Abcb1b

Summary

Gene Symbol: Abcb1b
Description: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Alias: Abcb1, Mdr1, Mdr1b, Pgy-1, Pgy1, mdr, multidrug resistance protein 1B, ATP-binding cassette sub-family B member 1, P glycoprotein 1, multidrug resistance protein 1
Species: mouse
Products:     Abcb1b

Top Publications

  1. Mallick S, Horwitz S. Transcriptional regulation of the murine multidrug resistance gene mdr1b by progesterone occurs via an indirect mechanism. DNA Cell Biol. 1997;16:807-18 pubmed
    The murine multidrug resistance gene mdr1b is highly induced in the endometrium during pregnancy. Evidence suggests that induction occurs mainly as a result of progesterone action...
  2. Tampal N, Robertson L, Srinivasan C, Ludewig G. Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1. Toxicol Appl Pharmacol. 2003;187:168-77 pubmed
    ..transport of (14)C-PCB 77 and (14)C-PCB153 in a cell-culture model using porcine kidney cells expressing the human MDR1 or the mouse mdr1a gene and compared it to the transport in control cells...
  3. Wein D, Gupta S. Expression of P-glycoprotein, encoded by MDR 1 gene, a metabolically active efflux pump in murine mast cells. Cancer Lett. 1996;101:241-6 pubmed
    ..These data suggest the presence of a functionally active P-gp in mast cells. A possible physiologic role for P-gp in the secretion of certain mediators/cytokines from mast cells is suggested. ..
  4. Schinkel A, Mayer U, Wagenaar E, Mol C, van Deemter L, Smit J, et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A. 1997;94:4028-33 pubmed
    ..To study their physiological roles, we have generated mice genetically deficient in the mdr1b gene [mdr1b (-/-) mice] and in both the mdr1a and mdr1b genes [mdr1a/1b (-/-) mice]...
  5. Yang J, Milton M, Yu S, Liao M, Liu N, Wu J, et al. P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor. Drug Metab Lett. 2010;4:201-12 pubmed
    ..Thus, co-administration of efflux pump inhibitors may be a useful strategy to enhance tandutinib absorption and brain penetration clinically...
  6. Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, et al. Cerebral amyloid-? proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011;121:3924-31 pubmed publisher
    ..Thus, by altering the temporal aggregation profile of A?, pharmacological activation of ABC transporters could impede the neurodegenerative cascade that culminates in the dementia of AD. ..
  7. Wijnholds J, deLange E, Scheffer G, van den Berg D, Mol C, van der Valk M, et al. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest. 2000;105:279-85 pubmed
    b>Multidrug resistance protein 1 (MRP1) is a transporter protein that helps to protect normal cells and tumor cells against the influx of certain xenobiotics...
  8. Xu D, Regner M, Smith D, Ruby J, Johnstone R, Mullbacher A. The multidrug resistance gene mdr1a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity. Immunol Cell Biol. 2004;82:462-70 pubmed
    P-glycoprotein (P-gp), an ATP-dependent membrane pump encoded by mdr, plays, in addition to its ability to efflux toxins, a role in the resistance to pathogens...
  9. Eisenbraun M, Miller R. mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cytotoxic effector function in mice. J Immunol. 1999;163:2621-7 pubmed
    ..studies revealed that peripheral T cells exclusively utilize the mdr1a-encoded isoform rather than the homologous mdr1b or mdr2 isoforms...

More Information

Publications96

  1. Schuetz E, Umbenhauer D, Yasuda K, Brimer C, Nguyen L, Relling M, et al. Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. Mol Pharmacol. 2000;57:188-97 pubmed
    ..However, because mdr1a ablation causes a compensatory increase in hepatic mdr1b (which can efflux intracellular glucocorticoids), we reasoned that mdr1b might mask the overall effect of mdr1a ..
  2. Johnson D, Finch R, Lin Z, Zeiss C, Sartorelli A. The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice. Cancer Res. 2001;61:1469-76 pubmed
    ..to the toxicity of cancer chemotherapy agents, we have used mice genetically deficient in both the mdr1a and mdr1b genes [mdr1a/1b(-/-) mice], the mrp1 gene [mrp1(-/-) mice], and the combined genes mdr1a/1b and mrp1 [mdr1a/1b(-/-)..
  3. Verbon A, Leemans J, Weijer S, Florquin S, van der Poll T. Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis. Clin Exp Immunol. 2002;130:32-6 pubmed
    ..These data suggest that Mrp1 plays an early but dispensable role in the protective immune response to pulmonary tuberculosis. ..
  4. Jonker J, Freeman J, Bolscher E, Musters S, Alvi A, Titley I, et al. Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice. Stem Cells. 2005;23:1059-65 pubmed
    ..Interestingly, bone marrow of Mdr1a/1b-/- mice frequently displayed an elevated SP, which was reversible by the Bcrp1 inhibitor Ko143, suggesting that Bcrp1 can compensate for the loss of Mdr1a/1b in bone marrow...
  5. de Vries N, Zhao J, Kroon E, Buckle T, Beijnen J, van Tellingen O. P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan. Clin Cancer Res. 2007;13:6440-9 pubmed
    ..Whereas the effect of P-glycoprotein (P-gp) at the BBB is well established, the role of breast cancer resistance protein (BCRP) that is also expressed at the BBB is not...
  6. Thornton S, Wong E, Lee S, Wasan K. Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism. Lipids Health Dis. 2008;7:21 pubmed publisher
    Pgp (P-glycoprotein, MDR1, ABCB1) is an energy-dependent drug efflux pump that is a member of the ATP-binding cassette (ABC) family of proteins...
  7. Raymond M, Gros P. Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene. Proc Natl Acad Sci U S A. 1989;86:6488-92 pubmed
    Analysis of the nucleotide and deduced amino acid sequences of the biologically active mouse mdr1 cDNA clone indicates that the protein is formed by two highly homologous halves, each containing six putative transmembrane domains and a ..
  8. Kooij G, Backer R, Koning J, Reijerkerk A, van Horssen J, van der Pol S, et al. P-glycoprotein acts as an immunomodulator during neuroinflammation. PLoS ONE. 2009;4:e8212 pubmed publisher
    ..Taken together, our work highlights a new physiological role for P-gp as an immunomodulatory molecule and reveals a possible new target for immunotherapy. ..
  9. Yeh S, Pan H, Lin C, Kao Y, Chen Y, Lin C. Hyperglycemia induced down-regulation of renal P-glycoprotein expression. Eur J Pharmacol. 2012;690:42-50 pubmed publisher
    ..Hyperglycemia induced reactive oxygen species and activated PKC in MDCK-II cells, leading to the decrease in P-glycoprotein expression. ..
  10. Tsuruoka S, Sugimoto K, Fujimura A, Imai M, Asano Y, Muto S. P-glycoprotein-mediated drug secretion in mouse proximal tubule perfused in vitro. J Am Soc Nephrol. 2001;12:177-81 pubmed
    ..studies were conducted in the isolated and perfused proximal tubule S2 segment from mice disrupting both mdr1a and mdr1b genes [mdr1a/1b(-)(-)] and their wild-type mice...
  11. Oswald S, Koll C, Siegmund W. Disposition of the cholesterol absorption inhibitor ezetimibe in mdr1a/b (-/-) mice. J Pharm Sci. 2007;96:3478-84 pubmed
    ..P-glycoprotein primary influences the oral absorption of ezetimibe in mice. Distribution, renal and fecal excretion of the drug seems not to be markedly affected by P-glycoprotein...
  12. Wang X, Cabrera R, Li Y, Miller D, Finnell R. Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. FASEB J. 2013;27:1167-75 pubmed publisher
    ..Taken together, these findings strongly suggest that folate deficiency disrupts the BBB function by targeting the transporter and tight junctions, which may contribute to the development of neurological disorders. ..
  13. Hasegawa H, Inui N, Suda T, Shibata K, Nakamura Y, Watanabe H, et al. Expressions of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells. Life Sci. 2011;89:282-7 pubmed publisher
    b>Multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 1 (MRP1) are ATP-binding cassette transporters that mediate the efflux of a broad spectrum of substances and xenobiotics from cells in barrier organs...
  14. Mercier C, Masseguin C, Roux F, Gabrion J, Scherrmann J. Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Brain Res. 2004;1021:32-40 pubmed
    P-glycoprotein (P-gp, ABCB1) and the multidrug resistance-associated protein 1 (Mrp1, ABCC1) are two ATP-driven pumps that mediate the export of organic anions from cells and may confer cellular resistance to many cytotoxic hydrophobic ..
  15. Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, et al. Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008;57:203-9 pubmed publisher
    ..system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1)...
  16. Mason B, Pariante C, Thomas S. A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice. Endocrinology. 2008;149:5244-53 pubmed publisher
    The ABCB1-type multidrug resistance efflux transporter P-glycoprotein (P-gp) has been hypothesized to regulate hypothalamic-pituitary-adrenal axis activity by limiting the access of glucocorticoids to the brain...
  17. Schuetz E, Schinkel A, Relling M, Schuetz J. P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci U S A. 1996;93:4001-5 pubmed
    ..wild type) and in two derivative clones overexpressing the human multidrug resistance gene MDR1 (also designated PGY1) because of either drug selection (LS 180/ADR) or transfection with MDRI cDNA (LS 180/MDR)...
  18. Su F, Ouyang N, Zhu P, Ouyang N, Jia W, Gong C, et al. Psychological stress induces chemoresistance in breast cancer by upregulating mdr1. Biochem Biophys Res Commun. 2005;329:888-97 pubmed
    ..Here, we reported that adrenaline, a hormone mediating the biological activities of stress, upregulates mdr1 gene expression in MCF-7 breast cancer cells via alpha(2)-adrenergic receptors in a dose-dependent manner...
  19. van der Bliek A, van der Velde Koerts T, Ling V, Borst P. Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986;6:1671-8 pubmed
    ..The nature of the four other genes is still unknown. Sequences of four of the five classes of cDNAs are conserved in mouse and human DNA. ..
  20. Tagen M, Zhuang Y, Zhang F, Harstead K, Shen J, Schaiquevich P, et al. P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010;4:195-201 pubmed
    The ATP-binding cassette transporters P-glycoprotein (ABCB1, MDR1) and multidrug resistance protein 4 (MRP4) efflux irinotecan and its active metabolite SN-38 in vitro, and thus may contribute to system clearance of these compounds...
  21. Kuo M, Julian J, Husain F, Song R, Carson D. Regulation of multidrug resistance gene mdr1b/mdr1 expression in isolated mouse uterine epithelial cells. J Cell Physiol. 1995;164:132-41 pubmed
    ..Steady-state levels of murine mdr1b mRNA, transcribed from a multidrug resistance gene encoding a membrane protein which functions as a transporter of ..
  22. Gros P, Croop J, Housman D. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 1986;47:371-80 pubmed
    The complete nucleotide and primary structure (1276 amino acids) of a full length mdr cDNA capable of conferring a complete multidrug-resistant phenotype is presented...
  23. Jakobsson A. The semistability of centric chromatin bodies during long-term passage of multidrug resistant mouse-Chinese hamster cell hybrids. Anticancer Res. 1988;8:307-12 pubmed
    ..numerous chromatin bodies (CB) were found that contained copies of a high molecular weight P-glycoprotein gene (PGY1) associated with the MDR condition...
  24. Uhr M, Holsboer F, Müller M. Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins. J Neuroendocrinol. 2002;14:753-9 pubmed
    ..We used mice deficient for both murine mdr1a and mdr1b P-gps [mdr1a/1b(-/-)] to determine the uptake of [3H]-cortisol, [3H]-corticosterone, [3H]-aldosterone and [3H]-..
  25. Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, et al. Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002;31:320-5 pubmed
    ..These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs...
  26. Foucaud Vignault M, Soayfane Z, Ménez C, Bertrand Michel J, Martin P, Guillou H, et al. P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice. PLoS ONE. 2011;6:e23614 pubmed publisher
  27. Roy K, Arunasree K, Dhoot A, Aparna R, Reddy G, Vali S, et al. C-Phycocyanin inhibits 2-acetylaminofluorene-induced expression of MDR1 in mouse macrophage cells: ROS mediated pathway determined via combination of experimental and In silico analysis. Arch Biochem Biophys. 2007;459:169-77 pubmed
    ..C-PC), a biliprotein from Spirulina platensis on the 2-acetylaminofluorene (2-AAF)-induced expression of MDR1, encoded by the multidrug resistance (MDR1) gene, in mouse macrophage cell line (RAW 264.7)...
  28. Inui N, Hasegawa H, Suda T, Nakamura Y, Watanabe H, Chida K. Expression and function of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells from aging mice. J Gerontol A Biol Sci Med Sci. 2012;67:1049-55 pubmed publisher
    b>Multidrug resistance protein 1 and multidrug resistance-associated protein 1 are transporters that efflux diverse xenobiotics from cells...
  29. Lecureur V, Thottassery J, Sun D, Schuetz E, Lahti J, Zambetti G, et al. Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo. Oncogene. 2001;20:303-13 pubmed
    The mdr1b gene is thought to be a "stress-responsive" gene, however it is unknown if this gene is regulated by p53 in the whole animal. Moreover, it is unknown if overexpression of mdr1b affects cell survival...
  30. Yu L, Cohen D, Piekarz R, Horwitz S. Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene. J Biol Chem. 1993;268:7520-6 pubmed
    ..2 overexpress the mdr1a and/or mdr1b genes, and overproduce P-glycoprotein...
  31. Zamek Gliszczynski M, Nezasa K, Tian X, Kalvass J, Patel N, Raub T, et al. The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice. Mol Pharmacol. 2006;70:2127-33 pubmed
    ..4MUG), and harmol sulfate (HS) and glucuronide (HG) was studied in Abcc2(-/-), Abcg2(-/-), and Abcb1a(-/-)/Abcb1b(-/-) mouse livers perfused with the respective parent compounds using a cassette dosing approach...
  32. Gavrilova O, Geyer J, Petzinger E. In vivo relevance of Mrp2-mediated biliary excretion of the Amanita mushroom toxin demethylphalloin. Biochim Biophys Acta. 2007;1768:2070-7 pubmed
  33. Mairinger S, Bankstahl J, Kuntner C, Römermann K, Bankstahl M, Wanek T, et al. The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood-brain barrier: a positron emission tomography study. Epilepsy Res. 2012;100:93-103 pubmed publisher
    ..was confirmed in vitro by performing concentration equilibrium transport assay in cell lines transfected with MDR1 or Mdr1a...
  34. Luz J, Wei L, Basu S, Roepe P. Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells. Biochemistry. 1994;33:7239-49 pubmed
    We have used single-cell photometry to measure intracellular pH (pHi) for several MDR cell lines constructed by stably transfecting LR73 chinese hamster ovary fibroblasts with mutant and wild type murine MDR 1 genes...
  35. Mueller C, Wassmann K, Widder J, Wassmann S, Chen C, Keuler B, et al. Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. Circulation. 2008;117:2912-8 pubmed publisher
    ..These findings indicate that MRP1 and LTC(4) exert proatherosclerotic effects and that both MRP1 and LTC(4) are potentially promising targets for atheroprotective therapy. ..
  36. Iwahashi T, Okochi E, Ariyoshi K, Watabe H, Amann E, Mori S, et al. Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model. Cancer Res. 1993;53:5475-82 pubmed
    ..The present results suggest that MRK16 may be useful for in vivo immunoscintigraphy and immunotherapy of multidrug-resistant colorectal carcinoma. ..
  37. Cirrito J, Deane R, Fagan A, Spinner M, Parsadanian M, Finn M, et al. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005;115:3285-90 pubmed
    ..These data establish a direct link between Pgp and Abeta metabolism in vivo and suggest that Pgp activity at the BBB could affect risk for developing AD as well as provide a novel diagnostic and therapeutic target. ..
  38. Yamada T, Mori Y, Hayashi R, Takada M, Ino Y, Naishiro Y, et al. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res. 2003;63:895-901 pubmed
    ..The human multidrug resistance (MDR)1 (ABCB1) gene contains multiple beta-catenin-T-cell factor4-binding elements in its promoter and is one of the immediate ..
  39. Chianale J, Vollrath V, Wielandt A, Miranda S, Gonzalez R, Fresno A, et al. Differences between nuclear run-off and mRNA levels for multidrug resistance gene expression in the cephalocaudal axis of the mouse intestine. Biochim Biophys Acta. 1995;1264:369-76 pubmed
    ..These results indicate that enterocytes of the ileum may be more actively involved in the P-glycoprotein-mediated transport of xenobiotics into the intestinal lumen. ..
  40. Goffinet A, Dernoncourt C. Localization of the reeler gene relative to flanking loci on mouse chromosome 5. Mamm Genome. 1991;1:100-3 pubmed
    ..Together with recently published evidence (Martin et al. 1989), our data suggest the following order: Cen-rl/Pgy-1-T31H-En-2. ..
  41. Goffinet A. The reeler gene: a clue to brain development and evolution. Int J Dev Biol. 1992;36:101-7 pubmed
    ..The characterization and thus the cloning of the reeler gene is therefore important for our understanding of brain development. Recent data on the fine chromosomal mapping of the mutation prior to its positional cloning are reported. ..
  42. Lin F, de Gooijer M, Roig E, Buil L, Christner S, Beumer J, et al. ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy. Clin Cancer Res. 2014;20:2703-13 pubmed publisher
    ..We have elucidated important factors controlling ABT-888 efficacy in glioblastoma...
  43. Muller M, Keck M, Binder E, Kresse A, Hagemeyer T, Landgraf R, et al. ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology. 2003;28:1991-9 pubmed
    Multidrug-resistance gene 1-type P-glycoproteins (ABCB1-type P-gps) protect the brain against the accumulation of many toxic xenobiotics and drugs...
  44. Breedveld P, Pluim D, Cipriani G, Wielinga P, van Tellingen O, Schinkel A, et al. The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib i. Cancer Res. 2005;65:2577-82 pubmed
    ..Imatinib is transported in vitro and in vivo by P-glycoprotein (P-gp; ABCB1), which thereby limits its distribution into the brain in mice...
  45. Ma L, Wei S, Yang B, Ma W, Wu X, Ji H, et al. Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine. Pharm Biol. 2017;55:374-380 pubmed
    ..The drugs were administrated intragastrically for seven consecutive days. MDR1 and P-gp expression levels in mice small intestine were examined by performing RT-PCR and western blot analysis...
  46. Pichler A, Prior J, Piwnica Worms D. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A. 2004;101:1702-7 pubmed
    ..analogues share structural and physiochemical properties of compounds transported by the multidrug resistance MDR1 P-glycoprotein (Pgp)...
  47. Kirkinezos I, Hernandez D, Bradley W, Moraes C. An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment. J Neurochem. 2004;88:821-6 pubmed
    ..These results demonstrate the usefulness of this combined mouse model for the testing of potentially therapeutic drugs and support the role of mitochondrial-mediated apoptosis in the pathway to motor neuron death in SOD1-associated ALS. ..
  48. Ernest S, Bello Reuss E. Expression and function of P-glycoprotein in a mouse kidney cell line. Am J Physiol. 1995;269:C323-33 pubmed
    ..Northern blot analysis demonstrated a 5.0-kb message identified as mdr1 by ribonuclease protection assay. Cyclosporin A (CSA) at 0...
  49. Trezise A, Ratcliff R, Hawkins T, Evans M, Freeman T, Romano P, et al. Co-ordinate regulation of the cystic fibrosis and multidrug resistance genes in cystic fibrosis knockout mice. Hum Mol Genet. 1997;6:527-37 pubmed
    The cystic fibrosis (Cftr and multidrug resistance (Mdr1) genes encode structurally similar proteins which are members of the ABC transporter superfamily...
  50. Croop J, Raymond M, Haber D, Devault A, Arceci R, Gros P, et al. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol. 1989;9:1346-50 pubmed
    The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse...
  51. Gros P, Croop J, Roninson I, Varshavsky A, Housman D. Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A. 1986;83:337-41 pubmed
    ..Our results strongly suggest that the 5-kb mRNA species plays a role in the mechanism of multidrug resistance common to the LZ and C5 cell lines. ..
  52. Tsuruoka S, Sugimoto K, Fujimura A, Imai M, Asano Y, Muto S. Protein kinase C and phosphatidylinositol 3-kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule. Pflugers Arch. 2001;442:321-8 pubmed
    ..WT mice) has the capacity for P-glycoprotein- (P-gp-) mediated drug efflux, whereas mice in which both mdr1a and mdr1b genes are disrupted (KO mice) do not...
  53. Kannan P, Brimacombe K, Kreisl W, Liow J, Zoghbi S, Telu S, et al. Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET. Proc Natl Acad Sci U S A. 2011;108:2593-8 pubmed publisher
    ..In summary, tariquidar and [(11)C]dLop can be used in combination to selectively measure the function of P-gp at the blood-brain barrier. ..
  54. Cho H, Yoo H, Lee Y. Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of levosulpiride in healthy subjects. Neuroscience. 2010;169:378-87 pubmed publisher
    ..in knockout mice that lack the Abcb1a/ 1b gene, and to evaluate the relationship between genetic polymorphisms in ABCB1 (exon 12, 21 and 26) and levosulpiride disposition in healthy subjects...
  55. Zhou S, Morris J, Barnes Y, Lan L, Schuetz J, Sorrentino B. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A. 2002;99:12339-44 pubmed
    ..These results show that Bcrp1 gene expression alone defines the SP stem cell phenotype, and suggest that the physiological function of Bcrp1 expression in HSCs is to provide protection from cytotoxic substrates...
  56. Tosi P, Radu D, Nicolau C. Immune response against the murine mdri protein induced by vaccination with synthetic lipopeptides in liposomes. Biochem Biophys Res Commun. 1995;212:494-500 pubmed
    ..cells overexpress a class of high molecular weight membrane glycoproteins associated with the multidrug resistance (mdr) of these cells...
  57. Hsu S, Cohen D, Kirschner L, Lothstein L, Hartstein M, Horwitz S. Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells. Mol Cell Biol. 1990;10:3596-606 pubmed
    ..reflects the amplification or transcriptional activation or both of two mdr gene family members, mdr1a and mdr1b. The mdr1a gene is a complex transcriptional unit whose expression is associated with multiple transcript sizes...
  58. Mittapalli R, Vaidhyanathan S, Sane R, Elmquist W. Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032). J Pharmacol Exp Ther. 2012;342:33-40 pubmed publisher
    ..This finding has important clinical significance given the ongoing trials examining the efficacy of vemurafenib in brain metastases of melanoma...
  59. de Vries N, Buckle T, Zhao J, Beijnen J, Schellens J, van Tellingen O. Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP. Invest New Drugs. 2012;30:443-9 pubmed publisher
    ..As erlotinib is a known substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) we have investigated the effect of these ABC-transporters on the brain penetration of erlotinib...
  60. Borst P, Schinkel A. What have we learnt thus far from mice with disrupted P-glycoprotein genes?. Eur J Cancer. 1996;32A:985-90 pubmed
  61. Zhang G, Fu X, Takeda T, Higuchi K, Mori M. Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains. Exp Anim. 2009;58:421-5 pubmed
    Genetic alterations in the gene for ATP-binding cassette, sub-family B (MDR/TAP), member 1A (ABCB1A) determine susceptibility to colitis in mice and humans...
  62. Song R, Ikeguchi M, Zhou G, Kuo M. Identification and characterization of a hepatoma cell-specific enhancer in the mouse multidrug resistance mdr1b promoter. J Biol Chem. 1995;270:25468-74 pubmed
    The expression of multidrug resistance/P-glycoprotein genes mdr1b(mdr1) and mdr1a(mdr3) is elevated during hepatocarcinogenesis...
  63. Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y. Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model. Diabetes. 2001;50:1943-8 pubmed
    ..However, there appear to be common genes contributing to different disease phenotypes. There are potentially important candidate genes that may be relevant to the disease. ..
  64. Oude Elferink R, Ottenhoff R, van Wijland M, Smit J, Schinkel A, Groen A. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest. 1995;95:31-8 pubmed
    ..Increased bile flow in (-/-) mice could be attributed completely to an increase in the bile salt-independent fraction and may therefore be caused by the bile duct proliferation in these mice. ..
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    Multidrug resistance-associated protein 4 (ABCC4) shares many features with P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2), including broad substrate affinity and expression at the blood-brain barrier (BBB)...
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    Expression of P-glycoprotein, encoded by the human MDR1 gene, results in cross-resistance to many lipophilic cytotoxic drugs (multidrug resistance)...
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