Abeta

Summary

Gene Symbol: Abeta
Description: amyloid beta (A4) precursor protein
Alias: Abeta, Abpp, Adap, Cvap, E030013M08Rik, betaApp, amyloid-beta A4 protein, amyloid beta A4 protein, alzheimer disease amyloid A4 protein homolog, amyloid precursor protein, amyloid-beta precursor protein, amyloidogenic glycoprotein, appican, beta-amyloid precursor protein, protease nexin II
Species: mouse
Products:     Abeta

Top Publications

  1. Devi L, Ohno M. Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice. Eur J Neurosci. 2010;31:110-8 pubmed publisher
    ..the phenotypes of hippocampus-independent and -dependent memory functions, respectively, in 5XFAD amyloid precursor protein/presenilin-1 transgenic mice that harbor five familial AD mutations...
  2. Tamayev R, Matsuda S, Giliberto L, Arancio O, D ADAMIO L. APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant. EMBO J. 2011;30:2501-9 pubmed publisher
    ..This evidence establishes a pathogenic sameness between familial Danish and Alzheimer's dementias. ..
  3. Weyer S, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, et al. APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J. 2011;30:2266-80 pubmed publisher
    Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and its proteolytic fragments are still poorly understood...
  4. Tamayev R, Matsuda S, Arancio O, D ADAMIO L. ?- but not ?-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. EMBO Mol Med. 2012;4:171-9 pubmed publisher
    ..Our data and the failures of anti-A? therapies in humans advise against targeting ?-secretase cleavage of APP and/or A?...
  5. Sclip A, Antoniou X, Colombo A, Camici G, Pozzi L, Cardinetti D, et al. c-Jun N-terminal kinase regulates soluble A? oligomers and cognitive impairment in AD mouse model. J Biol Chem. 2011;286:43871-80 pubmed publisher
    ..In conclusion, by regulating key pathogenic mechanisms of AD, JNK might hold promise as innovative therapeutic target. ..
  6. Guillot Sestier M, Sunyach C, Ferreira S, Marzolo M, Bauer C, Thevenet A, et al. ?-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid ? (A?)-associated cell death. J Biol Chem. 2012;287:5021-32 pubmed publisher
    In physiological conditions, both ?-amyloid precursor protein (?APP) and cellular prion (PrP(c)) undergo similar disintegrin-mediated ?-secretase cleavage yielding N-terminal secreted products referred to as soluble amyloid precursor ..
  7. Wittnam J, Portelius E, Zetterberg H, Gustavsson M, Schilling S, Koch B, et al. Pyroglutamate amyloid ? (A?) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease. J Biol Chem. 2012;287:8154-62 pubmed publisher
    ..No change in A?(x)(-42) or other A? isoforms was discovered by ELISA and mass spectrometry. These observations argue for a seeding effect of A?(pE-42) in FAD42 mice. ..
  8. Deyts C, Vetrivel K, Das S, Shepherd Y, Dupre D, Thinakaran G, et al. Novel G?S-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain. J Neurosci. 2012;32:1714-29 pubmed publisher
    ..including a role as a cell surface receptor, have been ascribed to Alzheimer's disease-associated amyloid precursor protein (APP). However, detailed analysis of intracellular signaling mediated by APP in neurons has been lacking...
  9. Boncompagni S, Moussa C, Levy E, Pezone M, Lopez J, Protasi F, et al. Mitochondrial dysfunction in skeletal muscle of amyloid precursor protein-overexpressing mice. J Biol Chem. 2012;287:20534-44 pubmed publisher
    ..the most common muscle disorder in the elderly, is partly characterized by abnormal expression of amyloid precursor protein (APP) and intracellular accumulation of its proteolytic fragments collectively known as ?-amyloid...

More Information

Publications77

  1. Ramaker J, Swanson T, Copenhaver P. Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration. J Neurosci. 2013;33:10165-81 pubmed publisher
    b>Amyloid precursor protein (APP) belongs to a family of evolutionarily conserved transmembrane glycoproteins that has been proposed to regulate multiple aspects of cell motility in the nervous system...
  2. Mallm J, Tschäpe J, Hick M, Filippov M, Müller U. Generation of conditional null alleles for APP and APLP2. Genesis. 2010;48:200-6 pubmed publisher
    Proteolytical cleavage of the beta-amyloid precursor protein (APP) generates beta-amyloid, which is deposited in the brains of patients suffering from Alzheimer's disease (AD)...
  3. Guo Q, Zheng H, Justice N. Central CRF system perturbation in an Alzheimer's disease knockin mouse model. Neurobiol Aging. 2012;33:2678-91 pubmed publisher
    ..Here, we show that amyloid precursor protein (APP) is endogenously expressed in important limbic, hypothalamic, and midbrain nuclei that regulate ..
  4. Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, et al. Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014;17:661-3 pubmed publisher
    Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP)...
  5. Matrone C, Luvisetto S, La Rosa L, Tamayev R, Pignataro A, Canu N, et al. Tyr682 in the A?-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell. 2012;11:1084-93 pubmed publisher
    ..The profound deficits caused by the Y682 mutation underscore the biological importance of APP and indicate that APP(YG/YG) are a valuable mouse model to study APP functions in physiological and pathological processes. ..
  6. Puig K, Floden A, Adhikari R, Golovko M, Combs C. Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity. PLoS ONE. 2012;7:e30378 pubmed publisher
    ..AD is associated with mutations in the gene coding for the ubiquitously expressed transmembrane protein, amyloid precursor protein (APP) and recent evidence demonstrates increased APP levels in adipose tissue during obesity it is ..
  7. Barbagallo A, Wang Z, Zheng H, D ADAMIO L. A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. J Biol Chem. 2011;286:8717-21 pubmed publisher
    ..Our results demonstrate that a single residue in the APP intracellular region, Tyr(682), is indispensable for the essential function of APP in developmental regulation. ..
  8. Kanekiyo T, Liu C, Shinohara M, Li J, Bu G. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-?. J Neurosci. 2012;32:16458-65 pubmed publisher
    ..These studies establish critical functions of the cerebrovasculature system in A? metabolism and identify a new pathway involved in the pathogenesis of both AD and CAA. ..
  9. Lombino F, Biundo F, Tamayev R, Arancio O, D ADAMIO L. An intracellular threonine of amyloid-? precursor protein mediates synaptic plasticity deficits and memory loss. PLoS ONE. 2013;8:e57120 pubmed publisher
    ..These data are consistent with a role for the carboxyl-terminal APP domain in the pathogenesis of dementia and suggest that averting the noxious role of Thr(668) is a viable therapeutic strategy for human dementias. ..
  10. Ahn H, Zamolodchikov D, Cortes Canteli M, Norris E, Glickman J, Strickland S. Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization. Proc Natl Acad Sci U S A. 2010;107:21812-7 pubmed publisher
    ..Overall, our study indicates that the interaction between A? and fibrinogen may be an important contributor to the vascular abnormalities found in AD. ..
  11. Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Brion J, Kienlen Campard P, et al. Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty. PLoS ONE. 2013;8:e74305 pubmed publisher
    Following transcriptome comparison of primary cultures isolated from brain of mice expressing or not the amyloid precursor protein APP, we found transcription of the EGR-1 gene to be regulated by APP...
  12. Dinet V, An N, Ciccotosto G, Bruban J, Maoui A, Bellingham S, et al. APP involvement in retinogenesis of mice. Acta Neuropathol. 2011;121:351-63 pubmed publisher
    Very few studies have examined expression and function of amyloid precursor protein (APP) in the retina. We showed that APP mRNA and protein are expressed according to the different waves of retinal differentiation...
  13. Ranganathan S, Noyes N, Migliorini M, Winkles J, Battey F, Hyman B, et al. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. J Neurosci. 2011;31:10836-46 pubmed publisher
    ..In the mouse hippocampal-derived cell line HT22, LRAD3 partially colocalizes with amyloid precursor protein (APP) and interacts with APP as revealed by coimmunoprecipitation experiments...
  14. Jawhar S, Wirths O, Bayer T. Pyroglutamate amyloid-? (A?): a hatchet man in Alzheimer disease. J Biol Chem. 2011;286:38825-32 pubmed publisher
  15. Barbagallo A, Weldon R, Tamayev R, Zhou D, Giliberto L, Foreman O, et al. Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS ONE. 2010;5:e15503 pubmed publisher
  16. Guo Q, Li H, Gaddam S, Justice N, Robertson C, Zheng H. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem. 2012;287:2437-45 pubmed publisher
    ..Our results clarify several key questions with regard to the fundamental properties of APP and offer critical cellular insights into the pathophysiology of APP. ..
  17. Duce J, Tsatsanis A, Cater M, James S, Robb E, Wikhe K, et al. Iron-export ferroxidase activity of ?-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010;142:857-67 pubmed publisher
    ..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD. ..
  18. Kessels H, Nguyen L, Nabavi S, Malinow R. The prion protein as a receptor for amyloid-beta. Nature. 2010;466:E3-4; discussion E4-5 pubmed publisher
    Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease...
  19. Szpankowski L, Encalada S, Goldstein L. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012;109:8582-7 pubmed publisher
    ..elucidate relative kinesin-1 and cytoplasmic dynein motor subunit composition of individual, endogenous amyloid precursor protein (APP) vesicles in mouse hippocampal cells...
  20. Okabayashi S, Kimura N. LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation. Neuroreport. 2010;21:606-10 pubmed publisher
    ..Moreover, the downregulation of the LGI3/Flo1 complex altered beta-amyloid precursor protein trafficking directly to late endosomes and disrupted exosome formation, suggesting that LGI3 is involved ..
  21. Kohjima M, Sun Y, Chan L. Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model. Endocrinology. 2010;151:1532-40 pubmed publisher
    ..a widely used transgenic mouse model for AD, to explore the relationship between increased amyloid beta-peptide (Abeta) and insulin resistance...
  22. Morel E, Chamoun Z, Lasiecka Z, Chan R, Williamson R, Vetanovetz C, et al. Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun. 2013;4:2250 pubmed publisher
    ..Silencing Vps34 causes an enlargement of neuronal endosomes, enhances the amyloidogenic processing of amyloid precursor protein in these organelles and reduces amyloid precursor protein sorting to intraluminal vesicles...
  23. Pérez González R, Gauthier S, Kumar A, Levy E. The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space. J Biol Chem. 2012;287:43108-15 pubmed publisher
  24. Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, et al. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem. 2010;285:30598-605 pubmed publisher
    Proteolytic processing of the amyloid precursor protein (APP) generates large soluble APP derivatives, ?-amyloid (A?) peptides, and APP intracellular domain...
  25. Yoon S, Park D, Ryu J, Ozer H, Tep C, Shin Y, et al. JNK3 perpetuates metabolic stress induced by A? peptides. Neuron. 2012;75:824-37 pubmed publisher
    ..This reveals AD as a metabolic disease that is under tight control by JNK3. ..
  26. Chasseigneaux S, Dinc L, Rose C, Chabret C, Coulpier F, Topilko P, et al. Secreted amyloid precursor protein ? and secreted amyloid precursor protein ? induce axon outgrowth in vitro through Egr1 signaling pathway. PLoS ONE. 2011;6:e16301 pubmed publisher
    sAPP? released after ? secretase cleavage of Amyloid Precursor Protein (APP) has several functions including the stimulation of neurite outgrowth although detailed morphometric analysis has not been done...
  27. Lee K, Moussa C, Lee Y, Sung Y, Howell B, Turner R, et al. Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines. Neuroscience. 2010;169:344-56 pubmed publisher
    ..Abeta is generated by proteolysis of amyloid precursor protein (APP), a synaptic receptor whose physiological function remains unclear...
  28. Aydin D, Filippov M, Tschäpe J, Gretz N, Prinz M, Eils R, et al. Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex. BMC Genomics. 2011;12:160 pubmed publisher
    The ?-amyloid precursor protein (APP) and the related ?-amyloid precursor-like proteins (APLPs) undergo complex proteolytic processing giving rise to several fragments...
  29. Kudo W, Lee H, Zou W, Wang X, Perry G, Zhu X, et al. Cellular prion protein is essential for oligomeric amyloid-?-induced neuronal cell death. Hum Mol Genet. 2012;21:1138-44 pubmed publisher
    ..These findings are the first to demonstrate that PrP(C) is required for A? oligomer-induced neuronal cell death, the pathology essential to cognitive loss. ..
  30. Bedrosian T, Herring K, Weil Z, Nelson R. Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice. Proc Natl Acad Sci U S A. 2011;108:11686-91 pubmed publisher
    ..In the present study, we explored the diurnal pattern of anxiety-like behavior in aged and amyloid precursor protein (APP) transgenic mice...
  31. Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, et al. Cerebral amyloid-? proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011;121:3924-31 pubmed publisher
    ..Thus, by altering the temporal aggregation profile of A?, pharmacological activation of ABC transporters could impede the neurodegenerative cascade that culminates in the dementia of AD. ..
  32. Barry A, Klyubin I, Mc Donald J, Mably A, Farrell M, Scott M, et al. Alzheimer's disease brain-derived amyloid-?-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J Neurosci. 2011;31:7259-63 pubmed publisher
    ..These data support the pathophysiological significance of SDS-stable A? dimer and the role of PrP(C) in mediating synaptic plasticity disruption by soluble A?. ..
  33. Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer R, et al. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A. 2010;107:17362-7 pubmed publisher
    Amyloidogenic processing of the amyloid precursor protein (APP) generates a large secreted ectodomain fragment (APPs?), ?-amyloid (A?) peptides, and an APP intracellular domain (AICD)...
  34. Tamboli I, Barth E, Christian L, Siepmann M, Kumar S, Singh S, et al. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. J Biol Chem. 2010;285:37405-14 pubmed publisher
    ..studies suggested that statins might decrease the generation of the amyloid ?-peptide (A?) from the ?-amyloid precursor protein. Here, we show that statins potently stimulate the degradation of extracellular A? by microglia...
  35. Belyaev N, Kellett K, Beckett C, Makova N, Revett T, Nalivaeva N, et al. The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem. 2010;285:41443-54 pubmed publisher
    Amyloidogenic processing of the amyloid precursor protein (APP) by ?- and ?-secretases generates several biologically active products, including amyloid-? (A?) and the APP intracellular domain (AICD)...
  36. Barbagallo A, Wang Z, Zheng H, D ADAMIO L. The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function. PLoS ONE. 2011;6:e18006 pubmed publisher
    ..Furthermore, they indicate that phosphorylation at this residue is not functionally involved in those APP-mediated functions that prevent (NMJ) defects and early lethality in APLP2 null mice. ..
  37. Bero A, Yan P, Roh J, Cirrito J, Stewart F, Raichle M, et al. Neuronal activity regulates the regional vulnerability to amyloid-? deposition. Nat Neurosci. 2011;14:750-6 pubmed publisher
    ..Long-term unilateral vibrissal deprivation decreased amyloid plaque formation and growth. Our results suggest a mechanism to account for the vulnerability of specific brain regions to A? deposition in Alzheimer's disease...
  38. Michaki V, Guix F, Vennekens K, Munck S, Dingwall C, Davis J, et al. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-? production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012;287:1100-11 pubmed publisher
    ..Reduced Abca2 levels in mammalian cells in vitro, in Drosophila melanogaster and in mice resulted in altered ?-secretase processing of APP, and thus A? generation, without affecting Notch cleavage...
  39. Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, et al. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J. 2004;23:4106-15 pubmed
    The Alzheimer's disease beta-amyloid precursor protein (APP) is a member of a larger gene family that includes the amyloid precursor-like proteins, termed APLP1 and APLP2...
  40. Calhoun M, Burgermeister P, Phinney A, Stalder M, Tolnay M, Wiederhold K, et al. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc Natl Acad Sci U S A. 1999;96:14088-93 pubmed
    Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer's disease pathology, namely the extracellular deposition of amyloid plaques...
  41. Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner J, et al. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2001;158:1345-54 pubmed
    Mutations in the amyloid precursor protein (APP) and presenilin-1 and -2 genes (PS-1, -2) cause Alzheimer's disease (AD). Mice carrying both mutant genes (PS/APP) develop AD-like deposits composed of beta-amyloid (Abeta) at an early age...
  42. Guenette S, Chang Y, Hiesberger T, Richardson J, Eckman C, Eckman E, et al. Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J. 2006;25:420-31 pubmed
    ..The defects observed in the double knockout may also involve the family of Ena/Vasp proteins, which participate in actin cytoskeleton remodeling and interact with the WW domains of FE65 proteins. ..
  43. Moechars D, Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999;274:6483-92 pubmed
    Transgenic mice overexpressing different forms of amyloid precursor protein (APP), i.e...
  44. Wang P, Yang G, Mosier D, Chang P, Zaidi T, Gong Y, et al. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci. 2005;25:1219-25 pubmed
    Biochemical and genetic studies place the amyloid precursor protein (APP) at the center stage of Alzheimer's disease (AD) pathogenesis...
  45. Siman R, Reaume A, Savage M, Trusko S, Lin Y, Scott R, et al. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci. 2000;20:8717-26 pubmed
    ..include increased neuronal sensitivity to degeneration and enhanced amyloidogenic processing of the beta-amyloid precursor protein (APP)...
  46. Qing H, He G, Ly P, Fox C, Staufenbiel M, Cai F, et al. Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med. 2008;205:2781-9 pubmed publisher
    ..Amyloid beta-protein (Abeta), the central component of neuritic plaques, is derived from beta-amyloid precursor protein (APP) after beta- and gamma-secretase cleavage...
  47. Reeves R, Irving N, Moran T, Wohn A, Kitt C, Sisodia S, et al. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet. 1995;11:177-84 pubmed
    ..The corresponding dosage imbalance for the human homologues of these genes may contribute to cognitive deficits in DS. ..
  48. Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A. 1999;96:11872-7 pubmed
    ..Absence of PS2 does not detectably alter processing of amyloid precursor protein and has little or no effect on physiologically important apoptotic processes, indicating that Alzheimer'..
  49. Stokin G, Lillo C, Falzone T, Brusch R, Rockenstein E, Mount S, et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005;307:1282-8 pubmed
    ..Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease.
  50. Young Pearse T, Chen A, Chang R, Marquez C, Selkoe D. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev. 2008;3:15 pubmed publisher
    Beta-amyloid precursor protein (APP) has been reported to play a role in the outgrowth of neurites from cultured neurons...
  51. Chishti M, Yang D, Janus C, Phinney A, Horne P, Pearson J, et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001;276:21562-70 pubmed
    ..TgCRND8 mice encode a double mutant form of amyloid precursor protein 695 (KM670/671NL+V717F) under the control of the PrP gene promoter...
  52. Flood D, Reaume A, Dorfman K, Lin Y, Lang D, Trusko S, et al. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. Neurobiol Aging. 2002;23:335-48 pubmed
    ..When crossed into Tg(HuAPP695.K670N/M671L)2576 mice, the PS-1(P264L) mutation accelerated the onset of amyloid (Abeta) deposition in a gene-dosage dependent manner...
  53. Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger P, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest. 2008;118:2190-9 pubmed publisher
    ..In transgenic mice that express human amyloid precursor protein (APP), a model for AD, genetic reduction of Becn1 expression increased intraneuronal amyloid beta (Abeta)..
  54. Scheinfeld M, Roncarati R, Vito P, Lopez P, Abdallah M, D ADAMIO L. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem. 2002;277:3767-75 pubmed
    The familial Alzheimer's disease gene product amyloid beta precursor protein (APP) is sequentially processed by beta- and gamma-secretases to generate the Abeta peptide...
  55. Langui D, Girardot N, El Hachimi K, Allinquant B, Blanchard V, Pradier L, et al. Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice. Am J Pathol. 2004;165:1465-77 pubmed
    In transgenic mice expressing human mutant beta-amyloid precursor protein (APP) and mutant presenilin-1 (PS1), Abeta antibodies labeled granules, about 1 microm in diameter, in the perikaryon of neurons clustered in the isocortex, ..
  56. Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, et al. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J Neurosci. 2003;23:5645-9 pubmed
    ..We have examined the impact of aberrant intracellular cholesterol transport on the processing of the amyloid precursor protein (APP) in a mouse model of Niemann-Pick type C (NPC) disease...
  57. Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, et al. Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease. Am J Pathol. 2009;175:2121-32 pubmed publisher
    ..Here, we showed that oAbeta but not fibrillar Abeta was neurotoxic, and microglia activated with unmethylated DNA CpG motif (CpG), a ligand for Toll-like receptor 9, ..
  58. Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lip. Neuroscience. 1995;65:1009-25 pubmed
    ..half of mouse embryonic development and in adult mouse brain: we compared the messenger RNA levels of amyloid precursor protein and of the two amyloid precursor protein-like proteins 1 and 2 and we have analysed expression of ..
  59. Parkin E, Watt N, Hussain I, Eckman E, Eckman C, Manson J, et al. Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A. 2007;104:11062-7 pubmed
    Proteolytic processing of the amyloid precursor protein (APP) by beta-secretase, beta-site APP cleaving enzyme (BACE1), is the initial step in the production of the amyloid beta (Abeta) peptide, which is involved in the pathogenesis of ..
  60. Brugg B, Dubreuil Y, Huber G, Wollman E, Delhaye Bouchaud N, Mariani J. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc Natl Acad Sci U S A. 1995;92:3032-5 pubmed
    ..a combination of genetic predisposition and environmental factors may contribute to changes in beta-amyloid precursor protein (APP) expression, beta-amyloid peptide deposition, and neuronal loss...
  61. Hirata Fukae C, Li H, HOE H, Gray A, Minami S, Hamada K, et al. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res. 2008;1216:92-103 pubmed publisher
    ..Though transgenic mouse models of AD develop AD-related amyloid beta (Abeta) and/or tau pathology, gender differences have not been well documented in these models...
  62. Gordon M, Holcomb L, Jantzen P, DiCarlo G, Wilcock D, Boyett K, et al. Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Exp Neurol. 2002;173:183-95 pubmed
    Doubly transgenic mice expressing both a mutated amyloid precursor protein and a mutated presenilin-1 protein accumulate A(beta) deposits as they age...
  63. Davis J, Xu F, Deane R, Romanov G, Previti M, Zeigler K, et al. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem. 2004;279:20296-306 pubmed
    Cerebrovascular deposition of amyloid beta-protein (Abeta) is a common pathological feature of Alzheimer's disease and related disorders...
  64. Kuo Y, Kokjohn T, Beach T, Sue L, Brune D, Lopez J, et al. Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J Biol Chem. 2001;276:12991-8 pubmed
    We have undertaken an integrated chemical and morphological comparison of the amyloid-beta (Abeta) molecules and the amyloid plaques present in the brains of APP23 transgenic (tg) mice and human Alzheimer's disease (AD) patients...
  65. Seabrook G, Smith D, Bowery B, Easter A, Reynolds T, Fitzjohn S, et al. Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology. 1999;38:349-59 pubmed
    Abnormal processing of amyloid precursor protein (APP), in particular the generation of beta-amyloid (Abeta) peptides, has been implicated in the pathogenesis of Alzheimer's disease...
  66. Akeson E, Lambert J, Narayanswami S, Gardiner K, Bechtel L, Davisson M. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Cytogenet Cell Genet. 2001;93:270-6 pubmed
    ..The significance of this finding is discussed in terms of the utility of this mouse model. ..
  67. Apelt J, Schliebs R. Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology. Brain Res. 2001;894:21-30 pubmed
    ..Alzheimer's disease, transgenic Tg2576 mice containing as transgene the Swedish double mutation of human amyloid precursor protein 695, were examined for the expression pattern of various cytokines using double immunocytochemistry and ..
  68. Shankar G, Li S, Mehta T, Garcia Munoz A, Shepardson N, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008;14:837-42 pubmed publisher
    ..We extracted soluble amyloid-beta protein (Abeta) oligomers directly from the cerebral cortex of subjects with Alzheimer's disease...