Abcg5

Summary

Gene Symbol: Abcg5
Description: ATP binding cassette subfamily G member 5
Alias: cmp, sterolin-1, trac, ATP-binding cassette sub-family G member 5, ATP-binding cassette, sub-family G (WHITE), member 5, sterolin 1
Species: mouse
Products:     Abcg5

Top Publications

  1. Lee M, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet. 2001;27:79-83 pubmed
    ..H.L. et al., manuscript submitted). We now report that a new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients.
  2. Lu K, Lee M, Hazard S, Brooks Wilson A, Hidaka H, Kojima H, et al. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet. 2001;69:278-90 pubmed
    ..Recently, we reported that a novel member of the ABC-transporter family, named "sterolin-1" and encoded by ABCG5, is mutated in 9 unrelated families with sitosterolemia; in the remaining 25 families, no mutations in sterolin-1 ..
  3. Yu L, Li Hawkins J, Hammer R, Berge K, Horton J, Cohen J, et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest. 2002;110:671-80 pubmed
    Two ATP-binding cassette (ABC) transporters, ABCG5 and ABCG8, have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans...
  4. Yu L, York J, von Bergmann K, Lutjohann D, Cohen J, Hobbs H. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J Biol Chem. 2003;278:15565-70 pubmed
    ..Here we show that expression of two target genes of LXRalpha, the ATP-binding cassette (ABC) transporters Abcg5 and Abcg8, is required for both the increase in sterol excretion and the decrease in fractional cholesterol ..
  5. Yang C, Yu L, Li W, Xu F, Cohen J, Hobbs H. Disruption of cholesterol homeostasis by plant sterols. J Clin Invest. 2004;114:813-22 pubmed
    The ABC transporters ABCG5 and ABCG8 limit absorption and promote excretion of dietary plant sterols. It is not known why plant sterols are so assiduously excluded from the body...
  6. McDaniel A, Alger H, Sawyer J, Kelley K, Kock N, Brown J, et al. Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice. Am J Pathol. 2013;182:1131-8 pubmed publisher
    ..To determine the significance of phytosterol exclusion from the body, we fed wild-type and ABCG5/G8 knockout mice a diet enriched with plant sterols...
  7. Solcà C, Tint G, Patel S. Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice. J Lipid Res. 2013;54:397-409 pubmed publisher
    ..Two genes, ABCG5 and ABCG8, located at the sitosterolemia locus, each encodes a membrane-bound ABC half-transporter and constitutes ..
  8. Tang W, Ma Y, Jia L, Ioannou Y, Davies J, Yu L. Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. J Lipid Res. 2009;50:293-300 pubmed publisher
    ..We found that mice lacking ABCG5/G8 and NPC1L1 [triple knockout (TKO) mice] did not accumulate phytosterols in plasma and the liver...
  9. Plosch T, Kruit J, Bloks V, Huijkman N, Havinga R, Duchateau G, et al. Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter. J Nutr. 2006;136:2135-40 pubmed
    ..g., Abcg5 and Abcg8, via the liver X receptor (LXR), but direct proof is lacking...

More Information

Publications67

  1. Yu L, Hammer R, Li Hawkins J, von Bergmann K, Lutjohann D, Cohen J, et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A. 2002;99:16237-42 pubmed
    ..In patients with sitosterolemia, mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8, lead to reduced secretion of sterols into bile, implicating these transporters in this process...
  2. Plosch T, Bloks V, Terasawa Y, Berdy S, Siegler K, Van Der Sluijs F, et al. Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology. 2004;126:290-300 pubmed
    ..It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux ..
  3. Yu L, von Bergmann K, Lutjohann D, Hobbs H, Cohen J. Selective sterol accumulation in ABCG5/ABCG8-deficient mice. J Lipid Res. 2004;45:301-7 pubmed
    The ATP binding cassette (ABC) transporters ABCG5 and ABCG8 limit intestinal absorption and promote biliary secretion of neutral sterols...
  4. Graf G, Yu L, Li W, Gerard R, Tuma P, Cohen J, et al. ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J Biol Chem. 2003;278:48275-82 pubmed
    b>ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette (ABC) transporters that limit intestinal absorption and promote biliary excretion of neutral sterols...
  5. Plosch T, van der Veen J, Havinga R, Huijkman N, Bloks V, Kuipers F. Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2006;291:G414-23 pubmed
    The ATP-binding cassette (ABC) half-transporters ABCG5 and ABCG8 heterodimerize into a functional complex that mediates the secretion of plant sterols and cholesterol by hepatocytes into bile and their apical efflux from enterocytes...
  6. van der Veen J, van Dijk T, Vrins C, van Meer H, Havinga R, Bijsterveld K, et al. Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol. J Biol Chem. 2009;284:19211-9 pubmed publisher
    ..Trans-intestinal cholesterol excretion is impaired in mice lacking Abcg5 (-4%), suggesting that the cholesterol transporting Abcg5/Abcg8 heterodimer is involved in this pathway...
  7. Wiersma H, Gatti A, Nijstad N, Oude Elferink R, Kuipers F, Tietge U. Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice. Hepatology. 2009;50:1263-72 pubmed publisher
    ..on biliary cholesterol secretion, especially in a functional context with ATP-binding cassette transporter g5 (Abcg5)/Abcg8 and Abcb4...
  8. Repa J, Berge K, Pomajzl C, Richardson J, Hobbs H, Mangelsdorf D. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem. 2002;277:18793-800 pubmed
    Mutations in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 have recently been shown to cause the autosomal recessive disorder sitosterolemia...
  9. Temel R, Tang W, Ma Y, Rudel L, Willingham M, Ioannou Y, et al. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007;117:1968-78 pubmed
    ..These findings suggest that in humans, ezetimibe may reduce plasma cholesterol by inhibiting NPC1L1 function in both intestine and liver, and hepatic NPC1L1 may have evolved to protect the body from excessive biliary loss of cholesterol...
  10. Klett E, Lu K, Kosters A, Vink E, Lee M, Altenburg M, et al. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2004;2:5 pubmed
    Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol ..
  11. Lu K, Lee M, Yu H, Zhou Y, Sandell S, Salen G, et al. Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8. J Lipid Res. 2002;43:565-78 pubmed
    ..We have recently identified two genes, ABCG5 and ABCG8, encoding sterolin-1 and -2 respectively, mutations of which cause the human disease sitosterolemia...
  12. Graf G, Li W, Gerard R, Gelissen I, White A, Cohen J, et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest. 2002;110:659-69 pubmed
    ..To determine the site of action of ABCG5 and ABCG8, we expressed recombinant, epitope-tagged mouse ABCG5 and ABCG8 in cultured cells...
  13. Kosters A, Frijters R, Schaap F, Vink E, Plosch T, Ottenhoff R, et al. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol. 2003;38:710-6 pubmed
    Mutations in genes encoding the ATP-binding cassette (ABC)-transporters ABCG5 and ABCG8 underlie sitosterolemia, which is characterized by elevated plasma levels of phytosterols due to increased intestinal absorption and impaired biliary ..
  14. Yu L, Gupta S, Xu F, Liverman A, Moschetta A, Mangelsdorf D, et al. Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J Biol Chem. 2005;280:8742-7 pubmed
    ..Biliary cholesterol secretion is mediated by the ATP-binding cassette (ABC) transporters ABCG5 (G5) and ABCG8 (G8) and is stimulated by cholesterol and by the non-cholesterol steroids cholate and diosgenin...
  15. Yu L, von Bergmann K, Lutjohann D, Hobbs H, Cohen J. Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. J Lipid Res. 2005;46:1739-44 pubmed
    The ATP binding cassette transporters ABCG5 (G5) and ABCG8 (G8) limit the accumulation of neutral sterols by restricting sterol uptake from the intestine and promoting sterol excretion into bile...
  16. Berge K, Tian H, Graf G, Yu L, Grishin N, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000;290:1771-5 pubmed
    ..of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter family (six mutations in ABCG8 and one in ABCG5) in nine patients with sitosterolemia...
  17. Calpe Berdiel L, Rotllan N, Fievet C, Roig R, Blanco Vaca F, Escola Gil J. Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8. J Lipid Res. 2008;49:1904-11 pubmed publisher
    ..In this study, we assessed the effects of ABCG5/G8 deficiency as well as those of LXR agonist-induction of RCT from macrophages to feces in vivo...
  18. Wang J, Sun F, Zhang D, Ma Y, Xu F, Belani J, et al. Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution. J Biol Chem. 2006;281:27894-904 pubmed
    ..These studies indicate that G5 and G8 are sufficient for reconstitution of sterol transfer activity in vitro and provide the first demonstration that sterols are direct transport substrates of the G5 and G8 heterodimer...
  19. Wittenburg H, Lyons M, Li R, Kurtz U, Mossner J, Churchill G, et al. Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice. Mamm Genome. 2005;16:495-504 pubmed
    ..Significantly higher mRNA expression of Abcg5 and Abcg8 in strain PERA compared with strains I/Ln and DBA/2 further substantiated that the PERA allele of Abcg5/..
  20. Jansen P, Lutjohann D, Abildayeva K, Vanmierlo T, Plosch T, Plat J, et al. Dietary plant sterols accumulate in the brain. Biochim Biophys Acta. 2006;1761:445-53 pubmed
    ..Here, we report that mice deficient for ATP-binding cassette transporter G5 (Abcg5) or Abcg8, with strongly elevated serum plant sterol levels, display dramatically increased (7- to 16-fold) plant ..
  21. Khovidhunkit W, Moser A, Shigenaga J, Grunfeld C, Feingold K. Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. J Lipid Res. 2003;44:1728-36 pubmed
    ..In the liver, ABCG5 and ABCG8 have been proposed to efflux sterols into the bile for excretion...
  22. Brufau G, Kuipers F, Lin Y, Trautwein E, Groen A. A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice. PLoS ONE. 2011;6:e21576 pubmed publisher
    ..Recent data demonstrate that the intestine directly mediates plasma cholesterol excretion into feces, i.e., without involvement of the hepato-biliary route...
  23. Groen A, Kunne C, Jongsma G, van den Oever K, Mok K, Petruzzelli M, et al. Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice. Gastroenterology. 2008;134:2091-100 pubmed publisher
    ..It has been established that biliary cholesterol excretion depends on transport by the heterodimer Abcg5/Abcg8...
  24. Bonde Y, Plosch T, Kuipers F, Angelin B, Rudling M. Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex. Hepatology. 2012;56:1828-37 pubmed publisher
    ..and hepatic gene expression of adenosine triphosphate (ATP)-binding cassette, subfamily G (WHITE), member 5 (ABCG5) and ATP-binding cassette, subfamily G (WHITE), member 8 (ABCG8), two half-transporters that act as a ..
  25. Wittenburg H, Lyons M, Li R, Churchill G, Carey M, Paigen B. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology. 2003;125:868-81 pubmed
    ..Cholesterol gallstone formation is a complex genetic trait. To identify additional cholesterol gallstone susceptibility loci, we performed a quantitative trait locus analysis using an intercross of PERA/Ei and I/LnJ inbred strains of mice...
  26. Lyons M, Wittenburg H, Li R, Walsh K, Korstanje R, Churchill G, et al. Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice. Physiol Genomics. 2004;17:60-8 pubmed
    ..Our analysis furthers the knowledge of the genetic control of lipoprotein levels and points to the importance of Hdlq10, which was detected repeatedly in multiple studies...
  27. Kanaji T, Kanaji S, Montgomery R, Patel S, Newman P. Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. Blood. 2013;122:2732-42 pubmed publisher
    ..autosomal recessive disease caused by mutations in the adenosine triphosphate-binding cassette transporter genes ABCG5 or ABCG8 that result in accumulation of xenosterols in the body...
  28. Dikkers A, Freak de Boer J, Annema W, Groen A, Tietge U. Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. Hepatology. 2013;58:293-303 pubmed publisher
    ..Using Sr-bI/Abcg5 double knockout mice (dko), the present study investigated the differential contribution of two of the most ..
  29. Nguyen T, Sawyer J, Kelley K, Davis M, Kent C, Rudel L. ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation. J Lipid Res. 2012;53:1598-609 pubmed publisher
    ..The data indicate that handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency...
  30. Cui J, Gunewardena S, Yoo B, Liu J, Renaud H, Lu H, et al. RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol Sci. 2012;127:592-608 pubmed publisher
    ..In conclusion, this study reveals the mRNA abundance of transporters in liver and demonstrates that the expression of liver transporters is both age and isoform specific. ..
  31. Altemus J, Patel S, Sehayek E. Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment. Metabolism. 2014;63:1334-41 pubmed publisher
    ..We set out to determine whether ezetimibe may increase RCT by mechanisms that are independent of its well-established inhibition of intestinal cholesterol absorption...
  32. Duan L, Wang H, Ohashi A, Wang D. Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects. Am J Physiol Gastrointest Liver Physiol. 2006;290:G269-76 pubmed
    ..significantly augmented cholesterol absorption mostly due to an upregulated expression of intestinal Npc1l1, Abcg5, and Abcg8 via the intestinal ERalpha pathway, which can be fully abolished by the antagonist...
  33. Wang J, Zhang D, Lei Y, Xu F, Cohen J, Hobbs H, et al. Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. Biochemistry. 2008;47:5194-204 pubmed publisher
    b>ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette half-transporters that limit intestinal uptake and promote biliary secretion of neutral sterols...
  34. Wittenburg H, Lyons M, Li R, Kurtz U, Wang X, Mossner J, et al. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006;47:1780-90 pubmed
    ..Haplotype analysis narrowed this QTL, and sequencing of the candidate genes Abcg5 and Abcg8 confirmed shared alleles in strains I/LnJ and DBA/2J that differed from the alleles in strain PERA/EiJ...
  35. Escola Gil J, Llaverias G, Julve J, Jauhiainen M, Méndez González J, Blanco Vaca F. The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathway. Arterioscler Thromb Vasc Biol. 2011;31:2493-9 pubmed publisher
    ..The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces...
  36. Patel S. Recent advances in understanding the STSL locus and ABCG5/ABCG8 biology. Curr Opin Lipidol. 2014;25:169-75 pubmed publisher
    ..an update on recent advances made in our mechanistic and pathophysiological understanding of the rare human disease Sitosterolemia, the role of ABCG5/ABCG8 in sterol trafficking and how newer data implicate a more wider role in the body.
  37. Basso F, Freeman L, Ko C, Joyce C, Amar M, Shamburek R, et al. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res. 2007;48:114-26 pubmed
    We previously reported that liver-specific overexpression of ABCG5/G8 in mice is not atheroprotective, suggesting that increased biliary cholesterol secretion must be coupled with decreased intestinal cholesterol absorption to increase ..
  38. Su K, Sabeva N, Liu J, Wang Y, Bhatnagar S, van der Westhuyzen D, et al. The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation. J Biol Chem. 2012;287:28564-75 pubmed publisher
    b>ABCG5 and ABCG8 form a complex (G5G8) that opposes the absorption of plant sterols but is also expressed in liver where it promotes the excretion of cholesterol into bile...
  39. Wang Y, Su K, Sabeva N, Ji A, van der Westhuyzen D, Foufelle F, et al. GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice. Metabolism. 2015;64:1435-43 pubmed publisher
    ..Leptin signaling does not directly regulate G5G8 abundance. The loss of G5G8 in mice harboring defects in the leptin axis is likely associated with compromised ER function. ..
  40. Méndez González J, Julve J, Rotllan N, Llaverias G, Blanco Vaca F, Escola Gil J. ATP-binding cassette G5/G8 deficiency causes hypertriglyceridemia by affecting multiple metabolic pathways. Biochim Biophys Acta. 2011;1811:1186-93 pubmed publisher
    Mutations in ABCG5 or ABCG8 transporters are responsible for sitosterolemia, an autosomal recessive disease characterized by the accumulation of plant sterols...
  41. Wang J, Grishin N, Kinch L, Cohen J, Hobbs H, Xie X. Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport. J Biol Chem. 2011;286:7308-14 pubmed publisher
    ATP-binding cassette transporters ABCG5 (G5) and ABCG8 (G8) form a heterodimer that transports cholesterol and plant sterols from hepatocytes into bile...
  42. Duan L, Wang H, Wang D. Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice. J Lipid Res. 2004;45:1312-23 pubmed
    In the present study, we investigated whether intestinal sterol efflux transporters Abcg5 and Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency, and we compared the physiological functions of the ..
  43. Yamanashi Y, Takada T, Yoshikado T, Shoda J, Suzuki H. NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport. Gastroenterology. 2011;140:1664-74 pubmed publisher
    ..homeostasis; it is regulated by the cholesterol exporter adenosine triphosphate-binding cassettes G5 and G8 (ABCG5/G8) and the cholesterol importer Niemann-Pick C1-like 1 (NPC1L1)...
  44. Wittenburg H, Carey M. Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8. J Clin Invest. 2002;110:605-9 pubmed
  45. Remaley A, Bark S, Walts A, Freeman L, Shulenin S, Annilo T, et al. Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster. Biochem Biophys Res Commun. 2002;295:276-82 pubmed
    The excretion of sterols from the liver and intestine is regulated by the ABCG5 and ABCG8 transporters...
  46. de Vogel van den Bosch H, de Wit N, Hooiveld G, Vermeulen H, van der Veen J, Houten S, et al. A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1171-80 pubmed publisher
    ..Protein 1 (Npc1l1) transports cholesterol into the enterocyte, whereas ATP-binding cassette transporters Abca1 and Abcg5/Abcg8 are presumed to be involved in cholesterol efflux from the enterocyte toward plasma HDL and back into the ..
  47. Vrins C, Vink E, Vandenberghe K, Frijters R, Seppen J, Groen A. The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. FEBS Lett. 2007;581:4616-20 pubmed
    The ATP binding cassette transporters ABCG5 and ABCG8 are indispensable for hepatobiliary cholesterol transport. In this study, we investigated the specificity of the heterodimer for cholesterol acceptors...
  48. Dikkers A, de Boer J, Groen A, Tietge U. Hepatic ABCG5/G8 overexpression substantially increases biliary cholesterol secretion but does not impact in vivo macrophage-to-feces RCT. Atherosclerosis. 2015;243:402-6 pubmed publisher
    Biliary cholesterol secretion is important for reverse cholesterol transport (RCT). ABCG5/G8 contribute most cholesterol mass secretion into bile. We investigated the impact of hepatic ABCG5/G8 on cholesterol metabolism and RCT...
  49. Chase T, Lyons B, Bronson R, Foreman O, Donahue L, Burzenski L, et al. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010;115:1267-76 pubmed publisher
    ..A G to A mutation in exon 10 of the adenosine triphosphate (ATP)-binding cassette subfamily G, member 5 (Abcg5) gene, alters a tryptophan codon (UGG) to a premature stop codon (UAG)...
  50. Imai S, Kikuchi R, Kusuhara H, Yagi S, Shiota K, Sugiyama Y. Analysis of DNA methylation and histone modification profiles of liver-specific transporters. Mol Pharmacol. 2009;75:568-76 pubmed publisher
    ..tissue-specific expression of mouse liver-specific transporters (Oatp1b2/Slco1b2, Ntcp/Slc10a1, Bsep/Abcb11, and Abcg5/g8)...
  51. Kruit J, Drayer A, Bloks V, Blom N, Olthof S, Sauer P, et al. Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia. J Biol Chem. 2008;283:6281-7 pubmed
    Mutations in either ABCG5 or ABCG8 cause sitosterolemia, an inborn error of metabolism characterized by high plasma plant sterol concentrations...
  52. Wang J, Mitsche M, Lütjohann D, Cohen J, Xie X, Hobbs H. Relative roles of ABCG5/ABCG8 in liver and intestine. J Lipid Res. 2015;56:319-30 pubmed publisher
    b>ABCG5 (G5) and ABCG8 (G8) form a sterol transporter that acts in liver and intestine to prevent accumulation of dietary sterols...
  53. Zhang L, Xu M, Yang Q, Lou D, Howles P, Tso P. ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph. Lipids. 2015;50:371-9 pubmed publisher
    ..Our data demonstrate that G5/G8 deficiency reduces the uptake and secretion of both dietary TAG and cholesterol by the intestine, suggesting a novel role for the sterol transporter in the formation and secretion of chylomicrons. ..
  54. Lyons M, Korstanje R, Li R, Walsh K, Churchill G, Carey M, et al. Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice. Physiol Genomics. 2004;17:114-21 pubmed
    ..4 LOD). Nhdlq3 colocalized with orthologous human QTLs for lipoprotein phenotypes, and with Abcg5 and Abcg8...
  55. Wang H, Li X, Patel S, Wang D. Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice. Hepatology. 2016;64:853-64 pubmed publisher
    The adenosine triphosphate-binding cassette (ABC) sterol transporter, Abcg5/g8, is Lith9 in mice, and two gallstone-associated variants in ABCG5/G8 have been identified in humans...
  56. Wilson D, Oslund K, Lyons B, Foreman O, Burzenski L, Svenson K, et al. Inflammatory dilated cardiomyopathy in Abcg5-deficient mice. Toxicol Pathol. 2013;41:880-92 pubmed publisher
    ..the spontaneous thrombocytopenia and cardiomyopathy (trac) mutation results from a single base pair change in the Abcg5 gene...
  57. Sabeva N, Rouse E, Graf G. Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. J Biol Chem. 2007;282:22397-405 pubmed
  58. Kim H, Kim J, Oh S, Yoo H. Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone. Dig Dis. 2017;35:439-443 pubmed publisher
    ..The half-transporters ABCG5 and ABCG8 mediate the efflux of cholesterol in hepatocytes and the intestine...