Gene Symbol: Actg1
Description: actin, gamma, cytoplasmic 1
Alias: AL023024, Actg, Actl, E51, actin, cytoplasmic 2, beta-actin FE-3, gamma-actin
Species: mouse
Products:     Actg1

Top Publications

  1. Belyantseva I, Perrin B, Sonnemann K, Zhu M, Stepanyan R, McGee J, et al. Gamma-actin is required for cytoskeletal maintenance but not development. Proc Natl Acad Sci U S A. 2009;106:9703-8 pubmed publisher
    ..Despite this widely held supposition, we show that gamma(cyto)-actin null mice (Actg1(-/-)) are viable...
  2. Sonnemann K, Fitzsimons D, Patel J, Liu Y, Schneider M, Moss R, et al. Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy. Dev Cell. 2006;11:387-97 pubmed
    ..We generated and analyzed skeletal muscle-specific gamma(cyto)-actin knockout (Actg1-msKO) mice...
  3. Perrin B, Sonnemann K, Ervasti J. ?-actin and ?-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. PLoS Genet. 2010;6:e1001158 pubmed publisher
    ..and ?-actin in stereocilia formation and maintenance by generating mice conditionally knocked out for Actb or Actg1 in hair cells...
  4. Zhang F, Saha S, Shabalina S, Kashina A. Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation. Science. 2010;329:1534-7 pubmed publisher
    ..This degradation mechanism, coupled to nucleotide coding sequence, may regulate protein arginylation in vivo. ..
  5. Bunnell T, Ervasti J. Delayed embryonic development and impaired cell growth and survival in Actg1 null mice. Cytoskeleton (Hoboken). 2010;67:564-72 pubmed publisher
    ..We found that gamma(cyto)-actin null (Actg1(-/-)) mice were fully viable during embryonic development, but most died within 48 h of birth due to respiratory ..
  6. Kathiresan T, Harvey M, Orchard S, Sakai Y, Sokolowski B. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Mol Cell Proteomics. 2009;8:1972-87 pubmed publisher
    ..The studies described herein provide insights into BK-related functions that include not only cell excitation, but also cell signaling and apoptosis, and involve proteins concerned with Ca(2+) regulation, structure, and hearing loss. ..
  7. Leitner L, Shaposhnikov D, Descot A, Hoffmann R, Posern G. Epithelial Protein Lost in Neoplasm alpha (Eplin-alpha) is transcriptionally regulated by G-actin and MAL/MRTF coactivators. Mol Cancer. 2010;9:60 pubmed publisher
    ..The tumor suppressor Eplin-alpha is thus a novel cytoskeletal target gene transcriptionally regulated by the actin-MAL-SRF pathway, which supports a role in cancer biology. ..
  8. Burns S, Killock D, Moulding D, Metelo J, Nunes J, Taylor R, et al. A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes. Blood. 2010;115:5355-65 pubmed publisher
    ..Together, our results demonstrate that WASp(I294T) significantly affects lymphocyte membrane topography and L-selectin-dependent adhesion, which may be linked to defective hematopoiesis and leukocyte function in affected patients. ..
  9. Doucet J, Provost P, Samuelsson B, Radmark O. Molecular cloning and functional characterization of mouse coactosin-like protein. Biochem Biophys Res Commun. 2002;290:783-9 pubmed
    ..However, association with actin was best observed at low salt concentrations, while association with 5LO was favored by salt, indicating different binding characteristics. ..

More Information


  1. Wu X, Lee S, Sheng J, Zhang Z, Zhao W, Wang D, et al. Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses. Neuron. 2016;92:1020-1035 pubmed publisher
    ..We conclude that polymerized actin provides mechanical force essential for all kinetically distinguishable forms of endocytosis at synapses. ..
  2. Peter B, Man Y, Begg C, Gall I, Leader D. Mouse cytoskeletal gamma-actin: analysis and implications of the structure of cloned cDNA and processed pseudogenes. J Mol Biol. 1988;203:665-75 pubmed
    ..One way of accounting for the features of this anomalous pseudogene is by postulating that it is derived from a second functional gene for gamma-actin, different from that represented by the cDNA described here. ..
  3. Albano R, Arkell R, Beddington R, Smith J. Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain. Development. 1994;120:803-13 pubmed
    ..These results are consistent with a role for activin in mesoderm formation in the mouse embryo, and suggest functions for follistatin in addition to its role as an inhibitor of activin. ..
  4. Vandekerckhove J, Weber K. Actin amino-acid sequences. Comparison of actins from calf thymus, bovine brain, and SV40-transformed mouse 3T3 cells with rabbit skeletal muscle actin. Eur J Biochem. 1978;90:451-62 pubmed
    ..In addition documentation for a few minor revisions of the amino acid sequence of rabbit skeletal muscle actin is provided. ..
  5. Poulsen R, McClaskey C, Rivkees S, Wendler C. The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development. BMC Dev Biol. 2011;11:37 pubmed publisher
  6. Willison K, Dudley K, Potter J. Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1. Cell. 1986;44:727-38 pubmed
    ..DNA sequence comparison of the Tcp-1 genes suggests that the t haplotype chromosome arose within the genus Mus more than one million years ago. ..
  7. Tokunaga K, Takeda K, Kamiyama K, Kageyama H, Takenaga K, Sakiyama S. Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells. Mol Cell Biol. 1988;8:3929-33 pubmed
    ..These results suggest that there are multiple regulatory mechanisms of cytoskeletal actin genes and are consistent with the argument that beta- and gamma-actins might have functional diversity in mammalian cells. ..
  8. Prins K, Lowe D, Ervasti J. Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype. PLoS ONE. 2008;3:e2419 pubmed publisher
  9. Kambe Y, Hayashi N, Tomita N. Adhesive force behavior of single ATDC5 cells in chondrogenic culture. Biochem Biophys Res Commun. 2012;420:241-6 pubmed publisher
  10. Ma Z, Sharp K, Janmey P, Finkel T. Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol. 2008;6:e43 pubmed publisher
    ..Based on these observations, we propose the receptor deformation model of TCR triggering to explain the remarkable sensitivity and specificity of TCR triggering. ..
  11. Ohno M, Aoki N, Sasaki H. Allele-specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture-induced changes in Igf2 imprinting during pre-implantation mouse development. Genes Cells. 2001;6:249-59 pubmed
    ..ASO-RNA-FISH is therefore a powerful technique for the study of allele-specific gene expression. ..
  12. Higashida C, Suetsugu S, Tsuji T, Monypenny J, Narumiya S, Watanabe N. G-actin regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers. J Cell Sci. 2008;121:3403-12 pubmed publisher
    ..Taken together, we propose that transient accumulation of G-actin works as a cue to promote mDia1-catalyzed actin nucleation to execute rapid reassembly of actin filaments. ..
  13. Lloyd C, Berendse M, Lloyd D, Schevzov G, Grounds M. A novel role for non-muscle gamma-actin in skeletal muscle sarcomere assembly. Exp Cell Res. 2004;297:82-96 pubmed
    ..Consequently, a modified model is proposed which describes the role of gamma-actin in skeletal sarcomere assembly. ..
  14. Legendre K, Safieddine S, Küssel Andermann P, Petit C, El Amraoui A. alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008;121:3347-56 pubmed publisher
    ..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin. ..
  15. Zhang D, Piazza V, Perrin B, Rzadzinska A, Poczatek J, Wang M, et al. Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia. Nature. 2012;481:520-4 pubmed publisher
    ..Thus, rapid turnover in stereocilia occurs only at the tips and not by a treadmilling process...
  16. Li C, Sathyamurthy A, Oldenborg A, Tank D, Ramanan N. SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014;34:4027-42 pubmed publisher
    ..Thus, our findings reveal a novel phosphorylation and activation of SRF by GSK-3 that is critical for SRF-dependent axon growth in mammalian central neurons. ..
  17. Brockmann C, Huarte J, Dugina V, Challet L, Rey E, Conne B, et al. Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes. Biol Reprod. 2011;85:1025-39 pubmed publisher
    ..Finally, differences in gamma-CYA expression are amongst the earliest markers of cell fate determination in development. ..
  18. Schevzov G, Lloyd C, Gunning P. High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture. J Cell Biol. 1992;117:775-85 pubmed
    ..In particular, we conclude that the beta- and gamma-actin genes encode functionally distinct cytoarchitectural information. ..
  19. Palis J, Kingsley P. Differential gene expression during early murine yolk sac development. Mol Reprod Dev. 1995;42:19-27 pubmed
    ..These results are consistent with the hypothesis that at E7.5, the yolk sac endoderm provides differentiated liver-like functions, while the newly developing extraembryonic mesoderm is still a largely undifferentiated tissue. ..
  20. Kim E, Waters S, Hake L, Hecht N. Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice. Mol Cell Biol. 1989;9:1875-81 pubmed
    ..These studies demonstrate the existence of an SMGA in male haploid germ cells. The implications of the existence of an SMGA in male germ cells are discussed. ..
  21. Rullo J, Becker H, Hyduk S, Wong J, Digby G, Arora P, et al. Actin polymerization stabilizes ?4?1 integrin anchors that mediate monocyte adhesion. J Cell Biol. 2012;197:115-29 pubmed publisher
    ..These included activation of Rap1, phosphoinositide 3-kinase ? isoform, and Rac but not Cdc42. Thus, rapid signaling and structural adaptations enable leukocytes to stabilize adhesion and resist detachment forces. ..
  22. Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, et al. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood. 2009;113:244-53 pubmed publisher
    ..Taken together, our results indicate that the directional migration of capillaries in the embryo is governed by the Amot:Patj/Mupp1:Syx signaling that controls local GTPase activity. ..
  23. Sympson C, Singleton D, Geoghegan T. Cytochalasin D-induced actin gene expression in murine erythroleukemia cells. Exp Cell Res. 1993;205:225-31 pubmed
    ..By contrast, a minimal 99-bp actin promoter-CAT construct containing a functional SRE did not respond to CD. ..
  24. Bunnell T, Burbach B, Shimizu Y, Ervasti J. ?-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 2011;22:4047-58 pubmed publisher
    ..These data support an essential role for ?-actin in regulating cell migration and gene expression through control of the cellular G-actin pool. ..
  25. Yuan B, Wan P, Chu D, Nie J, Cao Y, Luo W, et al. A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice. Am J Pathol. 2014;184:1967-80 pubmed publisher
    ..Taken together, these results demonstrate that AIP1-regulated actin dynamics play essential roles in heart function in mice. ..
  26. Tondeleir D, Drogat B, Slowicka K, Bakkali K, Bartunkova S, Goossens S, et al. Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels. PLoS ONE. 2013;8:e67855 pubmed publisher
    ..These results provide new molecular insights for a novel function of beta-actin in erythropoiesis by modulating the expression levels of Gata2 in vivo. ..
  27. Rivera G, Vasilescu D, Papayannopoulos V, Lim W, Mayer B. A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. Mol Cell. 2009;36:525-35 pubmed publisher
    ..This study uncovers a strong reciprocal interdependence between Nck and PI(4,5)P(2) in promoting localized N-WASp-mediated actin polymerization in cells. ..
  28. Dupuis L, Kern C. Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development. Dev Dyn. 2014;243:601-11 pubmed publisher
    ..Therefore, we speculate that SLRPs may not only be required to facilitate collagen fiber formation but may also regulate TGF? signaling in the murine heart. ..
  29. Cleveland D, Lopata M, MacDonald R, Cowan N, Rutter W, Kirschner M. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980;20:95-105 pubmed
  30. Schreiber J, Végh M, Dawitz J, Kroon T, Loos M, Labonté D, et al. Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels. J Cell Biol. 2015;211:569-86 pubmed publisher
    ..We show that synaptic γ-actin levels are regulated by the E3 ubiquitin ligase TRIM3. TRIM3 protein and Actg1 transcript are colocalized in messenger ribonucleoprotein granules responsible for the dendritic targeting of ..
  31. Schevzov G, Lloyd C, Gunning P. Impact of altered actin gene expression on vinculin, talin, cell spreading, and motility. DNA Cell Biol. 1995;14:689-700 pubmed
    ..However, a relationship between talin and cell motility was found to exist, suggesting a role for talin in the establishment of focal contacts necessary for motility. ..
  32. Rienhoff H, Groudine M. Regulation of amyloid A gene expression in cultured cells. Mol Cell Biol. 1988;8:3710-6 pubmed
    ..These observations suggest that conditioned medium contains a factor(s) that acts directly on hepatocytes to regulate SAA3 mRNA processing. ..
  33. Drummond M, Friderici K. A novel actin mRNA splice variant regulates ACTG1 expression. PLoS Genet. 2013;9:e1003743 pubmed publisher
    ..We identified a novel cytoplasmic-γ-actin (Actg1) transcript that includes a previously unidentified exon (3a)...
  34. Chen Y, Derin R, Petralia R, Li M. Actinfilin, a brain-specific actin-binding protein in postsynaptic density. J Biol Chem. 2002;277:30495-501 pubmed publisher
    ..The results showed the postsynaptic density distribution of actinfilin. Together, these results indicate that actinfilin may be a key player in the actin-based neuronal function...
  35. Percharde M, Wong P, Ramalho Santos M. Global Hypertranscription in the Mouse Embryonic Germline. Cell Rep. 2017;19:1987-1996 pubmed publisher
    ..This study provides a paradigm for transcriptional analyses during development and reveals a major global hyperactivity of the germline transcriptome. ..
  36. Lin G, McCormick J, Johnstone R. Is gamma-actin a regulator of amino acid transport?. Am J Physiol. 1996;270:C1647-55 pubmed
    ..The cloned cDNA (E51) was found to be 90% homologous to gamma-actin...
  37. Kiuchi T, Nagai T, Ohashi K, Mizuno K. Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension. J Cell Biol. 2011;193:365-80 pubmed publisher
  38. Lu Y, Adegoke O, Nepveu A, Nakayama K, Bedard N, Cheng D, et al. USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol. 2009;29:547-58 pubmed publisher
  39. Perkins A, Sharpe A, Orkin S. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995;375:318-22 pubmed
    ..Its stage-specific and beta-globin-gene-specific requirement suggests that EKLF may facilitate completion of the fetal-to-adult (haemoglobin gamma to beta) switch in humans. ..