Gene Symbol: Abcc5
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Alias: 2900011L11Rik, AI132311, Abcc5a, Abcc5b, Mrp5, multidrug resistance-associated protein 5, ATP-binding cassette, sub-family C (CFTR/MRP), member 5a, ATP-binding cassette, sub-family C (CFTR/MRP), member 5b, ATP-binding cassette, sub-family C, member 5, MOAT-C, SMRP, multi-specific organic anion transporter C
Species: mouse
Products:     Abcc5

Top Publications

  1. Maher J, Slitt A, Cherrington N, Cheng X, Klaassen C. Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos. 2005;33:947-55 pubmed
    ..ovary, and placenta; Mrp2 in intestine, followed by liver and kidney; Mrp3 in large intestine; Mrp4 in kidney; Mrp5 in brain, followed by lung and stomach; Mrp6 in liver; Mrp7 in testes, intestine, and kidney; and Mrp9 solely in ..
  2. Schriml L, Dean M. Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000;64:24-31 pubmed
    ..The mouse ABC genes could be grouped into the seven previously described human ABC subfamilies. Three mouse ABC genes mapped to regions implicated in cholesterol gallstone susceptibility...
  3. Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst. 2000;92:1295-302 pubmed
    ..The physiologic functions of the other MRPs are not known. Whether long-term inhibition of MRPs in humans can be tolerated (assuming that suitable inhibitors will be found) remains to be determined...
  4. De Wolf C, Yamaguchi H, van der Heijden I, Wielinga P, Hundscheid S, Ono N, et al. cGMP transport by vesicles from human and mouse erythrocytes. FEBS J. 2007;274:439-50 pubmed
    cGMP secretion from cells can be mediated by ATP-binding cassette (ABC) transporters ABCC4, ABCC5, and ABCC11. Indirect evidence suggests that ABCC4 and ABCC5 contribute to cGMP transport by erythrocytes...
  5. Suzuki T, Sasaki H, Kuh H, Agui M, Tatsumi Y, Tanabe S, et al. Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. Gene. 2000;242:167-73 pubmed
    ..1%). We further showed that our previously identified SMRP mRNA was a splicing variant of the MRP5 gene, which was expressed in various human tissues, suggesting that a short ..
  6. Zhang Y, Nguyen T, Tang P, Kennedy N, Jiao H, Zhang M, et al. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. J Biol Chem. 2015;290:14875-83 pubmed publisher
    ..Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders. ..
  7. Jansen R, Mahakena S, de Haas M, Borst P, van de Wetering K. ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs. J Biol Chem. 2015;290:30429-40 pubmed publisher
    The ubiquitous efflux transporter ABCC5 (ATP-binding cassette subfamily C member 5) is present at high levels in the blood-brain barrier, neurons, and glia, but its in vivo substrates and function are not known...
  8. Konig J, Nies A, Cui Y, Leier I, Keppler D. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta. 1999;1461:377-94 pubmed
    ..Because of its function in the terminal excretion of cytotoxic and carcinogenic substances, MRP2 as well as other members of the MRP family, play an important role in detoxification and chemoprevention...
  9. Meissner K, Kessler W, Meyer Zu Schwabedissen H, Schuster K, Saalfeld K, Grube M, et al. Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump. Shock. 2007;28:564-9 pubmed
    ..We have previously shown that the high-affinity cGMP export transporter, multidrug resistance protein 5 (MRP5), is expressed in the heart, which modulates intracellular concentrations and, hence, the effects of cGMP...

More Information


  1. Korolnek T, Zhang J, Beardsley S, Scheffer G, Hamza I. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab. 2014;19:1008-19 pubmed publisher
    ..Here, we show that the multidrug resistance protein MRP-5/ABCC5 likely acts as a heme exporter, and targeted depletion of mrp-5 in the intestine causes embryonic lethality...
  2. Borst P, Evers R, Kool M, Wijnholds J. The multidrug resistance protein family. Biochim Biophys Acta. 1999;1461:347-57 pubmed