Abcg1

Summary

Gene Symbol: Abcg1
Description: ATP binding cassette subfamily G member 1
Alias: AW413978, Abc8, White, ATP-binding cassette sub-family G member 1, ATP-binding cassette 8, ATP-binding cassette transporter 8, ATP-binding cassette, sub-family G (WHITE), member 1, white protein homolog
Species: mouse
Products:     Abcg1

Top Publications

  1. Terasaka N, Yu S, Yvan Charvet L, Wang N, Mzhavia N, Langlois R, et al. ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest. 2008;118:3701-13 pubmed publisher
    ..of HDL on ECs depend on its involvement in cholesterol efflux via the ATP-binding cassette transporters ABCA1 and ABCG1, which promote efflux of cholesterol and oxysterols from macrophages, has not been investigated...
  2. Tarr P, Edwards P. ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. J Lipid Res. 2008;49:169-82 pubmed
    Here, we describe the initial characterization of Abcg4(-/-) mice and identify overlapping functions of ABCG4 and ABCG1 in the brain...
  3. Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen I, Zhao Y, et al. Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1. Circ Res. 2008;102:113-20 pubmed
    ..ABCA1 and ABCG1 are two cholesterol transporters that may act sequentially to remove cellular cholesterol, but currently their ..
  4. Murphy A, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo C, et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest. 2011;121:4138-49 pubmed publisher
    ..progenitor cells (HSPCs) in mice with deficiencies of the cholesterol efflux-promoting ABC transporters ABCA1 and ABCG1 in BM cells...
  5. Adorni M, Zimetti F, Billheimer J, Wang N, Rader D, Phillips M, et al. The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res. 2007;48:2453-62 pubmed
    ..Using macrophages from scavenger receptor class B type I (SR-BI)-, ABCA1-, and ABCG1-knockout mice, together with inhibitors of SR-BI- and ABCA1-mediated efflux, we were able to quantitate efflux ..
  6. Sturek J, Castle J, Trace A, Page L, Castle A, Evans Molina C, et al. An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. J Clin Invest. 2010;120:2575-89 pubmed publisher
    ..The ATP-binding cassette transporter G1 (ABCG1) has been shown to play a role in cholesterol efflux, but its role in beta cells is currently unknown...
  7. Tansley G, Burgess B, Bryan M, Su Y, Hirsch Reinshagen V, Pearce J, et al. The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein. J Lipid Res. 2007;48:1022-34 pubmed
    ..The cholesterol transporter ABCG1 facilitates cholesterol efflux to HDL and is expressed in brain...
  8. Armstrong A, Gebre A, Parks J, Hedrick C. ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. J Immunol. 2010;184:173-83 pubmed publisher
    ..We demonstrate that ATP-binding cassette transporter G1 (ABCG1) regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells...
  9. Out R, Hoekstra M, Habets K, Meurs I, De Waard V, Hildebrand R, et al. Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels. Arterioscler Thromb Vasc Biol. 2008;28:258-64 pubmed
    The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis.

More Information

Publications89

  1. Bojanic D, Tarr P, Gale G, Smith D, Bok D, Chen B, et al. Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010;51:169-81 pubmed publisher
    b>ABCG1 and ABCG4 are highly homologous members of the ATP binding cassette (ABC) transporter family that regulate cellular cholesterol homeostasis...
  2. Yvan Charvet L, Ranalletta M, Wang N, Han S, Terasaka N, Li R, et al. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest. 2007;117:3900-8 pubmed
    ..can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporters ABCA1 and ABCG1. Experiments addressing the individual roles of ABCA1 and ABCG1 in the development of atherosclerosis have ..
  3. Wang N, Lan D, Chen W, Matsuura F, Tall A. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A. 2004;101:9774-9 pubmed
    ..We show that two ABC transporters of unknown function, ABCG1 and ABCG4, mediate isotopic and net mass efflux of cellular cholesterol to HDL...
  4. Yvan Charvet L, Pagler T, Gautier E, Avagyan S, Siry R, Han S, et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science. 2010;328:1689-93 pubmed publisher
    ..Mice deficient in the adenosine triphosphate-binding cassette (ABC) transporters ABCA1 and ABCG1, which promote cholesterol efflux from macrophages and suppress atherosclerosis in hypercholesterolemic mice, ..
  5. Whetzel A, Sturek J, Nagelin M, Bolick D, Gebre A, Parks J, et al. ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol. 2010;30:809-17 pubmed publisher
    ..Endothelial cells (EC) have a high capacity to efflux sterols and express the ABC transporter, ABCG1. Here, we define the role of ABCG1 in the regulation of lipid homeostasis and inflammation in aortic EC.
  6. Yvan Charvet L, Welch C, Pagler T, Ranalletta M, Lamkanfi M, Han S, et al. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation. 2008;118:1837-47 pubmed publisher
    Two macrophage ABC transporters, ABCA1 and ABCG1, have a major role in promoting cholesterol efflux from macrophages. Peritoneal macrophages deficient in ABCA1, ABCG1, or both show enhanced expression of inflammatory and chemokine genes...
  7. Pereira P, Magnol L, Sahún I, Brault V, Duchon A, Prandini P, et al. A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet. 2009;18:4756-69 pubmed publisher
    ..Here we show that the trisomy of the 12 genes, found in the 0.59 Mb (Abcg1-U2af1) Hsa21 sub-telomeric region, in mice (Ts1Yah) produced defects in novel object recognition, open-field and Y-..
  8. Bensinger S, Bradley M, Joseph S, Zelcer N, Janssen E, Hausner M, et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008;134:97-111 pubmed publisher
    ..Inactivation of the sterol transporter ABCG1 uncouples LXR signaling from proliferation, directly linking sterol homeostasis to the antiproliferative action of ..
  9. Meurs I, Lammers B, Zhao Y, Out R, Hildebrand R, Hoekstra M, et al. The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis. Atherosclerosis. 2012;221:41-7 pubmed publisher
    As ABCG1 plays a role in cholesterol efflux, macrophage ABCG1 expression has been suggested to protect against atherosclerosis. However, we and others observed varying effects of ABCG1 deficiency on atherosclerotic lesion size...
  10. Westerterp M, Gourion Arsiquaud S, Murphy A, Shih A, Cremers S, Levine R, et al. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell. 2012;11:195-206 pubmed publisher
    ..with defects in cholesterol efflux pathways due to deficiencies of the ATP binding cassette transporters ABCA1 and ABCG1 displayed a dramatic increase in HSPC mobilization and extramedullary hematopoiesis...
  11. Burgess B, Parkinson P, Racke M, Hirsch Reinshagen V, Fan J, Wong C, et al. ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo. J Lipid Res. 2008;49:1254-67 pubmed publisher
    ..The cholesterol transporter ABCG1 is LXR-responsive and highly expressed in brain...
  12. Nakamura K, Kennedy M, Baldán A, Bojanic D, Lyons K, Edwards P. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J Biol Chem. 2004;279:45980-9 pubmed
    The murine Abcg1 gene is reported to consist of 15 exons that encode a single mRNA (herein referred to as Abcg1-a) and protein...
  13. Westerterp M, Tsuchiya K, Tattersall I, Fotakis P, Bochem A, Molusky M, et al. Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2016;36:1328-37 pubmed publisher
    ..The ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) interact with high-density lipoproteins to promote cholesterol efflux from ECs...
  14. Zhao G, Tang S, Lv Y, Ouyang X, He P, Yao F, et al. NF-?B suppresses the expression of ATP-binding cassette transporter A1/G1 by regulating SREBP-2 and miR-33a in mice. Int J Cardiol. 2014;171:e93-5 pubmed publisher
  15. Chellan B, Yan L, Sontag T, Reardon C, HOFMANN BOWMAN M. IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1. J Lipid Res. 2014;55:443-54 pubmed publisher
    ..in myeloid cells [human bacterial artificial chromosome (hBAC)/S100] have increased lipid content and reduced ABCG1 expression and [(3)H]cholesterol efflux compared with WT littermates...
  16. Tsun J, Yung S, Chau M, Shiu S, Chan T, Tan K. Cellular cholesterol transport proteins in diabetic nephropathy. PLoS ONE. 2014;9:e105787 pubmed publisher
    ..cholesterol transport proteins including adenosine triphosphate binding cassette transporter A1 (ABCA1), G1 (ABCG1) and scavenger receptor class B type I (SR-BI) in diabetic nephropathy...
  17. Sag D, Cekic C, Wu R, Linden J, Hedrick C. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun. 2015;6:6354 pubmed publisher
    ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity...
  18. Ogura M, Ayaori M, Terao Y, Hisada T, Iizuka M, Takiguchi S, et al. Proteasomal inhibition promotes ATP-binding cassette transporter A1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2011;31:1980-7 pubmed publisher
    ATP-binding cassette transporter A1 (ABCA1) and ABCG1 are key molecules in an initial step of reverse cholesterol transport (RCT), a major antiatherogenic property of high-density lipoprotein (HDL)...
  19. Ji A, Meyer J, Cai L, Akinmusire A, de Beer M, Webb N, et al. Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis. 2011;217:106-12 pubmed publisher
    ..SR-BI, the other scavenger receptors SRA and CD36 and the ATP-binding cassette transporters ABCA1 and ABCG1 were each distinctly regulated during BMM differentiation...
  20. Cheng L, Su K, Kou Y, Shyue S, Ching L, Yu Y, et al. ?-Lipoic acid ameliorates foam cell formation via liver X receptor ?-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radic Biol Med. 2011;50:47-54 pubmed publisher
    ..LA treatment dose-dependently increased protein levels of ATP-binding cassette transporter A1 (ABCA1) and ABCG1 but had no effect on the protein expression of SR-A, CD36, or SR-BI involved in cholesterol homeostasis...
  21. Tarling E, Bojanic D, Tangirala R, Wang X, Lovgren Sandblom A, Lusis A, et al. Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arterioscler Thromb Vasc Biol. 2010;30:1174-80 pubmed publisher
    To generate Abcg1(-/-) Apoe(-/-) mice to understand the mechanism and cell types involved in changes in atherosclerosis after loss of ABCG1.
  22. Cheng H, Gaddis D, Wu R, McSkimming C, Haynes L, Taylor A, et al. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest. 2016;126:3236-46 pubmed publisher
    ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol accumulation and alters T cell homeostasis, which may contribute to progression of atherosclerosis...
  23. Tarling E, Edwards P. Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report. Arterioscler Thromb Vasc Biol. 2016;36:1323-7 pubmed publisher
    ..in Arteriosclerosis, Thrombosis, and Vascular Biology, it was reported that ATP-binding cassette transporter G1 (ABCG1) containing leucine at position 550 (ABCG1-L550) was localized to the plasma membrane, whereas ABCG1-P550 (proline ..
  24. Mostafa A, Hamdy N, El Mesallamy H, Abdel Rahman S. Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes. Biochem Biophys Res Commun. 2015;468:900-5 pubmed publisher
    ..Members of the ATP-binding cassette (ABC) transporters, including ABCA1 and ABCG1, play essential roles in reverse cholesterol transport and in high density lipoprotein (HDL) formation...
  25. Xue S, Wang J, Zhang X, Shi Y, Li B, Bao Q, et al. Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis. Biochem Biophys Res Commun. 2016;477:247-54 pubmed publisher
    ..ATP-binding cassette G1 (ABCG1) is a crucial factor maintaining sterol and lipid homeostasis by transporting cholesterol efflux to high-density ..
  26. Ji A, Wroblewski J, Cai L, de Beer M, Webb N, van der Westhuyzen D. Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI. J Lipid Res. 2012;53:446-55 pubmed publisher
    To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice...
  27. Matsuura F, Wang N, Chen W, Jiang X, Tall A. HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. J Clin Invest. 2006;116:1435-42 pubmed
    ..Recently, the ATP-binding cassette transporter ABCG1, a macrophage liver X receptor (LXR) target, has been shown to stimulate cholesterol efflux to HDL...
  28. Maréchal D, Lopes Pereira P, Duchon A, Herault Y. Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome. PLoS ONE. 2015;10:e0115302 pubmed publisher
    ..In this report we analyzed the contribution of the genetic dosage of 13 conserved mouse genes located between Abcg1 and U2af1, in the telomeric part of Hsa21...
  29. Nagelin M, Srinivasan S, Lee J, Nadler J, Hedrick C. 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. Arterioscler Thromb Vasc Biol. 2008;28:1811-9 pubmed publisher
    The purpose of this study was to evaluate the effect of 12/15-lipoxygenase (12/15LO) in macrophage ABCG1 expression and function associated with cholesterol efflux.
  30. Khovidhunkit W, Moser A, Shigenaga J, Grunfeld C, Feingold K. Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. J Lipid Res. 2003;44:1728-36 pubmed
    ..In macrophages, ABCA1 and ABCG1 mediate cholesterol removal from these cells to HDL...
  31. Pascual García M, Carbó J, Leon T, Matalonga J, Out R, Van Berkel T, et al. Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4. J Immunol. 2011;186:4656-67 pubmed publisher
    ..These observations suggest a role for LXR agonists in limiting macrophage proliferative responses associated to pathogenic disorders. ..
  32. Mostafa A, Hamdy N, Abdel Rahman S, El Mesallamy H. Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes. IUBMB Life. 2016;68:535-43 pubmed publisher
    ..the liver X receptor (LXR) which regulates the expression of the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1. A decrease in the expression of these transporters eventually leads to decreased cholesterol efflux from ..
  33. Shridas P, Bailey W, Gizard F, Oslund R, Gelb M, Bruemmer D, et al. Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages. Arterioscler Thromb Vasc Biol. 2010;30:2014-21 pubmed publisher
    ..a novel role for group X (GX) secretory phospholipase A(2) (sPLA(2)) in modulating ATP binding casette transporter A1 (ABCA1) and ATP binding casette transporter G1 (ABCG1) expression and, therefore, macrophage cholesterol efflux.
  34. Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel Wahab O, et al. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med. 2013;210:339-53 pubmed publisher
    ..These experiments suggest that inhibition of Glut-1 and HDL cholesterol-raising therapies could provide novel therapeutic approaches to treat the energy imbalance observed in myeloproliferative disorders...
  35. Sano O, Tsujita M, Shimizu Y, Kato R, Kobayashi A, Kioka N, et al. ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production. PLoS ONE. 2016;11:e0155400 pubmed publisher
    ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors...
  36. Wiersma H, Nijstad N, de Boer J, Out R, Hogewerf W, van Berkel T, et al. Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet. Atherosclerosis. 2009;206:141-7 pubmed publisher
    The ATP Binding Cassette transporter G1 (ABCG1) has been implicated in cholesterol efflux towards HDL and reverse cholesterol transport (RCT). Biliary cholesterol secretion is considered as an important step in RCT...
  37. Lammers B, Out R, Hildebrand R, Quinn C, Williamson D, Hoekstra M, et al. Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development. Atherosclerosis. 2009;205:420-6 pubmed publisher
    ATP-binding cassette transporter G1 (Abcg1) and apolipoprotein E (Apoe) play a role in macrophage cholesterol efflux and consequently the development of atherosclerosis...
  38. Wojcik A, Skaflen M, Srinivasan S, Hedrick C. A critical role for ABCG1 in macrophage inflammation and lung homeostasis. J Immunol. 2008;180:4273-82 pubmed
    ATP-binding cassette transporter G1 (ABCG1) effluxes cholesterol from macrophages and plays an important role in pulmonary lipid homeostasis...
  39. Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, et al. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition. Biochim Biophys Acta. 2016;1861:1180-1191 pubmed publisher
    Expression of ATP-binding cassette transporter G1 (ABCG1), a molecule facilitating cholesterol efflux to HDL, is activated by liver X receptor (LXR)...
  40. Wang N, Ranalletta M, Matsuura F, Peng F, Tall A. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Arterioscler Thromb Vasc Biol. 2006;26:1310-6 pubmed
    This study examines the ABCG1-mediated cholesterol efflux and intracellular cholesterol transport by studying the ABCG1 localization and function in macrophages.
  41. Lai L, Azzam K, Lin W, Rai P, Lowe J, Gabor K, et al. MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains. J Biol Chem. 2016;291:19651-60 pubmed publisher
    ..miRNAs regulate macrophage cholesterol by targeting the lipid efflux transporters ATP binding cassette (ABC)A1 and ABCG1. We and others have previously reported that Abca1(-/-) and Abcg1(-/-) macrophages have increased TLR ..
  42. Morales C, Marat A, Ni X, Yu Y, Oko R, Smith B, et al. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. Biochem Biophys Res Commun. 2008;376:472-7 pubmed publisher
    ..transporters are members of the ATP-binding cassette (ABC) transporter superfamily including ABCA1, ABCA7, ABCG1 and ABCG4, which have all been implicated in the transport of sterols and phospholipids to apolipoproteins and HDL...
  43. Wei H, Tarling E, McMillen T, Tang C, LeBoeuf R. ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction. J Lipid Res. 2015;56:2337-47 pubmed publisher
    ..We previously showed that ABCG1 is robustly upregulated in ATMs taken from obese mice and further enhanced by caloric restriction...
  44. Out R, Hoekstra M, Hildebrand R, Kruit J, Meurs I, Li Z, et al. Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2006;26:2295-300 pubmed
    b>ABCG1 has recently been identified as a facilitator of cellular cholesterol and phospholipid efflux to high-density lipoprotein (HDL)...
  45. Wang X, Collins H, Ranalletta M, Fuki I, Billheimer J, Rothblat G, et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest. 2007;117:2216-24 pubmed
    Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular acceptors in vitro and influence atherosclerosis in mice, but ..
  46. Miao L, Okoro E, Cao Z, Yang H, Motley Johnson E, Guo Z. High-density lipoprotein-mediated transcellular cholesterol transport in mouse aortic endothelial cells. Biochem Biophys Res Commun. 2015;465:256-61 pubmed publisher
    ..Knockdown of ATP-binding cassette transporter G1 (ABCG1) or scavenger receptor class B type I (SR-B1), or inhibition of SR-B1 diminished HDL-induced transendothelial ..
  47. Hirai T, Fukui Y, Motojima K. PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine. Biol Pharm Bull. 2007;30:2185-90 pubmed
    ..We propose that the transport processes can be coordinately regulated with intracellular metabolism by nutrient nuclear receptors...
  48. Venkateswaran A, Repa J, Lobaccaro J, Bronson A, Mangelsdorf D, Edwards P. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J Biol Chem. 2000;275:14700-7 pubmed
    ..The mRNA encoded the human White protein, a member of the ATP-binding cassette (ABC) transporter superfamily of proteins...
  49. Luquain Costaz C, Lefai E, Arnal Levron M, Markina D, Sakai S, Euthine V, et al. Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux. Arterioscler Thromb Vasc Biol. 2013;33:1803-11 pubmed publisher
    ..This study was designed to delineate the consequences of macrophage BMP accumulation on intracellular cholesterol distribution, metabolism, and efflux and to unravel the underlying molecular mechanisms...
  50. Engel T, Fobker M, Buchmann J, Kannenberg F, Rust S, Nofer J, et al. 3?,5?,6?-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency. Atherosclerosis. 2014;235:122-9 pubmed publisher
    ..Efficient oxysterol removal by the sub-family G member 1 of the ATP-binding cassette transporters (ABCG1) is essential for cell survival and control of cellular processes...
  51. Thomassen M, Barna B, Malur A, Bonfield T, Farver C, Malur A, et al. ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis. J Lipid Res. 2007;48:2762-8 pubmed
    ..We investigated ABCG1 and ABCA1 expression in alveolar macrophages of PAP patients and GM-CSF knockout (KO) mice, which exhibit PAP-like ..
  52. Tarling E, Edwards P. ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A. 2011;108:19719-24 pubmed publisher
    ..The residues responsible for this transport are unknown. The mechanism of action of ABCG1 is controversial and it has been proposed to act at the plasma membrane to facilitate the efflux of cellular ..
  53. Ito T. Physiological function of ABCG1. Drug News Perspect. 2003;16:490-2 pubmed
    ..b>ABCG1 is an ABC half transporter that facilitates efflux excess cholesterol from macrophages...
  54. Baldán A, Tarr P, Vales C, Frank J, Shimotake T, Hawgood S, et al. Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis. J Biol Chem. 2006;281:29401-10 pubmed
    We show that mice lacking the ATP-binding cassette transmembrane transporter ABCG1 show progressive and age-dependent severe pulmonary lipidosis that recapitulates the phenotypes of different respiratory syndromes in both humans and mice...
  55. Akiyama T, Sakai S, Lambert G, Nicol C, Matsusue K, Pimprale S, et al. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002;22:2607-19 pubmed
    ..in basal and troglitazone-stimulated expression of the genes encoding lipoprotein lipase, CD36, LXR alpha, and ABCG1 in thioglycolate-elicited peritoneal macrophages...
  56. Adlakha Y, Khanna S, Singh R, Singh V, Agrawal A, Saini N. Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXR? expression and cholesterol homeostasis. Cell Death Dis. 2013;4:e780 pubmed publisher
    ..Cholesterol efflux via ATP-binding cassette transporters (ABCA1 and ABCG1) is a mechanism for cells to eliminate excess cholesterol and prevent cellular cholesterol accumulation...
  57. A Gonzalez N, Bensinger S, Hong C, Beceiro S, Bradley M, Zelcer N, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009;31:245-58 pubmed publisher
    ..Thus, activation of LXR by apoptotic cells engages a virtuous cycle that promotes their own clearance and couples engulfment to the suppression of inflammatory pathways. ..
  58. Lorkowski S, Rust S, Engel T, Jung E, Tegelkamp K, Galinski E, et al. Genomic sequence and structure of the human ABCG1 (ABC8) gene. Biochem Biophys Res Commun. 2001;280:121-31 pubmed
    ..Nevertheless, both promoters responded in macrophages to stimulation by hydroxycholesterol and retinoic acid...
  59. Gelissen I, Sharpe L, Sandoval C, Rao G, Kockx M, Kritharides L, et al. Protein kinase A modulates the activity of a major human isoform of ABCG1. J Lipid Res. 2012;53:2133-40 pubmed publisher
    b>ABCG1 is an ABC half-transporter that exports cholesterol from cells to HDL...
  60. Yvan Charvet L, Pagler T, Seimon T, Thorp E, Welch C, Witztum J, et al. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 2010;106:1861-9 pubmed publisher
    ..The ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in promoting cholesterol efflux from macrophages to apolipoprotein A-1 and HDL and are ..
  61. Li D, Zhang Y, Ma J, Ling W, Xia M. Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2010;30:1354-62 pubmed publisher
    ..In this study, we examined whether the beneficial effects of AMPK on ECs are dependent on its involvement in cholesterol efflux and its impact on hypercholesterolemia-induced endothelial dysfunction...
  62. Nagelin M, Srinivasan S, Nadler J, Hedrick C. Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. J Biol Chem. 2009;284:31303-14 pubmed publisher
    ..We have previously demonstrated that 12/15LO enhances the turnover and serine phosphorylation of ABCG1. In the current study, we further elucidate the mechanisms by which 12/15LO regulates ABCG1...
  63. Olivier M, BottG R, Frisdal E, Nowick M, Plengpanich W, Desmarchelier C, et al. ABCG1 is involved in vitamin E efflux. Biochim Biophys Acta. 2014;1841:1741-51 pubmed
    ..aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcgl-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues ..
  64. Terasaka N, Wang N, Yvan Charvet L, Tall A. High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. Proc Natl Acad Sci U S A. 2007;104:15093-8 pubmed
    ..The ATP-binding cassette transporter ABCG1 was recently shown to promote efflux of cholesterol from macrophages to high-denisty lipoprotein (HDL)...
  65. Edgel K, McMillen T, Wei H, Pamir N, Houston B, Caldwell M, et al. Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice. Biochim Biophys Acta. 2012;1821:425-34 pubmed publisher
    ..The major finding was a marked elevation in epididymal adipose ABCG1 mRNA levels with obesity and CR (6-fold and 16-fold, respectively) over that seen for lean wild-type mice...
  66. Mauldin J, Srinivasan S, Mulya A, Gebre A, Parks J, Daugherty A, et al. Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation. J Biol Chem. 2006;281:21216-24 pubmed
    ..peritoneal macrophages isolated from Type 2 diabetic db/db mice have decreased expression of the ABC transporter ABCG1 and increased expression of the scavenger receptor CD36...
  67. Vaughan A, Oram J. ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. J Lipid Res. 2006;47:2433-43 pubmed
    ..the transport of cholesterol and phospholipids from cells to lipid-poor apolipoprotein A-I (apoA-I), whereas ABCG1 and ABCG4 mediate the transport of cholesterol from cells to lipidated lipoproteins...
  68. Baldán A, Gomes A, Ping P, Edwards P. Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol. 2008;180:3560-8 pubmed
    b>ABCG1, a member of the ATP-binding cassette transporter superfamily, is highly expressed in multiple cells of the lung...
  69. Freeman S, Jin X, Anzinger J, Xu Q, Purushothaman S, Fessler M, et al. ABCG1-mediated generation of extracellular cholesterol microdomains. J Lipid Res. 2014;55:115-27 pubmed publisher
    Previous studies have demonstrated that the ATP-binding cassette transporters (ABC)A1 and ABCG1 function in many aspects of cholesterol efflux from macrophages...
  70. Cavelier C, Lorenzi I, Rohrer L, von Eckardstein A. Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. Biochim Biophys Acta. 2006;1761:655-66 pubmed
    ..The ATP-binding cassette transporters ABCA1 and ABCG1 play a pivotal role in this process by effluxing lipids from foam cells to apoA-I and HDL, respectively...
  71. Lindegaard M, Wassif C, Vaisman B, Amar M, Wasmuth E, Shamburek R, et al. Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome. Hum Mol Genet. 2008;17:3806-13 pubmed publisher
    ..The cholesterol transporters Abca1, Abcg1, and Sr-b1 are present in placenta; however, their potential role in placental transport remains undetermined...
  72. Savary S, Denizot F, Luciani M, Mattei M, Chimini G. Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene. Mamm Genome. 1996;7:673-6 pubmed
    ..Three of them, white, brown, and scarlet, have been directly implicated in the import of pigment precursors into the cells...
  73. Cochran B, Hou L, Manavalan A, Moore B, Tabet F, Sultana A, et al. Impact of Perturbed Pancreatic ?-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism. Diabetes. 2016;65:3610-3620 pubmed
    ..cholesterol levels were generated by conditional deletion of the ATP-binding cassette transporters, ABCA1 and ABCG1, in ?-cells (?-DKO mice)...
  74. Lin Y, Jian D, Kwok C, Ho L, Juan C. VISFATIN PROMOTES FOAM CELL FORMATION BY DYSREGULATING CD36, SRA, ABCA1, AND ABCG1 EXPRESSION IN RAW264.7 MACROPHAGES. Shock. 2016;45:460-8 pubmed publisher
    ..and scavenger receptor A (SRA), decreased the expression of ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1), and had no effect on the expression of SR-B1...
  75. Sabeva N, McPhaul C, Li X, Cory T, Feola D, Graf G. Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells. J Nutr Biochem. 2011;22:777-83 pubmed publisher
    ..The effects of phytosterols on ABCA1 and ABCG1 abundance, cholesterol efflux and inflammatory cytokine secretion were determined in cultured macrophage foam ..
  76. Out R, Hoekstra M, Meurs I, de Vos P, Kuiper J, Van Eck M, et al. Total body ABCG1 expression protects against early atherosclerotic lesion development in mice. Arterioscler Thromb Vasc Biol. 2007;27:594-9 pubmed
    b>ABCG1 has recently been identified as a facilitator of cholesterol and phospholipid efflux from macrophages to HDL...
  77. Buchmann J, Meyer C, Neschen S, Augustin R, Schmolz K, Kluge R, et al. Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity. Endocrinology. 2007;148:1561-73 pubmed
    ..in a suggestive adiposity quantitative trait locus and was associated with higher expression of the gene in white adipose tissue. Targeted disruption of Abcg1 in mice resulted in reduced body weight gain (8.42+/-0...
  78. Burgess B, Naus K, Chan J, Hirsch Reinshagen V, Tansley G, Matzke L, et al. Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2008;28:1731-7 pubmed publisher
    The purpose of this study was to evaluate the effects of whole body overexpression of human ABCG1 on atherosclerosis in apoE(-/-) mice.
  79. Baldán A, Pei L, Lee R, Tarr P, Tangirala R, Weinstein M, et al. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol. 2006;26:2301-7 pubmed
    The lungs of Abcg1-/- mice accumulate macrophage foam cells that contain high levels of unesterified and esterified cholesterol, consistent with a role for ABCG1 in facilitating the efflux of cholesterol from macrophages to high-density ..
  80. Croop J, Tiller G, Fletcher J, Lux M, Raab E, Goldenson D, et al. Isolation and characterization of a mammalian homolog of the Drosophila white gene. Gene. 1997;185:77-85 pubmed
    The Drosophila melanogaster white gene is a member of the ABC transporter superfamily of ATPase transmembrane proteins and is involved in the cellular uptake of guanine and tryptophan...