Abcc9

Summary

Gene Symbol: Abcc9
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Alias: AI414027, AI449286, SUR2A, SUR2B, Sur2, ATP-binding cassette sub-family C member 9, ATP-binding cassette transporter sub-family C member 9, sulfonylurea receptor 2, sulfonylurea-binding protein 2
Species: mouse
Products:     Abcc9

Top Publications

  1. Ye B, Kroboth S, Pu J, Sims J, Aggarwal N, McNally E, et al. Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing. Circ Res. 2009;105:1083-93 pubmed publisher
    ..Cardioprotective pathways may involve a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel but its composition is not fully understood...
  2. Sukhodub A, Du Q, Jovanović S, Jovanović A. Nicotinamide-rich diet protects the heart against ischaemia-reperfusion in mice: a crucial role for cardiac SUR2A. Pharmacol Res. 2010;61:564-70 pubmed publisher
    ..nicotinamide-rich diet (mice were a week on nicotinamide-rich diet) as well as on transgenic mice overexpressing SUR2A (SUR2A mice), a regulatory subunit of cardioprotective ATP-sensitive K(+) (K(ATP)) channels and their littermate ..
  3. Sukhodub A, Sudhir R, Du Q, Jovanovic S, Reyes S, Jovanovic A. Nicotinamide-rich diet improves physical endurance by up-regulating SUR2A in the heart. J Cell Mol Med. 2011;15:1703-12 pubmed publisher
    b>SUR2A is an ATP-binding protein that serves as a regulatory subunit of cardioprotective ATP-sensitive K(+) (K(ATP) ) channels...
  4. Chutkow W, Samuel V, Hansen P, Pu J, Valdivia C, Makielski J, et al. Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle. Proc Natl Acad Sci U S A. 2001;98:11760-4 pubmed
    ..used a gene-targeting strategy to generate mice with a disruption in the muscle-specific K(ATP) regulatory subunit, SUR2. Insertional mutagenesis of the Sur2 locus generated homozygous null (Sur2(-/-)) mice and heterozygote (Sur2(+/-)) ..
  5. Stoller D, Kakkar R, Smelley M, Chalupsky K, Earley J, Shi N, et al. Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress. J Mol Cell Cardiol. 2007;43:445-54 pubmed
    ..Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2)...
  6. Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, et al. Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel. J Physiol. 1997;499 ( Pt 3):715-20 pubmed
    1. We analysed the K+ channel composed of the sulphonylurea receptor 2B (SUR2B) and an inwardly rectifying K+ channel subunit Kir6.1 coexpressed in a mammalian cell line, HEK293T, with the patch clamp technique. 2...
  7. Chutkow W, Pu J, Wheeler M, Wada T, Makielski J, Burant C, et al. Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channels. J Clin Invest. 2002;110:203-8 pubmed
    ..a pore-forming inwardly rectifying potassium channel and a sulfonylurea receptor regulatory subunit (SUR1 or SUR2)...
  8. Chutkow W, Makielski J, Nelson D, Burant C, Fan Z. Alternative splicing of sur2 Exon 17 regulates nucleotide sensitivity of the ATP-sensitive potassium channel. J Biol Chem. 1999;274:13656-65 pubmed
    ..has shown that alternative usage of exons 14, 39, and 40 of the muscle-specific KATP channel regulatory subunit, sur2, occurs in tissue-specific patterns...
  9. Isomoto S, Horio Y, Matsumoto S, Kondo C, Yamada M, Gilbert D, et al. Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6. Mamm Genome. 1997;8:790-1 pubmed

Scientific Experts

More Information

Publications48

  1. Morrissey A, Parachuru L, Leung M, Lopez G, Nakamura T, Tong X, et al. Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart. Pediatr Res. 2005;58:185-92 pubmed
    ..2 and SUR2A subunits, but the expression of other K(ATP) channel subunits (including SUR1, SUR2B, and Kir6.1) is poorly defined...
  2. Fang L, Spindler K. E1A-CR3 interaction-dependent and -independent functions of mSur2 in viral replication of early region 1A mutants of mouse adenovirus type 1. J Virol. 2005;79:3267-76 pubmed
    ..At a multiplicity of infection (MOI) of 1, viruses containing CR3 replicated better in Sur2+/+ mouse embryonic fibroblasts (MEFs) than in Sur2-/- MEFs...
  3. Aggarwal N, Shi N, Makielski J. ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant. Channels (Austin). 2013;7:493-502 pubmed publisher
    ..An unusual intra-exonic splice variant of SUR2 (SUR2A-55) was previously identified in mitochondria of mammalian heart and brain, and by analogy with sarcKATP we ..
  4. Benamer N, Moha Ou Maati H, Demolombe S, Cantereau A, Delwail A, Bois P, et al. Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. J Mol Cell Cardiol. 2009;46:508-17 pubmed publisher
    ..Among potassium channel transcripts which were screened by high-throughput real-time PCR, SUR2 and Kir6.1 mRNAs were found to be the most abundant in ventricular fibroblasts...
  5. Park S, Lim B, Perez Terzic C, Mer G, Terzic A. Interaction of asymmetric ABCC9-encoded nucleotide binding domains determines KATP channel SUR2A catalytic activity. J Proteome Res. 2008;7:1721-8 pubmed publisher
    ..Distinct from traditional ABC transporters, ABCC9-encoded sulfonylurea receptors (SUR2A) form, with Kir6...
  6. Mohammed Abdul K, Jovanovic S, Sukhodub A, Du Q, Jovanovic A. Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen. Biochim Biophys Acta. 2014;1843:2424-31 pubmed publisher
    ..b>SUR2A is an atypical ABC protein serving as a regulatory subunit of sarcolemmal ATP-sensitive K(+) (KATP) channels...
  7. Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, et al. Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015;112:4003-8 pubmed publisher
    ..This study thus provides a novel concept for somatic cell fate determination in testis development that may also represent an etiology of male infertility in human patients. ..
  8. Nichols C, Singh G, Grange D. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013;112:1059-72 pubmed publisher
    ..1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein subfamily has led to the elucidation of many details of channel gating and pore properties...
  9. Fahrenbach J, Stoller D, Kim G, Aggarwal N, Yerokun B, Earley J, et al. Abcc9 is required for the transition to oxidative metabolism in the newborn heart. FASEB J. 2014;28:2804-15 pubmed publisher
    ..b>Abcc9, an ATP-binding cassette family member, increases expression concomitant with this metabolic shift...
  10. Kang M, Hashimoto A, Gade A, Akbarali H. Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex. Am J Physiol Gastrointest Liver Physiol. 2015;308:G532-9 pubmed publisher
    ..1, sulphonylurea 2B (SUR2B), and nitrotyrosine measured by immunoblot...
  11. Chutkow W, Simon M, Le Beau M, Burant C. Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes. 1996;45:1439-45 pubmed
    ..2. In this article, we describe the isolation of cDNAs encoding SUR-like proteins from mouse, SUR2A and SUR2B. Northern blotting showed that the highest expression of the SUR2 isoforms is in the heart and skeletal muscle, ..
  12. Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, et al. A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. J Biol Chem. 1996;271:24321-4 pubmed
    ..Sequence analysis indicated that this clone is a variant of cardiac type sulfonylurea receptor (SUR2)...
  13. Stoller D, Pytel P, Katz S, Earley J, Collins K, Metcalfe J, et al. Impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant mice. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1144-53 pubmed publisher
    ..b>SUR2 mutant mice lack full-length K(ATP) channels in striated and smooth muscle and display a complex phenotype of ..
  14. Adebiyi A, McNally E, Jaggar J. Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. Am J Physiol Heart Circ Physiol. 2011;301:H1360-8 pubmed publisher
    ..Data indicate that SUR2B is the only SUR isoform expressed in murine cerebral artery smooth muscle cells...
  15. Aggarwal N, Pravdic D, McNally E, Bosnjak Z, Shi N, Makielski J. The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice. Am J Physiol Heart Circ Physiol. 2010;299:H1884-90 pubmed publisher
    The sulfonylurea receptor-2 (SUR2) is a subunit of ATP-sensitive potassium channels (K(ATP)) in heart. Mice with the SUR2 gene disrupted (SUR2m) are constitutively protected from ischemia-reperfusion (I/R) cardiac injury...
  16. Stevens J, Cantin G, Wang G, Shevchenko A, Shevchenko A, Berk A. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science. 2002;296:755-8 pubmed
    b>Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans...
  17. Misawa H, Ohtsubo M, Copeland N, Gilbert D, Jenkins N, Yoshimura A. Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem Biophys Res Commun. 1998;244:531-9 pubmed
    ..Cloning and biochemical characterization of the third member of class II PI3Ks provide a new insight into the function of this subfamily of PI3Ks. ..
  18. Pu J, Ye B, Kroboth S, McNally E, Makielski J, Shi N. Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity. J Mol Cell Cardiol. 2008;44:188-200 pubmed
    The cardiac sarcolemmal ATP-sensitive potassium channel (K(ATP)) consists of a Kir6.2 pore and an SUR2 regulatory subunit, which is an ATP-binding cassette (ABC) transporter...
  19. Mohammed Abdul K, Jovanović S, Du Q, Sukhodub A, Jovanović A. Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH. Biochim Biophys Acta. 2015;1852:709-19 pubmed publisher
    ..b>SUR2A is a cardioprotective ABC protein serving as a subunit of sarcolemmal ATP-sensitive K(+) channels...
  20. Chao C, Liang T, Kang Y, Lin X, Xie H, Feng Z, et al. Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A. J Mol Cell Cardiol. 2011;51:790-802 pubmed publisher
    ..Here, we examined for the precise domains within the NBFs of SUR2A that may interact with Syn-1A...
  21. Bao L, Kefaloyianni E, Lader J, Hong M, Morley G, Fishman G, et al. Unique properties of the ATP-sensitive K? channel in the mouse ventricular cardiac conduction system. Circ Arrhythm Electrophysiol. 2011;4:926-35 pubmed publisher
    ..1 but reduced Kir6.2 and SUR2A mRNA compared with ventricular myocytes (SUR1 expression was negligible). SUR2B mRNA expression was higher in CCS myocytes relative to SUR2A...
  22. Hong S, Kyeong K, Kim C, Kim Y, Choi W, Yoo R, et al. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse. J Vet Med Sci. 2016;78:1153-9 pubmed publisher
    ..b>SUR2B and Kir6.2 were detected by Western blot, whereas SUR1, SUR2A and Kir6.1 were not...
  23. Iwasa K, Zhu H, Shibata A, Maehara Y, Teramoto N. Molecular analysis of ATP-sensitive K? channel subunits expressed in mouse vas deferens myocytes. Br J Pharmacol. 2014;171:145-57 pubmed publisher
    ..1. Reverse transcription PCR analysis revealed the expression of K(IR)6.1 and SUR2B transcripts and immunohistochemical studies indicated the presence of K(IR)6.1 and SUR2B proteins in the myocytes...
  24. Jin X, Malykhina A, Lupu F, Akbarali H. Altered gene expression and increased bursting activity of colonic smooth muscle ATP-sensitive K+ channels in experimental colitis. Am J Physiol Gastrointest Liver Physiol. 2004;287:G274-85 pubmed
    ..Quantitative PCR showed that Kir 6.1 gene expression was upregulated by almost 22-fold, whereas SUR2B was downregulated by threefold after inflammation...
  25. Glukhov A, Uchida K, Efimov I, Nichols C. Functional roles of KATP channel subunits in metabolic inhibition. J Mol Cell Cardiol. 2013;62:90-8 pubmed publisher
    ..We showed previously that SUR1 with Kir6.2 forms the functional channel in mouse atria while Kir6.2 and SUR2A predominate in ventricles...
  26. Fatima N, Schooley J, Claycomb W, Flagg T. Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes. PLoS ONE. 2012;7:e41533 pubmed publisher
    Two mammalian genes encode the SURx (SUR1, Abcc8 and SUR2, Abcc9) subunits that combine with Kir6.2 (Kcnj11) subunits to form the ATP-sensitive potassium (KATP) channel in cardiac myocytes...
  27. Kakkar R, Ye B, Stoller D, Smelley M, Shi N, Galles K, et al. Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process. Circ Res. 2006;98:682-9 pubmed
    ..Two transgenic founder lines were generated and independently bred to sulfonylurea receptor 2 (SUR2) null mice to generate mice that restored expression of KATP channels in vascular smooth muscle...
  28. Liss B, Bruns R, Roeper J. Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. EMBO J. 1999;18:833-46 pubmed
    ..contrast to GABAergic neurons, single dopaminergic SN neurons displayed alternative co-expression of either SUR1, SUR2B or both SUR isoforms with Kir6.2...
  29. Liang G, Adebiyi A, Leo M, McNally E, Leffler C, Jaggar J. Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels. Am J Physiol Heart Circ Physiol. 2011;300:H2088-95 pubmed publisher
    ..1 (K(ir)6.1) channel and sulfonylurea receptor 2B (SUR2B) K(ATP) channel subunits...
  30. Du Q, Jovanović S, Sukhodub A, Jovanović A. Infection with AV-SUR2A protects H9C2 cells against metabolic stress: a mechanism of SUR2A-mediated cytoprotection independent from the K(ATP) channel activity. Biochim Biophys Acta. 2010;1803:405-15 pubmed publisher
    Transgenic mice overexpressing SUR2A, a subunit of ATP-sensitive K(+) (K(ATP)) channels, acquire resistance to myocardial ischaemia. However, the mechanism of SUR2A-mediated cytoprotection is yet to be fully understood...
  31. Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, et al. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet. 2007;39:1453-60 pubmed
    ..The phenotype is due to a null allele of Kcnj8, encoding Kir6.1, a protein that combines with SUR2 to form an ATP-sensitive potassium channel (K(ATP)) expressed in coronary artery smooth muscle and endothelial ..
  32. Lybaert P, Vanbellinghen A, Quertinmont E, Petein M, Meuris S, Lebrun P. KATP channel subunits are expressed in the epididymal epithelium in several mammalian species. Biol Reprod. 2008;79:253-61 pubmed publisher
    ..A positive immunostaining for Kir6.2 (KCNJ11) and SUR2 (ABCC9) was observed by immunoenzymatic and immunofluorescent approaches in the principal epithelial cells throughout all ..
  33. Liu Z, Li W, Ma X, Ding N, Spallotta F, Southon E, et al. Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development. J Biol Chem. 2014;289:29801-16 pubmed publisher
    ..TNNI2, TNNT1, and CKM; contractile fiber gene ACTA1; and cardiac arrhythmia associated ion channel coding genes ABCC9 and CACNA1D. The transcriptional regulation of some of these genes by Casz1 was also found in cellular models...
  34. Schriml L, Dean M. Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000;64:24-31 pubmed
    ..The mouse ABC genes could be grouped into the seven previously described human ABC subfamilies. Three mouse ABC genes mapped to regions implicated in cholesterol gallstone susceptibility...
  35. Yamada M, Ishii M, Hibino H, Kurachi Y. Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening. Mol Pharmacol. 2004;66:807-16 pubmed
    ..We made the corresponding mutation in the NBD1 (D834N) and/or NBD2 (E1471Q) of SUR2A and SUR2B. As measured in the inside-out configuration of the patch-clamp method, SUR2x(D834N, E1471)/Kir6...
  36. Choi S, Yeum C, Chang I, You H, Park J, Jeong H, et al. Activating of ATP-dependent K+ channels comprised of K(ir) 6.2 and SUR 2B by PGE2 through EP2 receptor in cultured interstitial cells of Cajal from murine small intestine. Cell Physiol Biochem. 2006;18:187-98 pubmed
    ..2-SUR 2B in ICC and this action of PGE(2) are through EP(2) receptor subtype and also the activation of ATP-dependent K(+) channels involves intracellular Ca(2+) mobilization...
  37. Stoller D, Fahrenbach J, Chalupsky K, Tan B, Aggarwal N, Metcalfe J, et al. Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation. Am J Physiol Heart Circ Physiol. 2010;299:H1100-8 pubmed publisher
    ..Mice deleted for the first nucleotide binding region of sulfonylurea receptor 2 (SUR2) are referred to as SUR2 null since they lack full-length SUR2 and glibenclamide-responsive K(ATP) ..
  38. Williams T, Yon J, Huxley C, Fried M. The mouse surfeit locus contains a very tight cluster of four "housekeeping" genes that is conserved through evolution. Proc Natl Acad Sci U S A. 1988;85:3527-30 pubmed
    ..The four human surfeit genes were also found to be transcriptionally active. ..
  39. Mohammed Abdul K, Jovanovic S, Jovanovic A. Exposure to 15% oxygen in vivo up-regulates cardioprotective SUR2A without affecting ERK1/2 and AKT: a crucial role for AMPK. J Cell Mol Med. 2017;21:1342-1350 pubmed publisher
    b>SUR2A is an 'atypical' ABC protein that forms sarcolemmal ATP-sensitive K+ (KATP ) channels by binding to inward rectifier Kir6.2...