Gene Symbol: Acot1
Description: acyl-CoA thioesterase 1
Alias: ACH2, CTE-1, CTE-I, Cte1, D12Ucla1, acyl-coenzyme A thioesterase 1, acyl-CoA thioesterase 1, cytosolic, cytosolic acyl-CoA thioesterase 1, inducible cytosolic acyl-coenzyme A thioester hydrolase, long chain acyl-CoA hydrolase, long chain acyl-CoA thioester hydrolase
Species: mouse
Products:     Acot1

Top Publications

  1. Yechoor V, Patti M, Saccone R, Kahn C. Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A. 2002;99:10587-92 pubmed
    ..These data point to as of yet undefined mechanisms for highly coordinated regulation of gene expression by insulin and potential new targets for therapy of diabetes mellitus. ..
  2. Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
    ..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12...
  3. Dongol B, Shah Y, Kim I, Gonzalez F, Hunt M. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. J Lipid Res. 2007;48:1781-91 pubmed
    The cytosolic acyl-coenzyme A thioesterase I (Acot1) is an enzyme that hydrolyzes long-chain acyl-CoAs of C(12)-C(20)-CoA in chain length to the free fatty acid and CoA...
  4. Xia C, Dong R, Chen C, Wang H, Wang D. Cardiomyocyte specific expression of Acyl-coA thioesterase 1 attenuates sepsis induced cardiac dysfunction and mortality. Biochem Biophys Res Commun. 2015;468:533-40 pubmed publisher
    ..Acyl-CoA thioesterase 1 (ACOT1) is involved in regulating cardiac energy production via altering substrate metabolism...
  5. Hunt M, Rautanen A, Westin M, Svensson L, Alexson S. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. 2006;20:1855-64 pubmed
    ..genes that apparently arose by gene duplications encoding acyl-CoA thioesterases with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6)...
  6. Jiang Y, Yu V, Buchholz F, O Connell S, Rhodes S, Candeloro C, et al. A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996;271:10723-30 pubmed
    ..Identification of a second mouse gene highly homologous to NZF-1, encoded by a distinct genomic locus, reveals a dispersed gene family encoding proteins containing Cys-Cys, His-Cys motifs. ..
  7. Lindquist P, Svensson L, Alexson S. Molecular cloning of the peroxisome proliferator-induced 46-kDa cytosolic acyl-CoA thioesterase from mouse and rat liver--recombinant expression in Escherichia coli, tissue expression, and nutritional regulation. Eur J Biochem. 1998;251:631-40 pubmed
    ..Dietary regulation and tissue-specific expression suggest that CTE-I and MTE-I play important roles in lipid metabolism. ..
  8. Huhtinen K, O Byrne J, Lindquist P, Contreras J, Alexson S. The peroxisome proliferator-induced cytosolic type I acyl-CoA thioesterase (CTE-I) is a serine-histidine-aspartic acid alpha /beta hydrolase. J Biol Chem. 2002;277:3424-32 pubmed
    ..Furthermore, kinetic characterization of recombinant CTE-I showed that this enzyme appears to be a true acyl-CoA thioesterase being highly specific for C(12)-C(20) acyl-CoAs. ..
  9. Yang S, Chen C, Wang H, Rao X, Wang F, Duan Q, et al. Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPAR?/PGC1? signaling. PLoS ONE. 2012;7:e50376 pubmed publisher
    ..By microarray analysis of metabolic gene expression, acyl-CoA thioesterase 1 (acot1) was clearly upregulated in the myocardia of db/db mice, compared with normal control C57BL/Ks...

More Information


  1. Hunt M, Nousiainen S, Huttunen M, Orii K, Svensson L, Alexson S. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem. 1999;274:34317-26 pubmed
    ..These results strongly support the existence of a novel multi-gene family cluster of mouse acyl-CoA thioesterases, each with a distinct function in lipid metabolism. ..
  2. Hunt M, Lindquist P, Nousiainen S, Huttunen M, Orii K, Svensson T, et al. Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism. Cell Biochem Biophys. 2000;32 Spring:317-24 pubmed
    ..The promoter regions of both the CTE-I and MTE-I genes contain putative PP response elements, suggesting an involvement of PP-activated receptors in the regulation of these genes. ..