Gene Symbol: Abcc3
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Alias: 1700019L09Rik, ABC31, MLP2, MOAT-D, MRP3, canalicular multispecific organic anion transporter 2, ATP-binding cassette protein C3, ATP-binding cassette sub-family C member 3, ATP-binding cassette transporter, multidrug resistance-associated protein 3, transporter
Species: mouse
Products:     Abcc3

Top Publications

  1. Csanaky I, Aleksunes L, Tanaka Y, Klaassen C. Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. Am J Physiol Gastrointest Liver Physiol. 2009;297:G419-33 pubmed publisher
    ..The mRNA and protein levels of the BA uptake transporter Ntcp were unchanged after PHx, whereas the canalicular Bsep protein increased twofold at 48 h...
  2. Bohan A, Chen W, Denson L, Held M, Boyer J. Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J Biol Chem. 2003;278:36688-98 pubmed
    Mrp3(Abcc3) is markedly induced following bile duct ligation (BDL) in the rat and in some human cholestatic liver diseases and is believed to ameliorate liver injury in this setting...
  3. Fernández Barrena M, Monte M, Latasa M, Uriarte I, Vicente E, Chang H, et al. Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice. J Hepatol. 2012;56:367-73 pubmed publisher
    ..We have investigated the role of the BA membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut, in the hepatic growth response elicited by BA and in ..
  4. Zelcer N, van de Wetering K, Hillebrand M, Sarton E, Kuil A, Wielinga P, et al. Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci U S A. 2005;102:7274-9 pubmed
    ..By using morphine as a model aglycone, we demonstrate that multidrug resistance protein 3 (MRP3/ABCC3), a protein present in the basolateral membrane of polarized cells, transports morphine-3-glucuronide (M3G) and ..
  5. Zelcer N, van de Wetering K, de Waart R, Scheffer G, Marschall H, Wielinga P, et al. Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol. 2006;44:768-75 pubmed
    Multidrug Resistance Protein 3 (MRP3) transports bile salts and glucuronide conjugates in vitro and is postulated to protect the liver in cholestasis. Whether the absence of Mrp3 affects these processes in vivo is tested...
  6. Manautou J, de Waart D, Kunne C, Zelcer N, Goedken M, Borst P, et al. Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Hepatology. 2005;42:1091-8 pubmed
    MRP3 is an ABC transporter localized in the basolateral membrane of epithelial cells such as hepatocytes and enterocytes. In this study, the role of Mrp3 in drug disposition was investigated...
  7. Wiel C, Gras B, Vindrieux D, Warnier M, Gitenay D, Le Calvé B, et al. Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape. Oncogene. 2016;35:1596-601 pubmed publisher
    ..ABCC3 participates in resistance to chemotherapy via its transporter activity...
  8. Li Q, Jiang Q, Larusso J, Klement J, Sartorelli A, Belinsky M, et al. Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process. Exp Dermatol. 2007;16:853-9 pubmed
    ..PXE is caused by mutations in the ABCC6 gene, which encodes a transporter protein, MRP6, and targeted ablation of Abcc6 in mice recapitulates the manifestations of PXE...
  9. Wang Z, Zhou Q, Kruh G, Gallo J. Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011;39:2155-61 pubmed publisher
    ..of two transporters-ABC subfamily C member 2 (Abcc2; multidrug resistance protein 2) and ABC subfamily C member 3 (Abcc3; multidrug resistance protein 3)-involved in MTX hepatobiliary disposition in vivo, MTX plasma, urine, and feces ..

More Information


  1. de Waart D, Vlaming M, Kunne C, Schinkel A, Oude Elferink R. Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009;37:1698-702 pubmed publisher
    ..Presently, it is not clear which mechanisms are responsible for this efficient enterohepatic circulation. Abcc2, Abcc3, and Abcg2 are ATP-binding cassette (ABC) transporters that are expressed in both liver and intestine and are ..
  2. Vergnes L, Lee J, Chin R, Auwerx J, Reue K. Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab. 2013;17:916-28 pubmed publisher
    ..Diet1 and FGF19 proteins exhibited overlapping subcellular localization in cultured intestinal cells. These results establish Diet1 as a control point in enterohepatic bile acid signaling and lipid homeostasis. ..
  3. Vasilyeva A, Durmus S, Li L, Wagenaar E, Hu S, Gibson A, et al. Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b. Cancer Res. 2015;75:2729-36 pubmed publisher
    ..According to this model, hepatocytic bilirubin glucuronide can follow a liver-to-blood shuttling loop via Abcc3 transporter-mediated efflux and subsequent Oatp1a/1b-mediated liver uptake...
  4. McCarthy T, Li X, Sinal C. Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids. J Biol Chem. 2005;280:23232-42 pubmed
    The multidrug resistance-associated protein 3 (MRP3) is a multispecific anion transporter that is capable of transporting a number of conjugated and unconjugated bile acids...
  5. Maher J, Slitt A, Cherrington N, Cheng X, Klaassen C. Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos. 2005;33:947-55 pubmed members is as follows: Mrp1 in testes, ovary, and placenta; Mrp2 in intestine, followed by liver and kidney; Mrp3 in large intestine; Mrp4 in kidney; Mrp5 in brain, followed by lung and stomach; Mrp6 in liver; Mrp7 in testes, ..
  6. Kitamura Y, Kusuhara H, Sugiyama Y. Functional characterization of multidrug resistance-associated protein 3 (mrp3/abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine. J Pharmacol Exp Ther. 2010;332:659-66 pubmed publisher
    ..of various glucuronide conjugates from the enterocytes to the portal blood in the small intestine together with unknown transporter(s), but the contribution of Mrp3 to the basolateral efflux of 4MUG was negligible in the colon.
  7. de Waart D, van de Wetering K, Kunne C, Duijst S, Paulusma C, Oude Elferink R. Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012;40:515-21 pubmed publisher
    Some cephalosporins, such as cefadroxil, are orally available. H(+)-coupled peptide transporter 1 mediates the transport of cephalosporins across the apical membrane of enterocytes...
  8. van de Wetering K, Zelcer N, Kuil A, Feddema W, Hillebrand M, Vlaming M, et al. Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides. Mol Pharmacol. 2007;72:387-94 pubmed
    ..of biliary M3G secretion in Mrp2(-/-) mice results in its increased sinusoidal transport that can be attributed to Mrp3. Combined loss of Mrp2 and Mrp3 leads to a substantial accumulation of M3G in the liver, from which it is ..
  9. Kruh G, Belinsky M, Gallo J, Lee K. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice. Cancer Metastasis Rev. 2007;26:5-14 pubmed
    ..Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed...
  10. Fukumoto K, Kikuchi S, Itoh N, Tamura A, Hata M, Yamagishi H, et al. Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3. Biochim Biophys Acta. 2007;1772:298-306 pubmed
    ..reported that the knockout of radixin resulted in Rdx(-/-) mice with displacement/loss of the canalicular transporter Mrp2, giving rise to Dubin-Johnson syndrome-like conjugated hyperbilirubinemia in the mixed genetic background (..
  11. van de Steeg E, Stránecký V, Hartmannova H, Noskova L, Hrebicek M, Wagenaar E, et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest. 2012;122:519-28 pubmed publisher
    ..Using mice deficient in Oatp1a/1b and in the multispecific sinusoidal export pump Abcc3, we found that Abcc3 secretes bilirubin conjugates into the blood, while Oatp1a/1b transporters mediate their ..
  12. Belinsky M, Dawson P, Shchaveleva I, Bain L, Wang R, Ling V, et al. Analysis of the in vivo functions of Mrp3. Mol Pharmacol. 2005;68:160-8 pubmed
    Multidrug resistance protein 3 (MRP3) is an ATP-binding cassette transporter that is able to confer resistance to anticancer agents such as etoposide and to transport lipophilic anions such as bile acids and glucuronides...
  13. Cruz L, Guerra M, Kruglov E, Mennone A, Garcia C, Chen J, et al. Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. Hepatology. 2010;52:327-37 pubmed publisher
    Multidrug resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion secretion into bile...
  14. Tai T, Mi Q, Ji J, Yin Q, Pan Y, Zhang M, et al. Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation. J Cardiovasc Pharmacol. 2016;68:433-440 pubmed inactive prodrug) has been recently reported to be associated with increased messenger RNA expression of ABCC3 that encodes MRP3 (multidrug resistance-associated protein 3)...
  15. Tanaka Y, Yoshikawa M, Kobayashi Y, Kuroda M, Kaito M, Shiroi A, et al. Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells. Biochem Biophys Res Commun. 2003;309:324-30 pubmed
    ..of organic anion transporting polypeptide 1 (oatp1), multidrug resistance-associated protein 1 (mrp1), mrp2, mrp3, and ugt1a1 was not seen in the undifferentiated HNF-3beta-ES cells by RT-PCR, whereas all were expressed in ..
  16. Vlaming M, van Esch A, Pala Z, Wagenaar E, van de Wetering K, van Tellingen O, et al. Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo. Mol Cancer Ther. 2009;8:3350-9 pubmed publisher
    The multidrug transporters ABCC2, ABCC3, and ABCG2 can eliminate potentially toxic compounds from the body and have overlapping substrate specificities...
  17. Rao A, Haywood J, Craddock A, Belinsky M, Kruh G, Dawson P. The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A. 2008;105:3891-6 pubmed publisher
    The apical sodium-dependent bile acid transporter (Asbt) is responsible for transport across the intestinal brush border membrane; however, the carrier(s) responsible for basolateral bile acid export into the portal circulation remains ..
  18. Sebastiani G, Krzywkowski P, Dudal S, Yu M, Paquette J, Malo D, et al. Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice. Hum Mol Genet. 2006;15:2313-23 pubmed
    ..Further characterization of these QTL regions may lead to the identification of genes involved in the pathogenesis of AD. ..
  19. Vlaming M, Pala Z, van Esch A, Wagenaar E, van Tellingen O, de Waart D, et al. Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate. Clin Cancer Res. 2008;14:8152-60 pubmed publisher
    ATP-binding cassette sub-family C member 2 [ABCC2; multidrug resistance-associated protein 2 (MRP2)] and ABCC3 (MRP3) mediate the elimination of toxic compounds, such as drugs and carcinogens, and have a large overlap in substrate ..
  20. Liu J, Glickman J, Masyuk A, Larusso N. Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains. J Gastroenterol Hepatol. 2008;23:1596-602 pubmed publisher
    ..Expression of cholangiocyte bile salt transporter proteins ASBT (SLC10A2), ILBP (FABP6), and MRP3 (ABCC3) were studied by Western blot analysis...
  21. Mazumdar M, Lee J, Sengupta K, Ried T, Rane S, Misteli T. Tumor formation via loss of a molecular motor protein. Curr Biol. 2006;16:1559-64 pubmed
    ..Our results support the notion that loss of a molecular motor leads to tumor formation and that aneuploidy can act as a primary trigger of tumorigenesis. ..