Gene Symbol: Acot2
Description: acyl-CoA thioesterase 2
Alias: AA571646, MTE-I, Mte1, acyl-coenzyme A thioesterase 2, mitochondrial, acyl coenzyme A thioester hydrolase, mitochondrial acyl-CoA thioesterase 1, very-long-chain acyl-CoA thioesterase
Hunt M, Nousiainen S, Huttunen M, Orii K, Svensson L, Alexson S. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem. 1999;274:34317-26 pubmed
..These results strongly support the existence of a novel multi-gene family cluster of mouse acyl-CoA thioesterases, each with a distinct function in lipid metabolism. ..
Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged. ..
Hunt M, Rautanen A, Westin M, Svensson L, Alexson S. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. 2006;20:1855-64 pubmed
..arose by gene duplications encoding acyl-CoA thioesterases with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6)...
Moffat C, Bhatia L, Nguyen T, LYNCH P, Wang M, Wang D, et al
. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. J Lipid Res. 2014;55:2458-70 pubmed publisher
..b>Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its ..
Hunt M, Lindquist P, Nousiainen S, Huttunen M, Orii K, Svensson T, et al
. Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism. Cell Biochem Biophys. 2000;32 Spring:317-24 pubmed
..The promoter regions of both the CTE-I and MTE-I genes contain putative PP response elements, suggesting an involvement of PP-activated receptors in the regulation of these genes. ..
Tzeng J, Byun J, Park J, Yamamoto T, Schesing K, Tian B, et al
. An Ideal PPAR Response Element Bound to and Activated by PPARÎ±. PLoS ONE. 2015;10:e0134996 pubmed publisher
..Taken altogether, the provided PPRE sequence definition contributes to the understanding of PPARÎ± signaling by identifying PPARÎ± direct target genes with functional PPARÎ± response elements. ..