Gene Symbol: Acaa1a
Description: acetyl-Coenzyme A acyltransferase 1A
Alias: Acaa, Acaa1, D9Ertd25e, PTL, 3-ketoacyl-CoA thiolase A, peroxisomal, acetyl-CoA acyltransferase A, beta-ketothiolase A, peroxisomal 3-ketoacyl-CoA thiolase, peroxisomal 3-oxoacyl-CoA thiolase A, peroxisomal 3-oxoacyl-Coenzyme A thiolase, thiolase A
Species: mouse
Products:     Acaa1a

Top Publications

  1. Huyghe S, Casteels M, Janssen A, Meulders L, Mannaerts G, Declercq P, et al. Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001;353:673-80 pubmed
  2. Cook W, Jain S, Jia Y, Cao W, Yeldandi A, Reddy J, et al. Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. Exp Cell Res. 2001;268:70-6 pubmed
  3. Chevillard G, Clémencet M, Latruffe N, Nicolas Francès V. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Biochimie. 2004;86:849-56 pubmed
    ..e. thiolase A, thiolase B and SCP2/thiolase) catalyse the thiolase activity...
  4. Chevillard G, Clémencet M, Etienne P, Martin P, Pineau T, Latruffe N, et al. Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes. BMC Biochem. 2004;5:3 pubmed
    ..In this study, we cloned and characterized two mouse peroxisomal 3-ketoacyl-CoA thiolase genes (termed thiolase A and B). Both thiolase A and B genes contain 12 exons and 11 introns...
  5. Nenicu A, Lüers G, Kovacs W, David M, Zimmer A, Bergmann M, et al. Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol Reprod. 2007;77:1060-72 pubmed
    ..Our results suggest a cell type-specific metabolic function of peroxisomes in the testis and point to an important role for peroxisomes in spermiogenesis and in the lipid metabolism of Sertoli cells. ..
  6. Abbott B, Wood C, Watkins A, Tatum Gibbs K, Das K, Lau C. Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol. 2012;33:491-505 pubmed publisher
    ..The metabolic disruption produced by PFOA may contribute to poor postnatal survival and persistent weight deficits of CD-1 mouse neonates. ..