Abcg2

Summary

Gene Symbol: Abcg2
Description: ATP-binding cassette, sub-family G (WHITE), member 2
Alias: ABC15, ABCP, AI428558, BCRP, Bcrp1, MXR, MXR1, ATP-binding cassette sub-family G member 2, breast cancer resistance protein 1 homolog, mitoxantrone resistance protein 1
Species: mouse

Top Publications

  1. ncbi Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 105:2571-6. 2005
  2. ncbi P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan
    Nienke A de Vries
    Department of Clinical Chemistry, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Clin Cancer Res 13:6440-9. 2007
  3. pmc Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
    Markus Krohn
    Department of Neurology, Neurodegeneration Research Laboratory, University of Rostock, Rostock, Germany
    J Clin Invest 121:3924-31. 2011
  4. ncbi P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor
    Johnny J Yang
    Drug Metabolism and Pharmacokinetics, Millennium Pharmaceuticals Inc, Takeda Oncology Company, 40 Landsdowne Street, Cambridge, MA 02139, USA
    Drug Metab Lett 4:201-12. 2010
  5. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
  6. doi Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells
    Cindy M Martin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Circ Res 102:1075-81. 2008
  7. pmc Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein
    A M S Hartz
    Department of Biochemistry and Molecular Biology, Medical School Duluth, University of Minnesota, Duluth, Minnesota 55812, USA
    J Pharmacol Exp Ther 334:467-76. 2010
  8. ncbi Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice
    Yuji Tanaka
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Biochem Biophys Res Commun 326:181-7. 2005
  9. doi The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 30:2128-35. 2010
  10. ncbi Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX
    Johan W Jonker
    Div of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 292:C2204-12. 2007

Scientific Experts

  • Sheng Zhou
  • Ana I Alvarez
  • C Brendel
  • Johnny J Yang
  • Dirk R de Waart
  • Markos Leggas
  • Alfred H Schinkel
  • Paul J Smith
  • Salvatore Cisternino
  • Tadayuki Takashima
  • Daniel Geschwind
  • Johan W Jonker
  • Jos H Beijnen
  • Els Wagenaar
  • Olaf van Tellingen
  • Antonius E van Herwaarden
  • Gracia Merino
  • Nienke A de Vries
  • Yi Zhang
  • Jashvant D Unadkat
  • Qingcheng Mao
  • Brian P Sorrentino
  • Hilde Rosing
  • Honggang Wang
  • John D Schuetz
  • Cindy M Martin
  • Konstantina Ioanna Sereti
  • Jurjen S Lagas
  • Soghra Fatima
  • Maria L H Vlaming
  • Lin Zhou
  • Yuichi Sugiyama
  • Hiroyuki Kusuhara
  • Sandra Musters
  • Carolyn M Porteous
  • Zhihui Rong
  • George L Scheffer
  • Hiroki Ueno
  • Seng Chuan Tang
  • Yu Zeng
  • Ahmed M Hamdan
  • Liwen Li
  • Debbie Callaghan
  • Sophie Petropoulos
  • Peilin Huang
  • Takuya Shimizu
  • Wandong Zhang
  • Guohua An
  • Jaya P Gnana-Prakasam
  • Huaqi Xiong
  • R Real
  • Jamie A Wright
  • Markus Krohn
  • Ronglih Liao
  • Angelos Oikonomopoulos
  • Serge A L Zander
  • Junichi Shigeta
  • Shanshan Shen
  • Anika M S Hartz
  • A M S Hartz
  • Joseph Tam
  • Yasutomi Higashikuni
  • Miyuki Kubota
  • Sung Won Cho
  • Jin Zhao
  • Tessa Buckle
  • Bjorn Bauer
  • Han Sung Jung
  • Hyuk Jae Kwon
  • Suresh V Ambudkar
  • Michel J Hillebrand
  • Suneet Shukla
  • Julie Cattelotte
  • Xingguo Cheng
  • Jun Shen
  • Christian Scharenberg
  • Kathleen Kelly Tanaka
  • Anne Marie Bleau
  • Piet Borst
  • Jan H M Schellens
  • Otmar Pfister
  • Jimmy Susanto
  • Jean Michel Scherrmann
  • Yeun Jung Kim
  • Uwe Muenster
  • Clinton F Stewart
  • G M Kalabis
  • Cornelia J F De Wolf
  • Toshitake Hirai
  • Masashi Adachi

Detail Information

Publications86

  1. ncbi Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 105:2571-6. 2005
    b>ABCG2/BCRP is a member of the adenosine triphosphate-binding cassette (ABC) transporter family and is expressed in intestine, kidney, and liver, where it modulates the absorption and excretion of xenobiotic compounds...
  2. ncbi P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan
    Nienke A de Vries
    Department of Clinical Chemistry, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Clin Cancer Res 13:6440-9. 2007
    ..Whereas the effect of P-glycoprotein (P-gp) at the BBB is well established, the role of breast cancer resistance protein (BCRP) that is also expressed at the BBB is not.
  3. pmc Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
    Markus Krohn
    Department of Neurology, Neurodegeneration Research Laboratory, University of Rostock, Rostock, Germany
    J Clin Invest 121:3924-31. 2011
    ..Thus, by altering the temporal aggregation profile of Aβ, pharmacological activation of ABC transporters could impede the neurodegenerative cascade that culminates in the dementia of AD...
  4. ncbi P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor
    Johnny J Yang
    Drug Metabolism and Pharmacokinetics, Millennium Pharmaceuticals Inc, Takeda Oncology Company, 40 Landsdowne Street, Cambridge, MA 02139, USA
    Drug Metab Lett 4:201-12. 2010
    ..In mice, after intravenous administration of tandutinib, the mean plasma AUC values in the Bcrp1(-/-) mice and Mdr1a/b(-/-) mice was 1.53- and 1.20-fold greater than that of the wild type (WT) mice, respectively...
  5. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival advantage under hypoxic conditions...
  6. doi Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells
    Cindy M Martin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Circ Res 102:1075-81. 2008
    ..We have previously established that the multidrug resistance protein Abcg2 is the molecular determinant of the side population (SP) progenitor cell population...
  7. pmc Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein
    A M S Hartz
    Department of Biochemistry and Molecular Biology, Medical School Duluth, University of Minnesota, Duluth, Minnesota 55812, USA
    J Pharmacol Exp Ther 334:467-76. 2010
    Breast cancer resistance protein (BCRP) is an ATP-driven efflux pump at the blood-brain barrier that limits central nervous system pharmacotherapy...
  8. ncbi Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice
    Yuji Tanaka
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Biochem Biophys Res Commun 326:181-7. 2005
    Breast cancer resistance protein (Bcrp/Abcg2) is a member of the ABC transporter family...
  9. doi The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 30:2128-35. 2010
    To clarify the impact of breast cancer resistance protein 1 (BCRP1)/ATP-binding cassette transporter subfamily G member 2 (ABCG2) expression on cardiac repair after myocardial infarction (MI).
  10. ncbi Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX
    Johan W Jonker
    Div of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 292:C2204-12. 2007
    ..We have previously shown that mice with a deficiency in the ABC transporter Bcrp1/Abcg2 display a novel type of protoporphyria...
  11. ncbi Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver
    Gracia Merino
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
    Mol Pharmacol 67:1765-71. 2005
    The breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette drug efflux transporter present in the liver and other tissues that affects the pharmacological behavior of many compounds...
  12. ncbi Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart
    Cindy M Martin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Dev Biol 265:262-75. 2004
    ..In this study, we confirm that Abcg2 is a determinant of the SP cell phenotype...
  13. pmc Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:12339-44. 2002
    ..Previous studies have implicated the ATP binding cassette transporter genes Mdr1a/1b and/or Bcrp1 in the SP phenotype...
  14. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
    ..Here we show that expression of the Bcrp1 (also known as Abcg2 murine/ABCG2 human) gene is a conserved feature of stem cells from a wide variety of sources...
  15. pmc The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
    Johan W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 99:15649-54. 2002
    ..Pheophorbide a occurs in various plant-derived foods and food supplements. Bcrp1 transports pheophorbide a and is highly efficient in limiting its uptake from ingested food...
  16. doi Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model
    Soghra Fatima
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Stem Cells 30:210-21. 2012
    The side population phenotype is associated with the Hoechst dye efflux activity of the Abcg2 transporter and identifies hematopoietic stem cells (HSCs) in the bone marrow...
  17. doi ATP-binding cassette G-subfamily transporter 2 regulates cell cycle progression and asymmetric division in mouse cardiac side population progenitor cells
    Konstantina Ioanna Sereti
    Cardiac Muscle Research Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, NRB 431, Boston, MA 02115, USA
    Circ Res 112:27-34. 2013
    ..We previously have found that the cell surface ATP-binding cassette G-subfamily transporter 2 (Abcg2) influences the proliferation of cardiac side population (CSP) progenitor cells, but through unclear mechanisms.
  18. doi Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice
    Yu Zeng
    Department of Clinical Medicine, Southeast University, Nanjing, China
    J Neurochem 122:456-69. 2012
    Oxidative stress and neuroinflammation play important roles in Alzheimer's disease (AD). ABCG2 is a transporter protein expressed in the brain and involved in GSH transport...
  19. doi Involvement of breast cancer resistance protein (BCRP/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectin
    R Real
    Departamento de Ciencias Biomedicas Fisiologia, Facultad de Veterinaria, Universidad de Leon, Leon, Spain
    J Vet Pharmacol Ther 34:313-21. 2011
    ..One of the main determinants of active drug secretion into milk is the transporter (BCRP/ABCG2)...
  20. doi Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP
    Nienke A de Vries
    Department of Clinical Chemistry, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Invest New Drugs 30:443-9. 2012
    ..As erlotinib is a known substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) we have investigated the effect of these ABC-transporters on the brain penetration of erlotinib.
  21. pmc Intestinal expression of mouse Abcg2/breast cancer resistance protein (BCRP) gene is under control of circadian clock-activating transcription factor-4 pathway
    Ahmed M Hamdan
    Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 287:17224-31. 2012
    b>ABCG2, encoding breast cancer resistance protein (BCRP), is a member of the ATP-binding cassette transporter family and is often associated with cancer chemotherapeutic resistance...
  22. doi Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability
    Zhihui Rong
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China
    Life Sci 92:245-51. 2013
    ..The purpose of the present study was to investigate the role of efflux transporters on the intestinal absorption of amtolmetin guacyl (MED-15)...
  23. doi PDZK1 regulates breast cancer resistance protein in small intestine
    Takuya Shimizu
    Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Drug Metab Dispos 39:2148-54. 2011
    ..blot analysis of intestinal brush-border membranes revealed that expression of breast cancer resistance protein (BCRP) but not of P-glycoprotein is reduced in pdzk1(-/-) mice...
  24. doi Bioavailability of the glucuronide and sulfate conjugates of genistein and daidzein in breast cancer resistance protein 1 knockout mice
    Ana I Alvarez
    Department of Biomedical Sciences Physiology, Veterinary Faculty, University of Leon 2407, Campus de Vegazana, Leon, Spain
    Drug Metab Dispos 39:2008-12. 2011
    ..Breast cancer resistance protein (ABCG2/BCRP) interacts with genistein and daidzein, which are among the natural substrates of the transporter and ..
  25. doi Evaluation of breast cancer resistance protein function in hepatobiliary and renal excretion using PET with 11C-SC-62807
    Tadayuki Takashima
    Molecular Probe Dynamics Laboratory, RIKEN Center for Molecular Imaging Science, Kobe, Japan
    J Nucl Med 54:267-76. 2013
    A quantitative PET imaging method was used to assess the in vivo kinetics of hepatobiliary and renal excretion of the breast cancer resistance protein (Bcrp) substrate (11)C-SC-62807 in mice.
  26. pmc Dependence of corneal stem/progenitor cells on ocular surface innervation
    Hiroki Ueno
    Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 53:867-72. 2012
    ..The purpose of this study was to identify the relationship between corneolimbal epithelial progenitor/stem cells and sensory nerves using a denervated mouse model of NK...
  27. pmc Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis
    Jaya P Gnana-Prakasam
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Invest Ophthalmol Vis Sci 52:9279-86. 2011
    FLVCR, BCRP, and PCFT/HCP-1 represent the three heme transporters identified thus far in mammalian cells, but there is very little known about their expression and regulation in the retina...
  28. doi P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain
    Carolyn M Porteous
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    Biochim Biophys Acta 1830:3458-65. 2013
    ..While this approach has delivered TPP-conjugated compounds to the brain, the amounts taken up are lower than by other organs...
  29. doi Breast cancer resistance protein BCRP (ABCG2)-mediated transepithelial nitrofurantoin secretion and its regulation in human intestinal epithelial (Caco-2) layers
    Jamie A Wright
    Epithelial Research Group, Institute of Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Eur J Pharmacol 672:70-6. 2011
    In order to determine the capacity and regulation of the breast cancer resistance protein (BCRP)-mediated transport in intact human intestinal epithelial monolayers (Caco-2) in which multiple ABC transporters are expressed, nitrofurantoin ..
  30. doi Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation
    Jurjen S Lagas
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cancer Ther 9:319-26. 2010
    ..We studied active transport of sorafenib in MDCK-II cells expressing human P-glycoprotein (P-gp/ABCB1) or ABCG2 (breast cancer resistance protein) or murine Abcg2...
  31. doi Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo
    Maria L H Vlaming
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cancer Ther 8:3350-9. 2009
    The multidrug transporters ABCC2, ABCC3, and ABCG2 can eliminate potentially toxic compounds from the body and have overlapping substrate specificities...
  32. doi ABCG2-associated resistance to Hoechst 33342 and topotecan in a murine cell model with constitutive expression of side population characteristics
    Paul J Smith
    Department of Pathology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Cytometry A 75:924-33. 2009
    ..side-populations," enriched in cancer stem cells and identified by reduced accumulation of Hoechst 33342 under ABCG2-mediated efflux, may compromise therapeutic outcome...
  33. pmc Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys
    Xingguo Cheng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Drug Metab Dispos 37:2178-85. 2009
    ..In conclusion, the mRNA expression of xenobiotic transporters in kidneys is determined by tissue, age, and sex hormones...
  34. pmc Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid
    Jun Shen
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer Res 69:5885-92. 2009
    ..The mean +/- SD ratios for wild-type, Mdr1a/b(-/-), Bcrp1(-/-), and Mdr1a/b(-/-)Bcrp1(-/-) mice were 3.07 +/- 0.09, 2.57 +/- 0.17, 1.63 +/- 0.12, and 0.86 +/- 0...
  35. doi Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2
    Dirk R de Waart
    Liver Center, Academic Medical Center, Meibergdreef 69 71, Amsterdam, The Netherlands
    Drug Metab Dispos 37:1698-702. 2009
    ..Abcc2, Abcc3, and Abcg2 are ATP-binding cassette (ABC) transporters that are expressed in both liver and intestine and are capable of ..
  36. pmc Effect of pregnancy on nitrofurantoin disposition in mice
    Yi Zhang
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195 7610, USA
    J Pharm Sci 98:4306-15. 2009
    We investigated the effect of pregnancy on nitrofurantoin (NFT) disposition in wild-type and Bcrp1(-/-) mice. Pregnant and non-pregnant mice were administered NFT intravenously (5 mg/kg) or orally (10 mg/kg)...
  37. doi Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan
    Serge A L Zander
    Division of Molecular Biology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands
    Cancer Res 70:1700-10. 2010
    ..As mechanisms of in vivo resistance, we identified overexpression of Abcg2/Bcrp and markedly reduced protein levels of the drug target Top1 (without altered mRNA levels)...
  38. pmc 17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity
    Anika M S Hartz
    Department of Biochemistry and Molecular Biology, University of Minnesota, Duluth, 55812, USA
    J Cereb Blood Flow Metab 30:1742-55. 2010
    The ATP-driven efflux transporter, breast cancer resistance protein (BCRP), handles many therapeutic drugs, including chemotherapeutics, limiting their ability to cross the blood-brain barrier...
  39. ncbi Akt signaling regulates side population cell phenotype via Bcrp1 translocation
    Masaki Mogi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:39068-75. 2003
    ..b>Bcrp1, which encodes the Hoechst dye transporter, was translocated from the membrane to the intracellular compartment ..
  40. doi Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
    Seng Chuan Tang
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Int J Cancer 130:223-33. 2012
    ..We aimed to investigate the in vivo roles of the ATP-binding cassette drug efflux transporters ABCB1 and ABCG2 in plasma pharmacokinetics and brain accumulation of oral sunitinib, and the feasibility of improving sunitinib ..
  41. doi Breast cancer-resistance protein (BCRP1) in the fetal mouse brain: development and glucocorticoid regulation
    Sophie Petropoulos
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Biol Reprod 84:783-9. 2011
    Breast cancer-resistance protein (BCRP1), encoded by Abcg2 mRNA, limits the penetration of a spectrum of compounds into the brain...
  42. doi Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor
    Liwen Li
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korean 21 Project, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, South Korea
    Gene Expr Patterns 11:163-70. 2011
    ..We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20...
  43. doi The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux
    Guohua An
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Bufflao, State University of New York, 517 Hochstetter Hall, Amherst, NY 14260 1200, USA
    Drug Metab Dispos 39:426-32. 2011
    ..The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of ..
  44. pmc Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
    Joseph Tam
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 120:2953-66. 2010
    ..These results suggest that targeting peripheral CB1R has therapeutic potential for alleviating cardiometabolic risk in obese patients...
  45. doi ABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer's disease
    Shanshan Shen
    Department of Clinical Medicine, Southeast University, Nanjing, China
    J Neurochem 114:1590-604. 2010
    ..We have previously observed that, in Alzheimer's disease brain, ABCG2 is up-regulated and AP-1 is activated, but NF-κB is not activated...
  46. doi The anti-oxidative role of ABCG2 in corneal epithelial cells
    Miyuki Kubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:5617-22. 2010
    b>ABCG2 is a putative marker of progenitor cells, including the corneal epithelium...
  47. doi BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization
    Junichi Shigeta
    Division of Chemotherapy, Faculty of Pharmacy, Keio University, Tokyo, Japan
    Cancer Sci 101:1813-21. 2010
    In previous studies, we demonstrated that the breast cancer resistance protein (BCRP, ABCG2) forms an S-S homodimer...
  48. pmc Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration
    Kathleen Kelly Tanaka
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    Cell Stem Cell 4:217-25. 2009
    ..We propose that this subset of SP cells (satellite-SP cells), characterized by ABCG2, Syndecan-4, and Pax7 expression, constitutes a self-renewing muscle stem cell capable of generating both ..
  49. pmc Porphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cells
    Jimmy Susanto
    Genomics Research Center, Academia Sinica, Taipei, Taiwan, Republic of China
    PLoS ONE 3:e4023. 2008
    ..The ATP binding cassette transporter ABCG2 is expressed in a wide variety of somatic and embryonic stem cells...
  50. ncbi Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice
    Johan W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Stem Cells 23:1059-65. 2005
    ..The ATP-binding cassette transporters Bcrp1 (Abcg2) and Mdr1a/1b (Abcb1a/1b) have been implicated as being responsible for this phenotype...
  51. pmc Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk
    Antonius E van Herwaarden
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 27:1247-53. 2007
    The multidrug transporter breast cancer resistance protein (BCRP/ABCG2) is strongly induced in the mammary gland during pregnancy and lactation...
  52. ncbi Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    J Am Soc Nephrol 18:37-45. 2007
    ..vesicles that expressed multidrug resistance-associated protein 4 (MRP4) and breast cancer resistance protein (BCRP)...
  53. ncbi Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors
    Honggang Wang
    Dept of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195 7610, USA
    Am J Physiol Endocrinol Metab 291:E1295-304. 2006
    ..Our goal was to investigate the effects of pregnancy on Bcrp1 expression in pregnant mice...
  54. ncbi Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promoters
    Yang Zong
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 281:29625-32. 2006
    b>ABCG2 encodes a transmembrane transporter associated with multidrug resistance in various cancer cells...
  55. ncbi Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo
    Markos Leggas
    Departments of Pharmaceutical Sciences, Hematology Oncology, and Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4802-7. 2006
    ..these effects have primarily been attributed to the inhibition of breast cancer resistance protein (BCRP; ABCG2)...
  56. ncbi Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele
    Mehrdad Tadjali
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Stem Cells 24:1556-63. 2006
    ..The Abcg2 transporter is expressed in hematopoietic stem cells (HSCs) and confers this dye efflux activity...
  57. ncbi Temporal/spatial expression and efflux activity of ABC transporter, P-glycoprotein/Abcb1 isoforms and Bcrp/Abcg2 during early murine development
    Wojciech T Sawicki
    Department of Histology and Embryology, Medical University of Warsaw, Poland
    Gene Expr Patterns 6:738-46. 2006
    ..Here, we present the study of temporal/spatial patterns of Abcb1 isoforms and Abcg2 transporter expression and efflux activity in pre- and early postimplantation murine embryos...
  58. ncbi Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk
    Antonius E van Herwaarden
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Carcinogenesis 27:123-30. 2006
    The breast cancer resistance protein (BCRP/ABCG2) usually protects the body from a wide variety of environmental and dietary xenotoxins by reducing their net uptake from intestine and by increasing their hepatobiliary, intestinal and ..
  59. ncbi The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in pat
    Pauline Breedveld
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 65:2577-82. 2005
    ..Previously, imatinib was shown to potently inhibit human breast cancer resistance protein (BCRP; ABCG2)...
  60. ncbi The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk
    Johan W Jonker
    The Netherlands Cancer Institute, Division of Experimental Therapy, Amsterdam, The Netherlands
    Nat Med 11:127-9. 2005
    ..Here we show that the multidrug transporter BCRP (encoded by ABCG2) is strongly induced in the mammary gland of mice, cows and humans during lactation and that it is responsible for ..
  61. ncbi A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice
    A Poltorak
    The Scripps Research Institute, La Jolla, CA 92037 Max Planck Institut für Immunbiologie, Freiburg, Germany
    J Immunol 167:2106-11. 2001
    ..Because the phosphorylation of STAT4 is a prerequisite for the IL-12-mediated induction of IFN-gamma, its absence in Cr mice is responsible for their defective IFN-gamma response to microorganisms...
  62. ncbi A genetic analysis of neural progenitor differentiation
    D H Geschwind
    Neurogenetics Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuron 29:325-39. 2001
    ..This combination of methods demonstrates the power of using custom microarrays derived from RDA-subtracted libraries for both gene discovery and gene expression analysis in the central nervous system...
  63. ncbi Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
    J W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Natl Cancer Inst 92:1651-6. 2000
    ..We also used the BCRP inhibitor GF120918 to assess the role of BCRP in protecting mice against xenobiotic drugs. Bcrp1, the murine homologue of BCRP, was expressed in the polarized mammalian cell lines LLC-PK1 and MDCK-II, and the ..
  64. ncbi Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus
    L M Schriml
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Genomics 64:24-31. 2000
    ..The mouse ABC genes could be grouped into the seven previously described human ABC subfamilies. Three mouse ABC genes mapped to regions implicated in cholesterol gallstone susceptibility...
  65. ncbi The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin
    J D Allen
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 59:4237-41. 1999
    ..Each of the resulting drug-resistant lines showed marked gene amplification of Bcrp1, the mouse homologue of the human ATP-binding cassette transporter gene BCRP/MXR/ABCP, and greatly elevated ..
  66. ncbi cGMP transport by vesicles from human and mouse erythrocytes
    Cornelia J F De Wolf
    Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    FEBS J 274:439-50. 2007
    ..by the ABCC4-specific substrate prostaglandin E1, cGMP transport into mouse vesicles was inhibited equally by Abcg2 and Abcc4 inhibitors/substrates...
  67. ncbi Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine
    Guoyu Pan
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Dispos 35:1165-73. 2007
    ..of this study was to characterize the interaction of these nucleoside reverse transcriptase inhibitors with the Abcg2/Bcrp1 transporter, the murine homolog of human breast cancer resistance protein (BCRP), using a Bcrp1-transfected ..
  68. doi ABCG2 is expressed in late spermatogenesis and is associated with the acrosome
    Christian Scharenberg
    Department of Anatomy and Cell Biology, Saarland University, Building 61, 66421 Homburg, Germany
    Biochem Biophys Res Commun 378:302-7. 2009
    ..for the isolation of stem cells is based on the increased efflux of Hoechst 33342 lipophilic dye mediated by ABCG2, an ATP-binding cassette transporter which is highly expressed in various stem cells...
  69. pmc Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice
    Suneet Shukla
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, 20892 4256, USA
    Pharm Res 26:480-7. 2009
    To evaluate the in vivo efficacy of curcumin as an inhibitor of the multidrug-resistance-linked ATP Binding Cassette (ABC) drug transporter, ABCG2.
  70. pmc Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells
    Otmar Pfister
    Cardiac Muscle Research Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:825-35. 2008
    ..SP cells are identified and characterized by a unique efflux of Hoechst 33342 dye. Abcg2 belongs to the ATP-binding cassette (ABC) transporter superfamily and constitutes the molecular basis for the dye ..
  71. doi Comparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland
    Yeun Jung Kim
    Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University, Seodaemoon Gu, Seoul, 120 752, Korea
    Cell Tissue Res 334:47-53. 2008
    ..We found that LRCs were distributed in the acinus, duct, myoepithelium, and connective tissue. Moreover, ABCG2 (a known stem cell marker) was used for the characterization of LRCs and the localization of cells as putative ..
  72. doi Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions
    Uwe Muenster
    Department of Metabolism and Pharmacokinetics, Bayer HealthCare AG, Aprather Weg, 42096, Wuppertal Aprath, Germany
    Pharm Res 25:2320-6. 2008
    ..To have well described experimental tools at hand, the objective of the study was to characterize substrates and inhibitors of Breast Cancer Resistance Protein (BCRP) and P-glycoprotein (P-gp).
  73. ncbi The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study
    Lin Zhou
    Department of Pharmaceutics, School of Pharmacy, Box 357610, University of Washington, Seattle, WA 98195, USA
    Mol Pharmacol 73:949-59. 2008
    ..In this study, we first determined whether GLB is a BCRP/Bcrp1 substrate...
  74. ncbi In vivo relevance of Mrp2-mediated biliary excretion of the Amanita mushroom toxin demethylphalloin
    Olga Gavrilova
    Institute of Pharmacology and Toxicology, Justus Liebig University of Giessen, Frankfurter Str 107, D 35392 Giessen, Germany
    Biochim Biophys Acta 1768:2070-7. 2007
    ..and in Mrp2 deficient TR(-) Wistar rats as well as in normal wild-type FVB mice, Mdr1a,b(-/-) knockout mice, and Bcrp1(-/-) knockout mice by in situ bile duct/gallbladder cannulation. A subtoxic dose of 0.03 mg DMP/kg b.w...
  75. ncbi Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier
    Sébastien Bihorel
    Universite Paris Descartes, Faculte de Pharmacie, Neuropsychopharmacologie des Addictions, CNRS, UMR7157 et Université Paris 7, France
    J Neurochem 102:1749-57. 2007
    ..by p-glycoprotein (p-gp or multidrug resistance protein Mdr1a), and probably by breast cancer resistance protein (Bcrp1), two efflux pumps expressed at the blood-brain barrier (BBB)...
  76. ncbi Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells
    C Brendel
    Department of Hematology, Oncology and Immunology, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Leukemia 21:1267-75. 2007
    ..The ATP binding-cassette transporters ABCB1 (MDR-1; P-glycoprotein) and ABCG2 are highly expressed on primitive hematopoietic stem cells (HSCs) and have been shown to interact with TKIs...
  77. ncbi Breast cancer resistance protein (Bcrp1/Abcg2) in mouse placenta and yolk sac: ontogeny and its regulation by progesterone
    G M Kalabis
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Placenta 28:1073-81. 2007
    ..We hypothesised that there are changes in placental Bcrp1 (the mouse orthologue of human BCRP) expression during pregnancy and that these correlate with changes in ..
  78. ncbi Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse
    Yi Zhang
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA
    Drug Metab Dispos 35:2154-8. 2007
    ..In the present study, we examined whether Bcrp1, the murine homolog of human BCRP, limits fetal distribution of the model BCRP/Bcrp1 substrate, nitrofurantoin (..
  79. pmc PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    Anne Marie Bleau
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 4:226-35. 2009
    ..By drug efflux, the ABCG2 transporter provides chemoresistance in stem cells and contributes to the blood brain barrier (BBB) when active in ..
  80. ncbi Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients
    Tetsuo Yamagata
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Drug Metab Dispos 35:1142-8. 2007
    Recently, breast cancer resistance protein (BCRP/ABCG2) has been shown to limit the oral absorption of its substrates in the intestine...
  81. ncbi Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution
    Kazumasa Takenaka
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Cancer Res 67:6965-72. 2007
    ..of the purine nucleotide analogue, 9-(2-(phosphonomethoxy)ethyl)-adenine (PMEA), and up-regulation of Abcg2 in some tissues of the Mrp4 KO mouse prompted us to evaluate the possibility that Abcg2 might transport purine-..
  82. ncbi Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein
    John D Allen
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Res 63:1339-44. 2003
    The breast cancer resistance protein [BCRP (BCRP/ABCG2)] has not previously been directly identified as a source of resistance to epipodophyllotoxins...
  83. ncbi Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier
    Salvatore Cisternino
    Institut National de la Santé et de la Recherche Médicale U26, Hopital Fernand Widal, Paris, France
    Cancer Res 64:3296-301. 2004
    The breast cancer resistance protein (BCRP/ABCG2) is, like P-glycoprotein (P-gp), a member of the ABC family of drug transporters. These proteins actively transport various anticancer drugs from cells, causing multidrug resistance...
  84. ncbi PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine
    Toshitake Hirai
    Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Biol Pharm Bull 30:2185-90. 2007
    ..seven nutrient/drug transporters (Abcd3, Octn2/Slc22a5, FATP2/Slc27a2, Slc22a21, Mct13/Slc16a13, Slc23a1 and Bcrp/Abcg2) in the intestine were up-regulated and the expression level of one (Mrp1/Abcc1) was down-regulated by PPARalpha; ..
  85. ncbi A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
    R Allikmets
    Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Cancer Res 58:5337-9. 1998
    ..The gene, ABCP, produces two transcripts that differ at the 5' end and encode the same 655-amino acid protein...
  86. doi Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2
    Julie Cattelotte
    INSERM U705, CNRS UMR 7157, Universite Paris Descartes, Universite Paris Diderot, Paris, France
    J Neurochem 108:767-75. 2009
    ..influence of BBB features like the ATP-binding cassette transporters (Abcb1/P-glycoprotein (P-gp), Abcc1/Mrp1, and Abcg2/Bcrp), organic cation transporters (Slc22a1-3/Oct1-3), the transmembrane potential and the dipole membrane ..

Research Grants32

  1. Identification of targets of FoxP2 in the brain
    Daniel Geschwind; Fiscal Year: 2006
    ..This proposal has a strong screening component in an area where no molecular mechanisms have been identified and fits well within the R21 framework. ..
  2. Phase I and Biological Studies of DB67 - A Blood Stable Camptothecin
    Markos Leggas; Fiscal Year: 2007
    ..Ultimately, the objective is to use DB-67 as a single agent or in combination with other molecular-targeted therapies or cytotoxics in frontline therapy with the goal to improve overall patient outcome. ..
  3. Training Grant in Neurobehavioral Genetics
    Daniel Geschwind; Fiscal Year: 2007
    ....
  4. Identification and Characterization of Asymmetrically-Expressed Genes
    Daniel Geschwind; Fiscal Year: 2007
    ..All of this will clearly inform the study of human neurodevelopmental disorders that are related to speech and language, as well as probe the utility and limitations of animal models for these disorders. ..
  5. Novel Genetic Risk Factors for Alzheimer's Disease (AD) & Frontotemporal Dementia
    Daniel Geschwind; Fiscal Year: 2007
    ..abstract_text> ..
  6. A Comprehensive Approach to Identification of Autism Susceptibility Genes
    Daniel H Geschwind; Fiscal Year: 2010
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, including minority families, further enhancing the value of this resource to the community. ..
  7. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2006
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  8. Genomewide Search--Autism Susceptibility Loci-supplement
    Daniel Geschwind; Fiscal Year: 2003
    ..This work is a direct response to Title 1 of the Pediatric Health Act of 2000 which authorizes and mandates an increased NIH commitment to autism gene banking. ..
  9. ASYMMETRICALLY EXPRESSED GENES IN DEVELOPING CEREBRUM
    Daniel Geschwind; Fiscal Year: 2003
    ..abstract_text> ..
  10. THE GENETICS OF IDIOPATHIC BASAL GANGLIA CALCIFICATION
    Daniel Geschwind; Fiscal Year: 2004
    ..Physical mapping and candidate screening for mutations will be pursued as the region is narrowed to identify the IBGC gene. A genome scan will be performed in families who are not linked to the chr.14 locus. ..
  11. Novel Genetic Risk Factors for Alzheimer's Disease (AD) & Frontotemporal Dementia
    Daniel Geschwind; Fiscal Year: 2009
    ..abstract_text> ..