Actb

Summary

Gene Symbol: Actb
Description: actin, beta
Alias: Actx, E430023M04Rik, beta-actin, actin, cytoplasmic 1, A-X actin-like protein, actin, beta, cytoplasmic, melanoma X-actin
Species: mouse
Products:     Actb

Top Publications

  1. Lionnet T, Czaplinski K, Darzacq X, Shav Tal Y, Wells A, Chao J, et al. A transgenic mouse for in vivo detection of endogenous labeled mRNA. Nat Methods. 2011;8:165-70 pubmed publisher
    ..The MBS cassette also enabled high-sensitivity fluorescence in situ hybridization (FISH), allowing detection and localization of single ?-actin mRNA molecules in various mouse tissues. ..
  2. Buxbaum A, Wu B, Singer R. Single ?-actin mRNA detection in neurons reveals a mechanism for regulating its translatability. Science. 2014;343:419-22 pubmed publisher
    ..Further, our work demonstrates that ?-actin mRNA and ribosomes are in a masked state that is alleviated by stimulation. ..
  3. Perrin B, Sonnemann K, Ervasti J. ?-actin and ?-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. PLoS Genet. 2010;6:e1001158 pubmed publisher
    ..of ?-actin and ?-actin in stereocilia formation and maintenance by generating mice conditionally knocked out for Actb or Actg1 in hair cells...
  4. Cheever T, Li B, Ervasti J. Restricted morphological and behavioral abnormalities following ablation of ?-actin in the brain. PLoS ONE. 2012;7:e32970 pubmed publisher
    ..Altogether, we identified novel roles for ?-actin in promoting complex CNS tissue architecture while also demonstrating that distinct functions for the ubiquitously expressed ?-actin are surprisingly restricted in vivo. ..
  5. Tondeleir D, Lambrechts A, Muller M, Jonckheere V, Doll T, Vandamme D, et al. Cells lacking ?-actin are genetically reprogrammed and maintain conditional migratory capacity. Mol Cell Proteomics. 2012;11:255-71 pubmed publisher
  6. Okamoto H, Nakae J, Kitamura T, Park B, Dragatsis I, Accili D. Transgenic rescue of insulin receptor-deficient mice. J Clin Invest. 2004;114:214-23 pubmed
    ..These data indicate, surprisingly, that insulin receptor signaling in noncanonical insulin target tissues is sufficient to maintain fuel homeostasis and prevent diabetes. ..
  7. Spencer V, Costes S, Inman J, Xu R, Chen J, Hendzel M, et al. Depletion of nuclear actin is a key mediator of quiescence in epithelial cells. J Cell Sci. 2011;124:123-32 pubmed publisher
    ..These data indicate a novel role for nuclear ?-actin in growth arrest of epithelial cells and underscore the importance of the integrity of the basement membrane in homeostasis. ..
  8. Karakozova M, Kozak M, Wong C, Bailey A, Yates J, Mogilner A, et al. Arginylation of beta-actin regulates actin cytoskeleton and cell motility. Science. 2006;313:192-6 pubmed
    ..Thus, posttranslational arginylation of a single protein target can regulate its intracellular function, inducing global changes on the cellular level, and may contribute to cardiovascular development and angiogenesis. ..
  9. Shawlot W, Deng J, Fohn L, Behringer R. Restricted beta-galactosidase expression of a hygromycin-lacZ gene targeted to the beta-actin locus and embryonic lethality of beta-actin mutant mice. Transgenic Res. 1998;7:95-103 pubmed
    ..5 (E8.5) but became growth retarded at E9.5 and subsequently died. The RT-PCR data indicate that this targeted mutation is a hypomorphic allele of beta-actin. ..

More Information

Publications98

  1. Tanaka K, Matsui K, Sasaki T, Sano H, Sugio S, Fan K, et al. Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system. Cell Rep. 2012;2:397-406 pubmed publisher
    ..This shows that our system is applicable not only to neuroscience but also to any biomedical study that requires understanding of how the activity of a selected population of cells propagates through the intricate organic systems. ..
  2. Cheever T, Olson E, Ervasti J. Axonal regeneration and neuronal function are preserved in motor neurons lacking ß-actin in vivo. PLoS ONE. 2011;6:e17768 pubmed publisher
    ..We therefore generated motor neuron specific ß-actin knock-out mice (Actb-MNsKO) to investigate the function of ß-actin in motor neurons in vivo...
  3. Katz Z, Wells A, Park H, Wu B, Shenoy S, Singer R. ?-Actin mRNA compartmentalization enhances focal adhesion stability and directs cell migration. Genes Dev. 2012;26:1885-90 pubmed publisher
    ..This will reveal the importance of localized protein translation on various cellular processes. ..
  4. Jägle U, Gasser J, Muller M, Kinzel B. Conditional transgene expression mediated by the mouse beta-actin locus. Genesis. 2007;45:659-66 pubmed
  5. Bunnell T, Burbach B, Shimizu Y, Ervasti J. ?-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 2011;22:4047-58 pubmed publisher
    ..We generated whole-body ?-actin-knockout (Actb(-/-)) mice and demonstrated that ?-actin is required for early embryonic development...
  6. Zhang F, Saha S, Shabalina S, Kashina A. Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation. Science. 2010;329:1534-7 pubmed publisher
    ..This degradation mechanism, coupled to nucleotide coding sequence, may regulate protein arginylation in vivo. ..
  7. Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, et al. In vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca(2+) indicator. Cell Rep. 2014;8:311-8 pubmed publisher
    ..These observations suggest that astrocytic fine processes function as a high-sensitivity detector of neuronal activities. Thus, the method provides a useful tool for studying the activity of astrocytes in brain physiology and pathology. ..
  8. Shmerling D, Danzer C, Mao X, Boisclair J, Haffner M, Lemaistre M, et al. Strong and ubiquitous expression of transgenes targeted into the beta-actin locus by Cre/lox cassette replacement. Genesis. 2005;42:229-35 pubmed
    ..Our results demonstrate ubiquitous expression of floxed transgenes in the endogenous beta-actin locus and they support the general use of the beta-actin locus for targeted transgenesis. ..
  9. Roelen B, Lin H, Knezevic V, Freund E, Mummery C. Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo. Dev Biol. 1994;166:716-28 pubmed
  10. Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, et al. Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ. BMC Genomics. 2016;17:979 pubmed
    ..Our results provide a technical platform for high-throughput knock-in. ..
  11. Cheng A, Robertson E. The murine LIM-kinase gene (limk) encodes a novel serine threonine kinase expressed predominantly in trophoblast giant cells and the developing nervous system. Mech Dev. 1995;52:187-97 pubmed
    ..Moreover, high levels of limk expression is associated with the overt formation of giant cells from diploid progenitors, suggesting an involvement for limk in the differentiation of this highly specialized extra-embryonic cell type. ..
  12. Fowlis G, Adelman S, Knight A, Simpson E. PCR-analyzed microsatellites of the mouse genome--additional polymorphisms among ten inbred mouse strains. Mamm Genome. 1992;3:192-6 pubmed
    ..This simple approach will, therefore, continue to be useful in genome mapping studies, leading eventually to high-resolution maps of both the mouse and human genomes; this should allow for physical mapping and cloning of specific genes. ..
  13. Pardossi Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, et al. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron. 2005;46:541-54 pubmed
    ..The presenilin-dependent regulation of neprilysin, mediated by AICDs, provides a physiological means to modulate Abeta levels with varying levels of gamma-secretase activity. ..
  14. Huang K, Yasruel Z, Guerin C, Holland P, Nalbantoglu J. Interaction of the Coxsackie and adenovirus receptor (CAR) with the cytoskeleton: binding to actin. FEBS Lett. 2007;581:2702-8 pubmed
    ..We previously demonstrated that CAR interacts with microtubules. These data suggest a role for CAR in processes requiring dynamic reorganization of the cytoskeleton such as neurite outgrowth and cell migration. ..
  15. Clark K, Langeslag M, van Leeuwen B, Ran L, Ryazanov A, Figdor C, et al. TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J. 2006;25:290-301 pubmed
    ..Collectively, our results demonstrate that regulation of cell adhesion by TRPM7 is the combined effect of kinase-dependent and -independent pathways on actomyosin contractility. ..
  16. Nudel U, Katcoff D, Zakut R, Shani M, Carmon Y, Finer M, et al. Isolation and characterization of rat skeletal muscle and cytoplasmic actin genes. Proc Natl Acad Sci U S A. 1982;79:2763-7 pubmed
    ..Several intron sites are conserved from at least the echinoderms to the vertebrates; others appear to be present in some actin genes and not in others. ..
  17. Robledo R, Ciciotte S, Gwynn B, Sahr K, Gilligan D, Mohandas N, et al. Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Blood. 2008;112:4298-307 pubmed publisher
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  18. Xu T, Rumsby M. Phorbol ester-induced translocation of PKC epsilon to the nucleus in fibroblasts: identification of nuclear PKC epsilon-associating proteins. FEBS Lett. 2004;570:20-4 pubmed
    ..We have confirmed that these proteins associate with PKC by gel overlay and/or dot blotting assays. The role of these PKC-associating proteins in the nucleus and their interaction with PKC are considered. ..
  19. Albershardt T, Iritani B, Ruddell A. Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes. J Immunol Methods. 2012;384:196-9 pubmed publisher
    ..Ubc) is the optimal reference gene for normalizing qPCR data obtained from mouse lymphocytes, whereas beta-actin (Actb) is not a suitable reference gene due to its extensive variability in expression...
  20. Tokunaga K, Takeda K, Kamiyama K, Kageyama H, Takenaga K, Sakiyama S. Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells. Mol Cell Biol. 1988;8:3929-33 pubmed
    ..These results suggest that there are multiple regulatory mechanisms of cytoskeletal actin genes and are consistent with the argument that beta- and gamma-actins might have functional diversity in mammalian cells. ..
  21. Carrascoso I, Sánchez Jiménez C, Izquierdo J. Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression. Mol Cancer. 2014;13:90 pubmed publisher
    ..methods, we have analyzed the regulatory role of TIA proteins in the post-transcriptional modulation of beta-actin (ACTB) mRNA...
  22. Kleinert H, Euchenhofer C, Ihrig Biedert I, Forstermann U. In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB. J Biol Chem. 1996;271:6039-44 pubmed
    ..These experiments indicate that NF-kappaB is the key control element for the induction of NOS II in response to at least three different second messenger pathways in 3T3 cells. ..
  23. Brockmann C, Huarte J, Dugina V, Challet L, Rey E, Conne B, et al. Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes. Biol Reprod. 2011;85:1025-39 pubmed publisher
    ..Finally, differences in gamma-CYA expression are amongst the earliest markers of cell fate determination in development. ..
  24. Honda K, Kim S, Kelly M, Burns J, Constance L, Li X, et al. Molecular architecture underlying fluid absorption by the developing inner ear. elife. 2017;6: pubmed publisher
    ..We propose a molecular mechanism for resorption of NaCl by MRCs during development, and conclude that disruption of this mechanism is the root cause of hearing loss associated with EES. ..
  25. Vastrik I, Kaipainen A, Penttila T, Lymboussakis A, Alitalo R, Parvinen M, et al. Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro. J Cell Biol. 1995;128:1197-208 pubmed
    ..The pattern of mad expression in tissues and its ability to inhibit cell growth in vitro suggests that Mad can cause the cessation of cell proliferation associated with cell differentiation in vivo. ..
  26. Shiokawa N, Nakamura M, Sameshima M, Deguchi A, Hayashi T, Sasaki N, et al. Chorein, the protein responsible for chorea-acanthocytosis, interacts with ?-adducin and ?-actin. Biochem Biophys Res Commun. 2013;441:96-101 pubmed publisher
    ..Expression of ?-adducin is restricted to the brain and hematopoietic tissues, corresponding to the main pathological lesions of ChAc, and thereby implicating ?-adducin and ?-actin in ChAc pathogenesis. ..
  27. Lee J, Ward W, Knapp G, Ren H, Vallanat B, Abbott B, et al. Transcriptional ontogeny of the developing liver. BMC Genomics. 2012;13:33 pubmed publisher
    ..Overall, these findings reveal the complexity of gene expression changes during liver development and maturation, and provide a foundation to predict responses to chemical and drug exposure as a function of early life-stages. ..
  28. Igarashi M, Guarente L. mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction. Cell. 2016;166:436-450 pubmed publisher
    ..We suggest that Paneth cell signaling overrides any direct nutrient sensing in ISCs to sculpt the observed response to CR. Moreover, drugs that modulate pathways important in CR may exert opposing effects on different cell types. ..
  29. Yao H, Hwang J, Sundar I, Friedman A, McBurney M, Guarente L, et al. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol. 2013;305:L615-24 pubmed publisher
    ..Thus redressing the TIMP-1/MMP-9 imbalance by pharmacological activation of SIRT1 is an attractive approach in the intervention of COPD. ..
  30. Kaminska B, Kaczmarek L, Grzelakowska Sztabert B. Inhibitors of polyamine biosynthesis affect the expression of genes encoding cytoskeletal proteins. FEBS Lett. 1992;304:198-200 pubmed
    ..These findings suggest mechanisms through which polyamines may exert their effects on the cytoskeleton integrity. ..
  31. Schevzov G, Lloyd C, Gunning P. High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture. J Cell Biol. 1992;117:775-85 pubmed
    ..In particular, we conclude that the beta- and gamma-actin genes encode functionally distinct cytoarchitectural information. ..
  32. Tondeleir D, Noelanders R, Bakkali K, Ampe C. Beta-actin is required for proper mouse neural crest ontogeny. PLoS ONE. 2014;9:e85608 pubmed publisher
    ..Furthermore, the absence of beta-actin affects cadherin-11 and N-cadherin function, which could partly be alleviated by ROCK inhibition, situating the Rho-ROCK signaling in a feedback loop with cadherin-11. ..
  33. Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey M, Kuum M, et al. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy. 2014;10:1105-19 pubmed publisher
    ..In sum, our results demonstrate that BECN1 interacts with PARK2 and regulates PARK2 translocation to mitochondria as well as PARK2-induced mitophagy prior to autophagosome formation. ..
  34. Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh V, Fang G, Dumont D, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci U S A. 1995;92:3566-70 pubmed
    ..Our results suggest that FLT4 is a marker for lymphatic vessels and some high endothelial venules in human adult tissues. They also support the theory on the venous origin of lymphatic vessels...
  35. Thundathil J, Filion F, Smith L. Molecular control of mitochondrial function in preimplantation mouse embryos. Mol Reprod Dev. 2005;71:405-13 pubmed
  36. Radtke A, Delbridge L, Balachandran S, Barber G, O Riordan M. TBK1 protects vacuolar integrity during intracellular bacterial infection. PLoS Pathog. 2007;3:e29 pubmed
    ..Taken together, these data demonstrate a requirement for TBK1 in control of bacterial infection distinct from its established role in antiviral immunity. ..
  37. Lin H, Accili D. Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes. J Biol Chem. 2011;286:9797-804 pubmed publisher
    ..The broader implication of our findings is that diabetes treatment should not necessarily target the same tissues that are responsible for disease pathogenesis. ..
  38. Fiorini E, Schmitz I, Marissen W, Osborn S, Touma M, Sasada T, et al. Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol Cell. 2002;9:637-48 pubmed
    ..Retroviral transduction of I kappa BNS in fetal thymic organ culture enhances TCR-triggered cell death consistent with its function in selection. ..
  39. Wang R, Islam B, Bridges A, Sharman S, Hu M, Hou Y, et al. cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. Am J Pathol. 2017;187:377-389 pubmed publisher
    ..Moreover, this pathway is regulated by endogenous cGMP/PKG2 signaling, and can be targeted using phosphodiesterase-5 inhibitors. ..
  40. Tudela C, Formoso M, Martínez T, Perez R, Aparicio M, Maestro C, et al. TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion. Int J Dev Biol. 2002;46:333-6 pubmed
    ..antibodies to a panel of cell adhesion and cytoskeletal molecules including E-cadherin, alpha and beta catenin, beta actin, vinculin and beta2 integrin...
  41. Takata N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, et al. Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI. PLoS ONE. 2015;10:e0121417 pubmed publisher
    ..Our findings suggest that the primary targets of dHP and vHP activation are distinct, which concurs with attributed functions of the dHP and RSP in spatial memory, as well as of the vHP and LS in emotional responses. ..
  42. Uchiumi T, Fotovati A, Sasaguri T, Shibahara K, Shimada T, Fukuda T, et al. YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation. J Biol Chem. 2006;281:40440-9 pubmed
    ..These results demonstrate that YB-1 is involved in early mouse development, including neural tube closure and cell proliferation. ..
  43. Miyanari Y, Torres Padilla M. Control of ground-state pluripotency by allelic regulation of Nanog. Nature. 2012;483:470-3 pubmed publisher
    ..Our data highlight an unexpected role for allelic expression in controlling the dose of pluripotency factors in vivo, adding an extra level to the regulation of reprogramming. ..
  44. Zhang D, Piazza V, Perrin B, Rzadzinska A, Poczatek J, Wang M, et al. Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia. Nature. 2012;481:520-4 pubmed publisher
    ..Thus, rapid turnover in stereocilia occurs only at the tips and not by a treadmilling process...
  45. Liou G, Wang M, Matragoon S. Timing of interphotoreceptor retinoid-binding protein (IRBP) gene expression and hypomethylation in developing mouse retina. Dev Biol. 1994;161:345-56 pubmed
    ..Taken together, these results indicate that IRBP gene activation is associated with hypomethylation during the last mitosis before photoreceptor cell differentiation. ..
  46. Dutta D, Zameer A, Mariani J, Zhang J, Asp L, Huynh J, et al. Combinatorial actions of Tgf? and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014;141:2414-28 pubmed publisher
    ..Here, we report that Tgf? ligands and activin B (ActB) act in concert in the mammalian spinal cord to promote oligodendrocyte generation and myelination...
  47. Ritvos O, Tuuri T, Erämaa M, Sainio K, Hilden K, Saxen L, et al. Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse. Mech Dev. 1995;50:229-45 pubmed
    ..Our results are suggestive of a potential role for the activin-follistatin system as an intrinsic regulator of epithelial branching morphogenesis during mammalian organogenesis. ..
  48. Zhou Z, Yon Toh S, Chen Z, Guo K, Ng C, Ponniah S, et al. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 2003;35:49-56 pubmed
    ..Our data thus indicate a role for Cidea in regulating energy balance and adiposity. ..
  49. Krapivinsky G, Krapivinsky L, Manasian Y, Clapham D. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 2014;157:1061-72 pubmed publisher
    ..These findings suggest that TRPM7-mediated modulation of intracellular Zn(2+) concentration couples ion-channel signaling to epigenetic chromatin covalent modifications that affect gene expression patterns. PAPERCLIP: ..
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    ..These data suggest the cdc25 genes may have distinct roles in regulating the pattern of cell division during mouse embryogensis and gametogenesis. ..
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    ..Two Cripto transcripts were detected: one is confined to the early embryo and teratocarcinoma cells, and the other, first found in the fetus, is the major form detected in adult organs. ..
  52. Sadano H, Taniguchi S, Kakunaga T, Baba T. cDNA cloning and sequence of a new type of actin in mouse B16 melanoma. J Biol Chem. 1988;263:15868-71 pubmed
    ..These differences between Ax and beta-actin cDNA indicate that the Ax actin is encoded by an unique gene set, independent of beta-actin. ..
  53. Crosier P, Lewis P, Hall L, Vitas M, Morris C, Beier D, et al. Isolation of a receptor tyrosine kinase (DTK) from embryonic stem cells: structure, genetic mapping and analysis of expression. Growth Factors. 1994;11:125-36 pubmed
    ..There is enrichment of transcripts encoding DTK in purified fetal liver hematopoietic stem cells, when compared with unfractionated fetal liver. The DTK gene maps to mouse chromosome 2, band F. ..
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    ..g. in choroid plexus and in kidney glomeruli. The data are consistent with a role of VEGF as a multifunctional regulator of endothelial cell growth and differentiation. ..
  55. Salinas E, Byrum S, Moreland L, Mackintosh S, Tackett A, Forrest J. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016;90:1397-413 pubmed publisher
    ..These experiments expand the known LANA-binding proteins to include MHV68 lytic replication and demonstrate a previously unappreciated role for Hsc70 in regulating viral replication. ..
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    ..Furthermore, components of branchpoints may induce pulmonary neuroendocrine cell differentiation as part of a positive feedback loop, which could account in part for the high prevalence of these cells at branchpoints. ..
  58. Holtz M, Misra R. Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium. BMC Dev Biol. 2011;11:18 pubmed publisher
    ..Furthermore, we provide evidence that supports a model in which loss of SRF protein results in a sustained proliferation defect due in part to failed integrin signaling. ..
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    ..Taken together, our data suggest normal functions for Nsk2 RTKs in distinctive aspects of skeletal muscle development, neurogenesis and mesenchymal-epithelial interactions during organ formation. ..
  60. Gómez Herreros F, Schuurs Hoeijmakers J, McCormack M, Greally M, Rulten S, Romero Granados R, et al. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nat Genet. 2014;46:516-21 pubmed publisher
    ..Collectively, these data implicate chromosome breakage by TOP2 as an endogenous threat to gene transcription and to normal neuronal development and maintenance. ..
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    ..abstract truncated at 400 words) ..
  62. Volkmann I, Kumarswamy R, Pfaff N, Fiedler J, Dangwal S, Holzmann A, et al. MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circ Res. 2013;113:997-1003 pubmed publisher
    ..TGF-? impairs endothelial angiogenic responses partly by downregulating miR-30a-3p and subsequent derepression of MeCP2-mediated epigenetic silencing of Sirt1. ..
  63. Rathod R, Havlicek S, Frank N, Blum R, Sendtner M. Laminin induced local axonal translation of ?-actin mRNA is impaired in SMN-deficient motoneurons. Histochem Cell Biol. 2012;138:737-48 pubmed publisher
    ..Taken together our findings suggest that local translation of ?-actin in growth cones of motoneurons is regulated by Laminin signalling and that this signalling is disturbed in SMA. ..
  64. Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. Proc Natl Acad Sci U S A. 2012;109:20720-5 pubmed publisher
    ..These findings demonstrate that glia can modulate the tone of neuronal activity and behavior. This animal model is expected to be a potentially powerful approach to study the role of glia in brain function. ..
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    ..Importantly, Panx1 has an interaction with actin microfilaments that regulates its cell surface localization and mobility. ..
  66. Chang H, Guarente L. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell. 2013;153:1448-60 pubmed publisher
    ..Our findings indicate that SIRT1 activates the central pacemaker to maintain robust circadian control in young animals, and a decay in this activity may play an important role in aging. ..
  67. Sympson C, Singleton D, Geoghegan T. Cytochalasin D-induced actin gene expression in murine erythroleukemia cells. Exp Cell Res. 1993;205:225-31 pubmed
    ..By contrast, a minimal 99-bp actin promoter-CAT construct containing a functional SRE did not respond to CD. ..
  68. Kiebish M, Han X, Cheng H, Lunceford A, Clarke C, Moon H, et al. Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. J Neurochem. 2008;106:299-312 pubmed publisher
    ..NS and Syn mitochondrial lipidomic heterogeneity could influence energy metabolism, which may contribute to metabolic compartmentation of the brain. ..
  69. Ueyama H, Kurokawa K, Sasaki I, Ueda K. Characterization of acidic actin in mouse sarcoma 180 cells. Cell Struct Funct. 1987;12:463-70 pubmed
    ..These results suggest that this variant actin is related to beta-cytoplasmic actin or, is a novel species whose N-terminal amino acid sequence is not Glu-Glu-Glu. ..
  70. Ikawa T, Masuda K, Lu M, Minato N, Katsura Y, Kawamoto H. Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood. 2004;103:530-7 pubmed
    ..We propose that the wave of p-Ts in fetal blood disclosed by this study represents the ontogenically earliest thymic immigrants. ..
  71. Nagamine C, Chan K, Hake L, Lau Y. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. Genes Dev. 1990;4:63-74 pubmed
    ..However, because the Zfy genes are apparently also expressed during spermatogenesis and in fetal organs other than testes, they may serve additional functions besides their postulated role in testis determination. ..
  72. Politi K, Szabolcs M, Fisher P, Kljuic A, Ludwig T, Efstratiadis A. A mouse model of uterine leiomyosarcoma. Am J Pathol. 2004;164:325-36 pubmed
    ..To begin exploring aberrant signaling events in the SVER-triggered tumorigenic pathways, we analyzed the expression profile of leiomyosarcomas by DNA microarray analysis. ..
  73. Cox R, Buckingham M. Actin and myosin genes are transcriptionally regulated during mouse skeletal muscle development. Dev Biol. 1992;149:228-34 pubmed
    ..Notably, transcription from the MLC3F promoter is activated after that of the MLC1F promoter, which is part of the same gene. These results are discussed in the context of published RNA data. ..
  74. Yuan B, Wan P, Chu D, Nie J, Cao Y, Luo W, et al. A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice. Am J Pathol. 2014;184:1967-80 pubmed publisher
    ..Taken together, these results demonstrate that AIP1-regulated actin dynamics play essential roles in heart function in mice. ..
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    ..Biochemical analyses indicate that Daam1 does not regulate cytoskeletal organization through RhoA, Rac1 or Cdc42. Our study highlights a crucial role for Daam1 in regulating the actin cytoskeleton and tissue morphogenesis. ..
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