm suggest that BAF53 can play a role distinct from its previously recognized function in transcriptional regulation. ..
  3. Yoo A, Staahl B, Chen L, Crabtree G. MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature. 2009;460:642-6 pubmed publisher
    ..This switch involves the exchange of the BAF53a (also known as ACTL6a) and BAF45a (PHF10) subunits within Swi/Snf-like neural-progenitor-specific BAF (npBAF) ..