Gene Symbol: Ablim1
Description: actin-binding LIM protein 1
Alias: 2210411C18Rik, 2610209L21Rik, 4833406P10Rik, 9330196J19Rik, AV079770, AW060987, AW215784, Limab1, mKIAA0059, actin-binding LIM protein 1, actin-binding LIM protein family member 1, actin-binding double zinc finger protein
Species: mouse
Products:     Ablim1

Top Publications

  1. Roof D, Hayes A, Adamian M, Chishti A, Li T. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. J Cell Biol. 1997;138:575-88 pubmed
    ..The developmental time course of abLIM expression in the retina suggests that the retina-specific isoform may have a specialized role in the development or elaboration of photoreceptor inner and outer segments. ..
  2. Erkman L, Yates P, McLaughlin T, McEvilly R, Whisenhunt T, O Connell S, et al. A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron. 2000;28:779-92 pubmed
    ..elegans homolog, UNC-115. Our findings provide insights into a Brn-3.2-directed hierarchical program linking signaling events to cytoskeletal changes required for axon pathfinding. ..
  3. Lu C, Huang X, Ma H, Gooley J, Aparacio J, Roof D, et al. Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein. Neuroscience. 2003;120:121-31 pubmed
    ..Retinofugal projections and synaptic maturation also appear normal. These data suggest that abLIM-M is likely the isoform performing the essential function related to axon guidance. ..
  4. Kim A, Peters L, Knoll J, Van Huffel C, Ciciotte S, Kleyn P, et al. Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers. Genomics. 1997;46:291-3 pubmed
    ..Here we report the murine and human chromosomal localizations of limatin (LIMAB1)...
  5. Kim H, Noben Trauth K, Morell R. Tectorin-beta (Tectb) maps to mouse chromosome 19. Genomics. 1998;53:419-20 pubmed
  6. Suriyapperuma S, Lozovatsky L, Ciciotte S, Peters L, Gilligan D. The mouse adducin gene family: alternative splicing and chromosomal localization. Mamm Genome. 2000;11:16-23 pubmed
    ..We also report here the localization of the gene encoding gamma adducin (Add3) to murine Chr 19, in a region that shows conserved synteny with human Chr 10. ..
  7. Pan L, Deng M, Xie X, Gan L. ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development. 2008;135:1981-90 pubmed publisher
    ..Thus, our results uncover a novel regulatory mechanism of BRN3B and ISL1 in RGC differentiation. ..
  8. Railo A, Pajunen A, Itäranta P, Naillat F, Vuoristo J, Kilpeläinen P, et al. Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets. Exp Cell Res. 2009;315:2690-704 pubmed publisher
    ..Taken together, our approaches give an insight into the complex context-dependent nature of Wnt pathway transcriptional responses and identify Disabled-2 as a potential new direct target for Wnt signalling. ..
  9. Stevens J, Ermakov A, Braganca J, Hilton H, Underhill P, Bhattacharya S, et al. Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow. BMC Dev Biol. 2010;10:54 pubmed publisher
    ..A L-R expression screen identified the cytoskeletally-associated gene, actin binding lim protein 1 (Ablim1), as asymmetrically expressed in both the node and left lateral plate mesoderm (LPM)...

More Information


  1. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, et al. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol. 2012;14:697-706 pubmed publisher
    ..Gene expression analysis further identified ARP2, TOCA1, ABLIM1 and ABLIM3 as its targets in ciliation-related actin dynamics...
  2. Pan L, Yang Z, Feng L, Gan L. Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis. Development. 2005;132:703-12 pubmed
    ..These results indicate that Brn3 factors are functionally equal and that their unique roles in neurogenesis are determined by the distinctive Brn3 spatiotemporal expression patterns. ..
  3. Barrientos T, Frank D, Kuwahara K, Bezprozvannaya S, Pipes G, Bassel Duby R, et al. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. J Biol Chem. 2007;282:8393-403 pubmed
    ..These findings suggest that the members of the novel ABLIM protein family may serve as a scaffold for signaling modules of the actin cytoskeleton and thereby modulate transcription. ..
  4. Fernandez E, Collins M, Uren R, Kopanitsa M, Komiyama N, Croning M, et al. Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol. 2009;5:269 pubmed publisher
    ..This targeted TAP tagging strategy is generally applicable to mammalian proteomics and systems biology approaches to disease. ..