Abcc1

Summary

Gene Symbol: Abcc1
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Alias: Abcc1a, Abcc1b, MRP, Mdrap, Mrp1, multidrug resistance-associated protein 1, ATP-binding cassette, sub-family C (CFTR/MRP), member 1a, ATP-binding cassette, sub-family C (CFTR/MRP), member 1b, LTC4 transporter, leukotriene C(4) transporter, multiple drug resistance-associated protein
Species: mouse
Products:     Abcc1

Top Publications

  1. Schultz M, Wijnholds J, Peppelenbosch M, Vervoordeldonk M, Speelman P, van Deventer S, et al. Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. J Immunol. 2001;166:4059-64 pubmed
    Leukotrienes (LTs) are considered important for antibacterial defense in the lung. Multidrug resistance protein 1 (mrp1) is a transmembrane protein responsible for the cellular extrusion of LTC(4)...
  2. Ma L, Pratt S, Cao J, Dantzig A, Moore R, Slapak C. Identification and characterization of the canine multidrug resistance-associated protein. Mol Cancer Ther. 2002;1:1335-42 pubmed
    Human multidrug resistance protein 1 (MRP1) confers resistance to the Vinca alkaloids, the anthracyclines, and the epipodophyllotoxins...
  3. Pohl A, Devaux P, Herrmann A. Function of prokaryotic and eukaryotic ABC proteins in lipid transport. Biochim Biophys Acta. 2005;1733:29-52 pubmed
    ..In particular, further purification and reconstitution experiments with an unambiguous role of ATP hydrolysis are needed to demonstrate a clear involvement of ABC proteins in lipid transbilayer asymmetry...
  4. Mueller C, Widder J, McNally J, McCann L, Jones D, Harrison D. The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress. Circ Res. 2005;97:637-44 pubmed
    ..We found that human endothelial cells express the multidrug resistance protein-1 (MRP1) and use this as their major exporter of GSSG...
  5. Silverstein P, Audus K, Qureshi N, Kumar A. Lipopolysaccharide increases the expression of multidrug resistance-associated protein 1 (MRP1) in RAW 264.7 macrophages. J Neuroimmune Pharmacol. 2010;5:516-20 pubmed publisher
    Multidrug resistance-associated protein 1 (MRP-1) is a ubiquitously expressed member of the ATP-binding cassette transporter family. MRP-1 is one of the primary transporters of glutathione and glutathione conjugates...
  6. Stride B, Valdimarsson G, Gerlach J, Wilson G, Cole S, Deeley R. Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. Mol Pharmacol. 1996;49:962-71 pubmed
    In vitro, overexpression of the human multidrug-resistance protein (MRP) causes a form of multidrug resistance similar to that conferred by P-glycoprotein, although the two proteins are only very distantly related...
  7. Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, et al. Cerebral amyloid-? proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011;121:3924-31 pubmed publisher
    ..were further genetically modified to lack specific ABC transporters, here we have shown that the transporter ABCC1 has an important role in cerebral A? clearance and accumulation...
  8. Robbiani D, Finch R, Jager D, Muller W, Sartorelli A, Randolph G. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell. 2000;103:757-68 pubmed
    ..skin to lymph nodes utilizes the leukotriene C(4) (LTC(4)) transporter multidrug resistance-associated protein 1 (MRP1)...
  9. Widder J, Guzik T, Mueller C, Clempus R, Schmidt H, Dikalov S, et al. Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arterioscler Thromb Vasc Biol. 2007;27:762-8 pubmed
    Human endothelial cells use the multidrug resistance protein-1 (MRP1) to export glutathione disulfide (GSSG). This can promotes thiol loss during states of increased glutathione oxidation...

More Information

Publications76

  1. Soontornmalai A, Vlaming M, Fritschy J. Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier. Neuroscience. 2006;138:159-69 pubmed
    ..We report that four ATP-binding cassette transporters, Mdr1, Mrp1, Mrp2 and Mrp5 can be detected in brain endothelial cells, forming three distinct layers, with Mdr1 and Mrp5 being ..
  2. Ito K, Olsen S, Qiu W, Deeley R, Cole S. Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J Biol Chem. 2001;276:15616-24 pubmed
    Multidrug resistance protein 1 (MRP1/ABCC1) belongs to the ATP-binding cassette transporter superfamily and is capable of conferring resistance to a broad range of chemotherapeutic agents and transporting structurally diverse conjugated ..
  3. Lorico A, Rappa G, Finch R, Yang D, Flavell R, Sartorelli A. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res. 1997;57:5238-42 pubmed
    The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in vivo...
  4. Brechot J, Hurbain I, Fajac A, Daty N, Bernaudin J. Different pattern of MRP localization in ciliated and basal cells from human bronchial epithelium. J Histochem Cytochem. 1998;46:513-7 pubmed
    The MRP (multidrug resistance-associated protein) transmembrane transporter, which actively transports a wide variety of lipophilic substrates out of cancer cells, has been suggested to play a major role in cell detoxification via efflux ..
  5. Johnson D, Finch R, Lin Z, Zeiss C, Sartorelli A. The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice. Cancer Res. 2001;61:1469-76 pubmed
    ..agents, we have used mice genetically deficient in both the mdr1a and mdr1b genes [mdr1a/1b(-/-) mice], the mrp1 gene [mrp1(-/-) mice], and the combined genes mdr1a/1b and mrp1 [mdr1a/1b(-/-), mrp1(-/-) mice] and embryonic ..
  6. Verbon A, Leemans J, Weijer S, Florquin S, van der Poll T. Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis. Clin Exp Immunol. 2002;130:32-6 pubmed
    ..To determine the role of Mrp1 in the pathogenesis of tuberculosis, Mrp1 deficient (-/-) and normal wild type mice were intranasally infected with ..
  7. Wijnholds J, Evers R, van Leusden M, Mol C, Zaman G, Mayer U, et al. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med. 1997;3:1275-9 pubmed
    The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many drugs, glutathione S-conjugates (GS-X) of lipophilic xenobiotics and endogenous cysteinyl leukotrienes...
  8. Wijnholds J, deLange E, Scheffer G, van den Berg D, Mol C, van der Valk M, et al. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest. 2000;105:279-85 pubmed
    Multidrug resistance protein 1 (MRP1) is a transporter protein that helps to protect normal cells and tumor cells against the influx of certain xenobiotics...
  9. Becher U, Ghanem A, Tiyerili V, Furst D, Nickenig G, Mueller C. Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. J Mol Cell Cardiol. 2011;50:570-7 pubmed publisher
    ..We investigated whether release of LTC(4)via the multidrug resistance related protein 1 (MRP1) induces apoptosis in cardiomyocytes in vitro and in vivo...
  10. Lok H, Suryo Rahmanto Y, Hawkins C, Kalinowski D, Morrow C, Townsend A, et al. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. J Biol Chem. 2012;287:607-18 pubmed publisher
    ..Biol. Chem. 276, 4724-4732) and that the GSH-conjugate transporter, multidrug resistance-associated protein 1 (MRP1), mediates this release potentially as a dinitrosyl-dithiol iron complex (DNIC; Watts, R. N., Hawkins, C., Ponka, P...
  11. Borst P, Evers R, Kool M, Wijnholds J. The multidrug resistance protein family. Biochim Biophys Acta. 1999;1461:347-57 pubmed
    The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6...
  12. Kleemann P, Casper B, Huber M, Schuetz J, Lohoff M. Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation. Int Immunol. 2006;18:1603-6 pubmed
    Previously, we have demonstrated that multidrug-resistance-associated protein 1 (Mrp1) represents an activation marker for murine Th1 cells and is constitutively expressed by Th2 cells...
  13. Molinas A, Sicard G, Jakob I. Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium. PLoS ONE. 2012;7:e36167 pubmed publisher
    P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP1) are membrane transporter proteins which function as efflux pumps at cell membranes and are considered to exert a protective function against the entry of xenobiotics...
  14. Udasin R, Wen X, Bircsak K, Aleksunes L, Shakarjian M, Kong A, et al. Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1). Toxicol Sci. 2016;149:202-12 pubmed publisher
    ..Multidrug resistance-associated protein 1 (Mrp1/MRP1) is a transmembrane ATPase known to efflux glutathione-conjugated electrophiles...
  15. Gordillo G, Biswas A, Khanna S, Spieldenner J, Pan X, Sen C. Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells. J Biol Chem. 2016;291:10089-103 pubmed publisher
    ..Multidrug resistance-associated protein-1 (MRP-1), an active GSSG efflux mechanism, showed 2-fold increased activity in EOMA compared with MAE cells...
  16. Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst. 2000;92:1295-302 pubmed
    ..However, MRP1, MRP2, and MRP3 can also cause resistance to neutral organic drugs that are not known to be conjugated to acidic ..
  17. ElAli A, Urrutia A, Rubio Araiz A, Hernández Jiménez M, Colado M, Doeppner T, et al. Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication. Stroke. 2012;43:1647-53 pubmed publisher
    ..cassette transporter ABCB1 on cerebral microvessels and reduced the expression of the abluminal transporter ABCC1. Elevated expression of ApoE was noted in the brain parenchyma by methamphetamine, activating ApoE receptor-2 on ..
  18. Rush T, Liu X, Nowakowski A, Petering D, Lobner D. Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1. Neurotoxicology. 2012;33:476-81 pubmed publisher
    ..Inhibition of multidrug resistance protein-1 (MRP1) potentiated MeHg neurotoxicity and increased cellular MeHg...
  19. Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, et al. Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol. 2006;169:1118-28 pubmed
    ..NF-E2-related factor (Nrf) 2 protein, a transcription factor crucial for MRP1 gene expression, was similarly increased in the kidneys of both strains of mice after NaAs treatment...
  20. Bočkor L, Bortolussi G, Vodret S, Iaconcig A, Jašprová J, Zelenka J, et al. Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia. Hum Mol Genet. 2017;26:145-157 pubmed publisher
    ..The Abcb1 and Abcc1 members of the ABC family of transporters have been suggested to have an active role in exporting unconjugated ..
  21. Sekine T, Miyazaki H, Endou H. Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol. 2006;290:F251-61 pubmed
    ..anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC...
  22. Lorico A, Rappa G, Flavell R, Sartorelli A. Double knockout of the MRP gene leads to increased drug sensitivity in vitro. Cancer Res. 1996;56:5351-5 pubmed
    Overexpression of the multidrug resistance-associated protein (MRP) gene has been implicated in the resistance of tumor cell lines to a wide array of chemotherapeutic agents, but its normal physiological function(s) remains unknown...
  23. Mueller C, Wassmann K, Widder J, Wassmann S, Chen C, Keuler B, et al. Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. Circulation. 2008;117:2912-8 pubmed publisher
    We recently showed that the multidrug resistance related protein-1 (MRP1) is important for the management of oxidative stress in vascular cells. However, the underlying mechanism and the in vivo relevance of these findings remain elusive...
  24. Dekkers D, Comfurius P, Schroit A, Bevers E, Zwaal R. Transbilayer movement of NBD-labeled phospholipids in red blood cell membranes: outward-directed transport by the multidrug resistance protein 1 (MRP1). Biochemistry. 1998;37:14833-7 pubmed
    ..mice for multidrug resistance P-glycoproteins (Mdr1a/1b-/- and Mdr2-/-) and multidrug resistance protein 1 (Mrp1-/-) revealed that Mrp1 is responsible for the observed flop of the fluorescent lipid analogues...
  25. Leite D, Echevarria Lima J, Calixto J, Rumjanek V. Multidrug resistance related protein (ABCC1) and its role on nitrite production by the murine macrophage cell line RAW 264.7. Biochem Pharmacol. 2007;73:665-74 pubmed
    Multidrug resistance related protein 1 (MRP1/ABCC1) is an ABC transporter protein related to the extrusion of reduced glutathione (GSH), oxidized glutathione (GSSG) and GSH-conjugates, as well as leukotriene C(4) and cyclopentane ..
  26. Chapy H, Saubaméa B, Tournier N, Bourasset F, Behar Cohen F, Declèves X, et al. Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier. Br J Pharmacol. 2016;173:497-510 pubmed publisher
    ..P-gp, Bcrp, Mrp1 and Mrp4 were studied by confocal retina imaging...
  27. Calligaris S, Cekic D, Roca Burgos L, Gerin F, Mazzone G, Ostrow J, et al. Multidrug resistance associated protein 1 protects against bilirubin-induced cytotoxicity. FEBS Lett. 2006;580:1355-9 pubmed
    We have shown that multidrug resistance associated protein 1 (MRP1) mediates ATP-dependent extrusion of bilirubin, possibly limiting its potentially toxic accumulation in cells...
  28. Cartwright T, Campos C, Cannon R, Miller D. Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers. J Cereb Blood Flow Metab. 2013;33:381-8 pubmed publisher
    ..and blood-spinal cord barriers and, importantly, identifies multidrug resistance-associated protein 1 (Mrp1, Abcc1) as the transporter that mediates S1P efflux from brain and spinal cord endothelial cells...
  29. Schriml L, Dean M. Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000;64:24-31 pubmed
    ..The mouse ABC genes could be grouped into the seven previously described human ABC subfamilies. Three mouse ABC genes mapped to regions implicated in cholesterol gallstone susceptibility...
  30. Leier I, Jedlitschky G, Buchler M, Buchholz U, Brom M, Keppler D. Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. Eur J Biochem. 1996;242:201-5 pubmed
    ..present study indicates that this protein represents the murine homolog of the human multidrug resistance protein (MRP)...
  31. Doggett N, Callen D. Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994. Cytogenet Cell Genet. 1995;68:165-84 pubmed
  32. Beedholm Ebsen R, van de Wetering K, Hardlei T, Nexø E, Borst P, Moestrup S. Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. Blood. 2010;115:1632-9 pubmed publisher
    ..cellular gene silencing showed a role in cellular Cbl efflux of the ATP-binding cassette (ABC)-drug transporter, ABCC1, alias multidrug resistance protein 1 (MRP1), which is present in the basolateral membrane of intestinal ..
  33. Sivils J, Gonzalez I, Bain L. Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes. Gen Comp Endocrinol. 2010;167:51-9 pubmed publisher
    The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (..
  34. Yoshioka M, Sagara H, Takahashi F, Harada N, Nishio K, Mori A, et al. Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2009;296:L30-6 pubmed publisher
    Multidrug resistance-associated protein 1 (MRP1) is a cysteinyl leukotriene (CysLT) export pump expressed on mast cells. CysLTs are crucial mediators in allergic airway disease...
  35. Stride B, Grant C, Loe D, Hipfner D, Cole S, Deeley R. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997;52:344-53 pubmed
    Overexpression of the human multidrug-resistance protein (MRP) causes a form of multidrug resistance similar to that conferred by P-glycoprotein, although the two proteins are only distantly related...
  36. Lorico A, Bertola A, Baum C, Fodstad O, Rappa G. Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice. Biochem Biophys Res Commun. 2002;291:617-22 pubmed
    The Multidrug Resistance Protein 1 (MRP1) is a membrane pump that mediates the efflux of a wide variety of xenobiotics, including arsenical and antimonial compounds, as demonstrated by the study of MRP1-transfected cell lines...
  37. Neuser J, Fraccarollo D, Wick M, Bauersachs J, Widder J. Multidrug resistance associated protein-1 (MRP1) deficiency attenuates endothelial dysfunction in diabetes. J Diabetes Complications. 2016;30:623-7 pubmed publisher
    The multidrug resistance associated protein-1 (MRP1) is the main transporter of oxidized glutathione in endothelial cells, and blockade of MRP1 improves endothelial cell dysfunction induced by reactive oxygen species...
  38. De Wolf C, Yamaguchi H, van der Heijden I, Wielinga P, Hundscheid S, Ono N, et al. cGMP transport by vesicles from human and mouse erythrocytes. FEBS J. 2007;274:439-50 pubmed
    ..The relative contribution of ABCC4/Abcc4 and ABCG2/Abcg2 in cGMP transport was confirmed with a new inhibitor of ABCC4 transport, the protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride...
  39. Hirrlinger J, Konig J, Keppler D, Lindenau J, Schulz J, Dringen R. The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress. J Neurochem. 2001;76:627-36 pubmed
    ..In the presence of cyclosporin A and the quinoline-derivative MK571, inhibitors of multidrug resistance proteins (MRP1 and MRP2), glutathione disulfide accumulated in cells and the release of glutathione disulfide from astrocytes ..
  40. Jakubzick C, Tacke F, Llodra J, Van Rooijen N, Randolph G. Modulation of dendritic cell trafficking to and from the airways. J Immunol. 2006;176:3578-84 pubmed
  41. Maher J, Slitt A, Cherrington N, Cheng X, Klaassen C. Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos. 2005;33:947-55 pubmed
    ..Highest expression of the Mrp family members is as follows: Mrp1 in testes, ovary, and placenta; Mrp2 in intestine, followed by liver and kidney; Mrp3 in large intestine; Mrp4 in ..
  42. Hummel I, Klappe K, Ercan C, Kok J. Multidrug resistance-related protein 1 (MRP1) function and localization depend on cortical actin. Mol Pharmacol. 2011;79:229-40 pubmed publisher
    MRP1 (ABCC1) is known to be localized in lipid rafts. Here we show in two different cell lines that localization of Mrp1/MRP1 (Abcc1/ABCC1) in lipid rafts and its function as an efflux pump are dependent on cortical actin...
  43. Bain L, Feldman R. Altered expression of sulfotransferases, glucuronosyltransferases and mrp transporters in FVB/mrp1-/- mice. Xenobiotica. 2003;33:1173-83 pubmed
    ..III (transporter) RNA expression, between FVB mice and mice lacking the multidrug resistance-associated protein 1 (mrp1) gene (FVB/mrp1-/- mice)...
  44. Mueller C, Becher M, Zimmer S, Wassmann S, Keuler B, Nickenig G. Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1. Mol Cell Biochem. 2010;333:261-7 pubmed publisher
    The multidrug resistance-related protein-1 (MRP1) is important for the management of oxidative stress in vascular cells in vivo...
  45. Fernetti C, Pascolo L, Podda E, Gennaro R, Stebel M, Tiribelli C. Preparation of an antibody recognizing both human and rodent MRP1. Biochem Biophys Res Commun. 2001;288:1064-8 pubmed
    Based on the high level of identity among human, mouse, and rat MRP1 protein sequence, we produced a specific polyclonal antibody (MRP1-A23) against a synthetic polypeptide covering the C-terminus of the human protein...
  46. Li Q, Jiang Q, Larusso J, Klement J, Sartorelli A, Belinsky M, et al. Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process. Exp Dermatol. 2007;16:853-9 pubmed
    ..Analysis of the transcript levels of Abcc1-10 and 12 in the liver of Abcc6 (-/-) mice by quantitative RT-PCR indicated that the levels of other C family ..
  47. Zhang W, St Clair D, Butterfield A, Vore M. Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts. Toxicol Sci. 2016;151:44-56 pubmed publisher
    ..We showed that loss of multidrug resistance-associated protein 1 (Abcc1/Mrp1) potentiates DOX-induced cardiac dysfunction in mice in vivo Here, we characterized DOX toxicity in cultured ..
  48. Mészaros P, Klappe K, Hummel I, Hoekstra D, Kok J. Function of MRP1/ABCC1 is not dependent on cholesterol or cholesterol-stabilized lipid rafts. Biochem J. 2011;437:483-91 pubmed publisher
    MRP1 (multidrug-resistance-related protein 1)/ABCC1 (ATP-binding cassette transporter C1) has been localized in cholesterol-enriched lipid rafts, which suggests a role for these lipid rafts and/or cholesterol in MRP1 function...
  49. Sivils J, Ancrum T, Bain L. LOSS of Mrp1 alters detoxification enzyme expression in a tissue- and hormonal-status-specific manner. J Appl Toxicol. 2013;33:766-73 pubmed publisher
    The multidrug resistance-associated protein1 (MRP1/ABCC1) is a member of the ABCC transporter subfamily that mediates the efflux of pharmaceuticals, xenobiotics and steroid hormones, typically as glutathione, glucuronide or sulfate ..
  50. Li Z, Wang H, Huang S, Zhou L, Wang L, DU C, et al. Establishment of stable MRP1 knockdown by lentivirus-delivered shRNA in the mouse testis Sertoli TM4 cell line. Toxicol Mech Methods. 2015;25:81-90 pubmed publisher
    ..The transporter multidrug-resistance-associated protein 1 (MRP1) is a xenobiotic efflux pump that can export glutathione S-conjugated metabolites and xenobiotics from cells...
  51. Zhai B, Shao Z, Zhao C, Hu K, Wu F. Development and characterization of multidrug resistant human hepatocarcinoma cell line in nude mice. World J Gastroenterol. 2006;12:6614-9 pubmed
    ..The mRNA expression of mdr1, mrp and lrp genes was detected using reverse transcriptase polymerase chain reaction (RT-PCR) in HepG2/nude and HepG2/..
  52. Schumacher T, Krohn M, Hofrichter J, Lange C, Stenzel J, Steffen J, et al. ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice. PLoS ONE. 2012;7:e35613 pubmed publisher
    ..Therefore, we sought to determine brain-related phenotypic changes in animals lacking the expression of distinct ABC transporters (ABCB1, ABCG2 or ABCC1).
  53. Cattelotte J, Tournier N, Rizzo Padoin N, Schinkel A, Scherrmann J, Cisternino S. Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2. J Neurochem. 2009;108:767-75 pubmed publisher
    ..determine the influence of BBB features like the ATP-binding cassette transporters (Abcb1/P-glycoprotein (P-gp), Abcc1/Mrp1, and Abcg2/Bcrp), organic cation transporters (Slc22a1-3/Oct1-3), the transmembrane potential and the dipole ..
  54. van der Deen M, Timens W, Timmer Bosscha H, van der Strate B, Scheper R, Postma D, et al. Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice. Respir Res. 2007;8:49 pubmed
    ..The ABC transporters multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp/MDR1) extrude a wide variety of toxic substances across cellular membranes and are highly ..
  55. Rappa G, Finch R, Sartorelli A, Lorico A. New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. Biochem Pharmacol. 1999;58:557-62 pubmed
    Growing interest in the MRP (multidrug resistance protein) gene stems from its importance in multidrug resistance to chemotherapy, its possible use in gene therapy, and its relationship with the glutathione system...
  56. Wijnholds J, Scheffer G, van der Valk M, van der Valk P, Beijnen J, Scheper R, et al. Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J Exp Med. 1998;188:797-808 pubmed
    The multidrug resistance protein 1 (MRP1) gene encodes a transporter protein that helps to protect cells against xenobiotics...
  57. Henderson M, Haber M, Porro A, Munoz M, Iraci N, Xue C, et al. ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux. J Natl Cancer Inst. 2011;103:1236-51 pubmed publisher
    ..related oncogene, neuroblastoma derived (MYCN)-driven transgenic mouse neuroblastoma model was crossed with an Abcc1-deficient mouse strain (658 hMYCN(1/-), 205 hMYCN(+/1) mice) or, alternatively, treated with the ABCC1 inhibitor, ..
  58. Mercier C, Masseguin C, Roux F, Gabrion J, Scherrmann J. Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Brain Res. 2004;1021:32-40 pubmed
    P-glycoprotein (P-gp, ABCB1) and the multidrug resistance-associated protein 1 (Mrp1, ABCC1) are two ATP-driven pumps that mediate the export of organic anions from cells and may confer cellular resistance to many cytotoxic hydrophobic ..
  59. Inui N, Hasegawa H, Suda T, Nakamura Y, Watanabe H, Chida K. Expression and function of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells from aging mice. J Gerontol A Biol Sci Med Sci. 2012;67:1049-55 pubmed publisher
    ..05). These data showed that LDCs from aged mice exhibited multidrug resistance protein 1- and multidrug resistance-associated protein 1-mediated efflux and that the age-associated changes differed according to transporters...
  60. Sreekumar P, Spee C, Ryan S, Cole S, Kannan R, Hinton D. Mechanism of RPE cell death in ?-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS ONE. 2012;7:e33420 pubmed publisher
    ..Multiple multidrug resistance protein (MRP) family isoforms were expressed in RPE, among which MRP1 was the most abundant...
  61. Okamura T, Kikuchi T, Okada M, Wakizaka H, Zhang M. Imaging of activity of multidrug resistance-associated protein 1 in the lungs. Am J Respir Cell Mol Biol. 2013;49:335-40 pubmed publisher
    Multidrug resistance-associated protein 1 (MRP1) transports various xenobiotics and metabolites across cell membranes, and the alteration of MRP1 expression is associated with certain lung diseases...
  62. Konig J, Nies A, Cui Y, Leier I, Keppler D. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta. 1999;1461:377-94 pubmed
    ..to glutathione, glucuronate, or sulfate have been identified as members of the multidrug resistance protein (MRP) family...
  63. Rappa G, Gamcsik M, Mitina R, Baum C, Fodstad O, Lorico A. Retroviral transfer of MRP1 and gamma-glutamyl cysteine synthetase modulates cell sensitivity to L-buthionine-S,R-sulphoximine (BSO): new rationale for the use of BSO in cancer therapy. Eur J Cancer. 2003;39:120-8 pubmed
    b>MRP1 (multidrug resistance protein 1) co-exports glutathione (GSH) and drug(s) and exports GSH, glucuronide, and sulphate-conjugated drugs...
  64. Zelcer N, van de Wetering K, Hillebrand M, Sarton E, Kuil A, Wielinga P, et al. Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci U S A. 2005;102:7274-9 pubmed
    ..The pharamacokinetics of injected morphine-glucuronides are altered as well in the absence of Mrp3, and this results in a decreased antinociceptive potency of injected morphine-6-glucuronide...
  65. Lorico A, Rappa G, Srimatkandada S, Catapano C, Fernandes D, Germino J, et al. Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene. Cancer Res. 1995;55:4352-60 pubmed
    ..Northern blot analyses using the human 10.1 probe for the 3'-terminal region of the multidrug-resistance protein (MRP) cDNA revealed a mRNA species of approximately 6 kb in WEHI-3B/NOVO cells but not in WEHI-3B/S cells...
  66. Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, et al. Accumulation of murine amyloid-β mimics early Alzheimer's disease. Brain. 2015;138:2370-82 pubmed publisher
    ..double-deficient for neprilysin (encoded by Mme), one major amyloid-β-degrading enzyme, and the ABC transporter ABCC1, a major contributor to amyloid-β clearance from the brain, develop various aspects of sporadic Alzheimer's ..
  67. Tanaka Y, Yoshikawa M, Kobayashi Y, Kuroda M, Kaito M, Shiroi A, et al. Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells. Biochem Biophys Res Commun. 2003;309:324-30 pubmed
    ..The expression of organic anion transporting polypeptide 1 (oatp1), multidrug resistance-associated protein 1 (mrp1), mrp2, mrp3, and ugt1a1 was not seen in the undifferentiated HNF-3beta-ES cells by RT-PCR, whereas all were ..