Abcg8

Summary

Gene Symbol: Abcg8
Description: ATP binding cassette subfamily G member 8
Alias: 1300003C16Rik, AI114946, sterolin-2, ATP-binding cassette sub-family G member 8, ATP-binding cassette, sub-family G (WHITE), member 8, sterolin 2
Species: mouse
Products:     Abcg8

Top Publications

  1. Guan Y, Ackert Bicknell C, Kell B, Troyanskaya O, Hibbs M. Functional genomics complements quantitative genetics in identifying disease-gene associations. PLoS Comput Biol. 2010;6:e1000991 pubmed publisher
    ..not observed in any previous GWAS/QTL studies) and found significant bone density defects for both Timp2 and Abcg8 deficient mice...
  2. Graf G, Li W, Gerard R, Gelissen I, White A, Cohen J, et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest. 2002;110:659-69 pubmed
    Mutations in either ATP-binding cassette (ABC) G5 or ABCG8 cause sitosterolemia, an autosomal recessive disorder of sterol trafficking...
  3. Yu L, Hammer R, Li Hawkins J, von Bergmann K, Lutjohann D, Cohen J, et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A. 2002;99:16237-42 pubmed
    ..In patients with sitosterolemia, mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8, lead to reduced secretion of sterols into bile, implicating these transporters in this process...
  4. Yang C, Yu L, Li W, Xu F, Cohen J, Hobbs H. Disruption of cholesterol homeostasis by plant sterols. J Clin Invest. 2004;114:813-22 pubmed
    The ABC transporters ABCG5 and ABCG8 limit absorption and promote excretion of dietary plant sterols. It is not known why plant sterols are so assiduously excluded from the body...
  5. Yu L, von Bergmann K, Lutjohann D, Hobbs H, Cohen J. Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. J Lipid Res. 2005;46:1739-44 pubmed
    The ATP binding cassette transporters ABCG5 (G5) and ABCG8 (G8) limit the accumulation of neutral sterols by restricting sterol uptake from the intestine and promoting sterol excretion into bile...
  6. Yu L, Gupta S, Xu F, Liverman A, Moschetta A, Mangelsdorf D, et al. Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J Biol Chem. 2005;280:8742-7 pubmed
    ..Biliary cholesterol secretion is mediated by the ATP-binding cassette (ABC) transporters ABCG5 (G5) and ABCG8 (G8) and is stimulated by cholesterol and by the non-cholesterol steroids cholate and diosgenin...
  7. Yu L, Li Hawkins J, Hammer R, Berge K, Horton J, Cohen J, et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest. 2002;110:671-80 pubmed
    Two ATP-binding cassette (ABC) transporters, ABCG5 and ABCG8, have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans...
  8. Kosters A, Frijters R, Schaap F, Vink E, Plosch T, Ottenhoff R, et al. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol. 2003;38:710-6 pubmed
    Mutations in genes encoding the ATP-binding cassette (ABC)-transporters ABCG5 and ABCG8 underlie sitosterolemia, which is characterized by elevated plasma levels of phytosterols due to increased intestinal absorption and impaired biliary ..
  9. Berge K, Tian H, Graf G, Yu L, Grishin N, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000;290:1771-5 pubmed
    ..encode new members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter family (six mutations in ABCG8 and one in ABCG5) in nine patients with sitosterolemia...

More Information

Publications64

  1. Yu L, von Bergmann K, Lutjohann D, Hobbs H, Cohen J. Selective sterol accumulation in ABCG5/ABCG8-deficient mice. J Lipid Res. 2004;45:301-7 pubmed
    The ATP binding cassette (ABC) transporters ABCG5 and ABCG8 limit intestinal absorption and promote biliary secretion of neutral sterols...
  2. Wang J, Sun F, Zhang D, Ma Y, Xu F, Belani J, et al. Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution. J Biol Chem. 2006;281:27894-904 pubmed
    ..These studies indicate that G5 and G8 are sufficient for reconstitution of sterol transfer activity in vitro and provide the first demonstration that sterols are direct transport substrates of the G5 and G8 heterodimer...
  3. Wang H, Patel S, Carey M, Wang D. Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice. Hepatology. 2007;45:998-1006 pubmed
    Sitosterolemia is caused by mutations in either ABCG5 or ABCG8, but simultaneous mutations of these genes have never been observed...
  4. Lu K, Lee M, Yu H, Zhou Y, Sandell S, Salen G, et al. Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8. J Lipid Res. 2002;43:565-78 pubmed
    ..We have recently identified two genes, ABCG5 and ABCG8, encoding sterolin-1 and -2 respectively, mutations of which cause the human disease sitosterolemia...
  5. Lu K, Lee M, Hazard S, Brooks Wilson A, Hidaka H, Kojima H, et al. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet. 2001;69:278-90 pubmed
    ..Mutational analyses revealed that this highly homologous protein, termed "sterolin-2" and encoded by ABCG8, is mutated in the remaining pedigrees...
  6. Plosch T, van der Veen J, Havinga R, Huijkman N, Bloks V, Kuipers F. Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2006;291:G414-23 pubmed
    The ATP-binding cassette (ABC) half-transporters ABCG5 and ABCG8 heterodimerize into a functional complex that mediates the secretion of plant sterols and cholesterol by hepatocytes into bile and their apical efflux from enterocytes...
  7. Klett E, Lu K, Kosters A, Vink E, Lee M, Altenburg M, et al. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2004;2:5 pubmed
    ..of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking ..
  8. Graf G, Yu L, Li W, Gerard R, Tuma P, Cohen J, et al. ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J Biol Chem. 2003;278:48275-82 pubmed
    ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette (ABC) transporters that limit intestinal absorption and promote biliary excretion of neutral sterols...
  9. Tang W, Ma Y, Jia L, Ioannou Y, Davies J, Yu L. Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. J Lipid Res. 2009;50:293-300 pubmed publisher
    ..In conclusion, NPC1L1 is essential for phytosterols to enter the body in mice...
  10. Solcà C, Tint G, Patel S. Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice. J Lipid Res. 2013;54:397-409 pubmed publisher
    ..Two genes, ABCG5 and ABCG8, located at the sitosterolemia locus, each encodes a membrane-bound ABC half-transporter and constitutes a ..
  11. McDaniel A, Alger H, Sawyer J, Kelley K, Kock N, Brown J, et al. Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice. Am J Pathol. 2013;182:1131-8 pubmed publisher
    ..We believe these new data support the conclusion that plant sterols are excluded from the body because they are toxic when present at high levels...
  12. de Vogel van den Bosch H, de Wit N, Hooiveld G, Vermeulen H, van der Veen J, Houten S, et al. A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1171-80 pubmed publisher
    ..1 (Npc1l1) transports cholesterol into the enterocyte, whereas ATP-binding cassette transporters Abca1 and Abcg5/Abcg8 are presumed to be involved in cholesterol efflux from the enterocyte toward plasma HDL and back into the ..
  13. Altemus J, Patel S, Sehayek E. Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment. Metabolism. 2014;63:1334-41 pubmed publisher
    ..We set out to determine whether ezetimibe may increase RCT by mechanisms that are independent of its well-established inhibition of intestinal cholesterol absorption...
  14. Wang J, Grishin N, Kinch L, Cohen J, Hobbs H, Xie X. Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport. J Biol Chem. 2011;286:7308-14 pubmed publisher
    ATP-binding cassette transporters ABCG5 (G5) and ABCG8 (G8) form a heterodimer that transports cholesterol and plant sterols from hepatocytes into bile...
  15. Jansen P, Lutjohann D, Abildayeva K, Vanmierlo T, Plosch T, Plat J, et al. Dietary plant sterols accumulate in the brain. Biochim Biophys Acta. 2006;1761:445-53 pubmed
    ..Here, we report that mice deficient for ATP-binding cassette transporter G5 (Abcg5) or Abcg8, with strongly elevated serum plant sterol levels, display dramatically increased (7- to 16-fold) plant sterol ..
  16. Jakulj L, Vissers M, van Roomen C, van der Veen J, Vrins C, Kunne C, et al. Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice. FEBS Lett. 2010;584:3625-8 pubmed publisher
    ..We investigated whether these effects are mediated via the sterol exporter ATP binding cassette transporter G8 (abcg8). Ezetimibe increased FNS excretion 2.7-fold in WT mice and 1...
  17. Wittenburg H, Lyons M, Li R, Kurtz U, Wang X, Mossner J, et al. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006;47:1780-90 pubmed
    ..Haplotype analysis narrowed this QTL, and sequencing of the candidate genes Abcg5 and Abcg8 confirmed shared alleles in strains I/LnJ and DBA/2J that differed from the alleles in strain PERA/EiJ...
  18. Yu L, York J, von Bergmann K, Lutjohann D, Cohen J, Hobbs H. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J Biol Chem. 2003;278:15565-70 pubmed
    ..we show that expression of two target genes of LXRalpha, the ATP-binding cassette (ABC) transporters Abcg5 and Abcg8, is required for both the increase in sterol excretion and the decrease in fractional cholesterol absorption ..
  19. Kosters A, Frijters R, Kunne C, Vink E, Schneiders M, Schaap F, et al. Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8. Hepatology. 2005;41:141-50 pubmed
    ..expression in wild-type mice, diosgenin did not stimulate biliary cholesterol secretion in mice deficient for Abcg8. Analysis of the kinetics of cholesterol secretion suggested that diosgenin probably activates a step before Abcg5/..
  20. Groen A, Kunne C, Jongsma G, van den Oever K, Mok K, Petruzzelli M, et al. Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice. Gastroenterology. 2008;134:2091-100 pubmed publisher
    ..It has been established that biliary cholesterol excretion depends on transport by the heterodimer Abcg5/Abcg8. We hypothesized that the increased cholesterol output was due to enhanced extraction from the altered canalicular ..
  21. Wittenburg H, Lyons M, Li R, Kurtz U, Mossner J, Churchill G, et al. Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice. Mamm Genome. 2005;16:495-504 pubmed
    ..Significantly higher mRNA expression of Abcg5 and Abcg8 in strain PERA compared with strains I/Ln and DBA/2 further substantiated that the PERA allele of Abcg5/Abcg8 was ..
  22. Calpe Berdiel L, Rotllan N, Fievet C, Roig R, Blanco Vaca F, Escola Gil J. Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8. J Lipid Res. 2008;49:1904-11 pubmed publisher
    ..Our data provide direct in vivo evidence of the crucial role of ABCG5 and ABCG8 in LXR-mediated induction of macrophage-specific RCT.
  23. Yamanashi Y, Takada T, Yoshikado T, Shoda J, Suzuki H. NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport. Gastroenterology. 2011;140:1664-74 pubmed publisher
  24. Zhang L, Xu M, Yang Q, Lou D, Howles P, Tso P. ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph. Lipids. 2015;50:371-9 pubmed publisher
    ..Our data demonstrate that G5/G8 deficiency reduces the uptake and secretion of both dietary TAG and cholesterol by the intestine, suggesting a novel role for the sterol transporter in the formation and secretion of chylomicrons. ..
  25. Wang Y, Su K, Sabeva N, Ji A, van der Westhuyzen D, Foufelle F, et al. GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice. Metabolism. 2015;64:1435-43 pubmed publisher
    ..Leptin signaling does not directly regulate G5G8 abundance. The loss of G5G8 in mice harboring defects in the leptin axis is likely associated with compromised ER function. ..
  26. Kruit J, Drayer A, Bloks V, Blom N, Olthof S, Sauer P, et al. Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia. J Biol Chem. 2008;283:6281-7 pubmed
    Mutations in either ABCG5 or ABCG8 cause sitosterolemia, an inborn error of metabolism characterized by high plasma plant sterol concentrations...
  27. Duan L, Wang H, Ohashi A, Wang D. Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects. Am J Physiol Gastrointest Liver Physiol. 2006;290:G269-76 pubmed
    ..by suppressing expression of the jejunal and ileal sterol efflux transporters [ATP-binding cassette (Abc)g5 and Abcg8] and upregulating expression of the putative duodenal and jejunal sterol influx transporter Npc1l1...
  28. Wittenburg H, Carey M. Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8. J Clin Invest. 2002;110:605-9 pubmed
  29. Kanaji T, Kanaji S, Montgomery R, Patel S, Newman P. Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. Blood. 2013;122:2732-42 pubmed publisher
    ..recessive disease caused by mutations in the adenosine triphosphate-binding cassette transporter genes ABCG5 or ABCG8 that result in accumulation of xenosterols in the body...
  30. Vrins C, Vink E, Vandenberghe K, Frijters R, Seppen J, Groen A. The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. FEBS Lett. 2007;581:4616-20 pubmed
    The ATP binding cassette transporters ABCG5 and ABCG8 are indispensable for hepatobiliary cholesterol transport. In this study, we investigated the specificity of the heterodimer for cholesterol acceptors...
  31. Méndez González J, Julve J, Rotllan N, Llaverias G, Blanco Vaca F, Escola Gil J. ATP-binding cassette G5/G8 deficiency causes hypertriglyceridemia by affecting multiple metabolic pathways. Biochim Biophys Acta. 2011;1811:1186-93 pubmed publisher
    Mutations in ABCG5 or ABCG8 transporters are responsible for sitosterolemia, an autosomal recessive disease characterized by the accumulation of plant sterols...
  32. Kosters A, Kunne C, Looije N, Patel S, Oude Elferink R, Groen A. The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. J Lipid Res. 2006;47:1959-66 pubmed
    The main player in biliary cholesterol secretion is the heterodimeric transporter complex, ABCG5/ABCG8, the function of which is necessary for the majority of sterols secreted into bile...
  33. Repa J, Berge K, Pomajzl C, Richardson J, Hobbs H, Mangelsdorf D. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem. 2002;277:18793-800 pubmed
    Mutations in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 have recently been shown to cause the autosomal recessive disorder sitosterolemia...
  34. Khovidhunkit W, Moser A, Shigenaga J, Grunfeld C, Feingold K. Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. J Lipid Res. 2003;44:1728-36 pubmed
    ..In the liver, ABCG5 and ABCG8 have been proposed to efflux sterols into the bile for excretion...
  35. Dikkers A, Freak de Boer J, Annema W, Groen A, Tietge U. Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. Hepatology. 2013;58:293-303 pubmed publisher
    ..Additional in vivo macrophage-to-feces RCT studies demonstrated an almost 50% decrease in overall RCT in Sr-bI/Abcg5 dko compared with Abcg5 ko mice (P < 0.01)...
  36. Patel S. Recent advances in understanding the STSL locus and ABCG5/ABCG8 biology. Curr Opin Lipidol. 2014;25:169-75 pubmed publisher
    ..an update on recent advances made in our mechanistic and pathophysiological understanding of the rare human disease Sitosterolemia, the role of ABCG5/ABCG8 in sterol trafficking and how newer data implicate a more wider role in the body.
  37. Lyons M, Korstanje R, Li R, Walsh K, Churchill G, Carey M, et al. Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice. Physiol Genomics. 2004;17:114-21 pubmed
    ..4 LOD). Nhdlq3 colocalized with orthologous human QTLs for lipoprotein phenotypes, and with Abcg5 and Abcg8. Overall, we detected eight QTLs for lipoprotein cholesterol concentrations on Chrs 1, 9, 12, and 17 (each two per ..
  38. Wang J, Mitsche M, Lütjohann D, Cohen J, Xie X, Hobbs H. Relative roles of ABCG5/ABCG8 in liver and intestine. J Lipid Res. 2015;56:319-30 pubmed publisher
    ABCG5 (G5) and ABCG8 (G8) form a sterol transporter that acts in liver and intestine to prevent accumulation of dietary sterols...
  39. Dikkers A, de Boer J, Groen A, Tietge U. Hepatic ABCG5/G8 overexpression substantially increases biliary cholesterol secretion but does not impact in vivo macrophage-to-feces RCT. Atherosclerosis. 2015;243:402-6 pubmed publisher
    ..Biliary and fecal sterol excretion (FSE) as well as RCT were determined using wild-type controls, Abcg8 knockout mice, Abcg8 knockouts with adenovirus-mediated hepatocyte-specific Abcg8 reinstitution and hepatic Abcg5/..
  40. Temel R, Tang W, Ma Y, Rudel L, Willingham M, Ioannou Y, et al. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007;117:1968-78 pubmed
    ..These findings suggest that in humans, ezetimibe may reduce plasma cholesterol by inhibiting NPC1L1 function in both intestine and liver, and hepatic NPC1L1 may have evolved to protect the body from excessive biliary loss of cholesterol...
  41. Su K, Sabeva N, Liu J, Wang Y, Bhatnagar S, van der Westhuyzen D, et al. The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation. J Biol Chem. 2012;287:28564-75 pubmed publisher
    ABCG5 and ABCG8 form a complex (G5G8) that opposes the absorption of plant sterols but is also expressed in liver where it promotes the excretion of cholesterol into bile...
  42. Chase T, Lyons B, Bronson R, Foreman O, Donahue L, Burzenski L, et al. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010;115:1267-76 pubmed publisher
    ..Crosses with mice doubly transgenic for the human ABCG5 and ABCG8 genes rescued platelet counts and volumes...
  43. Sabeva N, Rouse E, Graf G. Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. J Biol Chem. 2007;282:22397-405 pubmed
    ABGG5 (G5) and ABCG8 (G8) are ABC half-transporters that dimerize within the endoplasmic reticulum, traffic to the cell surface, and mediate cholesterol excretion into bile...
  44. Basso F, Freeman L, Ko C, Joyce C, Amar M, Shamburek R, et al. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res. 2007;48:114-26 pubmed
    ..These findings identify distinct roles for liver and intestinal ABCG5/G8 in modulating sterol metabolism and atherosclerosis...
  45. Wittenburg H, Lyons M, Li R, Churchill G, Carey M, Paigen B. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology. 2003;125:868-81 pubmed
    ..Cholesterol gallstone formation is a complex genetic trait. To identify additional cholesterol gallstone susceptibility loci, we performed a quantitative trait locus analysis using an intercross of PERA/Ei and I/LnJ inbred strains of mice...
  46. Remaley A, Bark S, Walts A, Freeman L, Shulenin S, Annilo T, et al. Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster. Biochem Biophys Res Commun. 2002;295:276-82 pubmed
    The excretion of sterols from the liver and intestine is regulated by the ABCG5 and ABCG8 transporters...
  47. Nguyen T, Sawyer J, Kelley K, Davis M, Kent C, Rudel L. ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation. J Lipid Res. 2012;53:1598-609 pubmed publisher
    ..The data indicate that handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency...
  48. Cui J, Gunewardena S, Yoo B, Liu J, Renaud H, Lu H, et al. RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol Sci. 2012;127:592-608 pubmed publisher
    ..In conclusion, this study reveals the mRNA abundance of transporters in liver and demonstrates that the expression of liver transporters is both age and isoform specific. ..
  49. Escola Gil J, Llaverias G, Julve J, Jauhiainen M, Méndez González J, Blanco Vaca F. The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathway. Arterioscler Thromb Vasc Biol. 2011;31:2493-9 pubmed publisher
    ..The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces...
  50. Wang J, Zhang D, Lei Y, Xu F, Cohen J, Hobbs H, et al. Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. Biochemistry. 2008;47:5194-204 pubmed publisher
    ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette half-transporters that limit intestinal uptake and promote biliary secretion of neutral sterols...
  51. van der Velde A, Vrins C, van den Oever K, Kunne C, Oude Elferink R, Kuipers F, et al. Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology. 2007;133:967-75 pubmed
    ..The contribution of this pathway to cholesterol excretion in mice is approximately twice that of the biliary pathway. In mice, the intestine plays a significant role in removal of cholesterol from the body. ..
  52. Wang H, Li X, Patel S, Wang D. Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice. Hepatology. 2016;64:853-64 pubmed publisher
    ..secretion, cholesterol is still secreted to bile in sitosterolemic patients with a defect in either ABCG5 or ABCG8 and in either Abcg5/g8 double- or single-knockout mice...
  53. Kim H, Kim J, Oh S, Yoo H. Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone. Dig Dis. 2017;35:439-443 pubmed publisher
    ..The half-transporters ABCG5 and ABCG8 mediate the efflux of cholesterol in hepatocytes and the intestine...
  54. Wiersma H, Gatti A, Nijstad N, Oude Elferink R, Kuipers F, Tietge U. Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice. Hepatology. 2009;50:1263-72 pubmed publisher
    ..biliary cholesterol secretion, especially in a functional context with ATP-binding cassette transporter g5 (Abcg5)/Abcg8 and Abcb4...
  55. Lyons M, Wittenburg H, Li R, Walsh K, Korstanje R, Churchill G, et al. Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice. Physiol Genomics. 2004;17:60-8 pubmed
    ..Our analysis furthers the knowledge of the genetic control of lipoprotein levels and points to the importance of Hdlq10, which was detected repeatedly in multiple studies...