Gene Symbol: Acsbg1
Description: acyl-CoA synthetase bubblegum family member 1
Alias: BG1, Bgm, E230019G03Rik, GR-LACS, Lpd, R75185, long-chain-fatty-acid--CoA ligase ACSBG1, bubblegum, gonadotropin-regulated long chain acyl CoA synthetase, lipidosin, lipidosis-related protein lipidosin, lipodisin
Species: mouse
Products:     Acsbg1

Top Publications

  1. Song S, Kato C, Adachi E, Moriya Sato A, Inagawa Ogashiwa M, Umeda R, et al. Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination. J Neurosci Res. 2007;85:3586-97 pubmed
    b>Lipidosin is an 80-kDa protein with long-chain acyl-CoA synthetase activity expressed in the brain, adrenal gland, testis, and ovary, which are selectively damaged in X-linked adrenoleukodystrophy (X-ALD)...
  2. Moriya Sato A, Hida A, Inagawa Ogashiwa M, Wada M, Sugiyama K, Shimizu J, et al. Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues. Biochem Biophys Res Commun. 2000;279:62-8 pubmed
    ..Here we cloned a mouse cDNA encoding a novel protein, Lipidosin, that possesses long-chain acyl-CoA synthetase (LCAS) activity...
  3. Fraisl P, Forss Petter S, Zigman M, Berger J. Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase. Biochem J. 2004;377:85-93 pubmed
    It has been suggested that a gene termed bubblegum (Bgm), encoding an acyl-CoA synthetase, could be involved in the pathogenesis of the inherited neurodegenerative disorder X-ALD (X-linked adrenoleukodystrophy)...
  4. Tang P, Tsai Morris C, Dufau M. Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase. Proc Natl Acad Sci U S A. 2001;98:6581-6 pubmed
    ..GR-LACS may contribute to the provision of energy requirements and to the biosynthesis of steroid precursors and could participate through acyl-CoA's multiple functions in the regulation of the male gonad. ..
  5. Pei Z, Oey N, Zuidervaart M, Jia Z, Li Y, Steinberg S, et al. The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. J Biol Chem. 2003;278:47070-8 pubmed
    ..We reported that hBG1, the human homolog of the acyl-CoA synthetase mutated in the Drosophila mutant "bubblegum," belongs to a previously unidentified enzyme family and is capable of activating both long- and very long-..
  6. Sheng Y, Tsai Morris C, Li J, Dufau M. Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. J Steroid Biochem Mol Biol. 2009;114:44-56 pubmed publisher
    ..Its mouse/human homologs, lipidosin/bubblegum, have been suggested to participate in X-linked adrenoleukodystrophy (X-ALD), an adreno/..
  7. Wang S, Liang Q, Qiao H, Li H, Shen T, Ji F, et al. DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7. Development. 2016;143:2732-40 pubmed publisher
    ..In summary, our results demonstrate that DISC1 regulates astrogenesis by modulating RAS/MEK/ERK signaling via RASSF7 and provide a framework for understanding how DISC1 dysfunction might lead to neuropsychiatric diseases. ..
  8. Sheng Y, Li J, Dufau M, Tsai Morris C. The gonadotropin-regulated long-chain acyl CoA synthetase gene: a novel downstream Sp1/Sp3 binding element critical for transcriptional promoter activity. Gene. 2005;360:20-6 pubmed
    ..Thus, functional analyses of this promoter domain indicate that transcription of GR-LACS gene requires an Sp1/Sp3 binding element downstream of the transcriptional start sites which is essential for basal promoter activity. ..
  9. Steinberg S, Morgenthaler J, Heinzer A, Smith K, Watkins P. Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids. J Biol Chem. 2000;275:35162-9 pubmed
    ..It was reported that the Drosophila melanogaster mutant bubblegum (BGM) had elevated VLCFA and that the product of the defective gene had sequence homology to acyl-CoA ..

More Information


  1. Jia Z, Pei Z, Li Y, Wei L, Smith K, Watkins P. X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Mol Genet Metab. 2004;83:117-27 pubmed
    ..Two enzymes with VLACS activity, ACSVL1 and BG1, were investigated for their potential role in X-ALD biochemical pathology...
  2. Li X, Newbern J, Wu Y, Morgan Smith M, Zhong J, Charron J, et al. MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron. 2012;75:1035-50 pubmed publisher
    ..We conclude that MEK is essential for acquisition of gliogenic competence by radial progenitors and that levels of MEK activity regulate gliogenesis in the developing cortex. ..