Ackr3

Summary

Gene Symbol: Ackr3
Description: atypical chemokine receptor 3
Alias: AW541270, CXC-R7, CXCR-7, Cmkor1, Cxcr7, RDC-1, Rdc1, atypical chemokine receptor 3, C-X-C chemokine receptor type 7, G-protein coupled receptor RDC1 homolog, chemokine (C-X-C motif) receptor 7, chemokine orphan receptor 1
Species: mouse
Products:     Ackr3

Top Publications

  1. Heesen M, Berman M, Charest A, Housman D, Gerard C, Dorf M. Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Immunogenetics. 1998;47:364-70 pubmed
    ..A receptor, termed RDC1, displaying the characteristic structural features of a chemokine receptor was cloned...
  2. Berahovich R, Zabel B, Penfold M, Lewén S, Wang Y, Miao Z, et al. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010;185:5130-9 pubmed publisher
    Since the discovery that CXCR7 binds to CXCL12/SDF-1?, the role of CXCR7 in CXCL12-mediated biological processes has been under intensive scrutiny...
  3. Yu S, Crawford D, Tsuchihashi T, Behrens T, Srivastava D. The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn. 2011;240:384-93 pubmed publisher
    b>CXCR7 (RDC1), a G-protein-coupled receptor with conserved motifs characteristic of chemokine receptors, is enriched in endocardial and cushion mesenchymal cells in developing hearts, but its function is unclear...
  4. Sierro F, Biben C, Martínez Muñoz L, Mellado M, Ransohoff R, Li M, et al. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007;104:14759-64 pubmed
    ..We noted differential expression of the chemokine receptor CXCR7 (RDC-1) on marginal zone B cells, a cell type associated with autoimmune diseases...
  5. Gerrits H, van Ingen Schenau D, Bakker N, van Disseldorp A, Strik A, Hermens L, et al. Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis. 2008;46:235-45 pubmed publisher
    b>CXCR7 is a G-protein coupled receptor that was recently deorphanized and shown to have SDF1 and I-TAC as high affinity ligands...
  6. Zheng K, Li H, Su X, Wang X, Tian T, Li F, et al. Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2010;29:31 pubmed publisher
    ..More recent studies have revealed that chemokine receptor CXCR7 plays an important role in cancer development...
  7. Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni P, et al. The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol. 2009;20:1714-23 pubmed publisher
    ..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney. ..
  8. Luker K, Gupta M, Steele J, Foerster B, Luker G. Imaging ligand-dependent activation of CXCR7. Neoplasia. 2009;11:1022-35 pubmed
    ..Functions of CXCL12 previously were believed to be controlled only by receptor CXCR4, but CXCR7 was recently identified as a second receptor for this chemokine...
  9. Wang Y, Li G, Stanco A, Long J, Crawford D, Potter G, et al. CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron. 2011;69:61-76 pubmed publisher
    ..No information is yet available on CXCR7, a newly defined CXCL12 receptor...

More Information

Publications69

  1. Sánchez Alcañiz J, Haege S, Mueller W, Pla R, Mackay F, Schulz S, et al. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011;69:77-90 pubmed publisher
    The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis...
  2. Cruz Orengo L, Holman D, Dorsey D, Zhou L, Zhang P, Wright M, et al. CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J Exp Med. 2011;208:327-39 pubmed publisher
    ..Here, we show that activation of CXCR7, which scavenges CXCL12, is essential for leukocyte entry via endothelial barriers into the central nervous system ..
  3. Monnier J, Boissan M, L Helgoualc h A, Lacombe M, Turlin B, Zucman Rossi J, et al. CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells. Eur J Cancer. 2012;48:138-48 pubmed publisher
    ..Here we investigated the novel chemokine receptor CXCR7/RDC1 in HCC progression, its two known ligands CXCL12 and CXCL11, as well as the other CXCL12 receptor, CXCR4...
  4. Cruz Orengo L, Chen Y, Kim J, Dorsey D, Song S, Klein R. CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity. J Neuroinflammation. 2011;8:170 pubmed publisher
    ..autoimmune encephalomyelitis (EAE), we previously demonstrated that antagonism of the chemokine receptor CXCR7 blocks endothelial cell sequestration of CXCL12, thereby enhancing the abluminal localization of CXCR4-expressing ..
  5. Kollmar O, Rupertus K, Scheuer C, Nickels R, Haberl G, Tilton B, et al. CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. Int J Cancer. 2010;126:1302-15 pubmed publisher
    ..In contrast to the neutralization of SDF-1, blockade of the SDF-1 receptors CXCR4 and CXCR7 significantly reduced tumor capillary density and tumor growth...
  6. Colasante G, Sessa A, Crispi S, Calogero R, Mansouri A, Collombat P, et al. Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity. Dev Biol. 2009;334:59-71 pubmed publisher
    ..Together, these data provide new insights into the molecular pathways regulated by Arx during telencephalon development. ..
  7. Burns J, Summers B, Wang Y, Melikian A, Berahovich R, Miao Z, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med. 2006;203:2201-13 pubmed
    ..This paper characterizes an alternate receptor, CXCR7, which binds with high affinity to SDF-1 and to a second chemokine, interferon-inducible T cell alpha ..
  8. Williams J, Patel J, Daniels B, Klein R. Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. J Exp Med. 2014;211:791-9 pubmed publisher
    ..Although the CXCL12 scavenging receptor CXCR7/ACKR3 (CXCR7) is also expressed by OPCs, its role in myelin repair in the adult CNS is unknown...
  9. Park I, Qian D, Kiel M, Becker M, Pihalja M, Weissman I, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302-5 pubmed
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs. ..
  10. Thomas M, Kalnins A, Andrassy M, Wagner A, Klussmann S, Rentsch M, et al. SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy. Transpl Int. 2015;28:1426-35 pubmed publisher
    ..Here, we investigate the potential therapeutic effect of inhibiting the SDF-1/CXCR4/CXCR7 axis with an anti-SDF-1 Spiegelmer (NOX-A12) on the development of chronic allograft vasculopathy...
  11. Zhang S, Lv C, Yang X, Han Z, Zhang S, Zhang J, et al. Corticosterone mediates the inhibitory effect of restraint stress on the migration of mesenchymal stem cell to carbon tetrachloride-induced fibrotic liver by downregulating CXCR4/7 expression. Stem Cells Dev. 2015;24:587-96 pubmed publisher
    ..decreased their expression of C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7)...
  12. Chen D, Chen Z, Zhang Y, Park C, Al Omari A, Moeckel G. Role of medullary progenitor cells in epithelial cell migration and proliferation. Am J Physiol Renal Physiol. 2014;307:F64-74 pubmed publisher
    ..We show that the medullary progenitor cells (MPCs) express CD24, CD44, CXCR7, CXCR4, nestin, and PAX7. MPCs are CD34 negative, which indicates that they are not bone marrow-derived stem cells...
  13. Ngamsri K, Müller A, Bösmüller H, Gamper Tsigaras J, Reutershan J, Konrad F. The Pivotal Role of CXCR7 in Stabilization of the Pulmonary Epithelial Barrier in Acute Pulmonary Inflammation. J Immunol. 2017;198:2403-2413 pubmed publisher
    ..The recently discovered chemokine receptor CXCR7 and its ligand stromal cell-derived factor (SDF)-1 are known to be involved in inflammation...
  14. Petruzziello Pellegrini T, Yuen D, Page A, Patel S, Soltyk A, Matouk C, et al. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice. J Clin Invest. 2012;122:759-76 pubmed publisher
    ..profiling of human microvascular endothelium treated with Stx implicated a role for activation of CXCR4 and CXCR7 by their shared cognate chemokine ligand (stromal cell-derived factor-1 [SDF-1]) in Stx-mediated pathophysiology...
  15. Liu H, Xue W, Ge G, Luo X, Li Y, Xiang H, et al. Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1? in MSCs. Biochem Biophys Res Commun. 2010;401:509-15 pubmed publisher
    ..HP (3% oxygen) induced the high expression of both chemokine stromal-derived factor-1 (SDF-1) receptors, CXCR4 and CXCR7, in MSCs. HP also improved in vitro migration, adhesion and survival of MSCs...
  16. Memi F, Abe P, Cariboni A, Mackay F, Parnavelas J, Stumm R. CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability. J Neurosci. 2013;33:17527-37 pubmed publisher
    ..Here, we investigated the role of the more recently identified second CXCL12 receptor, CXCR7, in GnRH neuron development...
  17. Li X, Zheng H, Huang L, Shi D, Peng J, Liang L, et al. Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer through ERK and ?-arrestin pathways. Int J Oncol. 2014;45:1649-57 pubmed publisher
    The CXC chemokine receptor 7 (CXCR7) has been reported to be involved in cell growth, metastasis and apoptosis in certain cancers...
  18. Chatterjee M, Borst O, Walker B, Fotinos A, Vogel S, Seizer P, et al. Macrophage migration inhibitory factor limits activation-induced apoptosis of platelets via CXCR7-dependent Akt signaling. Circ Res. 2014;115:939-49 pubmed publisher
    ..MIF interacted with CXCR4-CXCR7 on platelets, defining CXCR7 as a hitherto unrecognized receptor for MIF on platelets...
  19. Hunger C, Odemis V, Engele J. Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during mouse limb muscle development and regeneration. Exp Cell Res. 2012;318:2178-90 pubmed publisher
    ..This concept was recently challenged by the identification of CXCR7 as an alternative SDF-1 receptor, which can either act as a scavenger receptor, a modulator of CXCR4, or an active ..
  20. Peng H, Zhang H, Zhu H. Blocking CXCR7-mediated adipose tissue macrophages chemotaxis attenuates insulin resistance and inflammation in obesity. Biochem Biophys Res Commun. 2016;479:649-655 pubmed publisher
    ..In this study, we reported that CXCR7 expression is upregulated in adipose tissue, and specifically in ATMs during obesity...
  21. Konrad F, Meichssner N, Bury A, Ngamsri K, Reutershan J. Inhibition of SDF-1 receptors CXCR4 and CXCR7 attenuates acute pulmonary inflammation via the adenosine A2B-receptor on blood cells. Cell Death Dis. 2017;8:e2832 pubmed publisher
    ..Recent studies showed evidence that the chemokine stromal cell-derived factor (SDF)-1 and its receptors CXCR4 and CXCR7 influence migration of immune cells and their activity was linked to adenosine concentrations...
  22. Dai X, Yan X, Zeng J, Chen J, Wang Y, Chen J, et al. Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia. Circ Res. 2017;120:e7-e23 pubmed publisher
    Endothelial progenitor cells (EPCs) respond to stromal cell-derived factor 1 (SDF-1) through chemokine receptors CXCR7 and CXCR4. Whether SDF-1 receptors involves in diabetes mellitus-induced EPCs dysfunction remains unknown...
  23. Tiveron M, Boutin C, Daou P, Moepps B, Cremer H. Expression and function of CXCR7 in the mouse forebrain. J Neuroimmunol. 2010;224:72-9 pubmed
    ..Here we investigated the expression of CXCR7, the second receptor for CXCL12, in comparison to CXCR4...
  24. Bakondi B, Shimada I, Peterson B, Spees J. SDF-1? secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7. Stem Cells Dev. 2011;20:1021-9 pubmed publisher
    ..Pharmacological inhibition of the 2 known SDF-1 receptors, CXCR4 and CXCR7, revealed that only CXCR7 activity was functionally linked to survival signaling in mNPCs during hypoxia exposure...
  25. Saha A, Ahn S, Blando J, Su F, Kolonin M, DiGiovanni J. Proinflammatory CXCL12-CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice. Cancer Res. 2017;77:5158-5168 pubmed publisher
    ..In this study, we provide preclinical proof of concept for the role of a proinflammatory CXCL12-CXCR4/CXCR7 signaling axis in an obesity-driven mouse model of myc-induced prostate cancer...
  26. Mithal D, Ren D, Miller R. CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development. Glia. 2013;61:1288-305 pubmed publisher
    ..These data indicate that a specific chemokine signal derived from the meninges has multiple regulatory effects on radial glia. ..
  27. Ikeda Y, Kumagai H, Skach A, Sato M, Yanagisawa M. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013;155:1323-36 pubmed publisher
    ..Genetic and pharmacologic experiments demonstrated that intermediate opioid peptides secreted from SCH activate CXCR7, a ?-arrestin-biased G-protein-coupled receptor (GPCR), to augment circadian oscillation of glucocorticoid levels ..
  28. Bodea G, Spille J, Abe P, Andersson A, Acker Palmer A, Stumm R, et al. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development. 2014;141:661-73 pubmed publisher
  29. Chen Q, Zhang M, Li Y, Xu D, Wang Y, Song A, et al. CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4. Stem Cells. 2015;33:2574-85 pubmed publisher
    ..However, the discovery of CXCR7, a newly identified CXCL12 receptor, adds to the dynamics of the existing CXCL12/CXCR4 pair...
  30. Cao Z, Lis R, Ginsberg M, Chavez D, Shido K, Rabbany S, et al. Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nat Med. 2016;22:154-62 pubmed publisher
    ..Whereas the chemokine receptor CXCR7, expressed on PCECs, acts to prevent epithelial damage and ameliorate fibrosis after a single round of treatment ..
  31. Wani N, Nasser M, Ahirwar D, Zhao H, Miao Z, Shilo K, et al. C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment. Breast Cancer Res. 2014;16:R54 pubmed publisher
    Although C-X-C motif chemokine 12 (CXCL12) has been shown to bind to C-X-C chemokine receptor type 7 (CXCR7), the exact molecular mechanism regulations by CXCL12/CXCR7 axis in breast tumor growth and metastasis are not well understood...
  32. Brunn A, Utermohlen O, Mihelcic M, Sanchez Ruiz M, Carstov M, Blau T, et al. Differential effects of CXCR4-CXCL12- and CXCR7-CXCL12-mediated immune reactions on murine P0106-125 -induced experimental autoimmune neuritis. Neuropathol Appl Neurobiol. 2013;39:772-87 pubmed publisher
    ..neuritis, has not yet been elucidated in detail, Therefore, the role of the chemokine receptors CXCR4 and CXCR7 and their ligand CXCL12 was studied in autoimmune-mediated inflammation of the peripheral nervous system...
  33. Li X, Zhu M, Penfold M, Koenen R, Thiemann A, Heyll K, et al. Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation. 2014;129:1244-53 pubmed publisher
    The aim of this study was to determine the role of the chemokine receptor CXCR7 in atherosclerosis and vascular remodeling...
  34. Spinosa P, Luker K, Luker G, Linderman J. The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue. PLoS ONE. 2017;12:e0187357 pubmed publisher
    ..First, CXCL12-? and -? form higher magnitude (steeper) gradients compared to CXCL12-?. Second, endothelial CXCR7+ cells regulate CXCL12 gradient direction by controlling concentrations near but not far from the vasculature...
  35. Guillemot E, Karimdjee Soilihi B, Pradelli E, Benchetrit M, Goguet Surmenian E, Millet M, et al. CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver. Br J Cancer. 2012;107:1944-9 pubmed publisher
    ..Chemokine-receptor pairs have a critical role in determining the metastatic progression of tumours. Our hypothesis was that disruption of CXCR7/CXCR7 ligands axis could lead to a decrease in CRC metastases.
  36. Westernströer B, Terwort N, Ehmcke J, Wistuba J, Schlatt S, Neuhaus N. Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity. PLoS ONE. 2014;9:e112598 pubmed publisher
    ..More complexity arises since Cxcl12 also binds to the non-classical/atypical chemokine receptor Cxcr7. We explored the expression pattern of Cxcl12, Cxcr4 and Cxcr7 during postnatal development in mouse testes and ..
  37. Quille M, Carat S, Quémener Redon S, Hirchaud E, Baron D, Benech C, et al. High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies. PLoS ONE. 2011;6:e25181 pubmed publisher
    ..Overall, these results identified multiple new candidate targets for Arx and should help to better understand the pathophysiological mechanisms of intellectual disability and epilepsy associated with ARX mutations. ..
  38. Li W, Kohara H, Uchida Y, James J, Soneji K, Cronshaw D, et al. Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell. 2013;24:359-71 pubmed publisher
  39. Odemis V, Boosmann K, Heinen A, Küry P, Engele J. CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells. J Cell Sci. 2010;123:1081-8 pubmed publisher
    The alternative SDF-1 (stromal cell derived factor-1) receptor, CXCR7, has been suggested to act as either a scavenger of extracellular SDF-1 or a modulator of the primary SDF-1 receptor, CXCR4...
  40. Demir I, Kujundzic K, Pfitzinger P, Saricaoglu Ã, Teller S, Kehl T, et al. Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells. Proc Natl Acad Sci U S A. 2017;114:E85-E94 pubmed publisher
    ..Here we show a peculiar role for the chemokine CXCL12 secreted in early PDAC and for its receptors CXCR4/CXCR7 on SC in the initiation of neural invasion in the cancer precursor stage and the resulting delay in the onset of ..
  41. Chen D, Xia Y, Zuo K, Wang Y, Zhang S, Kuang D, et al. Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration. Sci Rep. 2015;5:16813 pubmed publisher
    ..By combining with its receptor CXCR4, SDF-1 induced stem and progenitor cells migration. CXCR7, a novel receptor for SDF-1, has been identified recently...
  42. Hoffmann F, Müller W, Schütz D, Penfold M, Wong Y, Schulz S, et al. Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. J Biol Chem. 2012;287:28362-77 pubmed publisher
    ..The second CXCL12-receptor CXCR7 modulates the CXCL12/CXCR4 pathway by acting as a CXCL12 scavenger and exerts G protein-independent functions...
  43. Ma W, Liu Y, Ellison N, Shen J. Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis. J Biol Chem. 2013;288:15481-94 pubmed publisher
    The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or "decoy" receptor has been in debate...
  44. Bao J, Zhu J, Luo S, Cheng Y, Zhou S. CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis. Biochem Biophys Res Commun. 2016;469:1-7 pubmed publisher
    ..In the current study, we report that CXCR7 expression is dynamic regulated in activated microglia during CNS autoimmunity and positively correlates with the ..
  45. Abe P, Molnár Z, Tzeng Y, Lai D, Arnold S, Stumm R. Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Axons and Interneurons through CXCL12 Chemokine Signaling. J Neurosci. 2015;35:13053-63 pubmed publisher
    ..This paracrine signal may ensure thalamocortical connectivity and dispersion of inhibitory neurons in the rapidly growing cortex. ..
  46. Banisadr G, Podojil J, Miller S, Miller R. Pattern of CXCR7 Gene Expression in Mouse Brain Under Normal and Inflammatory Conditions. J Neuroimmune Pharmacol. 2016;11:26-35 pubmed publisher
    ..b>CXCR7 was identified as an alternate receptor for SDF-1/CXCL12...
  47. Klein K, Karpinich N, Espenschied S, Willcockson H, Dunworth W, Hoopes S, et al. Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. 2014;30:528-40 pubmed publisher
    ..Loss of mammalian CXCR7, the most recently described decoy receptor, results in postnatal lethality due to aberrant cardiac development ..
  48. Huang Y, Liu X, Xu N, Xiao Y, Gao G. Expression and function of CXCR2, CXCR7 of acute leukemic cells in rat. Asian Pac J Trop Med. 2014;7:417-20 pubmed publisher
    To investigate the expression and function of chemokine receptor CXCR2 and CXCR7 in the rat with acute leukemia...
  49. Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, et al. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells. 2012;30:2571-83 pubmed publisher
    ..known to function through its receptor CXCR4, recent data have suggested that CXCL12 binds to chemokine receptor CXCR7 with higher affinity than to CXCR4. However, little is known about the function of CXCR7 in hNPCs...
  50. Stacer A, Fenner J, Cavnar S, Xiao A, Zhao S, Chang S, et al. Endothelial CXCR7 regulates breast cancer metastasis. Oncogene. 2016;35:1716-24 pubmed publisher
    Atypical chemokine receptor CXCR7 (ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple steps in tumor growth and metastasis in breast cancer and multiple other malignancies...
  51. Alampour Rajabi S, El Bounkari O, Rot A, Müller Newen G, Bachelerie F, Gawaz M, et al. MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J. 2015;29:4497-511 pubmed publisher
    ..We characterized the atypical chemokine receptor CXCR7 as a novel receptor for MIF...
  52. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Deficiency in cxcR3 resulted in decreased primary hair follicle density but otherwise normal hair development, indicating that chemokine signaling influences the patterning of primary hair placodes only. ..
  53. Qin Y, Zhou Z, Zhang F, Wang Y, Shen B, Liu Y, et al. Induction of Regulatory B-Cells by Mesenchymal Stem Cells is Affected by SDF-1α-CXCR7. Cell Physiol Biochem. 2015;37:117-30 pubmed publisher
    ..The main objective of this study was to examine the role of the SDF-1-CXCR4/CXCR7 axis in the secretory action of MSCs, and potential effects on the immunoregulatory function of these cells...
  54. Haege S, Einer C, Thiele S, Mueller W, Nietzsche S, Lupp A, et al. CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney. PLoS ONE. 2012;7:e42814 pubmed publisher
    ..Recently, a second CXCL12 receptor was identified and designated CXCR7. Although it is established that CXCR7 regulates heart and brain development in conjunction with CXCL12 and CXCR4, ..
  55. Probst S, Kraemer C, Demougin P, Sheth R, Martin G, Shiratori H, et al. SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 2011;138:1913-23 pubmed publisher
    ..In summary, SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module. ..
  56. Hick A, van Eyll J, Cordi S, Forez C, Passante L, Kohara H, et al. Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1. BMC Dev Biol. 2009;9:66 pubmed publisher
    ..Our data also suggest that SDF-1 controls the branching morphogenesis of several exocrine tissues. ..
  57. Yoshida D, Nomura R, Teramoto A. Signalling pathway mediated by CXCR7, an alternative chemokine receptor for stromal-cell derived factor-1?, in AtT20 mouse adrenocorticotrophic hormone-secreting pituitary adenoma cells. J Neuroendocrinol. 2009;21:481-8 pubmed publisher
    ..An alternative SDF-1 receptor, CXCR7, has recently been identified, but it has not been studied in the context of pituitary adenomas...
  58. Trousse F, Poluch S, Pierani A, Dutriaux A, Bock H, Nagasawa T, et al. CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells. Cereb Cortex. 2015;25:3446-57 pubmed publisher
    ..However, recent studies showed that CXCR7, a second CXCL12 receptor, is also expressed in CR cells at early developmental stages...
  59. Melchionna R, Di Carlo A, De Mori R, Cappuzzello C, Barberi L, Musaro A, et al. Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors. Muscle Nerve. 2010;41:828-35 pubmed publisher
    ..but its contribution to postnatal myogenesis and the role of the alternate SDF-1 receptor, CXC receptor 7 (CXCR7), are poorly characterized...
  60. Vogt D, Hunt R, Mandal S, Sandberg M, Silberberg S, Nagasawa T, et al. Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron. 2014;82:350-64 pubmed publisher
    ..Using an in vivo MGE complementation/transplantation assay, we show that Lhx6-regulated genes Arx and CXCR7 rescue divergent aspects of Lhx6?/? cell-fate and laminar mutant phenotypes and provide insight into a neonatal ..