Gene Symbol: Abr
Description: active BCR-related gene
Alias: active breakpoint cluster region-related protein
Cho Y, Cunnick J, Yi S, Kaartinen V, Groffen J, Heisterkamp N. Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol. 2007;27:899-911 pubmed
Small GTPases of the Rho family are key regulators of phagocytic leukocyte function. Abr and Bcr are homologous, multidomain proteins...
Cunnick J, Schmidhuber S, Chen G, Yu M, Yi S, Cho Y, et al
. Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009;29:5742-50 pubmed publisher
Bcr and Abr are GTPase-activating proteins for the small GTPase Rac. Both proteins are expressed in cells of the innate immune system, including neutrophils and macrophages...
Oh D, Han S, Seo J, Lee J, Choi J, Groffen J, et al
. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J Neurosci. 2010;30:14134-44 pubmed publisher
..We report here that BCR and its close relative active BCR-related (ABR) localize at excitatory synapses and directly interact with PSD-95, an abundant postsynaptic scaffolding protein...
Kaartinen V, Gonzalez Gomez I, Voncken J, Haataja L, Faure E, Nagy A, et al
. Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development. 2001;128:4217-27 pubmed
..Here we demonstrate that the simultaneous disruption of two negative regulators of Rac, Abr and Bcr, in mice leads to specific abnormalities in postnatal cerebellar development...
Kaartinen V, Nagy A, Gonzalez Gomez I, Groffen J, Heisterkamp N. Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn. 2002;223:517-25 pubmed
..To determine the biological function of two closely related GTPase activating proteins for the Cdc42/Rac GTPases, Abr and Bcr, we generated a mouse strain deficient in both of these proteins...
Yu M, Gong D, Lim M, Arutyunyan A, Groffen J, Heisterkamp N. Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS ONE. 2012;7:e49756 pubmed publisher
Bcr and Abr are GTPase activating proteins that specifically downregulate activity of the small GTPase Rac in restricted cell types in vivo...
Gong D, Fei F, Lim M, Yu M, Groffen J, Heisterkamp N. Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model. J Immunol. 2013;191:4514-20 pubmed publisher
b>Abr deactivates Ras-related C3 botulinum toxin substrate (Rac), a master molecular switch that positively regulates many immune cell functions, by converting it to its GDP-bound conformation...
Um K, Niu S, Duman J, Cheng J, Tu Y, Schwechter B, et al
. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014;29:701-15 pubmed publisher
..The finding that a Rac-specific GEF/GAP complex is required to maintain optimal levels of Rac1 signaling provides an important insight into the regulation of small GTPases. ..
Dillman A, Hauser D, Gibbs J, Nalls M, McCoy M, Rudenko I, et al
. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013;16:499-506 pubmed publisher
..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex. ..